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Thomas Jefferson University - Gyorgy Hajnoczky, MD, PhD
Gyorgy Hajnoczky, MD, PhD

Pathology, Anatomy & Cell Biology
Professor
Mailing Address
1020 Locust str Suite 261 JAH
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: (215) 503-1427
Gyorgy.Hajnoczky@jefferson.edu
Qualifications
M.D., Semmelweis University, Budapest, 1987

Ph. D., Semmelweis University, Budapest, 1987
Keywords
signaling, calcium, ER, mitochondria, metabolism, apoptosis, imaging
Publications
  • Pubmed
  • G Hajnóczky, C Lin and AP Thomas: Luminal communication between intracellular Ca2+ stores modulated by GTP and the cytoskeleton. Journal of Biological Chemistry (1994) 269, 10280-10287
  • G Hajnóczky & AP Thomas: The inositol trisphosphate activated Ca2+ channel is inactivated by inositol trisphosphate. Nature (1994) 370, 474-477
  • G Hajnóczky, L Robb-Gaspers, MB Seitz and AP Thomas: Decoding of cytosolic Ca2+ oscillations in the mitochondria. Cell (1995) 82, 415-424
  • G Hajnóczky & AP Thomas: Minimal requirements for calcium oscillations driven by the IP3 receptor. EMBO Journal (1997) 16, 3533-3543
  • G. Csordás, AP Thomas & G Hajnóczky: Quasi-synaptic calcium signal transmission between IP3 receptors and mitochondria. EMBO Journal (1999) 18, 96-108
  • G Hajnóczky, R Hager & AP Thomas: Mitochondria suppress feedback activation of IP3 receptors by calcium. Journal of Biological Chemistry (1999) 274, 14157-14162
  • G. Szalai, R. Krishnamurthy & G Hajnóczky: Apoptosis driven by IP3-linked mitochondrial calcium signals EMBO Journal (1999) 18, 6349-6361
  • G. Szalai, G. Csordás, B.M. Hantash, A.P. Thomas & G. Hajnóczky: Calcium signal transmission between ryanodine receptors and mitochondria. Journal of Biological Chemistry (2000) 275, 15305-15313
  • P. Pacher, G. Csordás, T.G. Schneider & G. Hajnóczky: Quantification of calcium signal transmission from sarco-endoplasmic reticulum to the mitochondria. Journal of Physiology (2000) 529, 553-564
  • G. Csordás& G Hajnóczky: Sorting of calcium signals at the junctions of endoplasmic reticulum and mitochondria. Cell Calcium (2001) 29, 249-262.
  • P. Pacher & G. Hajnóczky: Propagation of the apoptotic signal by mitochondrial waves. EMBO Journal (2001) 20, 4107-4121.
  • M. Madesh & G Hajnóczky: VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. Journal of Cell Biology (2001) 155:1003-15.
  • M. Madesh, Antonsson, B., Srinivasula, Alnemri, E. & G Hajnóczky: Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. Journal of Biological Chemistry (2002) 277(7):5651-9.
  • P. Pacher, A.P. Thomas & G Hajnóczky Ca2+ Marks: Miniature calcium signals in single mitochondria driven by ryanodine receptors. Proc Natl Acad Sci (2002) 99(4):2380-5.
  • G. Csordás, M. Madesh, B. Antonsson, and G. Hajnóczky tcBid promotes Ca2+ signal propagation to the mitochondria: Control of Ca2+ permeation through the outer mitochondrial membrane EMBO J. (2002) 21(9):2198-2206.
  • Csordás G and Hajnóczky G: Plasticity of mitochondrial calcium signaling. Journal of Biological Chemistry (2003) 278(43):42273-82.
  • Jones JM, Datta P, Srinivasula SM, Yi W, Gupta S, Zhang Z, Davies E, Hajnóczky G, Alnemri ES, Meisler MH: Loss ofOmi/HtrA2 protease activity causes the neuromuscular disorder of mnd2 mutant mice Nature (2003) 425(6959):721-7.
  • Yi M, Weaver D and Hajnóczky G Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit. J Cell Biol. (2004) 167(4): 661-72.
  • " Comment in: Rabya Tuma: Mitochondria move in on calcium JCB, (2004) 167, 4, 578-578
  • " Cell Biology Paper of the Week, Science STKE
  • Lin X, Várnai P, Csordás G, Balla A, Nagai T, Miyawaki A, Balla T and Hajnóczky G. Control of calcium signal propagation to the mitochondria by IP3-binding proteins. J Biol Chem. (2005)280(13): 12820-32.
  • Báthori G, Csordas G, Garcia-Perez C, Davies E and Hajnóczky G Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and VDAC. J Biol Chem. (2006) 281 (25) : 17347-58
  • Csordás G, Renken C, Várnai P, Walter L, Weaver D, Buttle KF, Balla T, Mannella CA and Hajnóczky G. Structural and functional aspects and significance of the physical links between ER and mitochondria. J Cell Biol. (2006) 174 :(7) 915-21
  • " Cover Article, J. Cell. Biol. (2006) 174 (5)
  • " Comment in: Rabiya Tuma Spaced just right (2006) 174(7), 907-907
  • Hajnóczky G and Hoek JB: Mitochondrial longevity pathways. Science (2007) 315:607-9.
  • Zhang H, Das S, Li Q, Dragatsis I, Repa JJ, Zeitlin S, Hajnóczky G and Bezprozvanny I Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts BMC Neuroscience (2008)9:38.
  • Garcia-Perez C, Hajnóczky G and Csordas G Physical coupling supports the local Ca2+ transfer between SR subdomains and the mitochondria in heart muscle J Biol Chem. (2008) 283(47):32771-80.
  • Saotome M, Safiulina D, Szabadkai G, Das S, Fransson ú, Aspenstrom P, Rizzuto R and Hajnóczky G Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase Proc Natl Acad Sci. (2008) 105(52):20728-33.
  • *highlighted in Leading Edge of CELL
  • Sinha Roy S, Madesh M, Davies E, Antonsson B, Danial N and Hajnóczky G Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death (2009) Molecular Cell in press

Individual Expertise profile of Gyorgy Hajnoczky, MD, PhD, Copyright © Gyorgy Hajnoczky, MD, PhD.
Last Updated by Administration : Tuesday, September 28, 2010 5:12:06 PM



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