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Thomas Jefferson University - Vitali Y. Alexeev
Vitali Y. Alexeev

Dermatology and Cutaneous Biology
Thomas Jefferson University
Jefferson Medical College
Department of Dermatology & Cutaneous Biology
Assistant Professor
Mailing Address
233 South 10th Street, BLSB, Rm 430
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: (215) 503-4835
vitali.vlexeev@jefferson.edu
Qualifications
Ph.D. Cell Biology, Institute of Cytology, Russian Academy of Science, 1996
Expertise and Research Interests
In physiological conditions, a complex network of cell-cell communications, cytokines and chemokines tightly control cutaneous melanocytes. In pathological conditions, genetic and environmental factors disturb this delicate homeostasis. The imbalance of the network may alter the fate of the cutaneous melanocytes to the uncontrolled cell proliferation associated with melanoma, or to the elimination of the pigment-producing cells via apoptosis, or autoimmune destruction associated with vitiligo. My research interests are in the understanding of the molecular events that drive these opposing processes.
Keywords
Ckit Receptor; Lymphatic Endothelium; Melanocytes; Melanoma; Vitiligo
Publications
  • Selected publications (chronological order).

  • 1. Alexeev V. and Yoon K. Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide. Nature Biotechnology, 1998, 16 :1343-13465.

  • 2. Alexeev V, Igoucheva O, Domashenko A, Cotsarelis G, and Yoon K. Localized in vivo genotypic and phenotypic correction of albino mutation in skin using RNA-DNA oligonucleotide. Nature Biotechnology, 2000, 18 :43-47.

  • 3. Alexeev V and Yoon K. Gene correction by RNA-DNA oligonucleotides. Pigment Cell Research, 2000, 13(2) : 72-79.

  • 4. Igoucheva O, Alexeev V and Yoon K. Targeted gene correction by small single-stranded oligonucleotides in mammalian cells. Gene Therapy, 2001, 8 :391-399.

  • 5. Igoucheva O, Alexeev V and Yoon K. Nuclear extracts promote gene correction and strand pairing of oligonucleotides to the homologous plasmid. Antisense and Nucl. Acid Drug Develop., 2002, 12: 235-246.

  • 6. Alexeev V, Igoucheva O and Yoon K. Simultaneous targeted alteration of the tyrosinase and c-kit genes by single-stranded oligonucleotides. Gene Therapy, 2002, 9: 1667-1675.

  • 7. Alexeev V, Igoucheva O and Yoon K. Simultaneous targeted alteration of the tyrosinase and c-kit genes by single-stranded oligonucleotides. Gene Therapy, 2002, 9: 1667-1675.

  • 8. Igoucheva O, Alexeev V, Pryce M and Yoon K. Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration. Nucl. Acid Res. 2003, 10:2659-2670.

  • 9. Igoucheva O, Alexeev V and Yoon K. Oligonucleotide-directed mutagenesis and targeted gene correction: a mechanistic point of view. Curr. Mol. Med. 2004, 4:445-463.

  • Cesarone G., Garofalo C, Abrams M, Igoucheva O, 10. Alexeev V, Yoon K, Surmacz E, and Wickstrom EJ. RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells. Cell Biol. 2006, 98 (2):440-450.

  • 11. Igoucheva O, Alexeev V and Yoon K. Differential cellular responses to exogenous DNA in mammalian cells and its affect on oligonucleotide directed gene modification. Gene therapy, 2006, 13, 266-275.

  • 12. Igoucheva O, Alexeev V and Yoon, K. Involvement of ERCC1/XPF and XPG in Oligodeoxynucleotide-Directed Gene Modification. Oligonucleotide, 2006, 16 (1):94-104.

  • 13. Alexeev V, Yoon K. Distinctive role of the cKit receptor tyrosine kinase in mammalian melanocytes. J. Invest. Dermatol. 2006, 126 (5):1102-1110

  • 14. Novak L., Igoucheva O, Cho S, and Alexeev V. Characterization of the CCL21-mediated melanoma-specific immune responses and in situ melanoma eradication. Molecular Cancer Therapeutics, 2007, 6 (6): 1755-1764.

  • 15. Igoucheva O, Kelly A., Uitto J, and Alexeev V. Protein therapeutics for junctional epidermolysis bullosa, J. Invest. Dermatol. 2008, 126(6): 1476-1486.

  • 16. Flagler K, Alexeev V, Pierce EA, Igoucheva O. Site-specific gene modification by oligodeoxynucleotides in mouse bone marrow-derived mesenchymal stem cells. Gene therapy 2008; 15(14):1035-48.

  • 17. Igoucheva O, and Alexeev V, MicroRNA-dependent regulation of cKit in cutaneous melanoma. Biochem Biophys Res Commun (2009).

  • 18. Terai M, Tamura Y, Alexeev V, Ohtsuka E, Berd D, Mastrangelo MJ, and Sato T, Human interleukin 10 receptor 1/IgG1-Fc fusion proteins: immunoadhesins for human IL-10 with therapeutic potential. Cancer Immunol Immunother (2009).

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View COS profile: http://myprofile.cos.com/alexeev

Individual Expertise profile of Vitali Y. Alexeev, Copyright © Vitali Y. Alexeev.
Last Updated by Vitali Alexeev : Saturday, February 7, 2009 10:51:31 AM


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