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Thomas Jefferson University - Paul F. Bray, MD
Paul F. Bray, MD

Medicine : Hematology
The Thomas Drake Martinez Cardeza Professor of Medicine

Director, Division of Hematology

Director, Cardeza Foundation for Hematologic Research

Director, Cardeza Hemostasis Laboratory

Thomas Jefferson University
Jefferson Medical College
Department of Medicine
Division of Hematology
Appointed: 2006
Mailing Address
705 Curtis Building 1015 Walnut Street
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-955-8544
Fax: 215-955-9170
paul.bray@jefferson.edu
Qualifications
MD, University of Utah, 1977

Hematology-Oncology fellowship, University of California, San Francisco,1982-85

Board certified in Internal Medicine, 1981

Board certified in Hematology, 1984

Board certified in Oncology, 1985
Expertise and Research Interests
Dr. Brays laboratory studies the role of platelets in cardiovascular disease, and disorders of bleeding and excessive blood clotting. His major areas of investigation include: (1) The role of platelets in arterial thrombosis, with the identification and functional characterization of platelet risk factors and their impact on cardiovascular therapy. He studies how genetic variations in platelet adhesive molecules affect both the clinical and platelet phenotypes. (2) Basic research on platelet physiology, focusing on signaling pathways of platelet activation. (3) Identification of novel genes and gene products involved in platelet reactivity using genome scan and platelet RNA expression array approaches. (4) Studies on the role of platelet microRNAs on platelet gene expression and physiology.
Other Expertise
Dr. Bray has had continuous funding from the National Institutes of Health (NIH) since 1986.
Keywords
platelets, hemostasis, thrombosis
Publications
  • Selected from more than 114 publications
  • Snoep JD, Gaussem P, Eikenboom JCJ, Emmerich J, Zwaginga JJ, Holmes CE, Vos HL, de Groot PG, Herrington DM, Bray PF, Rosendaal FR, van der Bom JG. The minor allele of GP6 T13254C is associated with decreased platelet activation and a reduced risk of recurrent cardiovascular events and mortality: Results from the SMILE-Platelets project. J Thromb Haemost, In Press.
  • Feldman AM, Force TL, Whellan DJ, Bray PF, Cheung JY, Koch WJ. Advancing the research mission in an academic department: the creation of a center for translational medicine. Clin Transl Sci 3:178-81, 2010.
  • Kondkar AA, Bray MS, Leal SM, Nagalla S, Liu DJ, Jin Y, Ma L, Ren Q, Whiteheart SW, Shaw C, Bray PF. VAMP8/endobrevin is over expressed in hyperreactive human platelets and is regulated by micro-RNA. J Thromb Haemost 8: 36978, 2010.
  • Bergmeier W, Oh-Hora M, McCarl CA, Roden RC, Bray PF, Feske S. R93W mutation in Orai1 causes impaired calcium influx in platelets. Blood 113:675-8, 2009.
  • Nambi V, Kimball KT, Bray PF, Bergeron AL, Johnson SL, Morrisett JD, Chen C, Lin PH, Lumsden AB, Ballantyne CM, Dong JF. Differences in responses of platelets to fluid shear stress in patients with peripheral artery disease (PAD) and coronary artery disease (CAD). Platelets 20:199-205, 2009.
  • Rossouw JE, Cushman M, Greenland P, Lloyd-Jones DM, Bray P, Kooperberg C, Pettinger M, Robinson J, Hendrix S, Hsia J. Inflammatory, lipid, thrombotic, and genetic markers of coronary heart disease risk in the women's health initiative trials of hormone therapy. Arch Intern Med 168:2245-53, 2008.
  • Ball C, Vijayan KV, Nguyen T, Anthony K, Bray PF, Essex DW, Dong JF. Glutathione regulates integrin aIIbb3-mediated cell adhesion under flow conditions. Thromb Haemost 100:857-63, 2008.
  • Geng H, Zhang H, Zhang W, Nieswandt B, Bray PF, Leng X. Transdermal 17-b estradiol replacement therapy reduces megakaryocyte GPVI expression. Thromb Res 123:93-9, 2008.
  • Bray PF, Larson JC, LaCroix AZ, Manson J, Limacher MC, Rossouw JE, Lasser NL, Lawson WE, Stefanick ML, Langer RD, Margolis KL. Usefulness of baseline lipids and C-reactive protein in women receiving menopausal hormone therapy as predictors of treatment-related coronary events. Am J Cardiol 101:1599-1605, 2008.
  • Sarabia SF, Raya JL, Hoogeveen RC, Bray PF. Human platelets differentially concentrate estradiol, estrone and testosterone. J Thromb Haemost 6:703-5, 2008.
  • Bray PF, Mathias RA, Faraday N, Yanek LR, Fallin MD, Herrera-Galeano JE, Wilson AF, Becker LC, Becker DM. Heritability of platelet function in families with premature coronary artery disease. J Thromb Haemost 5:1617-23, 2007.
  • Faraday N, Yanek LR, Mathias R, Herrera-Galeano JE, Vaidya D, Moy TF, Fallin MD, Wilson AF, Bray PF, Becker LC, Becker DM. Heritability of Platelet Responsiveness to Aspirin in Activation Pathways Directly and Indirectly Related to Cyclooxygenase-1. Circulation 115:2490-2496, 2007.
  • Bray PF, Howard TD, Vittinghoff E, Sane DC, Herrington DM. Effect of genetic variations in platelet glycoproteins Iba and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy. Blood 109:1862-1869, 2007.
  • Bushnell CD, Hurn P, Colton C, Miller VM, del Zoppo G, Elkind MS, Stern B, Herrington D, Ford-Lynch G, Gorelick P, James A, Brown CM, Choi E, Bray P, Newby LK, Goldstein LB, Simpkins J. Advancing the Study of Stroke in Women. Advancing the study of stroke in women: summary and recommendations for future research from an NINDS-Sponsored Multidisciplinary Working Group. Stroke 37:2387-2399, 2006.
  • Yee DL, Bergeron AL, Sun CW, Dong JF, Bray PF. Platelet hyperreactivity generalizes to multiple forms of stimulation. J Thromb Haemost 4:2043-50, 2006.
  • Faraday NF, Becker DM, Yanek LR, Segal J, Moy TF, McFillin A, Robarts P, Hasan AA, Bray PF, Becker LC. Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population. Am J Card 98:774-9, 2006.
  • Hendrix SL, Wassertheil-Smoller S, Johnson KC, Howard BV, Kooperberg C, Rossouw JE, Trevisan M, Aragaki A, Baird AE, Bray PF, Buring JE, Criqui MH, Herrington D, Lynch JK, Rapp SR, Torner J. Effect of estrogen alone and estrogen plus progestin on stroke in the Womens Health Initiative. Circulation 113:2425-2434, 2006.
  • Curb JD, Prentice RL, Bray PF, Langer RD, Van Horn L, Barnabei VM, Bloch MJ, Cyr MG, Gass M, Lepine L, Rodabough RJ, Sidney S, Uwaifo GI, Rosendaal FR. Venous thrombosis and conjugated equine estrogen in women without a uterus. Arch Int Med 166:772-780, 2006.
  • Vijayan KV, Liu Y, Souza S, Thiagarajan P, Bray PF. Fibrinogen and prothrombin binding is enhanced to the Pro33 isoform of purified integrin aIIbb3. J Thromb Haemost 4:905-906, 2006.
  • Becker DM, Segal J, Vaidya D, Yanek LR, Herrera-Galeano JE, Bray PF, Becker LC, Faraday N. Sex-differences in platelet reactivity and response to low-dose aspirin therapy. JAMA 295:1420-1427, 2006.
  • Cooke GE, Liu-Stratton Y, Ferketich AK, Moeschberger ML, Frid DJ, Magorien R, Bray PF, Brinkley PF, Goldschmidt-Clermont PJ. Effect of platelet antigen polymorphism on platelet inhibition by aspirin, clopidogrel, or their combination. J Am Coll Cardiol 47:541-6, 2006.
  • Lev EI, Patel RT, Maresh KJ, Guthikonda S, Granada J, DeLao T, Bray PF, Kleiman NS. Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention: the role of dual drug resistance. J Am Coll Cardiol 47:27-33, 2006.
  • Leng X-L, Zheng H, Nieswandt B, Bray PF. Effects of estrogen replacement therapies on mouse platelet function and glycoprotein VI levels. Circ Res 97:415-7 2005.
  • Yee DL, Bergeron A, Sun C, Wood J, Dong J-f, Bray PF. Aggregometry detects platelet hyperreactivity in healthy individuals. Blood 106:2723-2729, 2005.
  • Vijayan KV, Liu Y, Sun W, Ito M, Bray PF. The Pro33 isoform of integrin b3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases. J Biol Chem 280:21756-62, 2005.
  • Margolis KL, Manson JE, Greenland P, Rodabough RJ, Bray PF, Safford M, Grimm RH, Howard BV, Assaf AR, Prentice R. Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Womens Health Initiative Observational Study. Arch Int Med 165:500-508, 2005.
  • Faraday N, Martinez EA, Scharpf RB, Kasch-Semenza L, Dorman T, Pronovost PJ, Perler B, Gerstenblith G, Bray PF, Fleisher LA. Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patients. Anesthesiology 101:1291-7, 2004.
  • Vijayan KV, Liu Y, Li TT, Bray PF. Protein phosphatase 1 associates with the integrin aIIb subunit and regulates signaling. J Biol Chem 279:33039-42, 2004.
  • Li TT, Larrucea S, Souza S, Leal SM, López JA, Rubin EM, Nieswandt B, Bray PF. Genetic variation responsible for mouse strain differences in integrin a2 expression is associated with altered platelet responses to collagen. Blood 103:3396-3402, 2004.
  • Leng X-H, Hong SY, Larrucea S, Zhang W, Li T-T, López JA, Bray PF. The platelets of female mice are intrinsically more sensitive to agonists than platelets of males. Arterioscler Thromb Vasc Biol, 24:376-81, 2004.
  • Chen J, Dong J-F, Sun C, Bergeron A, McBride L, Pillai M, Barnard MR, Salmon J, Michelson AD, Bray PF. Platelet FcgRIIA His131Arg polymorphism and platelet function: antibodies to platelet bound fibrinogen induce platelet activation. J Thromb Haemost 1:355-362, 2003.
  • Wheeler GL, Braden GA, Bray PF, Marciniak SJ, Mascelli MA, Sane DC. Reduced inhibition by abciximab in platelets with the PlA2 polymorphism. Am Heart J 143:76-8, 2002.
  • Bray PF, Cannon CP, Goldschmidt-Clermont P, Moyé LA, Richardson C, Pham Y, Pfeffer MA, Sacks FM, Braunwald E. The platelet PlA2 and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarction. Am J Card 88:347-52, 2001.
  • Nealen ML, Vijayan KV, Bolton ED, Bray PF. Human platelets contain a glycosylated estrogen receptor b (ER b). Circ Res 28: 438-442, 2001.
  • Bray PF, Goldschmidt-Clermont P, Furman MI, Michelson AD, Barnard MR, Mascelli MA, Hendrix C, Coleman L, Hamlington J, Kickler T, Christie DJ, Kundu S. Platelet GPIIIa PlA polymorphisms display different sensitivity to agonists. Circulation 103:E33-E34, 2001.
  • Khetawat G, Faraday N, Nealen M, Bolton E, Noga S, Bray PF. Human megakaryocytes and platelets contain the estrogen receptor b and androgen receptor (AR): testosterone regulates AR expression. Blood 95:2289-2296, 2000.
  • Vijayan KV, Goldschmidt-Clermont PJ, Roos C, Bray PF. The PlA2 polymorphism of integrin b3 enhances outside-in signaling and adhesive functions. J Clin Invest 105:793-802, 2000.
  • Michelson AD, Furman MI, Goldschmidt-Clermont P, Mascelli MA, Hendrix C, Coleman L, Hamlington J, Barnard MR, Kickler T, Christie DJ, Kundu S, Bray PF. Platelet GPIIIa PlA polymorphisms display different sensitivity to agonists and antagonists. Circulation 101:1013-18, 2000.
  • Faraday N, Rade JJ, Johns DC, Khetawat G, Noga SJ, Dipersio JF, Jin Y, Nicol JL, Haug JS, Bray PF. Ex vivo cultured human megakaryocytes contain a functional GPIIb-IIIa receptor and can express exogenous gene products. Blood 94:4084-4092, 1999.
  • Pabla R, Weyrich AS, Dixon DA, Bray PF, McIntyre TM, Prescott SM, Zimmerman GA. Integrin-dependent control of translation: engagement of integrin aIIbb3 regulates synthesis of proteins in activated human platelets. J Cell Biol 144:175-184, 1999.
  • Yu DR, Bray PF. Through Thick and Thin (Clinical Problem-Solving case of hemorrhage and thrombosis). N Engl J Med 338:1684-1687, 1998.
  • Cooke GE, Bray PF, Hamlington J, Pham DM, Goldschmidt-Clermont PJ. PlA2 polymorphism and efficacy of aspirin. Lancet 351:1253, 1998.
  • Jin Y, Dietz HC, Montgomery R, Bell WR, McIntosh I, Coller B, Bray PF. Glanzmann Thrombasthenia: cooperation between sequence variants in cis during splice site selection. J Clin Invest 98:1745-1754, 1996.
  • Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, Weiss JL, Gerstenblith G, Goldschmidt-Clermont PJ. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med 334:1090-1094, 1996.
  • Kim H, Jin Y, Kickler TS, Blakemore K, Kwon OH, Bray PF. Gene frequencies of the five major human platelet antigens in African American, white, and Korean populations. Transfusion 35:863-867, 1995.
  • Wilhide CC, Dang CV, Dipersio J, Kenedy AA, Bray PF. Over expression of cyclin D1 in the Dami megakaryocytic cell line causes growth arrest. Blood 86:294-304, 1995.
  • Bertagnolli ME, Locke SJ, Hensler M, Bray PF, Beckerle MC. Talin distribution and phosphorylation in thrombin-activated platelets. J Cell Sci 106:1189-1199, 1993.
  • Bray PF and Shuman MA. Identification of an abnormal gene for the GPIIIa subunit of the platelet fibrinogen receptor resulting in Glanzmann thrombasthenia. Blood 75: 881-888, 1990.
  • Bray PF, Barsh G, Rosa J-P, Luo XY, Magenis E, Shuman MA. Physical linkage of the genes for platelet membrane glycoprotein IIb and IIIa. Proc Natl Acad Sci USA 85:8683-8687, 1988.
  • Bray PF, Rosa J-P, Johnston GI, Shiu DT, Cook R, Lau C, Kan YW, McEver RP, Shuman MA. Platelet glycoprotein IIb: chromosomal localization and tissue expression. J Clin Invest 80:1812-1817, 1987.
  • Bray PF, Rosa J-P, Lingappa VR, Kan YW, McEver RP, Shuman MA. Biogenesis of the platelet receptor for fibrinogen: Evidence for separate precursors for glycoproteins IIb and IIIa. Proc Natl Acad Sci USA 83: 1480-1484, 1986.
  • Edwards CQ, Carrol M, Bray P, Cartwright GE. Hereditary hemochromatosis: Diagnosis in siblings and children. N Engl J Med 297:7-13, 1977.

Individual Expertise profile of Paul F. Bray, MD, Copyright © Paul F. Bray, MD.
Last Updated by Paul Bray, MD : Wednesday, September 8, 2010 6:22:10 PM



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