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Thomas Jefferson University - Emad Alnemri, PhD
Emad Alnemri, PhD

Biochemistry & Molecular Biology
Thomas Jefferson University
Jefferson Medical College
Department of Biochemistry & Molecular Biology
Thomas Eakins Distinguished Professor
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Mailing Address
233, S. 10th Street, BLSB 904
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-503-4632
Fax: 215-923-1098
E_Alnemri@mail.jci.tju.edu
Personal Web Site
Qualifications
Ph.D. Temple University School of Medicine, 1991
Keywords
Apoptosis; Cell death; CPP32; Caspases; Pyrin; Nalp3; Inflammation; Innate immunity; Caspase-1; Pyroptosis; Pyroptosome; ASC; AIM; neurodegeneration; omi;
Publications
  • Fernandes-Alnemri, T., Litwack, G. and Alnemri, E.S. CPP32: a novel human apoptotic protein with homology to C. elegans cell death protein CED-3 and mammalian interleukin-1b converting enzyme. J. Biol. Chem. 269, 308761-30764.1994
  • Alnemri, E.S., Fernandes-Alnemri, T. and Litwack, G. Cloning and expression of four novel isoforms of human interleukin-1 b converting enzyme with different apoptotic activities. J. Biol. Chem. 270, 4312-4317. 1995
  • Fernandes-Alnemri, T., Armstrong, R., Krebs, J., Srinivasula, S.M., Wang, L., Yu, Z., Trapani, J.A., Tomaselli, K. J., Litwack, G., and Alnemri, E.S. Activation of CPP32 by Mch4, A Novel Human Apoptotic Cysteine Protease containing two FADD-like Domains. Proc. Natl. Acad. Sci. USA. 93, 7464-7469. 1996
  • Srinivasula, S.M., Ahmad, M., Fernandes-Alnemri, T., Litwack, G. and Alnemri, E.S. Molecular ordering of the Fas-apoptotic pathway: The Fas/Apo-I protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. USA. 93, 13706-13711 1996.
  • Srinivasula, S.M., Ahmad, M., Fernandes-Alnemri, T., and Alnemri, E.S. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol. Cell 1:949-957. 1998.
  • Srinivasula, S.M., Ahmad, M., Lin, J-H., Poyet, J.L., Fernandes-Alnemri, T., Tsichlis, P.N. and Alnemri, E.S. CLAP, a novel CARD-containing Protein in the TNF-receptor Pathway, Regulates NF-kappa B Activation and Apoptosis. J. Biol. Chem. 274, 17946-17954. 1999.
  • Qin, H., Srinivasula, S.M., Wu, G., Fernandes-Alnemri, T., Alnemri, E.S., and Shi, Y. Structural basis of procaspase-9 recruitment by the apoptotic protease activating factor (Apaf-1). Nature. 399:549-557. 1999.
  • Srinivasula, S.M., Hegde, R., Saleh, A., Datta, P., Shiozaki, E., Chai, J., Lee, R.A., Robbins, P.D., Fernandes-Alnemri, T., Shi, Y., Alnemri, E.S. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature, 410, 112-116. 2001
  • Poyet, J-L., Srinivasula, S.M., Tnani, M., Razmara, M., Fernandes-Alnemri, T., Alnemri, E.S. Identification Of Ipaf, A Human Caspase-1 Activating Protein Related To Apaf-1. J. Biol. Chem. 276(30):28309-28313. 2001.
  • Hegde, R., Srinivasula, S.M., Zhang, Z., Wassell, R., Mukattash, R., Cilenti, L., DuBois, G., Lazebnik, Y., Zervos, A.S., Fernandes-Alnemri, T., Alnemri, E.S. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J Biol Chem. 277(1):432-8. 2002
  • Jones, J.M., Datta, P., Srinivasula, S.M., Ji, W., Gupta, S., Zhang, Z., Davies, E., Hajnoczky, G., Saunders, T.L., Van, Keuren, M.L., Fernandes-Alnemri, T., Meisler, M.H. and Alnemri, E.S. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature. 425(6959):721-7 2004.
  • Yu, JW., Wu,J., Zhang,Z., Datta,P., Ibrahimi,I., Taniguchi,S., Sagara,J., Fernandes-Alnemri,T., Alnemri,E.S. 2006 Cryopyrin and Pyrin activate caspase-1, but not NF-kB, via ASC oligomerization. Cell Death and Differentiation, 13(2):236-49, 2006.
  • Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, Rosenberg S, Zhang J, Alnemri ES.The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death & Differentiation 14(9):1590-604, 2007.
  • Yu, JW., Fernandes-Alnemri T, Datta P., Wu J., Juliana,C., McCormick, M., Solorzano, L., Zhang. Z., Alnemri, E.S. 2007 Pyrin activates the ASC Pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol. Cell 28(2):214-27, 2007
  • Khan F., Fujioka, M., Datta, P., Fernandes-Alnemri, T., Jaynes, J. B., and Alnemri E. S. Drosophila Omi/HtrA2 targets the BIR1-Linker domain to inactivate DIAP1. Cell Death and Differentiation 15, 1073-1083, 2008.
  • Fernandes-Alnemri, T. and Alnemri E. S. Assembly, purification and assay of the activity of the ASC pyroptosome. Methods Enzymol. 442, 251-270, 2008.
  • Fernandes-Alnemri, T., Yu, J-W, Datta, P., Wu, J. and Alnemri, ES. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature AOP Jan 21, 2009

Individual Expertise profile of Emad Alnemri, PhD, Copyright © Emad Alnemri, PhD.
Last Updated by Admin : Tuesday, June 5, 2012 3:37:21 PM



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