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Thomas Jefferson University - Michael R. Sperling
Michael R. Sperling

Thomas Jefferson University
Jefferson Medical College
Department of Neurology
Baldwin Keyes Professor Appointed: 1997

Jefferson Medical College
Vice Chairman for Clinical Affairs

Director, Jefferson Comprehensive Epilepsy Center

Director, Clinical Neurophysiology Laboratory
Mailing Address
Jefferson Hospital for Neurosciences, 900 Walnut St
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-955-1222
Fax: 215-955-0606
B.A., Temple University, Biochemistry (magna cum laude, President's Scholar), 1974

M.D., Temple University School of Medicine, 1978

Internship: Internal Medicine, Mount Sinai Hospital, New York, NY

Residency: Neurology, Mount Sinai Hospital, New York, NY

Fellowship: Epilepsy and Clinical Neurophysiology, UCLA Medical Center, Los Angeles, CA

Medical Licensure: New York, Pennsylvania,

Board certification, National Board of Medical Examiners, 1979

Board Certification, American Board of Psychiatry and Neurology, Neurology, 1984

Board Certification, American Board of Clinical Neurophysiology (formerly American Board of Qualification in EEG), 1984

Board Certification, American Board of Psychiatry and Neurology, Subspecialty certification in Clinical Neurophysiology, 1999, 2009

Expertise and Research Interests
Surgical treatment of epilepsy: outcome after surgery, predictors of surgical outcome, neurobehavioral effects of surgery;
Mortality in epilepsy: research examining features associated with increased mortality in patients with epilepsy;
Electrophysiology of epilepsy: studies of EEG in epilepsy, intracranial EEG in epilepsy examining features related to seizure control, seizure propagation and spread;
Genetics of epilepsy: project examining genetic factors predisposing to heightened susceptibility for epilepsy;
Electrophysiology of cognition;
Investigational therapeutics in epilepsy: participation in multiple studies of new pharmaceuticals and devices to treat epilepsy.
Other Expertise
Graduate Hospital, Philadelphia, PA
Director, Neurophysiology Laboratory, 1985 - 1997
Director, Epilepsy Monitoring Unit 1985 - 1997
Director, Comprehensive Epilepsy Center, 1995- 1997
Thomas Jefferson University Hospital, Philadelphia, PA
Director, Jefferson Comprehensive Epilepsy Center, 1997 - present
Director, Clinical Neurophysiology Laboratory, 1997 - present


1999-2000 President of American Clinical Neurophysiology Society
2002-2003 President of Philadelphia Neurological Society
Fellow, American Academy of Neurology
Member, American Neurological Association
Member, American Epilepsy Society
Member, American Clinical Neurophysiology Society


Director of Fellowship Program in Epilepsy and Clinical Neurophysiology, Thomas Jefferson University Hospital
Medical student and resident lectures and teaching
Weekly morning report

1. Developed epilepsy program at the Graduate Hospital, including design and development of the epilepsy monitoring unit and EEG laboratory, epilepsy surgical program (with Dr. Michael O'Connor), contributing to development of experimental antiepileptic drug program, and clinical research program.
2. Developed the Comprehensive Epilepsy Center at Thomas Jefferson University, including designing and developing the epilepsy monitoring unit and EEG laboratory, epilepsy surgical program (with Dr. Michael O'Connor), experimental antiepileptic drug program, and clinical research program.
3. Developed intraoperative brain mapping program at Thomas Jefferson University Hospital

Associate Editor: Epilepsia 2007 - present
Member, Editorial Board: Journal of Epilepsy, 1991-1999, Epilepsy Advances, 1993-95, 1996-1998, Epilepsy Research, 1999-2007.

Reviewer: Electroencephalography and Clinical Neurophysiology, Annals of Neurology, Neurology, Epilepsia, Journal of Clinical Neurophysiology, Neuroradiology, Journal of Neurological Sciences, Archives of Neurology, JAMA, New England Journal of Medicine, Lancet

Neurology Epilepsy Seizures EEG
  • Sperling, M.R., Clancy, R.R. (eds) Atlas of Electroencephalography. Elsevier, Amsterdam, 1993.
  • Volume 1 - Clancy, R.R., Chung, H.J., Temple, J.P. Neonatal Electroencephalography, Elsevier, Amsterdam, 182 pages, 1993.
  • Volume 2 - Sperling, M.R., Morrell, M.J. Pediatric and adult Electroencephalography, Elsevier, Amsterdam, 256 pages, 1993.
  • Volume 3 - Sperling, M.R. Intracranial Electroencephalography, Elsevier, Amsterdam, 317 pages, 1993.
  • AA Asadi-Pooya, Sperling MR. Antiepileptic Drugs: A Clinicians Manual. Oxford University Press, New York, 2009.
  • Jenssen S, Roberts CM, Gracely EJ, Dlugos DJ, Sperling MR. Focal aseizure propagation in the intracranial EEG. Epilepsy Res 93:25-32, 2011.
  • Osipowicz K, Rickards T, Shah A, Sharan A, Sperling M, Kahn W, Tracy J. A test of the role of the medial temporal lobe in single-word decoding. Neuroimage 54:1455-64, 2011.
  • Asadi-Pooya AA, Sperling MR. Depression and anxiety in patients with epilepsy, with or without other chronic disorders. Iranian Red Crescent Med J. 13:112-116, 2011.
  • Zarroli K, Tracy, JI, Nei M, Sharan A, Sperling MR. Employment after anterior temporal lobectomy. Epilepsia (in press).
  • Hamid, H, Devinsky O, Sperling MR, Berg AT, VickreyBG, Shinnar S, Langfitt JT, Walczak TS, Bazil CW, Spencer SS. Suicide outcomes after resective epilepsy surgery. Epilepsy and Behavior (in press).
  • Sperling MR, Greenspan A, Cramer JA, Kwan P, Kälviäinen R|, Halford JJ, Schmitt J, Yuen E, Cook T, Haas M, Novak G. Carisbamate as adjunctive treatment of partial onset seizures in adults in two randomized, placebo-controlled trials. Epilepsia 51:333-43, 2010.
  • Zangaladze A, Asadi-Pooya AA, Ashkenazi A, Sperling MR. Sporadic hemiplegic migraine and epilepsy associated with CACNA1A gene mutation. Epilepsy and Behavior 17:293-5, 2010.
  • Chung S, Sperling MR, Biton V, Krauss G, Hebert D, Rudd GD, Doty P on behalf of the SP754 Study Group. Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial. Epilepsia 51:958-67, 2010.
  • Helbig KL, Bernhardt BA, Conway LJ, Balverde KD, Sperling MR. Genetic risk perception and reproductive decision-making among people with epilepsy. Epilepsia 51:1874-77, 2010.
  • Murray R, Spiegel J, Curry J, Evans J, Powell D, Sperling MR. Epileptic laryngospasm presenting as a primary sleep disturbance. Arch Otolaryngol Head Neck Surg. 136:1025-1027, 2010.
  • Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, et al. Electrical Stimulation of the Anterior Nucleus of Thalamus for Treatment of Refractory Epilepsy. Epilepsia 51:899-908, 2010.
  • Engel Jr J, McDermott MP, Wiebe S, Langfitt JT, Erba G, Gardiner I, Stern J, Dewar S, Sperling MR, Jacobs M, Kieburtz K; for the Early Randomized Surgical Epilepsy Trial (ERSET) Study Group. Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsy. Epilepsia 51:1978-86, 2010.
  • Buckingham SE, Chervoneva I, Sharan A, Zangaladze A, Mintzer S, Skidmore C, Nei M, Evans J, Pequignot E, Sperling MR. Latency to first seizure after temporal lobectomy predicts long-term outcome. Epilepsia 51:1987-93
  • Asbury AK, Sperling MR, Aguirre GK, Liu GT. Selected contributions to neurology by Philadelphia neurologists since 1980. (prepared in association with the 125th anniversary celebration meeting of the Philadelphia Neurological Society on Feb. 20, 2008). Rev Neurol Dis 7:140-149, 2010.
  • Chung S, Ben-Menachem E, Sperling MR, Rosenfeld W, Fountain NB, Benbadis S, Hebert D, Isojarvi J, Doty P. Examining the clinical utility of lacosamide: pooled analyses of three phase II/III clinical trials. CNS Drugs 24:1041-1054, 2010.
  • Bower CM, Hays RD, Devinsky O, Spencer SS, Sperling MR, Haut S, Vassar S, Vickrey BG. Expectations Prior to Epilepsy Surgery: An exploratory comparison of men and women. Seizure 18:228-231, 2009.
  • Mintzer S, Skidmore CT, Abidin CJ, Morales MC, Chervoneva I, Capuzzi DM, Sperling MR. Effects of antiepileptic drugs on lipids, homocysteine, and C-reactive protein. Ann Neurol 65(4):448-56, 2009.
  • Tracy JI, Waldron B, Glosser D, Sharan A, Mintzer S, Zangaladze A, Skidmore C, Siddiqui I, Caris E, Sperling MR. Hemispheric lateralization and language skill coherence in temporal lobe epilepsy. Cortex 45:1178-1189, 2009.
  • Mechanic-Hamilton D, Korczykowski M, Yushkevich PA, Lawler K, Pluta J, Glynn S, Tracy JI, Wolf RL, Sperling MR, French JA, Detre JA. Hippocampal volumetry and functional MRI of memory in temporal lobe epilepsy. Epilepsy Behav.16:128-38, 2009.
  • Sperling MR, Schilling CA, Glosser D, Tracy JI, Asadi-Pooya AA. Self-perception of seizure precipitants and their relation to anxiety level, depression, and health locus of control in epilepsy. Seizure 17:302-307, 2008.
  • Quigg M , Fowler KM, Herzog AG, Schomer D, Bromfield E, Dworetzky B, Replansky S, Harden CL, Nikolov B, Pack A, Randle A, Jobst B, Holmes G, Clough E, Pennell P, Newman M, Krauss G, Kaplan P, Muigai F, Tran T, Gapany S, Andermann E, Andermann F, Mercho S, Liporace J, Sperling M, Taylor G, Kalayjian L, Heck C, Oviedo S. Circalunar and ultralunar periodicities in women with partial seizures. Epilepsia 49:1081-1085, 2008.
  • Asadi-Pooya A, Mintzer S, Sperling MR. Nutritional supplements, foods, and epilepsy: Is there a relationship? Epilepsia 13:271-8, 2008.
  • Asadi-Pooya A, Sharan A, Nei, M, Sperling MR. Corpus callosotomy. Epilepsy and Behavior 13(2):271-8, 2008.
  • Asadi-Pooya AA, Nei M, Sharan AD, Mintzer S, Zangaladze A, Evans JG, Skidmore C, Sperling MR. Antiepileptic drugs and relapse after epilepsy surgery. Epileptic Disorders.10:193-198, 2008.
  • Zangaladze A, Nei M, Liporace J., Sperling MR. Characteristics and clinical significance of subclinical seizures Epilepsia 49:2016-21, 2008.
  • Bujarski K, Sperling MR. Post-ictal hyperfamiliarity syndrome in focal epilepsy. Epilepsy Behav. 13(3):567-569, 2008.
  • Sperling MR, Nei M, Zangaladze A, Sharan AD, Mintzer SE, Skidmore C, Evans JG, Schilling CA, Asadi-Pooya AA. Prognosis after late relapse following epilepsy surgery. Epilepsy Res 78:77-81, 2008.
  • Chandrasekar T, Sharan, A, Sperling MR. Postoperative auras and risk of recurrent seizures. Epilepsy Res 78:195-200, 2008.
  • Zangaladze A, Sharan A, Evans J, Wyeth EG, Wyeth DH, Tracy JI, Chervoneva I, Sperling MR. The effectivenss of low-ferquency stimulation for mapping cortical function. Epilepsia 49:481-487, 2008.
  • Asadi-Pooya A, Mintzer S, Sperling MR. Nutritional supplements, foods, and epilepsy: Is there a relationship? Epilepsia 13:271-8, 2008.
  • Asadi-Pooya A, Sharan A, Nei, M, Sperling MR. Corpus callosotomy. Epilepsy and Behavior 13(2):271-8, 2008.
  • Sperling MR, Schilling CA, Glosser D, Tracy JI,Asadi-Pooya AA. Self-perception of seizure precipitants and their relation to anxiety level, depression, and health locus of control in epilepsy. Seizure 17:302-307, 2008.
  • Asadi-Pooya, A, Sperling MR. Potentiation of anti-epileptic drugs effectiveness by pyronaridine in refractory epilepsy. Med Hypotheses.69(3):560-3, 2007.
  • Mitre E, Talaat KR, Sperling MR, Nash TE. Methotrexate as a corticosteroid-sparing agent in complicated neurocysticercosis. Clin Infect Dis. 44:549-53, 2007.
  • Langfitt JT, Westerveld M, Hamberger MJ, Walczak TS, Cicchetti CV, Betg AT, Vackrey BG, Barr WB, Sperling MR, Masur D, Spencer SS. Worsening of quality of life after epilepsy surgery: effect of seizures and memory decline. Neurology. 5;68:1988-94, 2007.
  • Tracy JI, Dechant V, Sperling MR, Cho R, Glosser D. The association of mood with quality of life ratings in epilepsy. Neurology 3;68(14):1101-7, 2007.
  • Langfitt JT, Holloway RG, McDermott MP, Messing S, Sarosky K, Berg AT, Spencer SS, Vickrey BG, Sperling MR, Bazil CW, Shinnar S. Health care costs decline after successful epilepsy surgery. Neurology. 17;68:1290-8, 2007.
  • Tracy JI, Ahmed N, Khan W, Sperling M. A test of the efficacy of the McSquare device for improving verbal memory, learning, and attention. International Journal of Learning Technology. (in press)
  • Spencer SS, Berg AT, Vickrey BG, Sperling MR, Bazil CW, Haut S, Langfitt JT, Walczak TS, Devinsky O. Health-related quality of life over time since resective epilepsy surgery. Ann Neurol. 62:327-34, 2007.
  • Asadi-Pooya AA, Schilling CA, Glosser D, Tracy JI, Sperling MR. Health locus of control in patients with epilepsy and its relation to anxiety and depression. Epilepsy Behav 11:347-350, 2007.
  • Chin PS, Berg AT, Spencer SS, Sperling MR, Haut SR, Langfitt JT, Bazil CW, Walczak TS, Pacia SV, Vickrey BG. Employment outcomes following resective epilepsy surgery. Epilepsia. 48(12):2253-7, 2007.
  • Asadi-Pooya AA, Sperling MR. Do foods precipitate seizures? A cross-cultural comparison.. Epilepsy Behav 11:450-453, 2007.
  • Tracy JI, Lippincott C, Mahmood T, Waldron B, Kanauss K, Glosser D, Sperling M. Are depression and cognitive performance related in temporal lobe epilepsy? Epilepsia 48:2327-35, 2007.
  • Jenssen, S, Liporace, J, Nei, M, O'Connor, MJ, Sperling, MR. Value of non-invasive testing when there are independent bitemporal seizures in the scalp EEG. Epilepsy Res. 68:115-22, 2006.
  • Berg AT, Vickrey BG, Langfitt, JT, Sperling, MR, Shinnar S, Bazil C, Walczak T, Spencer SS. Reduction of AEDS in postsurgical patients who attain remission. Epilepsia 47:64-71, 2006.
  • Nei, M., OConnor MJ, Liporace, J, Sperling, MR. Refractory generalized seizures: Response to corpus callosotomy and vagal nerve stimulation. Epilepsia 47:115-122, 2006.
  • Schwartz TH, Jeha L, Tanner A, Bingaman W, Sperling MR. Late seizures in patients initially seizure free after epilepsy surgery. Epilepsia 47:567-73, 2006.
  • Langfitt, JT, Vickrey, BG, McDermott, MP, Messing, S, Berg, AT , Spencer, SS Sperling, MR, Bazil, CW & Shinnar, S. Validity & responsiveness of generic preference-based HRQOL instruments in chronic epilepsy. Quality of Life Research 15:899-914, 2006.
  • Chin, PS, Berg, AT, Spencer, SS, Lee, ML, Shinnar, S, Sperling, MR, Langfitt, JT, Walczak, TS, Pacia, SV, Bazil, CW, Vassar, S, Vickrey, BG. Patient-perceived impact of resective epilepsy surgery. Neurology 66:1882-87, 2006.
  • Jenssen S, Gracely, EJ, Sperling, MR. How long do most seizures last? A systematic comparison of seizures recorded in the epilepsy monitoring unit. Epilepsia. 47:1499-503, 2006.
  • Jenssen, S., Sperling, M.R., Nei, M., Tracy, J.I., Glosser, D., Liporace, J., OConnor, M. Corpus callosotomy in refractory idiopathic generalized epilepsy. Seizure 15:621-9, 2006.
  • Jennsen S, Gracely, E, Mahmood T, Tracy JI, Sperling MR. Subjective somnolence relates mainly to depression among patients in a tertiary care epilepsy center.
  • Epilepsy Behav. 9:632-5, 2006.
  • Spencer SS, Berg AT, Vickrey BG, Sperling MR, Bazil CW, Shinnar S, Langfitt JT, Walczak TS, Pacia SV. Predicting long-term seizure outcome after resective epilepsy surgery: the multicenter study. Neurology. 65:912-8, 2005.
  • Lohoff FW, Ferraro TN, Dahl JP, Haldebrandt MA, Scattergood TM, OConnor MJ, Sperling MR, Dlugos DJ, Berrettini WH, Buono RJ. Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy. Epilepsy Res.66:59-62, 2005.
  • Devinsky, O., Barr, W, Vickrey, B., Berg, A., Pacia, S, Bazil, C, Langfitt, J, Walczak, T., Sperling, M, Shinnar, S., Spencer, S. Changes in depression and anxiety after resective surgery for epilepsy. Neurology 65:1744-49, 2005.
  • Sperling, M.R., Harris, A., Nei, M., Liporace, J.D., OConnor, M.J. Mortality after epilepsy surgery. Epilepsia 46 (Suppl 11): 49-53, 2005.
  • Khoury, J.S., Winokur, R.S., Tracy J.I., Sperling, M.R. Predicting seizure frequency in patients with recurrent seizures after epilepsy surgery. Epilepsy Research 67:89-99, 2005.
  • Siegel AM, Cascino GD, Elger CE, Devinsky O, Laff R, Najjar S, Sperling MR, LoRusso G, Cossu M, Urbach H, Aronica E, Meyer FB, Scheithauer BW, Dubeau F, Andermann F. Adult-onset epilepsy in focal cortical dysplasia of Taylor type. Neurology 64:1771-4, 2005.
  • Kulkarni K, Sperling MR, Intenzo C. Positron Emission Tomography in Dyke-Davidoff-Masson syndrome. Clinical Nuclear Medicine (in press, Sept 2005).
  • Paek S.H., Audu P.B., Sperling M.R., Cho J, Andrews D.W. Reevaluation of surgery for the treatment of brain metastases: review of 208 patients with single or multiple brain metastases treated at one institution with modern neurosurgical techniques. Neurosurgery J 56:1021-1034, 2005.
  • Rabin ML, Narayan VM, Kimberg DY, Casasanto DJ, Glosser G, Tracy JI, French JA, Sperling MR, Detre JA. Functional MRI predicts post-surgical memory following temporal lobectomy. Brain. 27:2286-98, 2004.
  • Del Vecchio, N, Liporace, J., Nei, M, Sperling M., Tracy, J. A dissociation between implicit and explicit verbal memory in left temporal lobe epilepsy. Epilepsia 45:1124-33, 2004.
  • Engel J Jr, Wiebe S, French J, Sperling M, Williamson P, Spencer D, Gumnit R, Zahn C, Westbrook E, Enos B. Practice parameter: Temporal lobe and localized neocortical resections for epilepsy: Report of the Quality Standards Subcommittee of the American Academy of Neurology, in Association with the American Epilepsy Society and the American Association of Neurological Surgeons. Neurology 60: 538-547, 2003.
  • Carran MA, Kohler CG, O'Connor MJ, Bilker WB, Sperling M.R., OConnor M.J. Mania following temporal lobectomy. Neurology 61:770-4, 2003.
  • Berg, A.T., Vickrey, B.G., Langfitt, J., Sperling, M.R., Walczak, T.,. Shinnar, S., Bazil, C., Pacia, S.V., Spencer, S.S. The Multicenter Study of Epilepsy Surgery: recruitment and selection for surgery. Epilepsia 44:1425-1433, 2003.
  • Spencer SS, Berg AT, Vickrey BG, Sperling MR, Bazil CW, Shinnar S, Langfitt JT, Walczak TS, Pacia SV, Ebrahimi N, Frobish D; Multicenter Study of Epilepsy Surgery.Initial outcomes in the Multicenter Study of Epilepsy Surgery.
  • Neurology. 23;61:1680-5, 2003
  • Nei, M., Ho, R.T., Abou-Khalil, B.W., Drislane, F.W., Liporace, J., Romeo, A., Sperling, M.R. EEG and EKG in sudden unexplained death in epilepsy. Epilepsia.45:338-45, 2004.
  • Rabin, M.L., Narayan, V.M., Kimberg, D.Y., Casasanto, D.J., Glosser, G, Tracy, J.I., French, J.A., Sperling, M.R., Detre, J.A. Functional MRI predicts post-surgical memory following temporal lobectomy. Brain, 127:2286-98m, 2004.
  • 89. Buono, R.J., Lohoff, F.W., Sander, T., Sperling, M.R., OConnor, M.J., Dlugos, D.J., Ryan, S.G., Golden, G.T., Zhao, H., Scattergood, T.M., Berrettini, W.H., Ferraro, T.N. Association between variation in the human KCNJ10 potassium ion channel gene and seizures susceptibility. Epilepsy Research 58:175-83, 2004.
  • Herzog AG, Harden CL, Liporace J, Pennell P, Schomer DL, Sperling M, Fowler K, Nikolov B, Shuman S, Newman M. Frequency of catamenial seizure exacerbation in women with localization-related epilepsy. Ann Neurol. 56:431-34, 2004.
  • Spencer, S.S., Schramm, J., Wyler, A, OConnor, M.J., Orbach, D., Krauss, G., Sperling, M., Devinsky, O., Elger, C., Lesser, R., Mulligan, L., Westerveld., M. Multiple subpial transection for intractable partial epilepsy: an international meta analysis. Epilepsia 43:141-146, 2002.
  • Sperling, M.R., Schnur, J. Temporal lobectomy. Arch Neurol 59:482-4, 2002.
  • Banh, H.L., Burton, M.E., Sperling, M.R. Interpatient and intrapatient variability in phenytoin protein binding. Therapeutic Drug Monitoring 24:379-385, 2002.
  • Haut SR, Berg AT, Shinnar S, Cohen HW,
  • Bazil CW, Sperling MR, Langfitt JT, Pacia SV, Walczak TS, Spencer SS. Interrater reliability among epilepsy centers: multicenter study of epilepsy surgery. Epilepsia. 43:1396-401, 2002.
  • Berg, A.T., Langfitt, J., Shinnar, S., Vickrey, B.G., Sperling, M.R., Walczak, T., Bazil, C., Pacia, S.V., Spencer, S.S. How long does it take for partial epilepsy to become intractable? Neurology 60:186-190, 2003.
  • Wieser H.G., Blume W.T., Fish D., Goldensohn E., Hufnagel A., King D., Sperling M.R., Luders H. Proposal for a new classification of outcome with respect to epileptic seizure following epilepsy surgery. Epilepsia 42:282-286, 2001.
  • Kohler, C.G., Carran, M.A., Bilker, W., OConnor, M.J., Sperling, M.R. Association of fear auras with mood and anxiety disorders following temporal lobectomy. Epilepsia 42:674-681, 2001.
  • Ma, S., Liporace, J.D., OConnor, M.J., Sperling, M.R. Neurosurgical treatment of prolonged medically intractable status epilepticus. Epilepsy Research 46:33-38, 2001.
  • Sirven J.I., Wingerchuk, D.M., Sperling,
  • M.R. When can AEDs be withdrawn: early versus late discontinuation of antiepileptic agents in seizure free patients. Cochrane Reviews Cochrane Database Syst Rev. (3):CD001902, 2001.
  • Buono, R.J., Ferraro, T.N. OConnor, M.J., Sperling, M.R., Ryan, S.G., Scattergood, T., Mulholland, N., Gilmore, J., Lohoff, F.W., Berretini, W.H. Lack of association between an interleukin 1 beta (IL01B) gene variation and refractory temporal lobe epilepsy. Epilepsia 42:782-4, 2001.
  • Liporace, J., Hucko, D., Morrow, R., Barolat, G., Nei, M., Schnur, J., Sperling, M. Vagal nerve stimulation: adjustments to reduce painful side effects. Neurology. 11:57:885-6, 2001.
  • Kohler C.G., Moberg, P.J., Gur, R.E., OConnor, M.J., Sperling, M.R., Doty, R.L. Olfactory dysfunction in schizophrenia and Temporal Lobe Epilepsy. Neuropsychiatry, Neuropsychology and Behavioral Neurology 14:83-8, 2001
  • Newberg AB, Alavi A, Berlin J, Mozley PD, O'Connor M, Sperling M. Ipsilateral and contralateral thalamic hypometabolism as a predictor of outcome after temporal lobectomy for seizures. J Nucl Med. 41:1964-8, 2000.
  • Sirven, J.I., Malamut, B.L., OConnor, M.J., Sperling, M.R. Temporal lobectomy outcome in older versus younger adults. Neurology 54(11):2166-70, 2000
  • Vickrey BG, Berg AT, Sperling MR, Shinnar S, Langfitt JT, Bazil CW, Walczak TS, Pacia S, Kim S, Spencer SS. Relationships between seizure severity and health-related quality of life in refractory localization-related epilepsy. Epilepsia. 41(6): 760-4, Jun 2000
  • Nei M, Ho RT, Sperling MR. EKG abnormalities during partial seizures in refractory epilepsy. Epilepsia. 41(5): 542-8, May 2000
  • Sirven JI, Sperling M, Naritoku D, Schachter S, Labar D, Holmes M, Wilensky A, Cibula J, Labiner DM, Bergen D, Ristanovic R, Harvey J, Dasheiff R, Morris GL, O'Donovan CA, Ojemann L, Scales D, Nadkarni M, Richards B, Sanchez JD. Vagus nerve stimulation therapy for epilepsy in older adults. Neurology. 54(5): 1179-82, Mar 2000
  • Berg AT, Vickrey BG, Sperling MR, Langfitt JT, Bazil CW, Shinnar S, Walczak TS, Pacia S, Spencer SS. Driving in adults with refractory localization-related epilepsy. Multi-Center Study of Epilepsy Surgery. Neurology. 54(3): 625-30, Feb 2000
  • Buono RJ, Ferraro TN, O'Connor MJ, Sperling MR, Abbey M, Finanger E, Lohoff F, Mulholland N, Berrettini WH. Lack of association between temporal lobe epilepsy and a novel polymorphism in the alpha 2 subunit gene (ATP1A2) of the sodium potassium transporting ATPase. American Journal of Medical Genetics. 96(1): 79-83, Feb 2000
  • Glosser G, Zwil AS, Glosser DS, O'Connor MJ, Sperling MR. Psychiatric aspects of temporal lobe epilepsy before and after anterior temporal lobectomy. Journal of Neurology, Neurosurgery and Psychiatry. 68(1): 53-8, Jan 2000
  • Sirven J, Whedon B, Caplan D, Liporace J, Glosser D, O'Dwyer J, Sperling MR. The ketogenic diet for intractable epilepsy in adults: preliminary results. Epilepsia. 40(12): 1721-6, Dec 1999
  • Sperling MR, Feldman H, Kinman J, Liporace JD, O'Connor MJ. Seizure control and mortality in epilepsy. Annals of Neurology. 46(1): 45-50, Jul 1999
  • Dlugos DJ, Jaggi J, O'Connor WM, Ding XS, Reivich M, O'Connor MJ, Sperling MR. Hippocampal cell density and subcortical metabolism in temporal lobe epilepsy. Epilepsia. 40(4): 408-13, Apr 1999
  • Kohler C, Norstrand JA, Baltuch G, O'Connor MJ, Gur RE, French JA, Sperling MR. Depression in temporal lobe epilepsy before epilepsy surgery. Epilepsia. 40(3): 336-40, Mar 1999
  • Nei M, Lee JM, Shanker VL, Sperling MR. The EEG and prognosis in status epilepticus. Epilepsia. 40(2): 157-63, Feb 1999
  • Schachter SC, Ito M, Wannamaker BB, Rak I, Ruggles K, Matsuo F, Wilner A, Jackel R, Gilliam F, Morris G, Skantz J, Sperling M, Buchhalter J, Drislane FW, Ives J, Schomer DL. Incidence of spikes and paroxysmal rhythmic events in overnight ambulatory computer-assisted EEGs of normal subjects: a multicenter study. Journal of Clinical Neurophysiology. 15(3): 251-5, May 1998
  • Swanson TH, Sperling MR, O'Connor MJ. Strong paired pulse depression of dentate granule cells in slices from patients with temporal lobe epilepsy. Journal of Neural Transmission. 105(6-7): 613-25, 1998
  • Sirven JI, Malamut BL, Liporace JD, O'Connor MJ, Sperling MR. Outcome after temporal lobectomy in bilateral temporal lobe epilepsy. Annals of Neurology. 42(6): 873-8, Dec 1997
  • King JT Jr, Sperling MR, Justice AC, O'Connor MJ. A cost-effectiveness analysis of anterior temporal lobectomy for intractable temporal lobe epilepsy. Journal of Neurosurgery. 87(1): 20-8, Jul 1997
  • Sperling MR, Bucurescu G, Kim B. Epilepsy management. Issues in medical and surgical treatment. Postgraduate Medicine. 102(1): 102-4 109-12 115-8 p, Jul 1997
  • Glosser G, Cole LC, French JA, Saykin AJ, Sperling MR. Predictors of intellectual performance in adults with intractable temporal lobe epilepsy. Journal of the International Neuropsychological Society. 3(3): 252-9, May 1997
  • Sirven JI, Liporace JD, French JA, O'Connor MJ, Sperling MR. Seizures in temporal lobe epilepsy: I. Reliability of scalp/sphenoidal ictal recording. Neurology. 48(4): 1041-6, Apr 1997
  • Masukawa LM, O'Connor WM, Burdette LJ, McGonigle P, Sperling MR, O'Connor MJ, Uruno K. Mossy fiber reorganization and its possible physiological consequences in the dentate gyrus of epileptic humans. Advances in Neurology. 72: 53-68, 1997
  • Sperling MR, O'Connor MJ, Saykin AJ, Plummer C. Temporal lobectomy for refractory epilepsy. Jama. 276(6): 470-5, Aug 1996
  • Detre JA, Alsop DC, Aguirre GK, Sperling MR. Coupling of cortical and thalamic ictal activity in human partial epilepsy: demonstration by functional magnetic resonance imaging. Epilepsia. 37(7): 657-61, Jul 1996
  • O'Connor WM, Masukawa L, Freese A, Sperling MR, French JA, O'Connor MJ. Hippocampal cell distributions in temporal lobe epilepsy: a comparison between patients with and without an early risk factor. Epilepsia. 37(5): 440-9, May 1996
  • Sirven JI, Sperling MR, French JA, O'Connor MJ. Significance of simple partial seizures in temporal lobe epilepsy. Epilepsia. 37(5): 450-4, May 1996
  • Wilson SB, Harner RN, Duffy FH, Tharp BR, Nuwer MR, Sperling MR. Spike detection. I. Correlation and reliability of human experts. Electroencephalography and Clinical Neurophysiology. 98(3): 186-98, Mar 1996
  • Saykin AJ, Stafiniak P, Robinson LJ, Flannery KA, Gur RC, O'Connor MJ, Sperling MR. Language before and after temporal lobectomy: specificity of acute changes and relation to early risk factors. Epilepsia. 36(11): 1071-7, Nov 1995
  • Tatum WO 4th, Sperling MR, O'Connor MJ, Jacobstein JG. Interictal single-photon emission computed tomography in partial epilepsy. Accuracy in localization and prediction of outcome. Journal of Neuroimaging. 5(3): 142-4, Jul 1995
  • Sperling MR, Alavi A, Reivich M, French JA, O'Connor MJ. False lateralization of temporal lobe epilepsy with FDG positron emission tomography. Epilepsia. 36(7): 722-7, Jul 1995
  • Burgerman RS, Sperling MR, French JA, Saykin AJ, O'Connor MJ. Comparison of mesial versus neocortical onset temporal lobe seizures: neurodiagnostic findings and surgical outcome. Epilepsia. 36(7): 662-70, Jul 1995
  • Legido A, Lago P, Chung HJ, Sperling M, Clancy RR. Serum prolactin in neonates with seizures. Epilepsia. 36(7): 682-6, Jul 1995
  • Sperling MR, Saykin AJ, Roberts FD, French JA, O'Connor MJ. Occupational outcome after temporal lobectomy for refractory epilepsy. Neurology. 45(5): 970-7, May 1995
  • Laskowitz DT, Sperling MR, French JA, O'Connor MJ. The syndrome of frontal lobe epilepsy: characteristics and surgical management. Neurology. 45(4): 780-7, Apr 1995
  • Sperling MR, Skolnick BE. Cerebral blood flow during spike-wave discharges. Epilepsia. 36(2): 156-63, Feb 1995
  • Crino PB, Sater RA, Sperling M, Katsetos CD. Renal cell carcinomatous meningitis: pathologic and immunohistochemical features. Neurology. 45(1): 189-91, Jan 1995
  • Liporace JD, Sperling MR, Dichter MA. Absence seizures and carbamazepine in adults. Epilepsia. 35(5): 1026-8, 1994
  • Adusumalli VE, Wichmann JK, Kucharczyk N, Kamin M, Sofia RD, French J, Sperling M, Bourgeois B, Devinsky O, Dreifuss FE, et al. Drug concentrations in human brain tissue samples from epileptic patients treated with felbamate. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 22(1): 168-70, 1994
  • Manno EM, Sperling MR, Ding X, Jaggi J, Alavi A, O'Connor MJ, Reivich M. Predictors of outcome after anterior temporal lobectomy: positron emission tomography. Neurology. 44(12): 2331-6, Dec 1994
  • Sperling MR, Saykin AJ, Glosser G, Moran M, French JA, Brooks M, O'Connor MJ. Predictors of outcome after anterior temporal lobectomy: the intracarotid amobarbital test. Neurology. 44(12): 2325-30, Dec 1994
  • Morrell MJ, Sperling MR, Stecker M, Dichter MA. Sexual dysfunction in partial epilepsy: a deficit in physiologic sexual arousal. Neurology. 44(2): 243-7, Feb 1994
  • O'Rourke DM, Saykin AJ, Gilhool JJ, Harley R, O'Connor MJ, Sperling MR. Unilateral hemispheric memory and hippocampal neuronal density in temporal lobe epilepsy. Neurosurgery. 32(4): 574-80, Apr 1993
  • Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). The Felbamate Study Group in Lennox-Gastaut Syndrome [see comments]. New England Journal of Medicine. 328(1): 29-33, Jan 1993
  • Brooks ML, O'Connor MJ, Sperling MR, Mayer DP. Magnetic resonance imaging in localization of EEG depth electrodes for seizure monitoring. Epilepsia. 33(5): 888-91, 1992
  • Masukawa LM, Uruno K, Sperling M, O'Connor MJ, Burdette LJ. The functional relationship between antidromically evoked field responses of the dentate gyrus and mossy fiber reorganization in temporal lobe epileptic patients. Brain Research. 579(1): 119-27, May 1992
  • Sperling MR, O'Connor MJ, Saykin AJ, Phillips CA, Morrell MJ, Bridgman PA, French JA, Gonatas N. A noninvasive protocol for anterior temporal lobectomy. Neurology. 42(2): 416-22, Feb 1992
  • Epstein MA, Sperling MR, O'Connor MJ. Cardiac rhythm during temporal lobe seizures. Neurology. 42(1): 50-3, Jan 1992
  • Morrell MJ, Phillips CA, O'Connor MJ, Sperling MR. Speech during partial seizures: intracranial EEG correlates. Epilepsia. 32(6): 886-9, 1991
  • Tatum WO, Sperling MR, Jacobstein JG. Epileptic palatal myoclonus [see comments]. Neurology. 41(8): 1305-6, Aug 1991
  • Kester DB, Saykin AJ, Sperling MR, O'Connor MJ, Robinson LJ, Gur RC. Acute effect of anterior temporal lobectomy on musical processing. Neuropsychologia. 29(7): 703-8, 1991
  • Sperling MR, Gur RC, Alavi A, Gur RE, Resnick S, O'Connor MJ, Reivich M. Subcortical metabolic alterations in partial epilepsy. Epilepsia. 31(2): 145-55, 1990
  • Sperling MR. Neuroimaging in epilepsy: contribution of MRI, PET and SPECT. Seminars in Neurology. 10(4): 349-56, Dec 1990
  • Gzesh D, Goldstein S, Sperling MR, Alavi A. Complex partial epilepsy: the role of neuroimaging in localizing a seizure focus for surgical intervention [clinical conference]. Journal of Nuclear Medicine. 31(11): 1839-43, Nov 1990
  • Stafiniak P, Saykin AJ, Sperling MR, Kester DB, Robinson LJ, O'Connor MJ, Gur RC. Acute naming deficits following dominant temporal lobectomy: prediction by age at 1st risk for seizures. Neurology. 40(10): 1509-12, Oct 1990
  • Sperling MR, O'Connor MJ. Auras and subclinical seizures: characteristics and prognostic significance. Annals of Neurology. 28(3): 320-8, Sep 1990
  • Sperling MR, Cahan LD, Brown WJ. Relief of seizures from a predominantly posterior temporal tumor with anterior temporal lobectomy. Epilepsia. 30(5): 559-63, 1989
  • Sperling MR, Lieb JP, Engel J Jr, Crandall PH. Prognostic significance of independent auras in temporal lobe seizures. Epilepsia. 30(3): 322-31, 1989
  • Sperling MR, Melmed S, McAllister T, Price TR. Lack of effect of naloxone on prolactin and seizures in electroconvulsive therapy. Epilepsia. 30(1): 41-4, 1989
  • Sperling MR, O'Connor MJ. Comparison of depth and subdural electrodes in recording temporal lobe seizures [see comments]. Neurology. 39(11): 1497-504, Nov 1989
  • Bridgman PA, Malamut BL, Sperling MR, Saykin AJ, O'Connor MJ. Memory during subclinical hippocampal seizures. Neurology. 39(6): 853-6, Jun 1989
  • Brewer K, Sperling MR. Neurosurgical treatment of intractable epilepsy. Journal of Neuroscience Nursing. 20(6): 366-72, Dec 1988
  • Sperling MR, Mendius JR, Engel J Jr. Mesial temporal spikes: a simultaneous comparison of sphenoidal, nasopharyngeal, and ear electrodes. Epilepsia. 27(1): 81-6, 1986
  • Sperling MR, Pritchard PB 3d, Engel J Jr, Daniel C, Sagel J. Prolactin in partial epilepsy: an indicator of limbic seizures. Annals of Neurology. 20(6): 716-22, Dec 1986
  • Sperling MR, Wilson G, Engel J Jr, Babb TL, Phelps M, Bradley W. Magnetic resonance imaging in intractable partial epilepsy: correlative studies. Annals of Neurology. 20(1): 57-62, Jul 1986
  • Sperling MR, Wilson CL. The effect of limbic and extralimbic electrical stimulations upon prolactin secretion in humans. Brain Research. 371(2): 293-7, Apr 1986
  • Sperling MR, Brown WJ, Crandall PH. Focal burst-suppression induced by thiopental. Electroencephalography and Clinical Neurophysiology. 63(3): 203-8, Mar 1986
  • Sperling MR. Childhood seizures after carbamazepine [letter]. New England Journal of Medicine. 314(13): 853, Mar 1986
  • Sperling MR, Engel J Jr. Sphenoidal electrodes. Journal of Clinical Neurophysiology. 3(1): 67-73, Jan 1986
  • Sperling MR, Herrmann C Jr. Syndrome of palatal myoclonus and progressive ataxia: two cases with magnetic resonance imaging. Neurology. 35(8): 1212-4, Aug 1985
  • Sperling MR, Engel J Jr. Electroencephalographic recording from the temporal lobes: a comparison of ear, anterior temporal, and nasopharyngeal electrodes. Annals of Neurology. 17(5): 510-3, May 1985
  • Sperling MR. Hypoglycemic activation of focal abnormalities in the EEG of patients considered for temporal lobectomy. Electroencephalography and Clinical Neurophysiology. 58(6): 506-12, Dec 1984
  • Bertoldi RV, Sperling MR. Nocardia brain stem abscess: diagnosis and response to medical therapy. Bulletin of Clinical Neurosciences. 49: 99-104, 1984

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Thomas Jefferson University