Thomas Jefferson University - Bonita Falkner
|
|
Bonita Falkner
Medicine
Thomas Jefferson University
Jefferson Medical College
Department of Medicine
Division of Nephrology
Professor Appointed: 2000
|
|
|
|
|
Mailing Address
|
Division of Nephrology
Philadelphia, Pennsylvania 19107
United States
|
|
 |
|
|
Qualifications
|
Specialty Board Certifications
June 1972 American Board of Pediatrics
October 1974 American Board of Pediatrics, Nephrology
Education
1960-63 Premedical: University of Minnesota, B.A.
1963-67 Medical: University of Minnesota, M.D.
1967-68 Internship: Philadelphia General Hospital, Medicine - Pediatrics
1968-70 Residency: Philadelphia General Hospital, Pediatrics
1970-71 Fellowship: Jefferson University,
Department of Medicine Division of Nephrology
Medical Licensure
Pennsylvania
Minnesota
New Jersey
|
|
|
Other Expertise
|
Present Academic and Hospital Appointments
Academic
2000 - present Thomas Jefferson University
Professor of Medicine and Pediatrics with tenure
Hospital
2000 - present Thomas Jefferson University Hospital
1993 - 2005 Bryn Mawr Hospital
OTHER PROFESSIONAL ACTIVITIES
1981-1984 Behavioral Medicine Study Section, NIH
1983-1984 Joint National Committee on Detection, Evaluation and Treatment of Hypertension III
1985-1987 Task Force on Hypertension in Children, NHLBI
1985 Board of Directors, Health Promotion Council of Southeastern Pennsylvania
1984-1988 Committee on Atherosclerosis and Hypertension in Childhood, American Heart Association, (Chairman, 1986 1988)
1986-1988 Executive Committee, Council on Cardiovascular Diseases in the Young; American Heart Association
1986-1990 Arteriosclerosis, Hypertension, and Lipid Metabolism Advisory Committee, NHLBI-NIH
1990-1991 Hypertension Task Force, NHLBI
1991-1992 Joint National Committee on Detection, Evaluation and Treatment of Hypertension V
1993-1994 Working Group on Hypertension in Diabetes, NHLBI
1993-1994 External Advisory Committee for the African-American Study of Kidney Disease and Hypertension (AASK) NIDDK
1994-1996 Medical Health Advisory Board: Society for Advancement of Research in Women's Health
1994-1995 Working Group on Hypertension in Childhood, NHLBI: Chair
1995-1999 Cardiovascular-Renal Study Section, NIH
1996-1997 Joint National Committee for detection, Evaluation and Treatment of Hypertension VI
1996-1998 Taskforce on Women's Health Research- OWHR/NIH
2002-2004 Working Group on Hypertension in Childhood. NHLBI:NHBPEP Chair
2005-2008 Clinical and Integrative Cardiovascular Sciences Study Section. NIH
2006-2009 Sixth Framework Program: Networks of Excellence. European Commission Project Reviewer
EDITORIAL ACTIVITIES
Editorial Board
Annals of Behavioral Medicine
Hypertension
Journal of Clinical Hypertension
Ethnicity & Disease
Journal of the CardioMetabolic Syndrome
Therapeutic Advances in Cardiovascular Disease
Journal of the American Society of Hypertension
The Medical Roundtable
RESEARCH GRANTS
Recent Sponsored Funding - Principal Investigator
2001-06 Androgens and Cardiovascular Risk in African Americans 2 RO1 HL051547 (NIH/NHLBI)
(Direct Costs $1,000,000;total costs $1,590,000)
2003-08 TGF-Beta, Glucose and Nephropathy in African American 2 RO1 DK46107(NIH/NIDDK)
(Direct Costs $1,000,000;total costs $1,570,000)
2004-2006 Effect of Toporol XL on Insulin Sensitivity in Hypertensive Patients
Astra-Zeneca (Total costs: $462,000)
2005-2007 Genomic Polymorphisms of Hypertension in African Americans W.W. Smith Charitable Trust
(Total costs: $200,000)
2006-2010 Adipokines and Genotypes: Injury vs Protection in Obesity Related Comorbidity.
Center of Excellence in Research on Obesity.
Pennsylvania Department of Public Health
(Total costs: $4,159,000)
2009-2011 Inflammation and Injury in Obesity Hypertension in African American Adolescents.
1 RO1 HL092030-01A1 (NIH/NHLBI)
(Total costs: $1,418,900)
Recent Sponsored Funding - Co-Investigator
2002-2004 Pirfenidone: A Novel Anti-Scarring Therapy for Diabetic Nephropathy 1 RO1 DK63017 (NIH/NIDDK0 PI: Kumar Sharma Co-investigator: B. Falkner(Direct Costs $500,000: total costs $782,000)
2006-2010 Efficacy of Web-based Feedback to Improve Blood Pressure Control PI: Sciamanna
Co-Investigator: Falkner (10%)1 RO1 HL083432-01
(Total costs: $2,071,034)
2004-2009 Vascular Alterations in the Prediabetic Conditition 1 K23 HL072825 (NIH/NHLBI)PI: Cynthia Cheng Mentor: B. Falkner
(Direct Costs: $719,059: total costs:$775,785)
2004-2009 Neurocognitive Function in Children with Hypertension K23 HL080068 (NIH/NHLBI)
PI: Marc Lande Mentor: B. Falkner
2011-2015 Impact of Adipokines and Insulin Resistance on Progression of Prehypertension.
PI: C. Cheng Co-Investigagor. B. Falkner (10%)
1RO1 HL096593 (Direct Costs $1,000,000. total costs $1,549,800)
|
|
|
Publications
|
- Stein E, Kushner H, Gidding S, Falkner B. Plasma Lipid Concentrations in Non-Diabetic, African American Adults: Associations with Insulin Resistance and the Metabolic Syndrome. Metabolism 56:954-960, 2007
- Boyd-Woschinko G, Kushner H, Falkner B. Androgen Excess is Associated with Insulin resistance and the Development of Diabetes in African American Women. J. of CardioMetabolic Syndrome 2:254-259, 2007
- Falkner B, Kushner H. Treatment with Metoprolol Succinate, a Selective Beta Adrenergic Blocker Lowers Blood Pressure Without Altering Insulin Sensitivity in Diabetic Patients. J of Clinical Hypertension 10:51-57, 2008
- Rosner B, Cook N, Portman R, Daniels S, Falkner B. Determination of Blood Pressure Percentiles in Normal Weight Children: Some methodological Issues. Am. J of Epidemiology 167:653-666, 2008
- Falkner B, Gidding SS, Portman R, Rosner B. Blood pressure variability and classification of prehypertension and hypertension in adolescence. Pediatrics 122:243-249, 2008
- Cheng C, Diamond JJ, Falkner B. Functional capillary rarefaction in mild blood pressure elevation. Clinical and Translational Science 1:75-79, 2008
- Cheng C, Daskalakis C, Falkner B. Capillary rarefaction in treated and untreated hypertensive subjects. Therapeutic Advances in Cardiovascular Disease 2:79-88, 2008
- Falkner B. Children and Adolescents with Obesity Associated Hypertension. J of the American Society of Hypertension 2:267-274, 2008
- Sharma K, Ramachandra S, Qiu G, Usui HK, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, Falkner B, Goldstein BJ. Adiponectin regulates albuminuria and podocyte function in mice. Journal of Clinical Investigation. 118(5):1645-1656, 2008
- Specchia C, Scott K, Fortina P, Devoto M, Falkner B. Association of a polymorphic variant of the adiponectin gene with insulin resistance in African Americans. Clinical and Translational Science 1:194-199, 2008
- Lande MB, Adams H, Falkner B, Waldstein SR, Schwartz GJ, Szilagyi PG, Wang H, Palumbo D. Parental assessments of internalizing and externalizing behavior and executive function in children with primary hypertension. J of Pediatrics 154:207-212, 2009
- Whincup PH, Kaye SJ, Owen CG, Huxley R, Cook DG, Anazawa S, Barrett-Connor E, Bhargava SK, Birgisdottir B, Carlsson S, DeRooij S, Dyck R, Erisksson JG, Falkner B, Fall C, Forsen T, Grill V, Gudnason V, Hulman S, Hypponen E, Jeffreys M, Lawlor D, Leon D, Mi J, Minami J, Mishra G, Osmond C, Power C, Rich-Edwards J, Roseboom TJ, Sachdev H PS, Suzuki T, Syddall H, Thorsdottir I, Vanhala M, Wadsworth M, Yarbrough DE. Birthweight and risk of type 2 diabetes: a quantitative systematic review of published evidence. JAMA 300 (24): 2886-2897, 2008
- Huan Y, Kushner H, Falkner B. Insulin resistance predicts deterioration in glucose tolerance in non-diabetic young African Americans. Metabolism Clinical and Experimental 58:689-695, 2009
- Cohn HI, Xi Y, Pesant S, Harris D, Hyslop T, Lo S, Backus J, Falkner B, Eckhart AD. G protein-coupled receptor kinase 2 (GRK2) expression and activity is associated with blood pressure in black Americans. Hypertension 54:71-83, 2009
- Rosner B, Cook N, Portman R, Daniels S, Falkner B. Blood pressure differences by ethnic group among US children and adolescents. Hypertension 54:502-508, 2009
- Falkner B, Lurbe E, Schaefer F. High blood pressure in children: Need for improved identification, management and health policy. J of Clinical Hypertension 12:261-276, 2010
- Cheng C, Daskalakis C, Falkner B. Association of capillary density and function measures with blood pressure, fasting plasma glucose and insulin sensitivity. J of CardioMetabolic Syndrome 12:125-135, 2010.
- Lande MB, Adams H, Falkner B, Waldstein SR, Schwartz GJ, Szilagyi PG, Wang H, Palumbo D. Parental Assessment of Executive Function and Internalizing and Externalizing Behavior in
- Primary Hypertension after Antihypertensive Therapy. J. of Pediatrics 157:114-119, 2010
- Huan Y, DeLoach S, Daskalakis C, Dunn SR, Sharma K, Falkner B. Regulation of TGF-B1 by Insulin in Pre-Diabetic African Americans. Kidney International 78:318-324. 2010
- Ussai KE, Keith SW, Pequignot E, Falkner B. Risk Factors Associated with Urinary albumin excretion in African Americans. Journal of Human Hypertension (25)1:3-10, 2011 (first published online July 2010 www.nature.com/doifinder/10.1038/jhh.2010.79 )
- Thiboutot, J., Stuckey, H., Binette, A., Kephart, D., Curry, W., Falkner, B., Sciamanna C. A web-based patient activation intervention to improve hypertension care: Study design and baseline characteristics in the web hypertension study. Contemporary Clinical Trials, 31(6):634-646, 2010
- Cheng C, Daskalakis C, Falkner B. Alterations in Capillary Morphology Are Found in Mild Blood Pressure Elevation. J of Hypertension 28:2258-2266, 2010
- DeLoach S, Huan Y, Daskalakis C, Falkner B. Endothelin-1 Response to Glucose and Insulin Among African Americans. J. Am Soc. Hypertens 4:227-235, 2010
- Cui J, Wu XD, Andrel J, Falkner B. Relationships of total adiponectin and molecular weight fractions of adiponectin with free testosterone in African men and premenopausal women. J of Clinical Hypertension 12:957-963, 2010
- Martinez Cantarin MP, Ertel A, Deloach S, Fortina P, Scott K, Burns TL, Falkner B. Variants in genes involved in functional pathways associated with hypertension in African Americans. Clinical and Translational Science P. 3(6):279 86. 2010 doi: 10.1111/j.1752-8062.2010.00242.x.
- Huan Y, DeLoach S, Keith SW, Falkner B. High blood pressure and obesity increase the risk of abnormal glucose tolerance in young adult African americans. J of Clinical Hypertens.(in Press 2010)
- Martinez Cantarin MP, Keith SW, Deloach S, Huan Y, Falkner B. Relationship of Adiponectin and Inflammatory Cytokines with Insulin Sensitivity in African Americans. Am J. of Medical Science (in Press 2010)
- Zeger-Bardsley M, Falkner B, Kowal K, Ross JL. Insulin resistance and metabolic syndrome in boys with Klinefelter syndrome. (in Press 2010)
- DeLoach S, Huan Y, Keith SW, Martinez Cantarin MP, Falkner B. Relationship of blood pressure and obesity with inflammatory cytokines among African Americans. Therapeutic Advances in Cardiovascular Disease. (in Press 2011)
- Sharma K, Ix JH, Mathew AV, Cho M, Pflueger A, Dunn SR, Francos B, Sharma S, Falkner B, McGowan TA, Donohue M, RamachandraRao S, Xu R, Fervenza FC, Kopp JB. Pirfenidone for diabetic Nephropathy. J Am Soc Nephrol 22:*****; 2011 (published on line April 2011)
|
|
Individual Expertise profile of
Bonita Falkner, Copyright © Bonita Falkner.
Last Updated
by Bonita Falkner : Friday, April 29, 2011 10:01:11 AM
|
|
|---|
|
|
|
|
