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Thomas Jefferson University - Elisabeth J. Van Bockstaele, Ph.D.
Elisabeth J. Van Bockstaele, Ph.D.

Neuroscience
Thomas Jefferson University
Jefferson Medical College

Professor, Department of Neurosurgery

Program Director, Neuroscience Graduate Program

Vice Chair for Research, Department of Neurosurgery

Professor, Farber Institute for Neurosciences
Mailing Address
900 Walnut St., Ste. 417
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-503-1245
Fax: 215-955-4949
Qualifications
B.A., Sarah Lawrence College, Biology, 1985

M.S., New York University, Neurobiology, 1988

Ph.D., New York University, Neurobiology, 1991

Expertise and Research Interests
Dr. Van Bockstaele is an active faculty member in the education of medical students and residents at TJU. She coordinates basic science research activities focused in the neurosciences and assists residents in developing research projects during their research rotations. As a mentor for numerous graduate and medical students over the past ten years, Dr. Van Bockstaele has demonstrated expertise in training postgraduate students. Her participation on NIH study sections aimed at supporting research programs for PhD, MD and MD/PhD applicants will facilitate the submission of such proposals from current neuroscience gradiaute students and neurosurgical residents.

She is a major participant in Medical Neuroscience ID150, a course offered at Jefferson Medical College during the first year of medical school as well as several graduate level neuroscience courses in the Jefferson College of Graduate Studies. She is currently the Program Director for the Neuroscience Graduate Program at TJU.

Dr. Van Bockstaele has successfully competed for extramural funds from federal agencies (including the National Institutes of Health and the National Science Foundation) as well as private foundations (including the American Heart Association and the National Association for Research on Schizophrenia and Depression). She has a strong, well-funded research program. She has received an Independent Scientist Award from the National Institute on Drug Abuse demonstrating the recognition by her peers of her valuable research work. She has been an invited speaker throughout the world. She was an invited speaker at the first Neuron-Glial Biology Gordon Conference in California, a prestigious honor.

Dr. Van Bockstaele is the current President of the local Chapter for the Society for Neuroscience in Philadelphia. She coordinated the last three annual meetings with funds sponsored by the Grass Traveling Lecture Series provided by the Society for Neuroscience in Washington DC. She also coordinates public outreach activities at the Franklin Science Institute during "Brain Awareness Week" held annually in March to teach the public about the importance of mental health research.


Research in our laboratory falls into several categories:

Cannabinoids and Noradrenergic Function
Our guiding hypothesis is that chronic cannabinoid administration results in a potentiated noradrenergic system that may contribute to the pathophysiology of affective disorders.

Cellular Mechanisms of Addictive Processes
Prior stress can influence the pharmacodynamics of opiates that are used in clinical settings. Conversely, these opiates could potentially predispose individuals to stress-related psychiatric disorders.

Glutamate Receptors and Anxiety
The noradrenergic nucleus locus coeruleus (LC) is an important mediator of stress responses and dysfunction of this system is implicated in affective disorders such as anxiety and depression.

HIV and the Brain
It has been suggested that the biochemical and molecular cascades by which neurons become dysfunctional and die in HIV dementia are similar to those that occur in Alzheimer's disease.

Models of Intracerebral Hemorrhage
Alterations in cholinergic neurotransmission may contribute to the cognitive deficits, such as impaired memory or language use, following intracerebral hemorrhage.

Stress and Noradrenergic Function
A history of stress alters the sensitivity of the noradrenergic system in the locus coeruleus to the stress-related neurohormone, corticotropin-releasing factor. This process may contribute to stress-related psychiatric symptoms such as hyperarousal or difficulty concentrating.

Cocaine Effects on Norepinephrine in the Amygdala
Cocaine-withdrawal induced anxiety is considered to be one of the most important factors in precipitating relapse to chronic cocaine abuse. The guiding hypothesis for this project is that this anxiety, and the stress-induced relapse to cocaine use, may be mediated by the effects of cocaine on noradrenergic circuits originating from brainstem nuclei (e.g. locus coeruleus) providing innervation to the amygdala.

Corticotropin-Releasing Factor (CRF)-serotonin (5-HT) interactions
The serotonergic system in the dorsal raphe nucleus has been implicated in acute responses to stress and in psychiatric disorders such as anxiety and depression. Substantial findings suggest that the neuropeptide corticotropin-releasing factor (CRF) is instrumental in modulating the activity of this system during stress.

Sex Differences in Anxiety During Cocaine Withdrawal
Current advances show statistically significant differences between males and females in all phases of drug exposure (acquisition, steady-state maintenance, escalation, dysregulation, withdrawal, relapse, and treatment). Clinical evidence demonstrates that females are more susceptible to relapse compared to males and that this relapse is accompanied by a negative emotional state, notably anxiety.


The techniques used in our laboratory include: tract-tracing of neural pathways, immunoelectron microscopy for determining synaptic interactions of multiple transmitter systems, subcellular localization of receptors, in situ hybridization, extra- and intracellular physiology, neurochemical studies and molecular biology.
Other Expertise
INSTITUTIONAL COMMITTEES

2005-present Member, Committee on Departmental Review, Jefferson Medical College of Thomas Jefferson University

2005-present Member, Committee on Faculty Appointments and Promotions, Jefferson Medical College of Thomas Jefferson University

2004-present Member, Graduate Council, Jefferson College of Graduate Studies, Thomas Jefferson University

2004-present Member, Curriculum Committee, Graduate Council, Jefferson College of Graduate Studies, Thomas Jefferson University

2003-2005 Chair, Subcommittee on Research Enhancement Awards, Committee on Research, Jefferson Medical College of Thomas Jefferson University

2003-2004 Chair, Task force on development of a Neuroscience Graduate Program in the College of Graduate Studies at Thomas Jefferson University

2002 Member, Search Committee for Chairman of Neurology, Jefferson Medical College of Thomas Jefferson University

2002-2004 Member, Professorial Advisory Committee, Thomas Jefferson University

2002-2004 Representative (Basic Science), Scientific and Academic Affairs Committee, Thomas Jefferson University

2001-2005 Member, Committee on Research, Jefferson Medical College of Thomas Jefferson University

1998-present Member, Judicial Board, College of Graduate Studies, Jefferson Medical College of Thomas Jefferson University

1998-present Member, Admissions Committee, College of Graduate Studies, Jefferson Medical College of Thomas Jefferson University

1997-2002 Co-Chair, Department of Pathology, Anatomy and Cell Biology Seminar Committee



EDITORIAL ACTIVITIES

Manuscript referee: The Journal of Comparative Neurology; Brain Research; Brain Research Interactive; Neuroscience Letters; The Journal of Chemical Neuroanatomy; Neuroscience; The Journal of Neuroendocrinology; Neuropharmacology; The Anatomical Record; The Journal of Pharmacology and Experimental Therapeutics; European Journal of Pharmacology; The Journal of Neuroscience; The Journal of Neurophysiology; The Journal of Neuroscience Research; The Journal of Neurophysiology; European Journal of Neuroscience; Synapse

GRANT REVIEW

2005 ZRG1 F02A (20) National Institute on Mental Health, NIH

2005 ZRG1 IFCN-A (02) National Institute on Mental Health, NIH

2005 ZDA1 MXS-M (05) National Institute on Drug Abuse, NIH

2005 National Institute on Mental Health, Conte Centers

2003 ZRG1 IFCN-4 Special Emphasis Panel, NIDA, NIH

2002-2003 National Institutes of Health, NIDA CEBRA review committee

2002-2003 NIDA-K, The Training and Career Development Review Committee, NIH

2002 ZRG1 IFCN-4 Special Emphasis Panel, NIDA, NIH

1998-present National Science Foundation, Ad hoc reviewer


TEACHING EXPERIENCE (1997-present)

2005-present Course Coordinator, Neurosurgery Board Review for residents, Jefferson Medical College of Thomas Jefferson University

2004-present Section Leader, Neurotransmitters and signaling, Cell and Molecular Neuroscience, Course Coordinator: Diane Merry, Ph.D

2002-present Lecturer, Molecular and Cellular Basis of Medicine, Jefferson Medical College of Thomas Jefferson University

2002-present Co-course coordinator, Mechanisms of Development, College of Graduate Studies, Thomas Jefferson University

2002-present Course Coordinator, Advanced Topics in Neuroscience, College of Graduate Studies, Thomas Jefferson University

1999-present Assistant Laboratory Coordinator for Freshman Medical Neuroscience ID150, Course Coordinator: G. Brainard, Ph.D

1999-present Neuroanatomy Assistant Coordinator for Freshman Medical Neuroscience ID150, Course Coordinator: G. Brainard, Ph.D

1998-present Lecturer and instructor for laboratory sessions and clinical conferences; Jefferson Medical College of Thomas Jefferson University, Freshman Medical Neuroscience ID150, Course Coordinator: G. Brainard, Ph.D

1997-present Lecturer, College of Graduate Studies, Jefferson Medical College of TJU: Introduction to Neuroscience, Course Directors: G. Grunwald, Ph.D., D. Horn Ph.D., Mechanisms of Development, Course Coordinator: K. McHugh, Ph.D., Developmental Biology, Course Coordinator: G. Grunwald, Ph.D.

Research Supervisor for Undergraduate Students, Westinghouse Award Research Students, Graduate Students, Postdoctoral Fellows.

INVITED LECTURES AND SEMINARS (1997-present)

July 2005 "Stress-opioid interactions in norepinephrine regulation"
St John's Medical Center, St Louis, MO

April 2005 "Stress peptide interactions with norepinephrine in drug abuse"
Farber Institute of Neuroscience Retreat, Philadelphia, PA

February 2003 "Functional coupling between neurons and glia and modulation by afferent input" Neuron-Glia Gordon Conference, Ventura, California

January 2003 "Anatomical substrates underlying electrical coupling in the locus coeruleus" Attention-Locus Coeruleus (Invited speaker in a WCBR panel), Snowmass, Utah

October 2002 "Perspectives on an academic career in neuroscience research"

"Women in Science" seminar series sponsored by the Graduate Student Association, Thomas Jefferson University

March 2002 "Opioids, stress and noradrenergic neurons". Temple University College of Medicine, Philadelphia, PA.

February 2001 "Stress, opiate withdrawal and noradrenergic function". Medical College of Pennsylvania/Hahnemann University, Philadelphia, PA.

January 2001 "Stress, opiate withdrawal and noradrenergic function"
Howard University, Washington DC.

October 2000 "Locus coeruleus and opiate withdrawal"
Department of Neurology, Neuroscience Seminar Series, Thomas Jefferson University

August 2000 "Topographic architecture of stress circuits influencing the noradrenergic locus coeruleus"
University of Parma, Italy

April 2000 "The mysterious limbic system"
Yoga Society, Thomas Jefferson University

March 2000 "New perspectives on the chemoarchitecture of the locus coeruleus"
University of Gottingen, Germany

July 1998 "Role of opioids and excitatory amino acids in the locus coeruleus in the opiate withdrawal syndrome"
Vollum Institute of Biomedical Sciences, Portland, Oregon

June 1997 "Opioid modulation of the locus coeruleus: implications for opiate withdrawal"
Hopital Pitie Salpetriere, Paris, France

June 1997 "Opioid modulation of the locus coeruleus: implications for opiate withdrawal"
Universite Pierre and Marie Curie, Paris, France

May 1997 "The locus coeruleus and opiate withdrawal"
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA
Keywords
Pathology; Norepinephrine; serotonin; drug abuse; morphine; electrophysiology; receptors; brain; electron microscopy
Languages
English
French
Publications
  • Van Bockstaele EJ, Rudoy C, Mannelli P, Oropeza V, Qian Y. Elevated ยต opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs following chronic very low naltrexone in opiate dependent rats. Journal of Neuroscience Research. Epub. Dec 2005
  • Rudoy CA, Van Bockstaele EJ. Cocaine effects on norepinephrine in the amygdala: cocaine withdrawal-related anxiety and stress-related relapse. Cellscience Reviews Volume 2 Number 2 October 29th 2005 ISSN 1742-8130; http://www.cellscience.com/reviews6/Amygdala_Cocaine_Withdrawal.html
  • Reyes, B, Valentino RJ, Van Bockstaele EJ. Hypothalamic projections to the noradrenergic nucleus locus coeruleus. European Journal of Neuroscience 22:93-106.
  • Oropeza, V, Page ME, Van Bockstaele EJ. Systemic administration of WIN 55,212-2 increases norepinephrine release in the rat frontal cortex. Brain Research. 1046(1-2):45-54 2005.
  • Barr J, Van Bockstaele EJ Vesicular glutamate transporter-1 co-localizes with endogenous opioids in axon terminals of the rat locus coeruleus. The Anatomical Record. 284(1):466-74. 2005.
  • Waselus M, Valentino RJ, Van Bockstaele EJ. Ultrastructural evidence for a role of GABA in mediating the effects of corticotropin releasing factor on the rat serotonin system. The Journal of Comparative Neurology. 482: 155-165. 2005.
  • Xu G-P, Van Bockstaele EJ, Reyes B, Bethea T, Valentino RJ. Chronic morphine sensitizes the brain norepinephrine system to stress. The Journal of Neuroscience. 24: 8193-8197. 2004.
  • Mannelli P, Gottheil E, Peoples J, Oropeza V, Van Bockstaele EJ. Chronic very low dose naltrexone administration attenuates opioid withdrawl expression. Biological Psychiatry. 56: 261-268. 2004.
  • Ambrose LM, Unterwald EM, Van Bockstaele EJ. Ultrastructural evidence for co-localization of dopamine D2 and micro-opioid receptors in the rat dorsolateral striatum. The Anatomical Record. 279A(1):583-91. 2004.
  • Zhang Q, Fukuda M, Van Bockstaele E, Pascual O, Haydon PG. Synaptotagmin IV regulates glial glutamate release. Proceedings of the National Academy of Sciences U S A. 101(25):9441-6. Epub Jun 14 2004.
  • Van Bockstaele EJ, Garcia-Hernandez F, Fox K, Alvarez VA, Williams JT. Input in the rat locus coeruleus. Neurochemistry International. 45(2-3):421-8. 2004.
  • Zhang Q, Pangrsic T, Kreft M, Krzan M, Li N, Sul JY, Halassa M, Van Bockstaele E, Zorec R, Haydon PG. Fusion-related release of glutamate from astrocytes. Journal of Biological Chemistry. 26;279(13):12724-33. Epub Jan 13 2004.
  • Tjoumakaris SI, Rudoy C, Peoples J, Valentino RJ, Van Bockstaele EJ. Cellular interactions between axon terminals containing endogenous opioid peptides or corticotropin-releasing factor in the rat locus coeruleus and surrounding dorsal pontine tegmentum. J Comp Neurol. 2003 Nov 24;466(4):445-56.
  • Johnson AD, Peoples J, Stornetta RL, Van Bockstaele EJ. Opioid circuits originating from the nucleus paragigantocellularis and their potential role in opiate withdrawal. Brain Res. 2002 Nov 15;955(1-2):72-84.
  • Peoples JF, Wessendorf MW, Pierce T, Van Bockstaele EJ. Ultrastructure of endomorphin-1 immunoreactivity in the rat dorsal pontine tegmentum: evidence for preferential targeting of peptidergic neurons in Barrington's nucleus rather than catecholaminergic neurons in the peri-locus coeruleus. J Comp Neurol. 2002 Jul 1;448(3):268-79.
  • Alvarez V, Chow C, Van Bockstaele EJ, Williams JT. Frequency dependent synchrony of locus coeruleus neurons: role of electrotonic coupling. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4032-6.
  • Van Bockstaele EJ and Commons KG. Internalization of mu-opioid receptors produced by etorphine in the rat locus coeruleus. Neuroscience. 2001;108:467-477.
  • Van Bockstaele EJ, Menko AS and Drolet G Neuroadaptations in brainstem noradrenergic nuclei following chronic morphine exposure. Mol Neurobiol. 2001;23:155-171.
  • Valentino RJ, Rudoy C, Saunders A, Liu XB and Van Bockstaele EJ. Corticotropin releasing factor is preferentially co-localized with excitatory rather than inhibitory amino acids in axon terminals in the peri-locus coeruleus region. Neuroscience. 2001;106(2):375-84
  • Van Bockstaele EJ, Bajic D, Proudfit H and Valentino RJ. Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus. Physiol Behav. 2001;73(3):273-83.
  • Valentino RJ, Liouterman L, and Van Bockstaele EJ. Evidence for regional heterogeneity in corticotropin-releasing factor interactions in the dorsal raphe nucleus. J Comp Neurol. 2001; 9;435(4):450-63.
  • Valentino RJ and Van Bockstaele EJ. Opposing regulation of the locus coeruleus by corticotropin releasing factor and opioids: potential for reciprocal interactions between stress and opioid sensitivity. Psychopharmacol. 2001;158:331-342.
  • Commons KG, Beck SG, Rudoy C, Van Bockstaele EJ. Anatomical evidence for presynaptic modulation by the delta opioid receptor in the ventrolateral periaqueductal gray of the rat. Journal of Comparative Neurology. 430(2): 200-8, 2001
  • Bajic D, Proudfit HK, Van Bockstaele EJ. Periaqueductal gray neurons monosynaptically innervate extranuclear noradrenergic dendrites in the rat pericoerulear region. Journal of Comparative Neurology. 427(4): 649-62, 2000
  • Alvarez-Maubecin V, Garcia-Hernandez F, Williams JT, Van Bockstaele EJ. Functional coupling between neurons and glia. Journal of Neuroscience. 20(11): 4091-8, Jun 2000
  • Van Bockstaele EJ. Multiple substrates for serotonergic modulation of rat locus coeruleus neurons and relationships with kainate receptors. Brain Research Bulletin. 51(5): 433-42, Mar 2000
  • Van Bockstaele EJ, Saunders A, Commons KG, Liu XB, Peoples J. Evidence for coexistence of enkephalin and glutamate in axon terminals and cellular sites for functional interactions of their receptors in the rat locus coeruleus. Journal of Comparative Neurology. 417(1): 103-14, Jan 2000
  • Van Bockstaele EJ, J Peoples, AS Menko, K McHugh, G Drolet. Decreases in endogenous opioid peptides in the rat medullo-coerulear pathway following chronic morphine treatment. Journal of Neuroscience. 20: 8659-8666, 2000
  • Van Bockstaele EJ, Peoples J, Valentino RJ. A.E. Bennett Research Award. Anatomic basis for differential regulation of the rostrolateral peri-locus coeruleus region by limbic afferents. Biological Psychiatry. 46(10): 1352-63, Nov 1999
  • Van Bockstaele EJ, Saunders A, Telegan P, Page ME. Localization of mu-opioid receptors to locus coeruleus-projecting neurons in the rostral medulla: morphological substrates and synaptic organization. Synapse. 34(2): 154-67, Nov 1999
  • Van Bockstaele EJ, Peoples J, Telegan P. Efferent projections of the nucleus of the solitary tract to peri-locus coeruleus dendrites in rat brain: evidence for a monosynaptic pathway. Journal of Comparative Neurology. 412(3): 410-28, Sep 1999
  • Commons KG, van Bockstaele EJ, Pfaff DW. Frequent colocalization of mu opioid and NMDA-type glutamate receptors at postsynaptic sites in periaqueductal gray neurons. Journal of Comparative Neurology. 408(4): 549-59, Jun 1999
  • Van Bockstaele EJ, Colago EE, Valentino RJ. Amygdaloid corticotropin-releasing factor targets locus coeruleus dendrites: substrate for the co-ordination of emotional and cognitive limbs of the stress response. Journal of Neuroendocrinology. 10(10): 743-57, Oct 1998
  • Van Bockstaele EJ. Morphological substrates underlying opioid, epinephrine and gamma-aminobutyric acid inhibitory actions in the rat locus coeruleus. Brain Research Bulletin. 47(1): 1-15, Sep 1998
  • Lee A, Rosin DL, Van Bockstaele EJ. alpha2A-adrenergic receptors in the rat nucleus locus coeruleus: subcellular localization in catecholaminergic dendrites, astrocytes, and presynaptic axon terminals. Brain Research. 795(1-2): 157-69, Jun 1998
  • Lee A, Rosin DL, Van Bockstaele EJ. Ultrastructural evidence for prominent postsynaptic localization of alpha2C-adrenergic receptors in catecholaminergic dendrites in the rat nucleus locus coeruleus. Journal of Comparative Neurology. 394(2): 218-29, May 1998
  • Van Bockstaele EJ, Colago EEO, Aicher S. Light and electron microscopic evidence for topographic and monosynaptic projections from neurons in the ventral medulla to noradrenergic dendrites in the rat locus coeruleus. Brain Research. 784(1-2): 123-38, Feb 1998
  • van Bockstaele EJ, Commons K, Pickel VM. Delta-opioid receptor is present in presynaptic axon terminals in the rat nucleus locus coeruleus: relationships with methionine5-enkephalin. Journal of Comparative Neurology. 388(4): 575-86, Dec 1997
  • Van Bockstaele EJ, Chan J. Electron microscopic evidence for coexistence of leucine5-enkephalin and gamma-aminobutyric acid in a subpopulation of axon terminals in the rat locus coeruleus region. Brain Research. 746(1-2): 171-82, Jan 1997
  • Van Bockstaele EJ, Colago EE, Moriwaki A, Uhl GR. Mu-opioid receptor is located on the plasma membrane of dendrites that receive asymmetric synapses from axon terminals containing leucine-enkephalin in the rat nucleus locus coeruleus. Journal of Comparative Neurology. 376(1): 65-74, Dec 1996
  • Moriwaki A, Wang JB, Svingos A, van Bockstaele E, Cheng P, Pickel V, Uhl GR. mu Opiate receptor immunoreactivity in rat central nervous system. Neurochemical Research. 21(11): 1315-31, Nov 1996
  • Van Bockstaele EJ, Colago EE. Ultrastructural localization of the kainate selective glutamate receptor in noradrenergic perikarya and dendrites of the nucleus locus coeruleus in the rat brain. Brain Research. 732(1-2): 223-31, Sep 1996
  • Van Bockstaele EJ, Colago EE, Cheng P, Moriwaki A, Uhl GR, Pickel VM. Ultrastructural evidence for prominent distribution of the mu-opioid receptor at extrasynaptic sites on noradrenergic dendrites in the rat nucleus locus coeruleus. Journal of Neuroscience. 16(16): 5037-48, Aug 1996
  • Van Bockstaele EJ, Chan J, Pickel VM. Input from central nucleus of the amygdala efferents to pericoerulear dendrites, some of which contain tyrosine hydroxylase immunoreactivity. Journal of Neuroscience Research. 45(3): 289-302, Aug 1996
  • Van Bockstaele EJ, Chan J, Pickel VM. Pre- and postsynaptic sites for serotonin modulation of GABA-containing neurons in the shell region of the rat nucleus accumbens. Journal of Comparative Neurology. 371(1): 116-28, Jul 1996
  • Van Bockstaele EJ, Colago EE. Selective distribution of the NMDA-R1 glutamate receptor in astrocytes and presynaptic axon terminals in the nucleus locus coeruleus of the rat brain: an immunoelectron microscopic study. Journal of Comparative Neurology. 369(4): 483-96, Jun 1996
  • Pickel VM, Van Bockstaele EJ, Chan J, Cestari DM. GABAergic neurons in rat nuclei of solitary tracts receive inhibitory-type synapses from amygdaloid efferents lacking detectable GABA-immunoreactivity. Journal of Neuroscience Research. 44(5): 446-58, Jun 1996
  • Van Bockstaele EJ, Chan J, Biswas A. Ultrastructural evidence for convergence of enkephalin and adrenaline-containing axon terminals on common targets and their presynaptic associations in the rat nucleus locus coeruleus. Brain Research. 718(1-2): 61-75, Apr 1996
  • Van Bockstaele EJ, Colago EE, Valentino RJ. Corticotropin-releasing factor-containing axon terminals synapse onto catecholamine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus coeruleus in the rat brain. Journal of Comparative Neurology. 364(3): 523-534, Jan 1996
  • Van Bockstaele EJ, Aston-Jones G. Integration in the ventral medulla and coordination of sympathetic, pain and arousal functions. Clinical and Experimental Hypertension. 17(1-2): 153-65, 1995
  • Van Bockstaele EJ, Branchereau P, Pickel VM. Morphologically heterogeneous met-enkephalin terminals form synapses with tyrosine hydroxylase-containing dendrites in the rat nucleus locus coeruleus. Journal of Comparative Neurology. 363(3): 423-38, Dec 1995
  • Pickel VM, van Bockstaele EJ, Chan J, Cestari DM. Amygdala efferents form inhibitory-type synapses with a subpopulation of catecholaminergic neurons in the rat Nucleus tractus solitarius. Journal of Comparative Neurology. 362(4): 510-23, Nov 1995
  • Van Bockstaele EJ, Pickel VM. GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brain. Brain Research. 682(1-2): 215-21, Jun 1995
  • Branchereau P, Van Bockstaele EJ, Chan J, Pickel VM. Ultrastructural characterization of neurons recorded intracellularly in vivo and injected with lucifer yellow: advantages of immunogold-silver vs. immunoperoxidase labeling. Microscopy Research and Technique. 30(5): 427-36, Apr 1995
  • Van Bockstaele EJ, Gracy KN, Pickel VM. Dynorphin-immunoreactive neurons in the rat nucleus accumbens: ultrastructure and synaptic input from terminals containing substance P and/or dynorphin. Journal of Comparative Neurology. 351(1): 117-33, Jan 1995
  • Van Bockstaele EJ, Wright AM, Cestari DM, Pickel VM. Immunolabeling of retrogradely transported Fluoro-Gold: sensitivity and application to ultrastructural analysis of transmitter-specific mesolimbic circuitry. Journal of Neuroscience Methods. 55(1): 65-78, Nov 1994
  • Valentino RJ, Page ME, Luppi PH, Zhu Y, Van Bockstaele E, Aston-Jones G. Evidence for widespread afferents to Barrington's nucleus, a brainstem region rich in corticotropin-releasing hormone neurons. Neuroscience. 62(1): 125-43, Sep 1994
  • Cowan RL, Sesack SR, Van Bockstaele EJ, Branchereau P, Chain J, Pickel VM. Analysis of synaptic inputs and targets of physiologically characterized neurons in rat frontal cortex: combined in vivo intracellular recording and immunolabeling. Synapse. 17(2): 101-14, Jun 1994
  • Van Bockstaele EJ, Cestari DM, Pickel VM. Synaptic structure and connectivity of serotonin terminals in the ventral tegmental area: potential sites for modulation of mesolimbic dopamine neurons. Brain Research. 647(2): 307-22, Jun 1994
  • Van Bockstaele EJ, Sesack SR, Pickel VM. Dynorphin-immunoreactive terminals in the rat nucleus accumbens: cellular sites for modulation of target neurons and interactions with catecholamine afferents. Journal of Comparative Neurology. 341(1): 1-15, Mar 1994
  • Van Bockstaele EJ, Biswas A, Pickel VM. Topography of serotonin neurons in the dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus accumbens. Brain Research. 624(1-2): 188-98, Oct 1993
  • Van Bockstaele EJ, Pickel VM. Ultrastructure of serotonin-immunoreactive terminals in the core and shell of the rat nucleus accumbens: cellular substrates for interactions with catecholamine afferents. Journal of Comparative Neurology. 334(4): 603-17, Aug 1993
  • Van Bockstaele EJ, Akaoka H, Aston-Jones G. Brainstem afferents to the rostral (juxtafacial) nucleus paragigantocellularis: integration of exteroceptive and interoceptive sensory inputs in the ventral tegmentum. Brain Research. 603(1): 1-18, Feb 1993
  • Van Bockstaele EJ, Aston-Jones G. Collateralized projections from neurons in the rostral medulla to the nucleus locus coeruleus, the nucleus of the solitary tract and the periaqueductal gray. Neuroscience. 49(3): 653-68, Aug 1992
  • Drolet G, Van Bockstaele EJ, Aston-Jones G. Robust enkephalin innervation of the locus coeruleus from the rostral medulla. Journal of Neuroscience. 12(8): 3162-74, Aug 1992
  • Van Bockstaele EJ, Aston-Jones G. Distinct populations of neurons in the ventromedial periaqueductal gray project to the rostral ventral medulla and abducens nucleus. Brain Research. 576(1): 59-67, Mar 1992
  • Valentino RJ, Page M, Van Bockstaele E, Aston-Jones G. Corticotropin-releasing factor innervation of the locus coeruleus region: distribution of fibers and sources of input. Neuroscience. 48(3): 689-705, 1992
  • Van Bockstaele EJ, Aston-Jones G, Pieribone VA, Ennis M, Shipley MT. Subregions of the periaqueductal gray topographically innervate the rostral ventral medulla in the rat. Journal of Comparative Neurology. 309(3): 305-27, Jul 1991
  • Ennis M, Behbehani M, Shipley MT, Van Bockstaele EJ, Aston-Jones G. Projections from the periaqueductal gray to the rostromedial pericoerulear region and nucleus locus coeruleus: anatomic and physiologic studies. Journal of Comparative Neurology. 306(3): 480-94, Apr 1991
  • Aston-Jones G, Shipley MT, Chouvet G, Ennis M, van Bockstaele E, Pieribone V, Shiekhattar R, Akaoka H, Drolet G, Astier B, et al. Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology. Progress in Brain Research. 88: 47-75, 1991
  • Astier B, Van Bockstaele EJ, Aston-Jones G, Pieribone VA. Anatomical evidence for multiple pathways leading from the rostral ventrolateral medulla (nucleus paragigantocellularis) to the locus coeruleus in rat. Neuroscience Letters. 118(2): 141-6, Oct 1990
  • Van Bockstaele EJ, Pieribone VA, Aston-Jones G. Diverse afferents converge on the nucleus paragigantocellularis in the rat ventrolateral medulla: retrograde and anterograde tracing studies. Journal of Comparative Neurology. 290(4): 561-84, Dec 1989

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