University Home | Hospital | Pulse Employment | Contact Us | Search | News 
Thomas Jefferson University Search Jefferson
Jefferson Medical College Jefferson College of Graduate Studies Jefferson College of Health Professions
Menu
Thomas Jefferson University - Linda E. Greenbaum, MD
Linda E. Greenbaum, MD

Cancer Biology
Associate Professor of Cancer Biology

Associate Professor of Medicine, Division of Gastroenterology and Hepatology
Image Placeholder
Mailing Address

Pennsylvania
United States
Contact Information
Linda.Greenbaum@jefferson.edu
Qualifications
M.D. Columbia University, College of Physicians and Surgeons, Medicine, 1980
Expertise and Research Interests
Regulation of liver regeneration: role of transcription factors for cell cycle regulation, regulation of hepatocyte proliferation by microRNAs.

Signaling pathways that regulate hepatic progenitor cell self-renewal and differentiation; role of progenitors in liver repair and development of stem cell liver cancers.
Keywords
hepatocyte, liver, stem cell, transcription, fibrosis, carcinogenesis, cholangiocyte, microRNA
Publications
  • Mukherjee, D., Kaestner, K. H., and L. E. Greenbaum, L Fas-induced apoptosis in murine hepatocytes is dependent on C/EBPbeta. Hepatology, 33, 1166-72, 2001. PMID: 11343245.
  • Strey, C.W, Markiewski, M., Mastellos, D., Tudoran, R., Spruce, L.A., Greenbaum, L. E. and J.D. Lambris. The Proinflammatory Mediators c3a and c5a are essential for liver regeneration. J. Exp. Med. 198:913-923, 2003. PMID: 12975457.
  • Friedman, J. R., Larris, B., Le, P.P., Peiris, T.H., Arsenlis, A., Schug, J., Tobias, J.W., Kaestner, K.H. and L.E. Greenbaum. Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation. Proc. Nat. Acad. Sci., USA, 101:12986-12991, 2004. PMID: 15317935.
  • White, P, Brestelli, J.E., Kaestner, K.H. and L.E. Greenbaum. Identification of transcriptional networks during liver regeneration. J. Biol. Chem., 280:3715-3722, 2005. PMID: 15546871.
  • Zhang, L., Rubins, N., Ahima, R., Greenbaum, L.E., and K.H. Kaestner. FoxA2 mediates the hepatocyte response to fasting, Cell Metabolism 2:141-8, 2005. PMID: 16098831.
  • Wang, H., Larris, B., Peiris, T.H., Zhang, L., Le Lay, J., Gao, Y. and L.E. Greenbaum. C/EBPbeta activates E2F regulated genes in vivo via recruitment of the coactivator CBP/p300 , J. Biol. Chem., 282:24679-88, 2007. PMID: 17599912.
  • Wang, H., Peiris, T.H., Mowery, A., Le Lay, J., Gao, Y. and L.E. Greenbaum. C/EBPbeta is a transcriptional activator of PGC-1alpha in the regenerating liver, Molecular Endocrinology, 22:1596-605. PMID: 18467525.
  • Mullany, L.K., White, P., Hanse, E.A., Nelsen, C.J., Goggin, M.M., Mullany, J.E., Anttila, C.K., Greenbaum L.E., Kaestner, K.H., and J.H. Albrecht. Distinct proliferative and transcriptional effects of the D-type cyclins in vivo. Cell Cycle, 15:2215-24, 2008 (epub May 12, 2008). PMID: 18635970.
  • Sackett, S.D., Li, Z., Hurtt, R., Gao, Y., Wells, R.G., Brondell, K., Kaestner, K.H. and L.E. Greenbaum. Foxl1 is a marker of bipotential hepatic progenitor cells in the liver. Hepatology, 49:920-9, 2009 (ePub October 24, 2008). PMID: 19105206.
  • Sackett, S.D., Gao, Y., Shin, S., Esterson, Tsingalia, A., Hurtt, R., Brondell, K., Kaestner, K.H., and L.E. Greenbaum. Foxl1 promotes liver repair following cholestatic injury in mice. Laboratory Investigation, 2009, 12:1387-96. PMID: 19841618.
  • Greenbaum, L.E. and R.G. Wells. The Role of Stem Cells in Liver Repair and Fibrosis. International Journal of Biochemistry and Cell Biology, 2009 November 13 (ePub ahead of print). PMID: 19914396
  • Gao, Y., Schug, J., McKenna, LB, Le Lay, J., Kaestner, K.H, and Greenbaum, L.E. Tissue-specific regulation of mouse MicroRNA genes in endoderm-derived tissues, Nucleic Acids Research, 2010 Sep 14 (epub ahead of print). PMID: 20843784
  • Shin, S., Walton, G., Aoki, R., Brondell, K, Schug, J., Fox, Al, Smirnova, O., Dorrell, C., Erker, Chu, A., Wells, R.G., Grompe, M., Greenbaum, L.E. and Kaestner, K. Foxl1-Cre-marked Adult Hepatic Progenitors Have Clonogenic and Bi-Lineage Differentiation Potential, Genes & Development, 2011 (In press).

Individual Expertise profile of Linda E. Greenbaum, MD, Copyright © Linda E. Greenbaum, MD.
Last Updated by Linda Greenbaum, MD : Wednesday, April 6, 2011 2:24:51 PM



 Printable Version

Thomas Jefferson University
Thomas Jefferson University