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Thomas Jefferson University - Kishore Alugupalli, PhD
Kishore Alugupalli, PhD

Microbiology & Immunology
Thomas Jefferson University
Assistant Professor

Kimmel Cancer Center
Member

Mailing Address
233 South 10th St., Room 726 BLSB
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-503-4554
Fax: 215-503-4153
Kishore.Alugupalli@mail.jci.tju.edu
Qualifications
Ph.D. 1996: Lund University, Sweden
Expertise and Research Interests
Immunology. B cell Memory - B1b Lymphocyte biology; Innate Immunity - Toll-like receptors and NOD-like receptors

B1b lymphocytes in T cell-independent memory:
Pathogenesis of infectious disease is not only determined by the virulence of the microbe but also by the immune status of the host. Vaccination is the most effective means to control infectious diseases. A hallmark of the adaptive immune system is the generation of B cell memory, which provides a long-lasting protective antibody response that is central to the concept of vaccination. Studies from our laboratory revealed a distinct function for B1b lymphocytes, a minor subset of mature B cells that closely resembles that of memory B cells in a number of aspects. In contrast to the development of conventional B cell memory, which requires the formation of germinal centers and T cells, the development of B1b cell-mediated long-lasting antibody responses occurs independent of T cell help. T cell-independent (TI) antigens are important virulence factors expressed by a number of bacterial pathogens, including those associated with biological threats. TI antigens cannot be processed and presented to T cells and therefore are known to possess restricted T cell-dependent (TD) immunogenicity. Nevertheless, specific recognition of TI antigens by B1b cells and the highly protective antibody responses mounted by them clearly indicate a crucial role for this subset of B cells. Understanding the mechanisms of long-term immunity conferred by B1b cells are among the major interests of my laboratory.

Publications
  • Dickinson GS, Alugupalli KR. 2012. Deciphering the role of Toll-like receptors in humoral responses to Borreliae. Front Biosci (Schol Ed). 2012 Jan 1;4:699-712.
  • Vuyyuru R, Liu H, Manser T, Alugupalli KR. 2011. Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever. Proc Natl Acad Sci U S A. Dec 20;108(51):20707-12.
  • Colombo MJ, Abraham D, Shibuya A, Alugupalli KR. 2011. B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fc alpha/Mu receptor and in the absence of host cell contact. Immunol Res. Dec;51(2-3):249-56.
  • Dickinson G. S., Piccone H., Sun G., Lien E., Gatto L., Alugupalli K. R. 2010. Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection. Infection and Immunity. Aug 9. [Epub ahead of print].
  • Colombo M. J., Sun G., Alugupalli K. R. 2010. T cell-independent immune responses do not require Cxcl13-mediated B1 cell migration. Infection and Immunity. 78(9):3950-6.
  • Shriner A.K., Liu H., Sun G., Guimond M., Alugupalli KR. 2010. IL-7Dependent B Lymphocytes are essential for the anti-polysaccharide response and protective immunity to Streptococcus pneumoniae. The Journal of Immunology. 185(10):525-31.
  • Liu H, Fitzgerald D, Gran B, Leong JM, Alugupalli KR. 2010. Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. The Journal of Immunology. 184(10):5859-64.
  • Benoit VM, Petrich A, Alugupalli KR, Marty-Roix R, Moter A, Leong JM, Boyartchuk VL. 2010. Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice. Infection & Immunity. 78(2):586-94.
  • Faber M, Li J, Kean RB, Hooper DC, Alugupalli KR, Dietzschold B. 2009. Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus. Proc Natl Acad Sci U S A. 2009;106(27):11300-5.
  • Alugupalli KR, Abraham D. 2009. B cell multitasking is required to control nematode infection. Immunity. 2009;30(3):317-9.
  • O'Brien K., Fitzgerald D. C., Naiken K., Alugupalli K. R., Rostami A. M., Gran B. 2008. Role of the innate immune system in autoimmune inflammatory demyelination. Curr Med Chem. 15:1105-1115.
  • Colombo M. J. & Alugupalli K. R. 2008. Complement Factor H-Binding protein, a putitive virulence determinant of Borrelia hermsii, is an antigenic target for protective B1b lymphocytes. Journal of Immunology. 180:4858-4864.
  • Alugupalli K. R. 2008. A distinct role for B1b lymphocytes in T cell-independent immunity. Current Topics in Microbiology and Immunology. 319:105-130.
  • Wong S. M. S., Alugupalli K. R., Ram. S., Akerley, B. A. 2007. The ArcA regulon and oxidative stress resistance in Haemophilus influenzae. Molecular Microbiology. 64:1375-1390.
  • Alugupalli K. R., Akira, S., Lien E. and Leong J. M. 2007. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses. The Journal of Immunology. 178: 3740-3749.
  • Alugupalli K. R. and Gerstein, R. M. 2005. Divide and conquer: division of labor by B-1 B cells. Immunity 23: 1-2.
  • Alugupalli K. R., Leong J. M., Woodland R. T., Muramatsu, M., Honjo, T., Gerstein R. M. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity. 21: 379-390.
  • Alugupalli K. R., Gerstein R. M., Chen J., Szomolanyi E. T., Woodland R. T., Leong J. M. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with the expansion of B1b lymphocytes. The Journal of Immunology. 170: 3819-3827.
  • Alugupalli K. R., Michelson A. D., Joris I., Schwan T. G., Hodivala-Dilke K, Hynes R. O., Leong J. M. 2003. Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis. Blood. 102: 2843-2850.
  • Alugupalli K. R., Michelson A. D., Barnard M. B., Leong J. M. 2001. Serial determinations of platelet counts in mice by flow cytometry. Thrombosis & Haemostasis. 86: 668-71.
  • Alugupalli K. R., Michelson A. D., Barnard M. B., Robbins D., Coburn J., Baker E. K., Ginsberg M. H., Schwan T. G., Leong J. M. 2001. Platelet activation by a relapsing fever spirochaete results in enhanced bacterium-platelet interaction via integrin aIIbb3 activation. Molecular Microbiology. 39: 330-340.
  • Magoun L. M., Zuckert W. R., Robbins D. R., Parveen N., Alugupalli K. R., Schwan T. G., Barbour A. G., Leong J. M. 2000. Variable small protein (Vsp)-dependent and Vsp-independent pathways for glycosaminoglycan recognition by relapsing fever spirochaetes. Molecular Microbiology 36: 886-897.
  • Alugupalli K. R., Kalfas S. 1997. Characterization of the lactoferrin-dependent inhibition of the adhesion of Actinobacillus actinomycetemcomitans, Prevotella intermedia and Prevotella nigrescens to fibroblasts and to a reconstituted basement membrane. Acta Pathologica Microbiologica et Immunologica Scandinavica. 105: 680-688.
  • Nyman M., Alugupalli K. R., Strömberg S., Forsgren A. 1997. Antibody response to Arcanobacterium haemolyticum infection in humans. Journal of Infectious Diseases 175: 1515-1518.
  • Alugupalli K. R., Kalfas S. 1996. Degradation of lactoferrin by periodontitis-associated bacteria. FEMS Microbiology Letters 145: 209-214.
  • Alugupalli K. R., Kalfas S., Forsgren A. 1996. Laminin binding to a major heat-modifiable outer membrane protein of Actinobacillus actinomycetemcomitans. Oral Microbiology & Immunology 11: 326-331.
  • Alugupalli K. R., Kalfas S. 1995. Inhibitory effect of lactoferrin on the adhesion of Actinobacillus actinomycetemcomitans and Prevotella intermedia to fibroblasts and epithelial cells. Acta Pathologica Microbiologica et Immunologica Scandinavica 103: 154-160.
  • Alugupalli K. R., Kalfas S., Edwardsson S., Naidu A. S. 1995. Lactoferrin interaction with Actinobacillus actinomycetemcomitans. Oral Microbiology & Immunology 10: 35-41.
  • Alugupalli K. R., Kalfas S., Edwardsson S., Forsgren A., Arnold R. R., Naidu A. S. 1994. Effect of lactoferrin on the interaction of plasma and subepithelial matrix proteins with Prevotella intermedia. Oral Microbiology & Immunology 9:174-179.
  • Paulsson M. A., Svensson U., Kishore A. R.*, Naidu A. S. 1993. Thermal behavior of bovine lactoferrin in relation to bacterial interaction and antibacterial activity. Journal of Dairy Sciences 76: 3711-3720.
  • Naidu S. S., Svensson U., Kishore A. R.*, Naidu A. S. 1993. Relation between anti-bacterial activity and porin binding of lactoferrin in Escherichia coli and Salmonella typhimurium. Antimicrobial Agents & Chemotherapy 37: 240-245.
  • Kishore A. R.*, Erdei J., Kalfas S., Forsgren A., Naidu A. S. 1992. Detection of bacterial interaction with lactoferrin by an enzyme-linked ligand binding assay (ELBA). Journal of Medical Microbiology 37: 341-345.
  • Tigyi Z., Kishore A. R.*, Maeland J. A., Forsgren A., Naidu A. S. 1992. Lactoferrin-Binding proteins in Shigella flexneri. Infection & Immunity 60: 2619-2626.
  • Kishore A. R.*, Erdei J., Naidu S. S., Falsen E., Forsgren A., Naidu A. S. 1991. Specific binding of lactoferrin to Aeromonas hydrophila. FEMS Microbiology Letters 83: 115-120.

Individual Expertise profile of Kishore Alugupalli, PhD, Copyright © Kishore Alugupalli, PhD.
Last Updated by Kishore Alugupalli, PhD : Monday, January 9, 2012 12:55:13 PM



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