University Home | Hospital | Pulse Employment | Contact Us | Search | News 
Thomas Jefferson University Search Jefferson
Jefferson Medical College Jefferson College of Graduate Studies Jefferson College of Health Professions
Menu
Thomas Jefferson University - Chenguang Wang, PhD
Chenguang Wang, PhD

Jefferson
Associate Professor
Thomas Jefferson University
Jefferson Medical College
Department of Cancer Biology
Kimmel Cancer Center

Mailing Address
233 S. 10th St.
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-503-9341
Fax: 215-923-4498
chenguang.wang@jefferson.edu
Qualifications
Ph.D.
Expertise and Research Interests
My laboratory focuses on understanding the mechanisms utilized by steroid nuclear receptors in regulation of cellular proliferation and progression. Our research is also directed towards the overall comprehension of the steroid nuclear receptor signaling and its role in tumorigenesis and differentiation.
The steroid receptor family of nuclear receptors is a large class of ligand-dependent transcription factors involved in a wide array of cellular processes, including proliferation, differentiation, and homeostasis. Alterations of nuclear receptor signaling have been linked to human diseases, including variety of cancers. Upon ligand binding, nuclear receptors undergo a dramatic conformational change, inducing a release of corepressors and subsequent recruitment of different coactivators. This results in transcriptional activation via mechanisms that include histone acetylation and chromatin remodeling. Function of nuclear receptors is also regulated by post-translational modification including phosphorylation, acetylation, and sumoylation. In our lab we have demonstrated that estrogen receptor and androgen receptor are acetylated by histone acetyltransferases, and current research is focusing on elucidating the role of acetylation of nuclear receptors (estrogen receptor, androgen receptor, and PPARg) in cellular proliferation/differentiation and their potential role in cancer initiation and progression.
Our previous results indicate that cyclin D1, at transcriptional level, is down regulated by activation of PPARg. Likewise, PPARg function can be antagonized by activated cyclin D1. A growing body of evidence suggests that cyclin D1 promotes cell survival and that PPARg induces cell death through non-apoptotic pathway. Our data shows that activation of PPARg induces HIF-1 and Bnip3 expression. Moreover, Bnip3 expression was found to be increased in cyclin D1-deficient cells, which is consistent with the reciprocal regulation between cyclin D1 and PPARg. Upregulation of Bnip3 was reported to correlate with the induction of autophagy, which, particularly under hypoxic condition (solid tumor), directly affects a number of malignant phenotypes, including programmed cell death (apoptosis and non-apoptotic cell death), therapeutic resistance, angiogenesis, tumor invasion and metastasis. These hypoxia-associated phenotypes are mainly controlled by specific hypoxia-induced transcription factors, including HIF-1a.
We are currently investigating whether PPARg and cyclin D1 cooperate in regulation of gene expression and autophagic cell death in tumors induced by stimuli (such as hormones) and/or hypoxic microenvironments.
Keywords
breast cancer, colon cancer, hepatocellular carcinoma, hormone nuclear receptor, oncogene, cyclin D1, cell proliferation, lipogenesis, cell fate determination
Publications
  • Articles:
  • 1. Hu B, Ying X, Wang J, Jordan K, Piriyapongsa J, Sheng J, Yu F, Zhao P, Li Y, Wang H, Ng WL, Hu S, Wang X, Wang
  • C, Xheng X, Li W, Curran WJ, and Wang Y. Identifying a Novel Member of MiR-548 Family in FHIT Intron Reveals the
  • Importance of the Human Specific miR Family on Suppressing Tumor Development. . Cancer Res. 2014. (In press).
  • 2. Gu W, Wang C, Li W, Hsu F-N, Tian L, Zhou J, Yuan C, Xie X-J, Jiang T, Addya S, Tai Y, Kong B, and Ji J-Y. Tumor
  • Suppressive Effects of CDK8 in Endometrial Cancer Cells. Cell Cycle. 2013 (In press).
  • 3. Bai Z, Tai Y, Li W, Zhen C, Gu W, Jian Z, Wang Q, Lin JE, Zhao Q, Liang B, Wang C*, and Zhou T*. Gankyrin
  • Promotes Hepatic Metastasis of Colorectal Cancer through Regulating IL-8 Pathway. Cancer Res. 2013 (In press).
  • (*Corresponding author).
  • 4. Chen K, Wu K, Cai S, Zhang W, Zhou J, Wang J, Ertel A, Li Z, Rui H, Quong A, Lisanti MP, Tozeren A, Tanes C,
  • Addya S, Wang C, McMahon SB, Pestell RG. Dachshund Binds p53 To Block The Growth of Lung Adenocarcinoma
  • Cells. Cancer Res. 2013 Mar 14. [Epub ahead of print]
  • 5. Avena P, Anselmo W, Whitaker-Menezes D, Wang C, Pestell RG, Lamb RS, Hulit J, Casaburi I, Andò S, Martinez-
  • Outschoorn UE, Lisanti MP, Sotgia F. Compartment-specific activation of PPAR³ governs breast cancer tumor growth,
  • via metabolic reprogramming and symbiosis. Cell Cycle. 2013 Apr 10;12(9). [Epub ahead of print].
  • 6. Quann K, Gonzales DM, Mercier I, Wang C, Sotgia F, Pestell RG, Lisanti MP, Jasmin JF. Caveolin-1 is a negative
  • regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide. Cell Cycle. 2013 Apr
  • 17;12(10). [Epub ahead of print]
  • 7. Chen K, Wu K, Gormley M, Ertel A, Wang J, Zhang W, Zhou J, Disante G, Li Z, Rui H, Quong AA, McMahon SB,
  • Deng H, Lisanti MP, Wang C, Pestell RG. Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and
  • Signaling Modules in Breast Cancer. Oncotarget. 2013 Jun 21. [Epub ahead of print]. PMID: 23798621.
  • 8. Casimiro MC, Wang C, Li Z, Disante G, Willmart NE, Addya S, Chen L, Liu Y, Lisanti MP, Pestell RG. Cyclin D1
  • Determines Estrogen Signaling in the Mammary Gland in Vivo. Mol Endocrinol. 2013 Jul 17. [Epub ahead of print]
  • PMID: 23864650.
  • 9. Qie S, Chu C, Li W, Wang C, and Sang N. ErbB2 Activation Upregulates Glutaminase 1 Expression Which
  • Promotes Breast Cancer Cell. Journal of Cellular Biochemistry. 2013 Oct 3. doi: 10.1002/jcb.24684. [Epub ahead of
  • print]. PMID: 24122876
  • 10. Yan G, Lanza-Jacoby S, and Wang C. Nexrutine Inhibits Survival and Induces G1 Cell Cycle Arrest, Which Is
  • Associated with Apoptosis or Autophagy Depending on the Breast Cancer Cell Line. Nutr Cancer. 2013 Nov 9. [Epub
  • ahead of print] PMID: 24206214
  • 11. Yu Z, Wang L, Wang C, Ju X, Wang M, Chen K, Loro E, Li Z, Zhang Y, Wu K, Casimiro MC, Gormley M, Ertel A,
  • Fortina P, Chen Y, Tozeren A, Liu Z, Pestell RG. Cyclin D1 induction of Dicer governs microRNA processing and
  • expression in breast cancer. Nat Commun. 2013 Nov 29;4:2812. doi: 10.1038/ncomms3812. PMID: 24287487
  • 12. Wu K, Chen K, Wang C, Jiao X, Wang L, Zhou J, Wang J, Li Z, Addya S, Sorensen PH, Lisanti MP, Quong A, Ertel A,
  • Pestell RG. Cell Fate Factor DACH1 Represses YB-1-mediated Oncogenic Transcription and Translation. Cancer Res.
  • 2013 Dec 12. [Epub ahead of print]. PMID: 24335958.
  • 13. Casimiro MC, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, Saria EA, Papanikolaou A, Stanek TJ, Li Z, Wang C,
  • Fortina P, Addya S, Tozeren A, Knudsen ES, Arnold A, Pestell RG. ChIP sequencing of cyclin D1 reveals a
  • transcriptional role in chromosomal instability in mice. J Clin Invest. 2012 Mar 1;122(3):833-43. doi:
  • 10.1172/JCI60256. Epub 2012 Feb 6.
  • 14. Zhao X, Feng D, Wang Q, Abdulla A, Xie XJ, Zhou J, Sun Y, Ellen S. Yang ES, Liu LP, Vaitheesvaran B, Bridges L,
  • Kurland IJ, Strich R, Ni JQ, Wang C, Ericsson J, Pessin JE, Ji JY, and Yang F. Conserved regulation of lipid homeostasis
  • by CDK8-mediated control of nuclear SREBP-1 protein stability. J Clin Invest. 2012 Jul 2;122(7):2417-27.
  • 15. Li W, Tai Y, Zhou J, Gu W, Bai Z, Zhou T, Zhong Z, McCue PA, Sang N, Ji JY, Kong B, Jiang J*, and Wang C*.
  • Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis. Cell Cycle. 2012 Jun 15;11(12):2348-
  • 58. (*Corresponding author).
  • 16. Fateye B, Li W, Wang C, Chen B. Combination of phosphatidylinositol 3-kinases pathway inhibitor and
  • photodynamic therapy in endothelial and tumor cells. Photochem Photobiol. 2012 Sep;88(5):1265-72. doi:
  • 10.1111/j.1751-1097.2012.01160.x. Epub 2012 May 21.
  • 17. Qie S, Liang D, Yin C, Gu W, Meng M, Wang C, Sang N. Glutamine depletion and glucose depletion trigger
  • growth inhibition via distinctive gene expression reprogramming. Cell Cycle. 2012 Aug 30;11(19).
  • 18. Gaughan L, Stockley J, Wang N, McCracken SR, Treumann A, Armstrong K, Shaheen F, Watt K, McEwan IJ, Wang
  • C, Pestell RG, Robson CN.Regulation of the androgen receptor by SET9-mediated methylation. Nucleic Acids Res.
  • 2011 Mar;39(4):1266-79.
  • 19. Powell MJ, Casimiro MC, Cordon-Cardo C, He X, Yeow WS, Wang C, McCue P, McBurney MW, Pestell RG.
  • Disruption of a Sirt1 Dependent Autophagy Checkpoint in the Prostate Results in Prostatic Intraepithelial Neoplasia
  • Lesion Formation. Cancer Res. 2011 Feb 1;71(3):964-75.
  • 20. Meng H, Tian L, Zhou J, Li Z, Jiao X, Li WW, Plomann M, Xu Z, Lisanti MP, Wang C*, Pestell RG*. PACSIN 2
  • represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b. Cell
  • Cycle. 2011 Jan 1;10(1):73-81. (*Corresponding author).
  • 21. Martinez-Outschoorn UE, Prisco M, Ertel A, Tsirigos A, Lin Z, Pavlides S, Wang C, Flomenberg N, Knudsen ES,
  • Howell A, Pestell RG, Sotgia F, Lisanti MP. Ketones and lactate increase cancer cell "stemness," driving recurrence,
  • metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via Metabolo-Genomics. Cell
  • Cycle. 2011 Apr 15;10(8):1271-86.
  • 22. Pan X*, Zhou T*, Tai YH*, Wang C, Zhao J, Cao Y, Zhang PJ, Yuan Chen Y, Yu M, Li HY, Li AL, Gao YF, Liang B,
  • Zhang WN, Zhen C, Bai ZF, Gong WL, Wei LX, and Zhang XM. Elevated expression of CUEDC2 protein confers
  • endocrine resistance in breast cancer. Nature Medicine. 2011 Jun;17(6):708-14.
  • 23. Yang M, Sun Y, Ma L, Wang C, Wu JM, Bi A, Liao DJ. Complex alternative splicing of the smarca2 gene suggests
  • the importance of smarca2-B variants. J Cancer. 2011;2:386-400. Epub 2011 Jul 6.
  • 24. Martinez-Outschoorn UE, Lin Z, Trimmer C, Flomenberg N, Wang C, Pavlides S, Pestell RG, Howell A, Sotgia F,
  • Lisanti MP. Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the
  • Warburg effect: implications for PET imaging of human tumors. Cell Cycle. 2011 Aug 1;10(15):2504-20. Epub 2011
  • Aug 1.
  • 25. Martinez-Outschoorn UE, Lin Z, Ko YH, Goldberg AF, Flomenberg N, Wang C, Pavlides S, Pestell RG, Howell A,
  • Sotgia F, Lisanti MP. Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg
  • effect kills cancer cells. Cell Cycle. 2011 Aug 1;10(15):2521-8. Epub 2011 Aug 1.
  • 26. Martinez-Outschoorn UE, Goldberg A, Lin Z, Ko YH, Flomenberg N, Wang C, Pavlides S, Pestell RG, Howell A,
  • Sotgia F, Lisanti MP. Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be
  • overcome by inhibiting mitochondrial function in epithelial cancer cells. Cancer Biol Ther. 2011 Nov 15;12(10).
  • 27. Thakur ML, Devadhas D, Zhang K, Pestell RG, Wang C, McCue P, Wickstrom E. Imaging Spontaneous MMTVneu
  • Transgenic Murine Mammary Tumors: Targeting Metabolic Activity Versus Genetic Products. J Nucl Med. 2010
  • Jan;51(1):106-11.
  • 28. Zhong Z, Yeow WS, Zou C, Wassell R, Wang C, Pestell RG, Quong JN, Quong AA. Cyclin D1/cyclin dependent
  • kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells. Cancer Res.
  • 2010 Mar 1;70(5):2105-14.
  • 29. Zhou J, Wang C*, Wang Z, Dampier W, Wu K, Casimiro MC, Chepelev I, Popov VM, Quong A, Tozeren A, Zhao K,
  • Lisanti MP, Pestell RG*. Attenuation of Forkhead Signaling by the Retinal Determination Factor DACH1. Proc Natl Acad
  • Sci U S A. 2010 Mar 29. [Epub ahead of print] (*Corresponding author).
  • 30. Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Pestell RG, Martinez-Outschoorn
  • UE, Howell A, Sotgia F, Lisanti MP. Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer
  • tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia
  • Metabolic Coupling". Aging (Albany NY). 2010 Apr;2(4):185-99.
  • 31. Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG,
  • Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia
  • and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": A transcriptional
  • informatics analysis with validation. Cell Cycle. 2010 Jun 22;9(11).
  • 32. Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, Chiavarina B, Pavlides S, Wang C, Whitaker-Menezes D,
  • Daumer KM, Lin Z, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Knudsen ES, Sotgia F, Lisanti MP. Oxidative
  • stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor
  • metabolism, the field effect and genomic instability in cancer cells. Cell Cycle. 2010 Aug 28;9(16).
  • 33. Li Z, Jiao X, Wang C, Shirley LA, Elsaleh H, Dahl O, Wang M, Soutoglou E, Knudsen ES, Pestell RG. Alternative
  • Cyclin D1 Splice Forms Differentially Regulate the DNA Damage Response. Cancer Res. 2010 Oct 12. [Epub ahead of
  • print]
  • 34. Chiavarina B, Whitaker-Menezes D, Migneco G, Martinez-Outschoorn UE, Pavlides S, Howell A, Tanowitz HB,
  • Casimiro MC, Wang C, Pestell RG, Grieshaber P, Caro J, Sotgia F, Lisanti MP. HIF1-alpha functions as a tumor
  • promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives
  • compartment-specific oncogenesis. Cell Cycle. 2010 Sep;9(17):3534-51. Epub 2010 Sep 4.
  • 35. Pavlides S, Tsirigos A, Migneco G, Whitaker-Menezes D, Chiavarina B, Flomenberg N, Frank PG, Casimiro MC,
  • Wang C, Pestell RG, Martinez-Outschoorn UE, Howell A, Sotgia F, Lisanti MP. The autophagic tumor stroma model of
  • cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle. 2010
  • Sep;9(17):3485-505.
  • 36. Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S,
  • Martinez-Cantarin MP, Capozza F, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Caro J, Lisanti MP, Sotgia F.
  • Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFºB
  • activation in the tumor stromal microenvironment. Cell Cycle. 2010 Sep;9(17):3515-33. Epub 2010 Sep 9.
  • 37. Zhou J, Liu Y, Zhang W, Popov VM, Wang M, Pattabiraman N, Suñe C, Cvekl A, Wu K, Jiang J, Wang C*, Pestell RG.
  • Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1. J
  • Biol Chem. 2010 Oct 18. [Epub ahead of print] (*Corresponding author).
  • 38. Martinez-Outschoorn UE, Whitaker-Menezes D, Pavlides S, Chiavarina B, Bonuccelli G, Trimmer C, Tsirigos A,
  • Migneco G, Witkiewicz AK, Balliet R, Mercier I, Wang C, Flomenberg N, Howell A, Lin Z, Caro J, Pestell RG, Sotgia F,
  • Lisanti MP. The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to
  • the autophagy paradox. Cell Cycle. 2010 Nov;9(21):4297-306. Epub 2010 Nov 30.
  • 39. Sotgia F, Casimiro MC, Bonuccelli G, Liu M, Whitaker-Menezes D, Er O, Daumer KM, Mercier I, Witkiewicz AK,
  • Minetti C, Capozza F, Gormley M, Quong AA, Rui H, Frank PG, Milliman JN, Knudsen ES, Zhou J, Wang C, Pestell RG,
  • Lisanti MP. Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor
  • formation. Am J Pathol. 2009 Feb; 174(2):613-29.
  • 40. Sotgia F, Del Galdo F, Casimiro MC, Bonuccelli G, Mercier I, Whitaker-Menezes D, Daumer KM, Zhou J, Wang C,
  • Katiyar S, Xu H, Bosco E, Quong AA, Aronow B, Witkiewicz AK, Minetti C, Frank PG, Jimenez SA, Knudsen ES, Pestell
  • RG, Lisanti MP. Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-
  • associated fibroblasts. Am J Pathol. 2009 Mar; 174(3):746-61.
  • 41. Witkiewicz AK, Casimiro MC, Dasgupta A, Mercier I, Wang C, Bonuccelli G, Jasmin J, Frank PG, Pestell RG, Kleer
  • CG, Sotgia F and Lisanti MP. Towards a new stromal-based classification system for human breast cancer prognosis
  • and therapy. Cell Cycle. 2009 Jun 1;8(11):1654-8.
  • 42. Liu M, Ju X, Willmarth NE, Casimiro MC, Ojeifo J, Sakamaki T, Katiyar S, Jiao X, Popov VM, Yu Z, Wu K, Joyce D,
  • Wang C, and Pestell RG. NFºB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo. Am J
  • Pathol. 2009 May;174(5):1910-20.
  • 43. Liu M, Casimiro MC, Wang C, Shirley LA, Jiao X, Katiyar S, Ju X, Li Z, Yu Z, Zhou J, Johnson M, Fortina P, Hyslop T,
  • Windle JJ, Pestell RG. p21CIP1 Governs Oncogene-Dependent Breast Tumor Epithelial Mesenchymal Transformation In
  • Vivo. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19035-9. Epub 2009 Oct 26.
  • 44. Nan F, Lü Q, Zhou J, Cheng L, Popov VM, Wei S, Kong B, Pestell RG, Lisanti MP, Jiang J, Wang C. Altered
  • expression of DACH1 and cyclin D1 in endometrial cancer. Cancer Biol Ther. 2009 Aug;8(16):1534-9. Epub 2009 Aug
  • 8. (*Corresponding author).
  • 45. Zhou J, Zhang W, Liang B, Casimiro MC, Whitaker-Menezes D, Wang M, Lisanti MP, Lanza-Jacoby S, Pestell RG,
  • Wang C. PPARgamma Activation Induces Autophagy in Breast Cancer Cells. Int J Biochem Cell Biol. 2009
  • Nov;41(11):2334-42. Epub 2009 Jun 26. (*Corresponding author).
  • 46. Popov VM, Zhou J, Shirley LA, Quong J, Yeow WS, Wright JA, Wu K, Rui H, Vadlamudi RK, Jiang J, Kumar R, Wang
  • C, Pestell RG. The Cell Fate Determination Factor DACH1 is expressed in Estrogen Receptor-± (ER±) positive breast
  • cancer and represses ER± signaling. Cancer Res. 2009 Jul 15;69(14):5752-60.
  • 47. Genander M, Halford MM, Yu Z, Martling A, Xu NJ, Greicius G, Chumley MJ, Zdunek S, Wang C, Holm T,
  • Pettersson S, Pestell RG, Henkemeyer M and Frisén J. Dissociation of EphB2 signaling pathways mediating progenitor
  • cell proliferation and tumor suppression. Cell. 2009 Nov 13;139(4):679-92.
  • 48. Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang
  • C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP. The Reverse Warburg Effect: Aerobic
  • Glycolysis in Cancer Associated Fibroblasts and the Tumor Stroma. Cell Cycle. 2009 Dec;8(23):3984-4001
  • 49. Tian L, Zhou J, Casimiro MC, Liang B, Ojeifo JO, Wang M, Hyslop T, Wang C*, Pestell RG. Activation of
  • Peroxisome Proliferator-activated Receptor ³ Promotes Tumor Growth by Enhancing Angiogenesis. Cancer Res. 2009
  • Dec 15;69(24):9236-44. (*Corresponding author).
  • 50. Li Z, Wang C*, Jiao X, Katiyar S, Casimiro MC, Prendergast GC, Powell MJ, Pestell RG*. Alternate cyclin D1 mRNA
  • splicing modulates p27KIP1 binding and cell migration. J Biol Chem. 2008 Mar 14;283(11):7007-15. (*Corresponding
  • author).
  • 51. Jiao X, Katiyar S, Liu M, Mueller SC, Lisanti MP, Li A, Pestell TG, Wu K, Ju X, Li Z, Wagner EF, Takeya T, Wang C,
  • Pestell RG.Disruption of c-Jun Reduces Cellular Migration and Invasion through Inhibition of c-Src and
  • Hyperactivation of ROCK II Kinase.Mol Biol Cell. 2008 Apr; 19(4):1378-1390.
  • 52. Rao M, Casimiro MC, Lisanti MP, D'Amico M, Wang C, Shirley LA, Leader JE, Liu M, Stallcup M, Engel DA, Murphy
  • DJ, Pestell RG.Inhibition of cyclin D1 gene transcription by Brg-1.Cell Cycle. 2008 Mar;7(5):647-55. Epub 2007 Dec
  • 12.
  • 53. Mercier I, Casimiro MC, Wang C, Rosenberg AL, Quong J, Allen KG, Danilo C, Sotgia F, Bonnucelli G, Jasmin JF, Xu
  • H, Bosco E, Aronow B, Witkiewicz A, Pestell RG, Knudsen ES, Lisanti MP.Human Breast Cancer-Associated Fibroblasts
  • (CAFs) Show Caveolin-1 Down-regulation and RB Tumor Suppressor Functional Inactivation: Implications for the
  • Response to Hormonal Therapy. Cancer Biol Ther. 2008 Apr 30;7(8).
  • 54. Yu Z, Wang C, Wang M, Li Z, Casimiro MC, Liu M, Wu K, Whittle J, Ju X, Hyslop T, McCue P, Pestell RG. A cyclin
  • D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol. 2008 Aug
  • 11;182 (3):509-17.
  • 55. Ju X, Katiyar S, Wang C, Liu M, Shengwen Li S, Jiao X, Zhou J, Turner J, Lisanti MP, Russell RG, Mueller S, Ojeifo J,
  • Chen WS, Hay N, and Pestell RG. Akt1 governs breast cancer progression in vivo. Natl Acad Sci U S A. 2007 May
  • 1;104(18):7438-43.
  • 56. Yin Y, Yuan H, Wang C, Pattabiraman N, Rao M, Pestell RG, and Glazer RI. 3-Phosphoinositide-Dependent
  • Protein Kinase-1 Activates the Peroxisome Proliferator-Activated Receptor g and Promotes Adipocyte Differentiation.
  • Mol Endocrinol. 2006 Feb; 20(2):268-78.
  • 57. Li Z, Wang C, Jiao X, Lu Y, Fu M, Quong AA, Dye C, Yang J, Dai M, Ju X, Zhang X, Li A, Burbelo P, Stanley R,
  • Pestell RG Cyclin D1 regulates cellular migration through the inhibition of thrombospondin-1 and ROCK signaling.
  • Mol Cell Biol. 2006 Jun; 26(11):4240-56.
  • 58. Sakamaki T, Casimiro M, Ju X, Quong A, Katiyar S, Liu M, Jiao X, Li A, Zhang X, Lu Y, Wang C, Nicholson R, Link
  • T, Shemluck M, Yang J, Fricke ST, Novikoff PM, Papanikolaou A, Arnold A, Albanese C and Pestell RG. Cyclin D1
  • determines Mitochondrial Function In Vivo. Mol Cell Biol. 2006 Jul; 26(14):5449-69.
  • 59. Hulit J, Lee RJ, Li Z, Wang C, Yang J, Quong A, Wu K, Albanese C, Russell R, Di Vizio D, Koff A, Thummala S,
  • Zhang H, Harrell J, Sun H, Muller WJ, Inghirami G, and Pestell RP. p27Kip1 repression of ErbB2-induced mammary
  • tumor growth in transgenic mice involves Skp2 and Wnt/b-catenin signaling. Cancer Res. 2006 Sep 1;66(17):8529-
  • 41.
  • 60. Wang C, Li Z, Lu Y, Du R, Katiyar S, Yang J, Fu M, Leader JE, Quong A, Novikoff PM, and Pestell RP. Cyclin D1
  • Repression of NRF-1 Integrates Nuclear DNA Synthesis and Mitochondrial Function. Proc Natl Acad Sci U S A. 2006
  • Aug 1; 103(31):11567-72.
  • 61. Wu K, Li A, Rao M, Liu M, Dailey V, Yang Y, Vizio DD, Wang C, Lisanti MP, Sauter G, Russell RG, Cvekl A, Pestell
  • RG. DACH1 is a Cell Fate Determination Factor That Inhibits Cyclin D1 and Breast Tumor Growth. Mol Cell Biol. 2006
  • Oct; 26(19):7116-29.
  • 62. Fu M, Liu M, Sauve AA, Jiao X, Zhang X, Powell M, Yang T, Gu W, Avantaggiati ML, Pattabiraman N, Pestell TG,
  • Wang F, Quong A, Wang C, Pestell RG. The Hormonal Control of Androgen Receptor Function through SIRT1. Mol Cell
  • Biol. 2006 Nov; 26(21):8122-35.
  • 63. Li Z, Jiao X, Wang C, Ju X, Lu Y, Yuan L, Lisanti MP, Katiyar S, Pestell RG. Related Articles, Cyclin D1 induction of
  • cellular migration requires p27 (KIP1). Cancer Res. 2006 Oct 15; 66(20):9986-94.
  • 64. Wang C, Fan S, Li Z, Fu M, Rao M, Ma Y, Lisanti MP, Albanese C, Katzenellenbogen BS, Kushner PJ, Weber B,
  • Rosen EM, and Pestell RG. Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. Cancer Res.
  • 2005 Aug 1; 65(15):6557-67.
  • 65. Fu M, Wang C, Rao M, Wu X, Bouras T, Zhang X, Li Z, Jiao X, Yang J, Li A, Perkins ND, Thimmapaya B, Kung AL,
  • Munoz A, Giordano A, Lisanti MP, Pestell RG. Cyclin D1 represses p300 transactivation through a CDK-independent
  • mechanism. J Biol Chem. 2005 Aug 19; 280(33):29728-42.
  • 66. Wu K, D'Amico M, Wang C, Albanese C, Pestell RG, Mani S. A study of cytotoxic synergy of UCN-01 and
  • flavopiridol in syngeneic pair of cell lines. Invest New Drugs. 2005 Aug; 23(4):299-309.
  • 67. Fu M, Rao M, Bouras T, Wang C, Wu K, Zhang X, Li Z, Yao TP, Pestell RG. Cyclin D1 inhibits peroxisome
  • proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem.
  • 2005 Apr 29; 280(17):16934-41. Epub 2005 Feb 14.
  • 68. Hulit J*, Wang C*, Li Z, Albanese C, Rao M, Di Vizio D, Shah S, Byers SW, Mahmood R, Augenlicht LH, Russell R,
  • Pestell RG. Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in
  • ApcMin Mice. Mol Cell Biol. 2004 Sep; 24(17): 7598-611. *Equal contribution.
  • 69. Fu M, Rao M, Wu K, Wang C, Zhang X, Hessien M, Yeung YG, Gioeli D, Weber MJ, Pestell RG. The androgen
  • receptor acetylation site regulates cAMP and AKT but not ERK-induced activity. J Biol Chem. 2004 Jul 9; 279(28):
  • 29436-49.
  • 70. Wang C, Pattabiraman N, Zhou JN, Fu M, Sakamaki T, Albanese C, Li Z, Wu K, Hulit J, Neumeister P, Novikoff PM,
  • Brownlee M, Scherer PE, Jones JG, Whitney KD, Donehower LA, Harris EL, Rohan T, Johns DC, Pestell RG. Cyclin D1
  • repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol. 2003
  • Sep; 23(17): 6159-73.
  • 71. Fu M, Rao M, Wang C, Sakamaki T, Wang J, Di Vizio D, Zhang X, Albanese C, Balk S, Chang C, Fan S, Rosen E,
  • Palvimo JJ, Janne OA, Muratoglu S, Avantaggiati ML, Pestell RG. Acetylation of Androgen Receptor Enhances
  • Coactivator Binding and Promotes Prostate Cancer Cell Growth. Mol Cell Biol. 2003 Dec 1; 23(23): 8563-8575.
  • 72. Xiong J, Fan S, Meng Q, Schramm L, Wang C, Bouzahza B, Zhou J, Zafonte B, Goldberg ID, Haddad BR, Pestell RG,
  • Rosen EM. BRCA1 Inhibition of Telomerase Activity in Cultured Cells. Mol Cell Biol. 2003 Dec 1; 23(23): 8668-8690.
  • 73. Wu K, Yang Y, Wang C, Davoli MA, D'Amico M, Li A, Cveklova K, Kozmik Z, Lisanti MP, Russell RG, Cvekl A,
  • Pestell RG. DACH1 inhibits TGF-beta signaling through binding Smad4. J Biol Chem. 2003 Dec 19; 278(51): 51673-
  • 84.
  • 74. Fan S, Ma YX, Wang C Yuan RQ, Meng Q, Wang JA, Erdos M, Goldberg ID, Webb P, Kushner PJ, Pestell RG, Rosen
  • EM. Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. Oncogene. 2001 Jan 4; 20(1): 77-87.
  • 75. Wang C, Fu M, Angeletti RH, Siconolfi-Baez L, Reutens AT, Albanese C, Lisanti MP, Katzenellenbogen BS, Kato S,
  • Hopp T, Fuqua SA, Lopez GN, Kushner PJ, Pestell RG. Direct acetylation of the estrogen receptor alpha hinge region
  • by p300 regulates transactivation and hormone sensitivity. J Biol Chem. 2001 May 25; 276(21): 18375-83.
  • 76. Wang C, Fu M, D'Amico M, Albanese C, Zhou JN, Brownlee M, Lisanti MP, Chatterjee VK, Lazar MA, Pestell RG.
  • Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated
  • receptor gamma-dependent repression of cyclin D1. Mol Cell Biol. 2001 May; 21(9): 3057-70.
  • 77. Reutens AT, Fu M, Wang C, Albanese C, McPhaul MJ, Sun Z, Balk SP, Janne OA, Palvimo JJ, Pestell RG. Cyclin D1
  • binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-
  • dependent manner. Mol Endocrinol. 2001 May; 15(5): 797-811.
  • 78. Schlegel A, Wang C, Pestell RG, Lisanti MP. Ligand-independent activation of oestrogen receptor alpha by
  • caveolin-1. Biochem J. 2001 Oct 1; 359(Pt 1): 203-10.
  • 79. Fan S, Ma YX, Wang C, Yuan RQ, Meng Q, Wang JA, Erdos M, Goldberg ID, Webb P, Kushner PJ, Pestell RG, Rosen
  • EM. p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res. 2002 Jan 1; 62(1): 141-51.
  • 80. Chi Y, Diaz-Griffero F, Wang C, Young JA, Brojatsch J. An NF-kappa B-dependent survival pathway protects
  • against cell death induced by TVB receptors for avian leukosis viruses. J Virol. 2002 Jun; 76(11): 5581-7.
  • 81. Fu M, Wang C, Wang J, Zhang X, Sakamaki T, Yeung YG, Chang C, Hopp T, Fuqua SA, Jaffray E, Hay RT, Palvimo
  • JJ, Janne OA, Pestell RG. Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis
  • without affecting in vitro sumoylation and trans-repression function. Mol Cell Biol. 2002 May; 22(10): 3373-88.
  • 82. Wu K, Wang C, D'Amico M, Lee RJ, Albanese C, Pestell RG, Mani S. Flavopiridol and trastuzumab synergistically
  • inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent
  • kinase and Akt signaling pathways. Mol Cancer Ther. 2002 Jul; 1(9): 695-706.
  • 83. Wang C, Francis R, Harirchian S, Batlle D, Mayhew B, Bassett M, Rainey WE, Pestell RG. The application of high-
  • density microarray for analysis of mitogenic signaling and cell-cycle in the adrenal. Endocr Res. 2000 Nov; 26(4):
  • 807-23.
  • 84. Fu M, Wang C, Reutens AT, Wang J, Angeletti RH, Siconolfi-Baez L, Ogryzko V, Avantaggiati ML, Pestell RG. p300
  • and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites
  • governing hormone-dependent transactivation. J Biol Chem. 2000 Jul 7; 275(27): 20853-60.
  • 85. Schlegel A, Wang C, Katzenellenbogen BS, Pestell RG, Lisanti MP. Caveolin-1 potentiates estrogen receptor alpha
  • (ERalpha) signaling. Caveolin-1 drives ligand-independent nuclear translocation and activation of ERalpha. J Biol
  • Chem. 1999 Nov 19; 274(47): 33551-6.
  • 86. Lou SJ, Wang C, Huang XY, Chen YZ. Effect of glucocorticoid on [Ca2+]i induced by high-K+ in single PC12 cells
  • and its characteristics. Sheng Li Xue Bao. 1998; 50(5): 563-9. Chinese.
  • 87. Wang C, Deng MQ, Sun FZ. (1998). Intracellular Ca2+ distribution and its role in mouse oocytes maturation.
  • Acta Biol. Exp. Sinica. 31, 147-53.
  • 88. Wang C, He QY, Zhang HQ, Zhang J, Lu YL, Chen LZ, and Chen ZQ. (1995). Multidrug-resistance gene
  • expression in human lung cancer. Basal Med. Clinical, 15(3), 36-9.
  • 89. Wang C, Ge YP, Chen ZQ, He QY, Zhang HQ. (1995). Reversal of resistance to doxorubicin in HL-60/Har cells by
  • cyclosporine A. Chinese J. Cell Biol. 17(1), 32-6.
  • 90. Wang C, Ge YP, Chen ZQ, He QY, Zhang HQ. (1995). Reversal of resistance of HL-60/Har cells to anti-tumor
  • drugs by calmodulin antagonist. Chinese J. Pathophysiology. 11(5), 496-9.
  • 91. Wang C, Ge YP, He QY, Cui J, Zhang HQ, and Chen ZQ. (1995). The effect of agents to reverse multidrug
  • resistance on level of calmodulin. J. Curr. Med. BioEngineering. 1(1) 44-6.
  • Reviews and Book Chapters:
  • 92. Wang C, Ge YP, and Chen ZQ. (1995). Current clinical research on multidrug resistance of cancer. J. Curr. Med.
  • BioEngineering. 1(1) 73-6.
  • 93. Zafonte BT, Hulit J, Amanatullah DF, Albanese C, Wang C, Rosen E, Reutens A, Sparano JA, Lisanti MP, Pestell RG.
  • Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycle. Front Biosci. 2000 Dec 1;
  • 5:D938-61.
  • 94. Wang C, Fu M, Mani S, Wadler S, Senderowicz AM, Pestell RG. Histone acetylation and the cell-cycle in cancer.
  • Front Biosci. 2001 Apr 1; 6:D610-29.
  • 95. Fu M, Wang C, Wang J, Zafonte BT, Lisanti MP, Pestell RG. Acetylation in hormone signaling and the cell cycle.
  • Cytokine Growth Factor Rev. 2002 Jun; 13(3): 259-76.
  • 96. Wang C, Fu M, Pestell RG. Chapter. Histone acetylation/deacetylation as a regulator of cell-cycle gene
  • expression In the book. "Cell cycle checkpoint control protocols" Methods in Molecular Biology and Medicine (H.
  • Lieberman, ed.), Humana Press, Inc., Totowa, NJ. 2004; 241:207-16.
  • 97. Fu M, Wang C, Zhang X, Pestell RG. Nuclear receptor modifications and endocrine cell proliferation. J. Steroid
  • Biochem. & Mol. Biol. 2003, June; 85 (2-5): 133-8.
  • 98. Mani S, Wang C, Wu K, Francis R, Pestell R. Cyclin-dependent kinase inhibitors: novel anticancer agents. Expert
  • Opin Investig Drugs. 2000 Aug; 9(8): 1849-70.
  • 99. Wang C, Li Z, Fu M, Bouras T, Pestell RG. Signal tranduction mediated by cyclin D1: from mitogens to cell
  • proliferation: A molecular target with therapeutic potential. Rakesh Kumar, ed. Molecular Targeting & Signal
  • Transduction. Kluwer Academic Publisher Cancer Treat Res. 2004;119:217-37.
  • 100. Fu M, Wang C, Zhang X, Pestell RG. Signal Transduction Inhibitors in Cellular Function. Chapter 2, Signal
  • Transduction Protocols, Editor: Robert C. Dickson and Michael D. Mendenhall. Second Edition Humana Press Inc.
  • Totowa, NJ. 2004. Method in Molecular Biology. Vol 284, page15-36.
  • 101. Fu M, Wang C, Zhang X, Pestell RG. Biochem Pharmacol. 2004 Sep 15; 68(6): 1199-208.
  • 102. Fu M, Wang C, Li Z, Sakamaki T, Pestell RG. Minireview: Cyclin D1: Normal and Abnormal Functions.
  • Endocrinology. 2004 Aug 26
  • 103. Hilakivi-Clarke L, Wang C, Kalil M, Riggins R, Pestell RG. Nutritional modulation of the cell cycle and breast
  • cancer. Endocr Relat Cancer. 2004 Dec; 11(4): 603-22.
  • 104. Wang C, Fu M, Pestell RG. Estrogen receptor acetylation and phosphorylation in hormone responses. Breast
  • Cancer Online. 2005.
  • 105. Leader JE, Wang C, Fu M, Pestell RG. Epigenetic regulation of nuclear steroid receptors. Biochem Pharmacol.
  • 2006 Jul 14; [Epub ahead of print]
  • 106. Li Z, Wang C, Prendergast G, Pestell RG. Cyclin D1 Functions in Cell Migration. Cell Cycle. 2006 Nov 1;5(21).
  • 107. Leader JE, Wang C, Popov VM, Fu M, Pestell RG. Epigenetics and the estrogen receptor. Ann N Y Acad Sci. 2006
  • Nov; 1089:73-87.
  • 108. Popov VM, Wang C, Shirley LA, Rosenberg A, Li S, Nevalainen M, Fu M, Pestell RG. The functional significance of
  • nuclear receptor acetylation. Steroids. 2007 Feb 6; [Epub ahead of print]
  • 109. Whittle JR, Powell MJ, Popov VM, Shirley LA, Wang C, Pestell RG. Sirtuins, nuclear hormone receptor acetylation
  • and transcriptional regulation. Trends Endocrinol Metab. 2007 Nov;18(9):356-64.
  • 110. Wang C, Powell MJ, Popov VM, Pestell RG. Acetylation in Nuclear Receptor Signaling and the Role of Sirtuins. Mol
  • Endocrinol. 2008 Mar;22(3):539-45.
  • 111. Popov VM, Wu K, Zhou J, Powell MJ, Mardon G, Wang C, Pestell RG. The Dachshund gene in development and
  • hormone-responsive tumorigenesis. Trends Endocrinol Metab. 2010 Jan;21(1):41-9. Epub 2009 Nov 5.
  • 112. Yu Z, Baserga R, Chen L, Wang C, Lisanti MP, Pestell RG. microRNA, Cell Cycle, and Human Breast Cancer. Am J
  • Pathol. 2010 Mar;176(3):1058-64.
  • 113. Wang C, Tian L, Popov VM, Pestell RG. Acetylation and Nuclear Receptor Action. J Steroid Biochem Mol Biol. 2011
  • Feb;123(3-5):91-100.
  • 114. Wang C, Lisanti MP, Liao DJ. Reviewing once more the c-myc and Ras collaboration: Converging at the cyclin
  • D1-CDK4 complex and challenging basic concepts of cancer biology. Cell Cycle. 2011 Jan 1;10(1). [Epub ahead of
  • print]
  • 115. Wang C, Tai Y, Lisanti MP, Liao DJ. c-Myc induction of programmed cell death may contribute to carcinogenesis:
  • A perspective inspired by several concepts of chemical carcinogenesis. Cancer Biol Ther. 2011 Apr 1;11(7). [Epub
  • ahead of print]
  • 116. Wang C, Powell M, Tian L, Pestell RG. Analysis of nuclear receptor acetylation. Methods Mol Biol. 2011;776:169-
  • 81.
  • 117. Wang C, Ji JY, Tian LF, Pestell RG. Transcriptional regulation of lipogenesis as a therapeutic target for cancer
  • treatment. Book entitled "Nuclear Signaling Pathways and Targeting Transcription in Cancer". Editor: Dr. Rakesh
  • Kumar. Springer Press, 2013.
  • 118. Wang C, Pestell TG, D. Liao DJ, Pestell RG. The New Perspective on the Role of Cyclin D1: beyond Cell Cycle
  • Regulation. Book entitled "Cell and Molecular Biology of Breast Cancer". Editor: Dr. Heide Schatten. Humana Press
  • (Springer Science+Business Media LLC), 2013
  • 119. Lin J, Wang C, Kelly WK. Targeting epigenetics for the treatment of prostate cancer: recent progress and future
  • directions. Semin Oncol. 2013 Jun;40(3):393-401.
  • 120. Wang C, Zhang X, and Pestell RG. Emerging roles of peroxisome proliferator-activated receptor gamma in
  • cancer. Molecular Oncology, ed. Edward P. Gelmann, Charles L. Sawyers, and Frank J. Rauscher. Published by
  • Cambridge University Press. Cambridge University Press 2014.

Individual Expertise profile of Chenguang Wang, PhD, Copyright © Chenguang Wang, PhD.
Last Updated by Chenguang Wang, PhD : Monday, June 13, 2011 5:33:54 PM



 Printable Version

Thomas Jefferson University
Thomas Jefferson University