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Thomas Jefferson University - Olga Igoucheva
Olga Igoucheva

Dermatology and Cutaneous Biology
Thomas Jefferson University
Jefferson Medical College
Department of Dermatology & Cutaneous Biology
Assistant Professor
Mailing Address
233 South 10th street, BLSB, Rm. 326
Philadelphia, Pennsylvania 19107-5541
United States
Contact Information
Phone: (215) 503-4835
Fax: (215) 503-5788
Olga.Igoucheva@jefferson.edu
Keywords
cDNA Microarrays; DNA Repair; Gene Correction; Gene Therapy; Oligodeoxynucleotides; Rna-Dna Oligonucleotides; Transcription
Publications
  • Igoucheva, O.A., Peritz, A.E., Levy, D., and Yoon, K. A sequence-specific gene correction by an RNA-DNA oligonucleotide in mammalian cells characterized by trancfection and nuclear extract using a LacZ shuttle system. Gene Therapy, 6, 1960-1971, 1999.
  • Alexeev, V., Igoucheva, O., Domashenko, A., Cotsarelis, G., and Yoon, K. Localized
  • In vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide. Nature Biotechnology, 18, 43-47, 2000.
  • Igoucheva, O. and Yoon K. Improvement of RNA-DNA oligonucleotide design by using mammalian nuclear extracts. Gene Therapy and Regulation, 1, 165-175, 2000.
  • Igoucheva, O., Alexeev, V. and Yoon, K. Targeted gene correction by small single-stranded oligonucleotides in mammalian cells. Gene Therapy, 8, 391-399, 2001.
  • Igoucheva. O., Alexeev, V. and Yoon, K. Nuclear extracts promote gene correction and strand pairing of oligonucleotide to the homologous plasmid, Antisense and Nucleic Acid Drug Development, 12, 235-246, 2002.
  • Alexeev, V., Igoucheva, O. and Yoon, K. Simultaneous targeted alteration of the
  • tyrosinase and C-kit genes by single-stranded oligonucleotides. Gene Therapy, 9, 1667-1675, 2002.
  • Pierce E.A., Liu Q., Igoucheva O., Omarrudin R., Ma H.C., Diamond S. and Yoon K. Oligonucleotide-directed single base DNA alterations in mouse embryonic stem cells. Gene Therapy, 10, 24-33, 2003.
  • Igoucheva, O., Alexeev, V., Pryce, M. and Yoon, K. Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration. Nucleic Acids Research, 31, 2659-2670, 2003.
  • Reviews, Book Chapters:
  • Igoucheva, O. and Yoon K. Targeted single-base correction by RNA-DNA oligonucleotides. Human Gene Therapy, 11, 2307-2312, 2000.
  • Igoucheva, O. and Yoon, K. "Methods for determining gene correction frequency by chimeric RNA-DNA oligonucleotide using nuclear extracts". Gene Therapy Protocols, Methods in Molecular Medicine, ed., Morgan, J.R. Humana Press, pp 95-108, 2001.
  • Yoon, K., Igoucheva, O. and Alexeev V. Expectations and reality in gene repair.
  • Nature Biotechnology, 20, 1197-1198, 2002.
  • Yoon, K., Alexeev, V. and Igoucheva, O. Biased gene repair needs unbiased review.
  • Correspondence in Nature Review Genetics, 4, 279-689, 2003.
  • Igoucheva, O. and Yoon, K. Gene targeting by oligonucleotides in keratinocytes. Epidermal Cell Protocols, ed. Turksen, K. Humana Press, 2004.
  • Igoucheva. O., Alexeev, V. and Yoon, K. Site-directed mutagenesis and targeted gene correction. Current Molecular Medicine, 4, 445-463, 2004.
  • Igoucheva, O., Alexeev, V. and Yoon, K. Mechanism of gene repair open for
  • discussion. Oligonucleotides (in press) 2004.
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View COS profile: http://myprofile.cos.com/igoucheva

Individual Expertise profile of Olga Igoucheva, Copyright © Olga Igoucheva.
Last Updated by Olga Igoucheva : Wednesday, April 19, 2006 2:31:42 PM



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