Thomas Jefferson University - Reza F. Ghohestani
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Reza F. Ghohestani
Dermatology and Cutaneous Biology
Thomas Jefferson University
Jefferson Medical College
Department of Dermatology & Cutaneous Biology
Jefferson Institute of Molecular Medicine
Associate professor and Director, Immunodermatology Unit
Faculty Since 1998
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Mailing Address
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233 S 10th Street
Philadelphia, Pennsylvania 19107
United States
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Qualifications
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M.D., Medicine, Shiraz University
M.Sc., Immunology & Immunopathology, CLaude Bernard University
Master (DEA), Cutaneous Biology, Cosmetology & Pharmacology, University of Paris VII &Claude Bernard University
Ph.D., Cutaneous Biology & Immunology, CLaude Bernard University
Internship, General Surgery, University of Pennsylvania Health System
Residency, Dermatology, Thomas Jefferson University
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Expertise and Research Interests
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Subjects of interest:
1. Extracellular matrix and their role in autoimmune skin diseases, skin ageing, and wound healing.
2. Autoimmune blistering skin diseases: Characterization of target molecules, Development of animal models, and Immunotherapy
Dr. Ghohestani is both a molecular biologist and immuno-dermatologist whose expertise in identification and molecular characterization of dermal-epidermal proteins has broadened our understanding of the underlying molecular defects in blistering skin disorders. He has recently identified a novel autoimmune disease characterized by glomerulonephritis and skin blisters with IgG autoantibodies to a5 chain of type IV collagen. His group was the first to identify a subest of linear IgA disease with autoantibodies to the 180 and 230 kDa bullous pemphigoid antigens.
He continues to study novel target antigens in autoimmune skin diseases, including laminin-5 and a novel 168-kD antigen implicated in the pathogenesis of cicatricial pemphigoid as well the dermatitis herpetiformis autoantigen.
Dr. Ghohestani's group is developing in vivo mouse models for blistering skin diseases in order to obtain a better insight about the pathogenesis of these devastating dermatoses.
Specifically, his interests center on:
1. Molecular characterization of target antigens in autoimmune blistering skin diseases
2. Development of in vivo models of blistering skin diseases by DNA immunization
3. Immunotherapy of autoimmune skin diseases
4. Role of cell/matrix molecules in wound healing
5. Effect of cutaneous ageing and UV exposure on expression of extracellular matrix molecules
Dr. Ghohestani's works were presented in more than 110 national and international meetings. He has received several national and international awards and fellowships including:
- R.TOURAINE Foundation for Dermatological Research Fellowship, St. Louis Hospital, Paris
- Charles GRUPPER-French Society of Dermatology 1st Prize in Dermatological Research, Paris
- Regional UNESCO-Kharazmi International Research Prize in Medical Research,
- French Foundation for Medical Research Fellowship (Fondation pour la Recherche Medicale), Paris
- International Ligue of Dermatological Societies Fellowship, Sydney
- French Foundation (Foundation de France) Award in Medical Research, Paris
- European Academy of Dermatology and Venereology/Yamanouchi Research Fellowship Award, Dublin
- Research Scientist Career Development Award, American Skin Association, New York
- Robert Degos Award for Best Publication in Dermatology Research, French Society of Dermatology, Paris
- American Association of Immunologists Junior Faculty Award, New Orleans
- Stelwagon Award for Best Publication in Dermatology Research, College of Physicians of Philadelphia
- Johnson Award for Dermatology Research, College of Physicians of Philadelphia
- Commitment to Professional Competence, Pennsylvania Medical Society, Hershey, PA
- Physician-Scientist Career Award, Dermatology Foundation, San Francisco
- Johnson-Beerman Award, College of Physicians of Philadelphia, PA
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Industrial Relevance
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Characterization of key cell/matrix adhesion molecules implicated in wound healing, skin ageing, cancer.
Novel markers of skin ageing
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Keywords
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Autoimmune Skin Disease; Cell Adhesion; Cicatricial; Dermatitis Herpetiformis; Immunodermatology; Pemphigoid; Pemphigus; Wound Healing; Laminin; Collagen; Blister; Wrinkle; Ageing
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Publications
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- Selected from 36 peer reviewed papers
- 1: Metz BJ, Ruggeri SY, Hsu S, Reed JA, Ghohestani AS, Uitto J, Ghohestani RF.Linear IgA dermatosis with IgA and IgG autoantibodies to the 180 kDa bullous pemphigoid antigen (BP180): evidence for a distinct subtype.Int J Dermatol. 2004 Jun;43(6):443-6.
- 2: Hisamatsu Y, Nishiyama T, Amano S, Matsui C, Ghohestani R, Hashimoto T. Usefulness of immunoblotting using purified laminin 5 in the diagnosis of anti-laminin 5 cicatricial pemphigoid. J Dermatol Sci. 2003 Nov;33(2):113-9.
- 3: Ghohestani RF, Rotunda SL, Hudson B, Gaughan WJ, Farber JL, Webster G, Uitto J. Crescentic glomerulonephritis and subepidermal blisters with autoantibodies to alpha5 and alpha6 chains of type IV collagen.Lab Invest. 2003 May;83(5):605-11.
- 4: Olivry T, Joubeh S, Dunston SM, Nishiyama T, Ghohestani RF. Desmoglein-3 is a target autoantigen in spontaneous canine pemphigus vulgaris.Exp Dermatol. 2003 Apr;12(2):198-203.
- 5: Olivry T, Dunston SM, Zhang G, Ghohestani RF.Laminin-5 is targeted by autoantibodies in feline mucous membrane (cicatricial)pemphigoid. Vet Immunol Immunopathol. 2002 Sep 25;88(3-4):123-9.
- 6: Chan LS, Ahmed AR, Anhalt GJ, Bernauer W, Cooper KD, Elder MJ, Fine JD,Foster CS, Ghohestani R, Hashimoto T, et al.The first international consensus on mucous membrane pemphigoid: definition,diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators.Arch Dermatol. 2002 Mar;138(3):370-9. Review.
- 7: Ghohestani RF, Novotney J, Chaudhary M, Agah RS.Bullous pemphigoid: from the bedside to the research laboratory. Clin Dermatol. 2001 Nov-Dec;19(6):690-6. Review.
- 8: Debenedictis C, Joubeh S, Zhang G, Barria M, Ghohestani RF.Immune functions of the skin.Clin Dermatol. 2001 Sep-Oct;19(5):573-85.Review.
- 9: Ghohestani RF, Li K, Rousselle P, Uitto J.Molecular organization of the cutaneous basement membrane zone.Clin Dermatol. 2001 Sep-Oct;19(5):551-62.Review.
- 10: Olivry T, Alhaidari Z, Ghohestani RF.Anti-plakin and desmoglein autoantibodies in a dog with pemphigus vulgaris.Vet Pathol. 2000 Sep;37(5):496-9.
- 11: Cozzani E, Cacciapuoti M, Parodi A,Ghohestani R, Rebora A.Desmosomes and their autoimmune pathologies.Eur J Dermatol. 2000 Jun;10(4):255-61. Review.
- 12: Ghohestani RF, Hudson BG, Claudy A, Uitto J.The alpha 5 chain of type IV collagen is the target of IgG autoantibodies in a novel autoimmune disease with subepidermal blisters and renal insufficiency.J Biol Chem. 2000 May 26;275(21):16002-6.
- 13: Hsu S, Ghohestani RF, Uitto J.Lichen planus pemphigoides with IgG autoantibodies to the 180 kd bullous pemphigoid antigen (type XVII collagen).J Am Acad Dermatol. 2000 Jan;42(1 Pt 1):136-41.
- 14: Swensson O, Stuber E, Nickel T, Sticherling M, Ghohestani RF, Nitsche R,Christophers E. Linear IgA disease associated with lymphocytic colitis.Br J Dermatol. 1999 Feb;140(2):317-21.
- 15: Ghohestani RF, Cozzani E, Delaporte E, Nicolas JF, Parodi A, Claudy A.IgE antibodies in sera from patients with bullous pemphigoid are autoantibodies preferentially directed against the 230-kDa epidermal antigen (BP230). J Clin Immunol. 1998 May;18(3):202-9. Erratum in: J Clin Immunol 1998 Nov;18(6):441.
- 16: Ghohestani R, Joly P, Gilbert D, Nicolas JF, Thomine E, Cozzani E, Lauret PH, Claudy A, Tron F. Autoantibody formation against a 190-kDa antigen of the desmosomal plaque in pemphigus foliaceus. Br J Dermatol. 1997 Nov;137(5):774-9.
- 17: Ghohestani RF, Nicolas JF, Rousselle P, Claudy AL. Diagnostic value of indirect immunofluorescence on sodium chloride-split skin
- in differential diagnosis of subepidermal autoimmune bullous dermatoses. Arch Dermatol. 1997 Sep;133(9):1102-7.
- 18: Ghohestani RF, Claudy A.Immunofluorescence-negative bullous pemphigoid sera contain antibodies mostly directed against the 180 kDa bullous pemphigoid antigen (BPAg2)Br J Dermatol. 1997 Aug;137(2):306-7.
- 19: Ghohestani RF, Nicolas JF, Kanitakis J, Claudy A.Linear IgA bullous dermatosis with IgA antibodies exclusively directed against the 180- or 230-kDa epidermal antigens. J Invest Dermatol. 1997 Jun;108(6):854-8.
- 20: Joly P, Gilbert D, Thomine E, Zitouni M, Ghohestani R, Delpech A, Lauret P,Tron F. Identification of a new antibody population directed against a desmosomal plaque antigen in pemphigus vulgaris and pemphigus foliaceus. J Invest Dermatol. 1997 Apr;108(4):469-75.
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Individual Expertise profile of
Reza F. Ghohestani, Copyright © Reza F. Ghohestani.
Last Updated
by Reza Ghohestani : Thursday, February 22, 2007 6:13:22 PM
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