Thomas Jefferson University - Phyllis Flomenberg, M.D.
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Phyllis Flomenberg, M.D.
Medicine
Thomas Jefferson University
Jefferson Medical College
Department of Medicine
Associate Professor
Appointed: 2004
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Mailing Address
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1015 Walnut St., Rm 812
Philadelphia, Pennsylvania 19107
United States
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Expertise and Research Interests
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My focus of my research lab is on the analysis of human cellular immune responses to both viral pathogens and tumors and potential immunotherapy applications. I have had a longstanding interest in adenovirus infections in patients with hematologic malignancies who undergo stem cell transplant recipients. I have an RO1 grant to characterize human T cell responses to adenoviruses in stem cell transplant recipients who develop adenovirus infections in order to develop immunotherapy strategies to help control invasive infections post-transplant, in collaboration with the Bone Marrow Transplant Program. Additionally, in collaboration with the Dept. of Neurosurgery, I have identified tumor-specific T cell responses in newly diagnosed patients with glioblastoma multiforme, suggesting that glioblastomas are immunogenic and may be amenable to immunotherapy.
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Keywords
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Adenovirus; Vaccinia virus; Cytotoxic T lymphocytes; Glioblastoma; Immunotherapy
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Publications
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- Tang J, Olive M, Champagne K, Flomenberg N, Eisenlohr L, Hsu S, and P Flomenberg. 2004. Adenovirus hexon T cell epitope is recognized by most adults and is restricted by HLA DP4, the most common class II allele. Gene Therapy 11:1408-1415.
- Tang J, Flomenberg P, Harshyne L, Kenyon L, and DW Andrews. 2005. Glioblastoma patients exhibit circulating tumor-specific CD8+ T cells. Clin Cancer Res 11:5292-5298.
- Tang J, Muradha M, Schnell M, Eisenlohr LC, Hooper J, and P Flomenberg. 2006. Human T-cell responses to vaccina virus envelope proteins. J. Virology 80:10010-10020.
- Tang J, Olive M, Pulmanausahakul R, Schnell M, Flomenberg N, Eisenlohr L, and P Flomenberg. 2006. Human CD8+ cytotoxic T cell responses to adenovirus capsid proteins. Virology 350:312-322.
- Neofytos D, Ojha A, Mookerjee G, Wagner J, Filicko J, Ferber A, Dessain S, Grosso D, Brunner J, Flomenberg N, and P Flomenberg. 2007. Treatment of adenovirus disease in stem cell transplant recipients with cidofovir. Biol. Blood Marrow Transplant. 13:74-81.
- Joshi A, Tang J, Kuzma M, Wagner J, Mookerjee B, Filicko J, Carabasi M, Flomenberg N, and P Flomenberg. 2009. Adenovirus DNA polymerase is recognized by human CD8+ T cells. J Gen Virol 90:84-94.
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Individual Expertise profile of
Phyllis Flomenberg, M.D., Copyright © Phyllis Flomenberg, M.D..
Last Updated
by Phyllis Flomenberg, M.D. : Tuesday, January 6, 2009 10:23:09 AM
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