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Thomas Jefferson University - Renato V. Iozzo, M.D.
Renato V. Iozzo, M.D.

Pathology, Anatomy & Cell Biology
Thomas Jefferson University
Jefferson Medical College
Department of Pathology & Cell Biology
Professor with Tenure, Appointed: 1988


Thomas Jefferson University
Jefferson Medical College
Kimmel Cancer Center
Professor, Appointed: 1991

Thomas Jefferson University
Biochemistry and Molecular Biology
Professor (Secondary)
Appointed: 2010

Mailing Address
1020 Locust Street, Suite 336 Jefferson Alumni Hall
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-503-2208
Fax: 215-923-7969
iozzo@kimmelcancercenter.org
Personal Web Site
Qualifications
M.D., Florence, University of Florence School of Medicine (Summa Cum Laude ), Italy

Anatomic Pathology Residency, University of Washington, Seattle WA

NIH Post-Doctoral Fellowship, University of Washington, Seattle WA


Board Certification, American Board of Pathology

Medical Licensure (Active), Commonwealth of Pennsylvania

Medical Licensure (Active), Washington State

Expertise and Research Interests
Renato Iozzo is currently a Professor of Pathology and Cell Biology, at Thomas Jefferson University. After receiving an M.D. degree summa cum laude from the University of Florence, Italy, he moved to the Department of Pathology at the University of Washington, where he completed a five-year Residency/Fellowship. Following a six-year faculty appointment at the University of Pennsylvania, he was promoted to Associate Professor and then moved the same year to Thomas Jefferson University as Full Professor with tenure. Dr. Iozzo has received many awards including the Benjamin Castleman Award from the International Academy of Pathology, the Junior Faculty Research Award from the American Cancer Society, the Burlington Resources Foundation Faculty Achievement Award, the Faculty Research Award from the American Cancer Society, and the Distinguished Mentor Award from Jefferson College of Graduate Studies. In 1989 he was elected to the Pluto Society, the American Association of Academic Pathologists. He was the chair of the Gordon Research Conference on Proteoglycans in 2000, and a council member of both ISMB (2001-2006) and ASMB (2001-2003). He was President of the American Society for Matrix Biology (2007-2008) and he is currently President of the International Society for Matrix Biology. In 2008, Dr. Iozzo received an Honorary Professorship at the School of Life Sciences, University of Manchester, UK, and in 2009 he received an Honorary Medal Award from the University of Patras, Greece. In 2010, Dr. Iozzo was invited to become a member of the College of CSR reviewers of the NIH. Dr. Iozzo has been on the editorial board of many journals including, Laboratory Investigation (five terms), the Journal of Biological Chemistry (two terms), the Journal of Clinical Investigation (three terms), the American Journal of Pathology, and is currently Review Editor for Matrix Biology. His research focuses on the biology of proteoglycans and their roles in cancer and angiogenesis. He has published over 275 peer-reviewed articles, numerous reviews and edited two books on proteoglycans. His work is one of the most cited in the Matrix Biology field, with over 17,500 citations and an h-index of 75 and a g-index of 125.

PROFESSIONAL MILESTONES:
1975 - M.D. Summa Cum Laude, University of Florence School of Medicine, Florence, Italy
1982 - Completed Residency and Postdoctoral Fellowship (NRSA NIH), Dept. of Pathology, University of Washington School of Medicine, Seattle, WA.
1982 - Board Certified in Anatomic Pathology, American Board
1982 - Assistant Professor and Director, Electron Microscopy, Dept. of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA
1983 - Benjamin Castleman Award, International Academy of Pathology
1984 - Junior Faculty Research Award, American Cancer Society
1988 - Associate Professor, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA
1988 - Professor, Dept. of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, PA
1989 - Elected to the Pluto Society, American Association of Academic Pathologists
1990 - Faculty Research Award, American Cancer Society
1991 - Professor, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
1993 - Chairman, East Coast Connective Tissue Society Meeting, Philadelphia, PA 1994 - Burlington Resources Foundation Faculty Achievement Award
1997-99 - Co-Director, Cell Biology Program, Kimmel Cancer Center, Thomas Jefferson University
1999 - Director, Extracellular Matrix Program, Kimmel Cancer Center, Thomas Jefferson University
2000 - Chair, Gordon Research Conference on Proteoglycans, Proctor Academy, NH
2001-2006 - Council Member, International Society for Matrix Biology
2001-2005 - Council Member, American Society for Matrix Biology
2006-2007 - Co-Leader, Cell Biology & Signaling Program, Kimmel Cancer Center, Thomas Jefferson University
2005-2008 - Vice-President and President, American Society for Matrix Biology
2007-2010 - Vice-President and President, International Society for Matrix Biology
2008 - Honorary Professor, School of Life Sciences, University of Manchester, UK
20
2009 - Honorary Medal Award, University of Patras, Patras, Greece
2010 - Member of the College of CSR Reviewers, NIH
2011 - Doctor Honoris Causa, Semmelveis University, Budapest, Hungary
Other Expertise

ACADEMIC COMMITTEES

At University of Pennsylvania
1983-1988 Member, Service Center Review Committee
1985-1988 Member, Medical School Admission Committee
1988 Member, Committee for Reviewing Cardiovascular Teaching

At Thomas Jefferson University
1989-1999 Member, Admission Committee for Gibbon Scholar, M.D./Ph.D. Program
1989-2000 Member, Career Planning Program Committee, Department of Pathology
1991-present Member, Kimmel Cancer Institute
1991-2001 Member, Pathology Residency Review Committee, Department of Pathology
1993-1997 Member, Committee on Research, Jefferson Medical College
1994-1997 Chairman, Subcommittee on Award Nomination, Committee on Research
1995-2005 Member, Curriculum Committee, Department of Pathology
1996-1999 Advisory Committee of the Professorial Faculty, Jefferson Medical College
2002-2006 Member, Committee on Students Affairs, Thomas Jefferson University
2005-2006 Member, Cancer Biology Strategic Plan Committee, Kimmel cancer Center
2005-2006 Member, Bone and Matrix Biology Strategic Plan Committee, Thomas Jefferson University
2009- Member Executive Committee, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University
2010- Member, Executive Committee, Kimmel Cancer Center, Thomas Jefferson University

INVITED LECTURES AND SYMPOSIA (SELECTED since 2005)
2005 Invited Speaker, University of Delaware, Wilmington, DE
2005 Invited Speaker, Symposium in honor of Robert Rosenberg, MIT, Boston
2005 Chair and Speaker, Symposium on Extracellular Matrix Regulation of Angiogenesis Co-sponsored by ASIP and ASMB, Experimental Biology Meeting, San Diego, CA
2005 Invited Speaker, International Symposium on Proteoglycans in Signaling, Stockholm, Sweden
2005 Visiting Professor, Medical College of Wisconsin, Milwaukee, WI
2005 Invited Speaker, 13th Symposium on Glycosaminoglycans, Lake Como, Italy
2005 Invited Speaker, 18th International Symposium on Glycoconjugates, Florence, Italy
2005 Co-organizer and Session Chair, 12th International Symposium on Basement Membranes, Philadelphia, PA
2005 Visiting Professor, Darthmouth Medical School, Hannover, NH
2005 Visiting Professor, Boston University Medical School, Boston, MA
2005 Visiting Professor, Vanderbilt University Medical Center, Nashville, TN
2006 Visiting Professor, Case Western Reserve University School of Medicine, Cleveland, OH
2006 Visiting Professor, University of Alabama, Birmingham, AL
2006 Visiting Professor, McGill University, Montreal, Canada
2006 Session Chair and Speaker, International Symposium on Extracellular Glycomatrix in Health and Disease, Awaji, Japan
2006 Session Chair/Speaker, Gordon Research Conference on Basement Membranes, Il Ciocco, Italy
2006 Session Chair and Speaker, Gordon Research Conference on Proteoglycans, Proctor Academy, NH
2006 Invited Speaker, Priority Research Program on Basement Membranes, Freiburg, Germany
2006 Session Chair, 3rd annual meeting, American Society for Matrix Biology, Nashville, TN
2007 Visiting Professor, Harvard School of Dental Medicine, Boston, MA
2007 Visiting Professor, University of Alabama at Birmingham, AL
2007 Session Chair, International Conference on Proteoglycans, Rio De Janeiro, Brazil
2007 Invited speaker, Pan-Pacific Connective Tissue Society Meeting, Cairns, Australia
2008 Invited Speaker, Gordon Research Conference on Basement Membranes, Bidderford, ME
2008 Session Chair, Gordon Research Conference on Proteoglycans, Proctor Academy, NH
2008 Invited Speaker, International Conference of Cell Biology, Seul, South Korea
2008 Chair, Biennial Meeting of the American Society for Matrix Biology, San Diego, CA
2009 Keynote Speaker, Hellenic Society for Matrix Biology, Patras, Greece
2009 Plenary Speaker, FEBS Advance Lecture Course on Matrix Pathobiology, Patras, Greece
2009 Inivited Speaker, 6th International Conference on Proteoglycans, Aix les Bains, France
2009 Invited Speaker, Klenk Symposium on Molecular Medicine, Cologne, Germany
2009 Invited Speaker, Annual Meeting of the Society for Glycobiology, San Diego, CA
2010 Visiting Professor, University of Pennsylvania, Philadelphia, PA

2010 Visiting Professor, University of Pittsburgh, Pittsburgh, PA
2010 Keynote Speaker, German and British Society for Matrix Biology, Frankfurt, Germany
2010 Visiting Professor, University of Georgia, Athens, GA
2010 Plenary Speaker and Session Chair, XXII FECTS Meeting, Davos, Switzerland
2010 Visiting Professor, University of Zurich, Zurich, Switzerland
2010 Session Chair and Member of the Organizing Committee, Gordon Research Conference on Proteoglycans, Proctor Academy, NH
2010 Session Chair and Member of the Organizing Committee, Biennial Meeting of the American Society for Matrix Biology, Charleston, SC
2010 Visiting Professor, Washington University, St. Louis, MO
2010 Visiting Professor, Harvard School of Dental Medicine, Boston, MA
2010 Visiting Professor, University of Florence school of Medicine, Florence, Italy
2011 Invited Speaker, Symposium in honor of Bjorn Olsen, Harvad Medical School, Boston, MA
2011 Plenary Speaker, FEBS Advance Lecture Course on Matrix Pathobiology, Spetses, Greece
2012 Invited Speaker, ASIP Minisymposium, EB Meeting, San Diego CA
2012 Session Chair and Invited Speaker, Gordon Research Conference on Proteoglycans, Proctor Academy, NH

PEER REVIEW PARTICIPATION/STUDY SECTIONS

1986- Ad Hoc reviewer: Netherlands Cancer Foundation; Pathobiochemistry Study Section, NIH; Cell Biology Study Section, NIH; Pathology A, Study Section, NIH; Reviewer, Medical Research Council of Canada; Veterans Administration, National Science Foundation
1991 Member, Site Visit Team, National Heart and Lung and Blood Institute
1992 Ad hoc Reviewer, Pathobiochemistry Study Section, NIH
1993 Member, External Review Committee for the Department of Biochemistry, American Red Cross, Holland Laboratories, Rockville, MA
2000 Special Reviewer, Pathobiochemistry Study Section
2002- Member, NIH Special Emphasis Review Panel (ZRG1 BIO)
2003 Tumor Microenvironment Study Section, NIH
2006-08 Special Emphasis Panel Reviewer, NIHLB, NIH
2008 Member, External Review Panel for Molecular Biology Section, NIDCR, NIH
2009 Special Emphasis Panel/Scientific Review Group 2010/01 HLBP
2009 Special Emphasis Panel/Scientific Review Group 2010/01 ZRG1 OTC-D
2010- Member of the College of CSR Reviewers, NIH

Keywords
Basement Membrane; Cancer; Cancer Biology; Cancer Prevention; Carcinogenesis; Cell Cycle; Cell Growth Regulation; Cell Stroma; Colon Neoplasm; Decorin; Embryogenesis; Embryonic Stem Cell; Gene Expression; Gene Targeting; Genetic Regulatory Element; Glycoprotein Structure; Heparan Sulfate; Host Neoplasm Interaction; Human Tissue; Laboratory Mouse; Mesenchyme; Metastasis; Molecular Cloning; Molecular Oncology; Neoplasm Cancer Invasiveness; Neoplastic Cell; Neoplastic Growth; Neoplastic Transformation; Oncoprotein; Protein Biosynthesis; Protein Metabolism; Protein Structure Function; Proteoglycan; Scid Mouse; Tissue Cell Culture; Transfection; Transgenic Animal
Publications
  • Pubmed
  • Nikitovic, D., Aggelidakis, G., Young, M.F., Iozzo, R.V., Karamanos, N.K., and Tzanakakis, G.N. The biology of small leucine-rich proteoglycans in bone pathophysiology. J. Biol. Chem. In press 2012. PMID:22879588
  • Buraschi, S., Neill, T., Owens, R.T, Iniguez, L.A., Purkins, G., Vadigepalli, R., Evans, B., Schaefer, L., Peiper, S.C., Wang, Z., Iozzo, R.V., Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model. PLoS One In press, 2012.
  • Genua, M., Xu, S-Q., Buraschi, S., Peiper, S.C., Gomella, L.G., Belfiore, A., Iozzo, R.V., and Morrione, A. Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells. PLoS One 7:e40148, 2012. PMID:22859931
  • Neill, T., Schaefer, L., and Iozzo, R.V. Decorin, a guardian from the matrix. Am. J. Pathol. 181:380-387, 2012. PMID:22735579
  • Moreth, K., Iozzo, R.V., Schaefer, L. Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation. Cell Cycle 11:2084-2091, 2012. PMID:22580469
  • Sanderson R.D., and Iozzo, R.V. Targeting heparanase for cancer therapy at the tumor-matrix interface. Matrix Biol. 31:283-284, 2012. PMID:22655968
  • Wu,Z., Aron, A.W., Macksoud, E.E., Iozzo, R.V., Hai, C-M., and Lechner, B.E. Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition. PLoS One 7:e29627, 2012. PMID:22253749
  • Neill,T., Painter,H., Buraschi, S., Owens, R.T., Lisanti, M.P., Schaefer, L., and Iozzo, R.V. Decorin antagonizes the angiogenic network: concurrent inhibition of Met, HIF-1a and VEGFA and induction of thrombospondin-1 and TIMP-3. J. Biol. Chem. 287: 5492-5506, 2012. PMID:22194599[This paper was selected by the Faculty of 1000 in 2012 with a rating of 6; http://f1000.com/13420966]
  • Bi X, Pohl NM, Qian Z, Yang GR, Gou Y, Guzman G, Balla A, Iozzo RV, and Yang W. Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-Cadherin in vitro and in mice. Carcinogenesis 33:326-330, 2012. PMID:22159220
  • Schaefer, L., and Iozzo, R.V. Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation. Current Opin. Genet. Dev. 22:56-57, 2012. PMID:22326829
  • Baghy, K., Iozzo, R.V. and Kovalszky, I. Decorin-TGFb axis in hepatic fibrosis and cirrhosis. J. Histochem. Cytochem 60: 262-268, 2012. PMID:22260996
  • Merline,R., Iozzo, R.V., and Schaefer, L. Small leucine-rich proteoglycans: Multifunctional signaling effectors. In : Extracellular Matrix: Pathobiology and Signaling. N. Karamanos Editor; De Gruyter, Publisher, Berlin, Germany, In press, 2012.
  • Willis, C.D., Schaefer, L., and Iozzo, R.V., The Biology of perlecan and its bioactive modules In : Extracellular Matrix: Pathobiology and Signaling. N. Karamanos Editor; De Gruyter, Publisher, Berlin, Germany, In press, 2012.
  • Morcavallo, A., Genua, M., Palummo, A., Iozzo, R.V., Belfiore, A., and Morrione, A. Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of the insulin receptor isoform A. J. Biol. Chem. 287:11422-11436, 2012. PMID:22318726
  • Ichii,M., Garrett,K.P., Frank,M.B., Iozzo, R.V, and Kincade, P.W. The canonical Wnt pathway shapes niches supportive for hematopoietic stem/progenitor cells. Blood 119:1683-1692, 2012. PMID:22117039
  • Dourte, L.M., Pathmanathan, L., Jawad, A.F., Iozzo, R.V., Mienaltowski, M.J., Birk, D., and Soslowsky, L.J. Influence of decorin on the mechanical, compositional and structural properties of the mouse patellar tendon. J. Biomech. Eng. In press, 2012. PMID:22482685
  • Trimmer, C., Sotgia, F., Whitaker-Menezes, D., Balliet, R.M., Eaton, G., Martinez-Outschoorn, U.E., Pavlides, S., Howell, A., Iozzo, R.V., Pestell, R.G., Scherer, P.E., Capozza, F. and Lisanti, M.P. Caveolin-1 and mithochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment. A new genetically tractable model for human cancer associated fibroblasts Cancer Biol. Ther. 11:383-394, 2011. PMID: 2115082
  • Iozzo R.V. and Sanderson, R.D. Proteoglycans in cancer biology, tumor microenvironment and angiogenesis. J. Cell. Mol. Med. 15:1013-1031, 2011. PMID: 21155971
  • Marchica, C., Pinelli, V., Zummer, J., Venkatesan,N., Iozzo, R.V., and Ludwig, M.S. A role for decorin in a murine model of allergen-induced asthma. Am. J. Physiol. - Lung Cell. Mol. Physiol. 300:L863-L873, 2011. PMID: 21378022
  • Fassan, M., DArca, D., Letko, J., Vecchione, A., Gardiman, M.P., McCue, P., Wildemore, B., Rugge, M., Scorrano, L., Shupp-Byrne, D., Gomella, L.G., Morrione, A., Iozzo, R.V., and Baffa, R. Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells. PLoS One 6:e19771, 2011. PMID: 21573075
  • Calmus, M.L., Macksoud, E.E., Tucker, R., Iozzo, R.V. and Lechner, B.E. A mouse model of spontaneous preterm birth based on the genetic ablation of biglycan and decorin. Reproduction 142:183-194, 2011. PMID: 21502335
  • Goyal, A., Pal, N., Concannon,M., Paul, M., Doran, M., Poluzzi,C., Sekiguchi, K., Whitelock, J.M., Neill, T., and Iozzo, R.V. Endorepellin, perlecans angiostatic module, interacts with both the a2b1 integrin and vascular endothelial growth factor 2 (VEGFR)2 receptor 2: A dual receptor antagonism. J. Biol.Chem. 286:25947-25962, 2011. PMID:21596751[This paper was selected by the Faculty of 1000 in 2011 with a rating of 9; http://f1000.com/11744956]
  • Castello-Cros, R., Whitaker-Menezes, D., Molchansky, A., Purkins, G., Soslowsky, L., Beason, D.P., Sotgia, F., Iozzo, R.V.*, and Lisanti, M.P. Scleroderma-like properties of skin from caveolin-1 deficient mice: Implications for new treatment strategies in patients with fibrosis and systemic sclerosis. Cell Cycle 10:2140-2150, 2011. PMID: 21670602. *Co-senior Author.
  • Iozzo, R.V.*, Buraschi,S., Genua, M., Xu, S., Solomides, C.C., Peiper, S.P., Gomella, L.G., Owens, R.C., and Morrione, A. Decorin antagonizes IGF-IR function by interfering with IGF-IR activity and attenuating downstream signaling. J. Biol.Chem. 286:34712-34721, 2011. PMID:21840990 *Co-senior Author
  • Merline, R., Moreth, K., Beckman, J., Nastase,M., Zeng-Brouwers,J.,Tralhão, J.G., Lemarchand, P., Pfeilshiffter, J., Schaefer, R.M., Iozzo, R.V.* and Schaefer, L. Signaling by the matrix proteoglycan decorin controls inflammation and cancer via PDCD4 and miR-21. Science Signal.15: ra75, 2011. PMID: 22087031 *Co-senior Author [Editors Choice, Science 334:1033, 2011 http://www.sciencemag.org/content/334/6059/1033.2.full.pdf?sid=496004ca-837f-41ce-9524-9ead67ae98e0; Highlighted in Nature Immunol. 13:19, 2012]
  • Iozzo, R.V. The autophagic tumor stroma: A biofuel for cancer growth. Cell Cycle 10:3231-3232, 2011. PMD: 21946523
  • Chen, S., Mei, S., Meng, X., Iozzo, R.V., Kao, W. W-Y., and Birk, D.E. Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy: C-terminal truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans. Am. J. Pathol. 179: 2409-2419, 2011. PMID: 21893019
  • Seidler, D.G., Mohmmed, N., Bocian, C., Stadtman,A., Hermann, S., Schäfers, K., Schäfers, M., Iozzo, R.V., Zarbick,A., and Götte M. The role for decorin in delayed-type hypersensitivity. J. Immun. 187:6108-6119, 2011. PMID:22043007
  • Sanches, J.C.T., Jones, C.J. P., Aplin, J.D., Iozzo, R.V., Zorn, T.M.T., Oliveira, S.F. Collagen fibril organization in the pregnant endometrium of decorin-deficient mice J. Anat. 216:144-155, 2010. PMID: 19900179
  • Rees, M.D., Chuang, C.Y., Iozzo, R.V., Malle, E., Whitelock, J.M. and Davies, M.J. Oxidation of perlecan by the myeloperoxidase-derived products hypochlorous acid and hypobromous acid: Disruption of structure and function via protein core degradation. Matrix Biol. 29:63-73, 2010. PMID: 19788922
  • Ferdous, Z., Peterson, S.B., Anderson, D.K., Iozzo, R.V., and Grande-Allen, K.J. A Role for decorin in controlling proliferation, adhesion, and migration of murine embryonic fibroblasts. J. Biomed. Mater. Res. 93A:419-428, 2010. PMID: 19569212
  • Metalli, D., Lovat, F., Tripodi, F., Xu, S-Q., Alberghina, L., Vanoni, M., Gomella, L.G., Iozzo, R.V., and Morrione A. The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin. Am. J. Pathol. 176:2997-3006, 2010. PMID: 20395438
  • Chuang, C., Lord, M., Melrose, J., Rees, M.D., Knox, S., Freeman, C., Iozzo, R.V., and Whitelock, J. Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan. Biochemistry 49:5524-5532, 2010. PMID: 20507176
  • Iozzo, R.V., and Karamanos, N. Proteoglycans in health and disease: Emerging concepts and future directions. FEBS J., 277:3863, 2010. PMID: 20812984
  • Iozzo, R.V., and Schaefer, L. Proteoglycans in health and disease: Novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans. FEBS J. 277:3864-3875, 2010. PMID: 20812983
  • Buraschi, S., Pal, N., Tyler-Rubinstein, N., Owens, R.T., Neill, T. and Iozzo, R.V. Decorin antagonizes Met receptor activity and downregulates b-catenin and Myc levels. J. Biol. Chem. 285:42075-42085, 2010. PMID: 20974860 [This paper was selected by the Faculty of 1000 in 2011; http://f1000.com/7256956].
  • Iozzo, R.V., Goldoni, S., Berendsen, A. and Young, M. Small leucine-rich proteoglycans. In the Extracellular Matrix: An overview. Robert P. Mecham (editor) Springer Series: Biology of Extracellular Matrix. Chapter 6, pp 197-266, Springer (publisher), New York, NY, 2011.
  • Baghy, K., DezsQ, K, László,V., Fullár, A., Péterfia, B., Paku, S., Nagy, P., Schaff, Z., Iozzo, R.V. and Kovalszky, I. Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice. Lab. Invest. 91:439-451, 2011. PMID: 20956977
  • San Antonio, J.D., Zoeller,J.J., Habursky, K., Turner, K., Pimtong, W., Burrows, M., Choi, S., Basra, S., Bennet, J.S., De Grado, W.F., and Iozzo, R.V. A key role for the integrin ±2²1 in experimental and developmental angiogenesis. Am. J. Pathol. 175: 1138-1147, 2009.
  • Smith, S.M., Whitelock, J.M., Iozzo, R.V., Little, C.B. and Melrose, J. Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development. Histochem. Cell Biol. 132: 491-503, 2009.
  • Nyström, A., Shaik, Z.P., Gullberg, D., Krieg, T., Eckes, B., Zent, R., Pozzi, A. and Iozzo, R.V. Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood 114:4897-4906, 2009.
  • Merline, R., Lazaroski, S., Babelova, A., Pfeilschifter, J., Schlüter, K-D., Günther, A., Iozzo, R.V. , Schaefer, R.M., and Schaefer, L. Decorin deficiency in diabetic mice: Aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration. J. Physiol. Pharmacol. 60(Suppl 4): 5-13, 2009.
  • Vecchione,A., Fassan, M., Anesti, V., Morrione, A., Goldoni, S., Baldassarre, G., Byrne, D., DArca, D., Palazzo, J.P., Lloyd, J., Scorrano, L., Gomella, L.G., Iozzo, R.V., and Baffa R. MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is down-regulated in human bladder and breast cancer. Oncogene 28:257-269, 2009.
  • Monami, G., Emiliozzi, V., Bitto,A., Goldoni, S., Fassan, M., Serrero,G., Gomella, L.G., Baffa, R., Iozzo, R.V., Morrione, A. Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration and anchorage-independent growth. Am. J. Pathol. 175:1037-1047, 2009.
  • Zhang, G., Chen, S., Goldoni, S., Calder, B.W., Simpson, H.C., Owens, R.T., McQuillan, D.J.,Young, M.F., Iozzo, R.V., and Birk, D.E. Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan. J. Biol. Chem. 284:8888-8897, 2009.
  • Lovat, F., Bitto, A., Xu, S-Q., Fassan, M., Goldoni, S., Metalli, D., Wubah, V., McCue, P., Serrero, G., Gomella, L.G., Baffa, R., Iozzo, R.V., and Morrione, A. Proepithelin is an autocrine growth factor for bladder cancer. Carcinogenesis 30:861-868, 2009.
  • Haruyama, N., Sreenath, T.L., Suzuki, S., Yao, X., Wang, Z., Wang, Y., Honeycutt, C., Iozzo, R.V., Young, M.F., and Kulkarni, A.B. Genetic evidence for key roles of decorin and biglycan in dentin mineralization. Matrix Biol. 28:129-136, 2009.
  • Merline, R., Lazaroski, S., Babelova, A., Pfeilschifter, J., Schlüter, K-D., Günther, A., Iozzo, R.V. , Schaefer, R.M., and Schaefer, L. Decorin deficiency in diabetic mice: Aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and inflammatory infiltration. Submitted, 2009.
  • Zoeller, J.J., Pimtong, W., Corby, H., Goldoni, S., Iozzo, A.E., Owens, R.T., Ho, S-Y., and Iozzo, R.V. A central role for decorin during vertebrate convergent extension. J. Biol. Chem. 284:11498-11506, 2009.
  • Zoeller, J.J., Whitelock, J.M. and Iozzo, R.V. Perlecan regulates developmental angiogenesis by modulating VEGF-VEGFR2 axis. Matrix Biol., In press, 2009.
  • Iozzo, R.V., Zoeller, J.J., and Nyström, A. Basement membrane proteoglycans: modulators par excellence of cancer growth and angiogenesis. Mol. Cells , In press, 2009.
  • Goldoni, S., Humphries, A., Nyström, A., Sattar, S., Owens, R.T., McQuillan, D.J., Ireton, K., and Iozzo, R.V. Decorin is a novel antagonistic ligand of the Met receptor. J. Cell Biol. 185:743-754, 2009. http://jcb.rupress.org/cgi/content/full/185/4/566-b?etoc
  • Ferdous, Z., Peterson, S.B., Anderson, D.K., Iozzo, R.V., Höök, M., and Grande-Allen, K.J. Decorin deficiency enhances proliferation, adhesion, and migration of murine embryonic fibroblasts. J. Biomed. Mater. Res. In press, 2009.
  • Woodall, B.P., Nyström, A., Iozzo, R.A., Eble, J.A., Niland, S., Krieg, T., Eckes, B., Pozzi, A., and Iozzo, R.V. Integrin a2b1 is the required receptor for endorepellin angiostatic activity. J. Biol.Chem. 283:2335-2344, 2008.
  • Zoeller, J.J., and Iozzo, R.V. Proteomic profiling of endorepellin angiostatic activity on human endothelial cells. Proteome Sci. 6:7, 2008
  • Zoeller, J.J., McQuillan, A, Whitelock, J., Ho, S-Y., and Iozzo, R.V. A central function for perlecan in skeletal muscle and cardiovascular development. J. Cell Biol. 181:381-394, 2008. [This paper was selected by the Faculty of 1000 in 2008; http://www.f1000biology.com/article/id/1109031/evaluation]
  • Baffa, R., Fassan, M., Sevignani, C., Vecchione,A., Ishii, H., Giarnieri, G., Iozzo, R.V., Gomella, L.G., and Croce, C.M. Fez1/Lzts1 deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine carcinogenesis. Carcinogenesis, 29: 846-848, 2008.
  • Ferdous, Z., Lazaro, L.D., Iozzo, R.V., Höök, M., and Grande-Allen, K.J. Influence of cyclic strain and decorin deficiency on 3-D cellularized collagen matrices. Biomaterials 29:2740-2748, 2008.
  • Whitelock, J., Ma, J.L., Davies, N., Nielsen, N., Chuang, C., Rees, M., Iozzo, R.V., Knox, S., and Lord, M. Recombinant heparan sulfate for use in tissue engineering applications. J. Chem. Tech. Biotech. 83:496-504, 2008.
  • Bix, G, and Iozzo, R.V. Novel interactions of perlecan: Unraveling perlecans role in angiogenesis. Microsc. Res. 71:338-348, 2008.
  • ORiordan, E., Orlova, T.N., Mendelev, N., Patschan, D., Kemp,R., Chander, P.N., Hu, R., Hao, G., Gross, S.S., Iozzo, R.V., Delaney, V., and Goligorsky, M.S. Urinary proteomic analysis of chronic renal allograft nephropathy Proteomics Clin. Appl. 2:1025-1035, 2008.
  • Schaefer, L. and Iozzo, R.V. Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction J. Biol.Chem. 283:2135-2139, 2008.
  • Bi, X., Tong, C., Dockendorff, A., Bancroft, L., Gallagher, L., Guzman-Hartman, G., Iozzo, R.V., Augenlicht, L.H., and Yang, W. Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis 29:1435-1440, 2008.
  • Baker, A.B., Ettenson, D.S., Jonas, M., Nugent, M.A., Iozzo, R.V., and Edelman, E.R. Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-b signaling pathway. Circ. Res. 103:289-297, 2008.
  • Goldoni, S., Seidler, D.G., Heath, J., Fassan, M., Baffa, R., Thakur, M.L., Owens, R.T., McQuillan, D.J., and Iozzo, R.V. An anti-metastatic role for decorin in breast cancer. Am. J. Pathol. 173:844-855, 2008.
  • Goldoni, S. and Iozzo, R.V. Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int. J. Cancer. 123:2473-2479, 2008.
  • Cailhier, J-F., Sirois, I., Laplante, P., Lepage, S., Raymond, M-A., Brassard, N., Prat, A., Iozzo, R.V., Pshezhetsky, A.V., and Hébert, M-J. Caspase-3 activation triggers extra-cellular cathepsin L release and endorepellin proteolysis. J. Biol. Chem. 283:27220-27229, 2008.
  • Whitelock, J.M., Melrose, J., and Iozzo, R.V. Diverse cell signaling events modulated by perlecan. Biochemistry 47:11174-11183, 2008.
  • Schaefer, L, Tsalastra, W., Babelova, A., Baliova, M. Minnerup, J., Sorokin, L., Gröne, H-J., Reinhardt, D.P., Pfeilschifter, J., Iozzo, R.V., and Schaefer, R.M. Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and mammalian target of rapamycin Am. J. Pathol.170: 301-315, 2007.
  • Wadhwa, S., Bi, Y., Ortiz, A.T., Embree, M.C., Kilts, T., Iozzo, R.V., Opperman, L.A., and Young, M.F. Impaired posterior frontal sutural fusion in biglycan/decorin double deficient mice. Bone 40:861-866, 2007.
  • Goldoni, S., Iozzo, R.A., Kay, P., Campbell, S., McQuillan, A., Agnew, C., Zhu, J-X., Keene, D.R., Reed, C.C., and Iozzo, R.V. A soluble ectodomain of LRIG1 inhibits cancer growth by attenuating basal and ligand-dependent EGFR activity. Oncogene 26:368-381 2007.
  • Bix, G, Iozzo, R.A., Woodall, B., Burrows, M., McQuillan, A., Campbell, S., Fields, G.B., and Iozzo, R.V. Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the a2b1 integrin receptor Blood 109:3745-3749, 2007.
  • Williams, K.J., Qiu, G., Dunn, S.R., McCue, P., Bottinger, E., Iozzo, R.V., and Sharma, K. Decorin deficiency enhances progressive nephropaty in diabetic mice. Am. J. Pathol. 171:1441-1450, 2007.
  • Rühland, C., Schönherr, E., Robenek,H. , Hansen, U., Iozzo, R.V., Bruckner, P., and Seidler, D.G. The glycosaminoglycan chain of decorin plays a limiting role on collagen fibril formation at early stages of fibrillogenesis. FEBS J. 274:4246-4255, 2007.
  • Salerno, F.G., Pinelli, V., Pini, L., Tuma, B., Iozzo, R.V., and Ludwig M.S. Effect of PEEP on induced constriction is enhanced in decorin-deficient mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 293:L1111-7, 2007
  • Ferdous, Z., Wei, V.M., Iozzo, R.V., Höök, M., and Grande-Allen, K.J. Decorin-TGFb interaction regulates matrix organization and mechanical characteristics of 3-D collagen matrices. J. Biol.Chem. 282:35887-35898, 2007.
  • Sher, I., Zisman-Rozen, S., Eliahu, L., Whitelock, I.M., Maas-Szabowski, N., Yamada, Y., Breitkreutz, D., Fusenig, N.E., Arikawa-Hirasawa, E., Iozzo, R.V., Bergman, R., and Ron D. Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation J. Biol. Chem. 281:5178-5187, 2006. [This paper was selected by the Faculty of 1000 in 2005].
  • San Antonio, J. and Iozzo, R.V.: Two phase model for angiogenesis regulation by extracellular matrix. In Encyclopedia of the Microvasculature, Shepro, D. Editor (Elsevier, San Diego, CA), pp 127-137, 2006.
  • Zhang,G., Ezura,Y., Chervoneva, I., Robinson, P.S., Beason, D.P., Carine,E.T., Soslowsky, L.J., Iozzo, R.V. and Birk, D.E. Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development. J. Cell. Biochem. 98:1436-1449, 2006.
  • Monami, G., Gonzalez, E.M., Gomella, L.G., Baffa, R., Iozzo, R.V., and Morrione, A. Proepithelin promotes cell migration and invasion of bladder cancer cells. Cancer Res. 66:7103-7110, 2006.
  • Järveläinen, H., Puolakkainen, P., Pakkanen, S., Brown, E., Höök, M., Iozzo, R.V., Sage, E.H., and Wight, T.N. A role for decorin in cutaneous wound healing and angiogenesis. Wound Rep. Reg.14:443-452, 2006.
  • Seidler, D.G., Goldoni, S., Agnew, C., Cardi, C., Thakur, M.L., Owens, R.T., McQuillan, D.J., and Iozzo, R.V. Decorin protein core inhibits in vivo cancer growth and metabolism by hindering EGF receptor function and triggering apoptosis via caspase-3 activation. J. Biol. Chem.281: 26408-26418, 2006. [This paper was selected by the Faculty of 1000 in 2006; http://www.f1000biology.com/article/id/1040509/evaluation]
  • Laplante, P., Raymond, M-A., Labelle, A., Abe, J-I., Iozzo, R.V., Hébert, M-J. Perlecan proteolysis induces an a2b1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. J. Biol. Chem. 281:30383-30392, 2006.
  • Bix, G., Castello, R., Burrows, M., Zoeller, J.Z., Weech, M., Iozzo, R.A., Cardi, C., Thakur, M.L., Barker, C., Camphausen, K., and Iozzo, R.V. Endorepellin in vivo: Targeting the tumor vasculature and retarding cancer growth. J. Natl. Cancer Inst. 15: 1634-1646, 2006. [This paper was selected by the Faculty of 1000 in 2006; http://www.f1000biology.com/article/id/1049362/evaluation]
  • Robinson, P.S. Huang, T.F., Kazam, E., Iozzo, R.V., Birk, D.E., and Soslowsky, L.J. Influence of decorin and biglycan on mechanical properties of multiple tendons in knockout mice. J. Biomech. Engin. 127:181-185, 2005.
  • Reed, C.C., Waterhouse, A., Kirby, S., Kay, P.Owens, R.T., McQuillan, D.J. and Iozzo, R.V. Decorin prevents metastatic spreading of breast cancer. Oncogene 24: 1104-1110, 2005.
  • Fust, A., LeBellego,F., Iozzo, R.V., Roughley,P.J. and Ludwig, M.S. Alterations in lung mechanics in decorin deficient mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 288: L159-166, 2005.
  • Bix, G, and Iozzo, R.V. Matrix revolutions: tails of basement membrane components with angiostatic functions. Trends Cell Biol. 15:51-60, 2005.
  • Gonzalez, E.M., Reed,C.C., Bix G., Fu, J., Zhang, Y., Gopalakrishnan, B., Greenspan, D.S. and Iozzo, R.V. BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. J. Biol. Chem. 280:7080-7087, 2005.
  • Schönherr, E., Sunderkötter, C., Iozzo, R.V., and Schaefer, L. Decorin, a novel player in the insulin-like growth factor system. J. Biol. Chem. 280:15767-15772, 2005. [This paper was selected by the Faculty of 1000 in 2005]
  • Iozzo, R.V. Basement membrane proteoglycans: from cellar to ceiling. Nature Rev. Mol. Cell. Biol. 6:646-656, 2005.
  • Whitelock, J. and Iozzo, R.V. Heparan sulfate: A complex biopolymer charged with biological activity. Chem. Rev. 105:2745-2764, 2005.
  • Thadikkaran, L., Crettaz, D., Siegenthaler, M.A., Gallot, D., Sapin, V., Iozzo, R.V., Queloz, P-A., Schneider, P. and Tissot, J-D. The role of proteomics in the assessment of premature rupture of fetal membranes. Clin. Chim. Acta 360:27-36, 2005.
  • Weis, S.M., Zimmerman, S.D., Sha,M., Covell, J.W., Omens, J.H., Ross, J., Dalton, N., Jones, Y., Reed, C.C., Iozzo, R.V. and McCulloch, D. A role for decorin in the remodeling of myocardial infarction. Matrix Biol. 24:313-324, 2005.
  • Seidler, D.G., Schaefer, L., Robenek, H., Iozzo, R.V., Kresse, H. and Schönherr, E. A physiologic three-dimensional cell culture system to investigate the role of decorin in matrix organization and cell survival. Biochem. Biophys. Res. Commun. 332: 1162-1170, 2005.
  • Bi, Y., Stuelten, C.H., Kilts, T, Wadhwa, S., Iozzo, R.V., Robey, P.G., Chen X-D., and Young, M.F. Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. J. Biol. Chem. 280:30481-30489, 2005.
  • Zhu, J-X., Goldoni,S., Bix, G., Owens, R.T., McQuillan, D.J., Reed, C.C., and Iozzo, R.V. Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveloar endocytosis. J. Biol. Chem. 280:32468-32479, 2005. [This paper was selected by the Faculty of 1000 in 2005, http://www.facultyof1000.com/article/15994311/evaluation].
  • Goldberg, M., Septier, D. Rapoport, O., Iozzo, R.V., Young, M.F., and Ameye, L.G. Targeted disruption of two small leucine-rich proteoglycans, biglycan and decorin, exerts divergent effects on enamel and dentin formation. Calcif. Tissue. Int. 77:297-310, 2005.
  • Goldoni, S., Owens, R.T., McQuillan, D.J., Shriver, Z., Sasisekharan, R., Birk, D.E., Campbell, S. and Iozzo, R.V. Biologically active decorin is a monomer in solution. J. Biol. Chem. 279:6606-6612, 2004.
  • Schaefer, L., Mihalik, D., Babelova, A., Krzyzankova, M., Gröne, H-J., Iozzo, R.V. Young, M.F., Seidler, D.G., Tiedemann, K., Reinhardt, D.P. and Schaefer, R.M. Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury. Am. J. Pathol. 165:383-396, 2004.
  • Robinson, P.S., Lin,T.W., Jawad, A.F., Iozzo, R.V. and Soslowsky, L.J. Investigating tendon fascicle structure-function relationship in a transgenic age mouse model using multiple regression models. Ann. Biomed. Eng. 32:924-931, 2004.
  • Bix, G., Fu, J., Gonzalez, E., Macro, L., Barker, A., Campbell, S., Zutter, M.M., Santoro, S.A., Kim, J.K., Höök, M., Reed, C.C. and Iozzo, R.V. Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through a2b1 integrin. J. Cell Biol. 166:97-109, 2004. [This paper was selected by the Faculty of 1000 in 2004; it was also reviewed by Nature Rev. Mol. Cell. Biol. 5:592, 2004, and reviewed in Matrix Biol. 23:265-266, 2004].
  • Liang, F.T., Wang, T., Brown, E.L., Iozzo, R.V. and Fikring, E. Protective niche for Borrelia burgdorferi to evade humoral immunity. Am. J. Pathol. 165:977-985, 2004.
  • Schönherr, E., Sunderkötter, C., Schafer, L., Thanos, S., Grässel, S., Oldberg, Å., Iozzo, R.V., Young, M.F. and Kresse, H. Decorin deficiency leads to impaired angiogenesis in injured mouse cornea. J. Vasc. Res. 41:499-508, 2004.
  • Csordas G, Santra M, Reed CC, Eichstetter I, McQuillan DJ, Gross D, Nugent MA, Hajnoczky G, Iozzo RV. Sustained down-regulation of the epidermal growth factor receptor by decorin. A mechanism for controlling tumor growth in vivo. Journal of Biological Chemistry. 275(42): 32879-87, 2000
  • Santra M, Eichstetter I, Iozzo RV. An anti-oncogenic role for decorin. Down-regulation of ErbB2 leads to growth suppression and cytodifferentiation of mammary carcinoma cells. Journal of Biological Chemistry. 275(45): 35153-61, 2000
  • Fuki IV, Iozzo RV, Williams KJ. Perlecan heparan sulfate proteoglycan: a novel receptor that mediates a distinct pathway for ligand catabolism. Journal of Biological Chemistry. 275(33): 25742-50, Aug 2000
  • Ghiselli G, Iozzo RV. Overexpression of bamacan/SMC3 causes transformation. Journal of Biological Chemistry. 275(27): 20235-8, Jul 2000
  • Keene DR, San Antonio JD, Mayne R, McQuillan DJ, Sarris G, Santoro SA, Iozzo RV. Decorin binds near the C terminus of type I collagen. Journal of Biological Chemistry. 275(29): 21801-4, Jul 2000
  • Nugent MA, Nugent HM, Iozzo RV, Sanchack K, Edelman ER. Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia. Proceedings of the National Academy of Sciences (USA). 97(12): 6722-7, Jun 2000
  • Nugent MA, Iozzo RV. Fibroblast growth factor-2. International Journal of Biochemistry and Cell Biology. 32(2): 115-20, Feb 2000
  • Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV. The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7. Journal of Biological Chemistry. 275(10): 7095-100, 10 2000
  • Laine, P.,Reunanen, N., Ravanti, L., Foschi, M., Santra, M., Iozzo, R.V., and Kähäri, V-M. Activation of extracellular signal-regulated kinase 1,2 inhibits expression of decorin in fibroblasts. Biochemical Journal. 349: 19-25, 2000
  • Mozersky,S.M., Iandola,S.K., Liu, C.-K., Phillips,J.G., Marmer,W.N., Eichstetter,I., and Iozzo, R.V. The physical properties of leathers made from the skins of mice genetically deficient in decorin or thrombospondin-2. Journal of the American Leather Chemists Association. 95: 229-276, 2000
  • Iozzo, R. V., Editor. Proteoglycans: Structure, Biology and Molecular Interactions. (Marcel Dekker, Publishing Company, New York, NY). , 2000
  • Sevignani C, Cranston A, Iozzo RV, Fishel R, Calabretta B. Spontaneous and mutagen-induced transformation of primary cultures of Msh2-/- p53-/- colonocytes. Cancer Research. 59(23): 5882-6, Dec 1999
  • Iozzo RV. The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. Journal of Biological Chemistry. 274(27): 18843-6, 2 Jul 1999
  • Ghiselli G, Siracusa LD, Iozzo RV. Complete cDNA cloning, genomic organization, chromosomal assignment, functional characterization of the promoter, and expression of the murine Bamacan gene. Journal of Biological Chemistry. 274(24): 17384-93, 11 Jun 1999
  • Whitelock JM, Graham LD, Melrose J, Murdoch AD, Iozzo RV, Underwood PA. Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells. Matrix Biology. 18(2): 163-78, Apr 1999
  • Iozzo RV, Chakrani F, Perrotti D, McQuillan DJ, Skorski T, Calabretta B, Eichstetter I. Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis. Proceedings of the National Academy of Sciences (USA). 96(6): 3092-7, 16 Mar 1999
  • Iozzo RV, Moscatello DK, McQuillan DJ, Eichstetter I. Decorin is a biological ligand for the epidermal growth factor receptor. Journal of Biological Chemistry. 274(8): 4489-92, 19 Feb 1999
  • Danielson KG, Siracusa LD, Donovan PJ, Iozzo RV. Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants. Mammalian Genome. 10(2): 201-3, Feb 1999
  • Iozzo RV, Danielson KG. Transcriptional and posttranscriptional regulation of proteoglycan gene expression. Prog Nucleic Acid Res Mol Biol. 62: 19-53, 1999
  • San Antonio, J. and Iozzo, R.V. Glycosaminoglycans: Structure and biological functions. In: Embryonic Encyclopedia of Life Sciences, Nature Publishing Company, London. www.els.net. , 1999
  • Fleischmajer R, Perlish JS, MacDonald ED 2nd, Schechter A, Murdoch AD, Iozzo RV, Yamada Y. There is binding of collagen IV to beta 1 integrin during early skin basement membrane assembly. Annals of the New York Academy of Sciences. 857: 212-27, Oct 1998
  • Sharma B, Handler M, Eichstetter I, Whitelock JM, Nugent MA, Iozzo RV. Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. Journal of Clinical Investigation. 102(8): 1599-608, Oct 1998
  • Perrotti D, Bonatti S, Trotta R, Martinez R, Skorski T, Salomoni P, Grassilli E, Lozzo RV, Cooper DR, Calabretta B. TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. Embo Journal. 17(15): 4442-55, Aug 1998
  • Kovalszky I, Dudas J, Olah-Nagy J, Pogany G, Tovary J, Timar J, Kopper L, Jeney A, Iozzo RV. Inhibition of DNA topoisomerase I activity by heparan sulfate and modulation by basic fibroblast growth factor. Molecular and Cellular Biochemistry. 183(1-2): 11-23, Jun 1998
  • Sevignani C,Wlodarski P,Kirillova J,Mercer WE,Danielson K G,Iozzo R V,Calabretta B. Tumorigenic conversion of p53-deficient colon epithelial cells by an activated Ki-ras gene. Journal of Clinical Investigation. 101(8): 1572-80, 15 Apr 1998
  • Sharma B,Iozzo R V. Transcriptional silencing of perlecan gene expression by interferon-gamma. Journal of Biological Chemistry. 273(8): 4642-6, 20 Feb 1998
  • Keene DR, Ridgway CC, Iozzo RV. Type VI microfilaments interact with a specific region of banded collagen fibrils in skin. Journal of Histochemistry and Cytochemistry. 46(2): 215-20, Feb 1998
  • Patel S,Santra M,McQuillan D J,Iozzo R V,Thomas A P. Decorin activates the epidermal growth factor receptor and elevates cytosolic Ca2+ in A431 carcinoma cells. Journal of Biological Chemistry. 273(6): 3121-4, Feb 1998
  • Kyriakides T R,Zhu Y H,Smith L T,Bain S D,Yang Z,Lin M T,Danielson K G,Iozzo R V,LaMarca M,McKinney C E,Ginns E I,Bornstein P. Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. Journal of Cell Biology. 140(2): 419-30, 26 Jan 1998
  • Moscatello D K,Santra M,Mann D M,McQuillan D J,Wong A J,Iozzo R V. Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor. Journal of Clinical Investigation. 101(2): 406-12, 15 Jan 1998
  • Iozzo RV. Matrix proteoglycans: from molecular design to cellular function. Annual Review of Biochemistry. 67: 609-52, 1998
  • Handler M,Yurchenco P D,Iozzo R V. Developmental expression of perlecan during murine embryogenesis. Developmental Dynamics. 210(2): 130-45, Oct 1997
  • Fuki I V,Kuhn K M,Lomazov I R,Rothman V L,Tuszynski G P,Iozzo R V,Swenson T L,Fisher E A,Williams K J. The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro. Journal of Clinical Investigation. 100(6): 1611-22, 15 Sep 1997
  • Werner J, Laposata M, Fernandez-del Castillo C, Saghir M, Iozzo RV, Lewandrowski KB, Warshaw AL. Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol [see comments]. Gastroenterology. 113(1): 286-94, Jul 1997
  • Santra M,Mann D M,Mercer E W,Skorski T,Calabretta B,Iozzo R V. Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. Journal of Clinical Investigation. 100(1): 149-57, Jul 1997
  • Mathiak M,Yenisey C,Grant D S,Sharma B,Iozzo R V. A role for perlecan in the suppression of growth and invasion in fibrosarcoma cells. Cancer Research. 57(11): 2130-6, Jun 1997
  • Aviezer D, Iozzo RV, Noonan DM, Yayon A. Suppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNA. Molecular and Cellular Biology. 17(4): 1938-46, Apr 1997
  • DeRocco S E,Iozzo R,Ma X P,Schwarting R,Peterson D,Calabretta B. Ectopic expression of A-myb in transgenic mice causes follicular hyperplasia and enhanced B lymphocyte proliferation. Proceedings of the National Academy of Sciences (USA). 94(7): 3240-4, Apr 1997
  • Iozzo R V,Pillarisetti J,Sharma B,Murdoch A D,Danielson K G,Uitto J,Mauviel A. Structural and functional characterization of the human perlecan gene promoter. Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element. Journal of Biological Chemistry. 272(8): 5219-28, 21 Feb 1997
  • Danielson K G,Baribault H,Holmes D F,Graham H,Kadler K E,Iozzo R V. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. Journal of Cell Biology. 136(3): 729-43, 10 Feb 1997
  • Skorski T,Nieborowska-Skorska M,Wlodarski P,Perrotti D,Hoser G,Kawiak J,Majewski M,Christensen L,Iozzo R V,Calabretta B. Treatment of Philadelphia leukemia in severe combined immunodeficient mice by combination of cyclophosphamide and bcr/abl antisense oligodeoxynucleotides [see comments]. Journal of The National Cancer Institute. 89(2): 124-33, 15 Jan 1997
  • Santra, M., Mann, D. M., Mercer, E., Skorsky, T., Calabretta, B. and Iozzo , R. V. Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires p21, an inhibitor of cyclin-dependent kinases. Journal of Clinical Investigation. 100: 149-157, 1997
  • Kovalszky, I., Nagy, J. O., Gallai, M., Sebestyén, A., Schaff, Z., Paku, S., Jeney, A., and Iozzo, R.V. Altered proteoglycan gene expression in human biliary cirrhosis. Pathol. Onc. Res. 3: 51-58, 1997
  • Iozzo R V. The family of the small leucine-rich proteoglycans: key regulators of matrix assembly and cellular growth. Critical Reviews In Biochemistry and Molecular Biology. 32(2): 141-74, 1997
  • Weber I T,Harrison R W,Iozzo R V. Model structure of decorin and implications for collagen fibrillogenesis. Journal of Biological Chemistry. 271(50): 31767-70, 13 Dec 1996
  • Mauviel A;Korang K;Santra M;Tewari D;Uitto J;Iozzo R V. Identification of a bimodal regulatory element encompassing a canonical AP-1 binding site in the proximal promoter region of the human decorin gene. Journal of Biological Chemistry. 271(40): 24824-9, 4 Oct 1996
  • De Luca A;Santra M;Baldi A;Giordano A;Iozzo R V. Decorin-induced growth suppression is associated with up-regulation of p21, an inhibitor of cyclin-dependent kinases. Journal of Biological Chemistry. 271(31): 18961-5, 2 Aug 1996
  • Skorski T;Nieborowska-Skorska M;Wlodarski P;Zon G;Iozzo R V;Calabretta B. Antisense oligodeoxynucleotide combination therapy of primary chronic myelogenous leukemia blast crisis in SCID mice. Blood. 88(3): 1005-12, 1 Aug 1996
  • Whitelock J M;Murdoch A D;Iozzo R V;Underwood P A. The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases. Journal of Biological Chemistry. 271(17): 10079-86, 26 Apr 1996
  • Iozzo R V;Murdoch A D. Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function. Faseb Journal. 10(5): 598-614, Apr 1996
  • Eftychiadis, A.S., Iozzo, R.V., Ackerman, A. B. Sebocyte-like melanocytes in melanocytic nevi. Dermatopathology. 2: 49-50, 1996
  • Nieborowska-Skorska M;Bialek A P;Nicolaides N C;Iozzo R V;Kawalec M;Calabretta B;Kawiak J;Marlicz K;Skorski T. The influence of phosphorothioate oligodeoxynucleotides on various organs in vivo. Folia Histochemica Et Cytobiologica. 34(2): 69-73, 1996
  • Danielson K G;Pillarisetti J;Cohen I R;Sholehvar B;Huebner K;Ng L J;Nicholls J M;Cheah K S;Iozzo R V. Characterization of the complete genomic structure of the human WNT-5A gene, functional analysis of its promoter, chromosomal mapping, and expression in early human embryogenesis. Journal of Biological Chemistry. 270(52): 31225-34, 29 Dec 1995
  • Skorski T;Nieborowska-Skorska M;Campbell K;Iozzo R V;Zon G;Darzynkiewicz Z;Calabretta B. Leukemia treatment in severe combined immunodeficiency mice by antisense oligodeoxynucleotides targeting cooperating oncogenes. Journal of Experimental Medicine. 182(6): 1645-53, 1 Dec 1995
  • Wegrowski Y;Pillarisetti J;Danielson K G;Suzuki S;Iozzo R V. The murine biglycan: complete cDNA cloning, genomic organization, promoter function, and expression. Genomics. 30(1): 8-17, 1 Nov 1995
  • Naso M F;Morgan J L;Buchberg A M;Siracusa L D;Iozzo R V. Expression pattern and mapping of the murine versican gene (Cspg2) to chromosome 13. Genomics. 29(1): 297-300, 1 Sep 1995
  • Iozzo R V;Eichstetter I;Danielson K G. Aberrant expression of the growth factor Wnt-5A in human malignancy. Cancer Research. 55(16): 3495-9, 15 Aug 1995
  • Iozzo R V. Tumor stroma as a regulator of neoplastic behavior. Agonistic and antagonistic elements embedded in the same connective tissue [editorial]. Laboratory Investigation. 73(2): 157-60, Aug 1995
  • Santra M;Skorski T;Calabretta B;Lattime E C;Iozzo R V. De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells. Proceedings of the National Academy of Sciences (USA). 92(15): 7016-20, 18 Jul 1995
  • Mauviel A;Santra M;Chen Y Q;Uitto J;Iozzo R V. Transcriptional regulation of decorin gene expression. Induction by quiescence and repression by tumor necrosis factor-alpha. Journal of Biological Chemistry. 270(19): 11692-700, 12 May 1995
  • Grassel S;Cohen I R;Murdoch A D;Eichstetter I;Iozzo R V. The proteoglycan perlecan is expressed in the erythroleukemia cell line K562 and is upregulated by sodium butyrate and phorbol ester. Molecular and Cellular Biochemistry. 145(1): 61-8, 12 Apr 1995
  • Naso M F;Zimmermann D R;Iozzo R V. Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter. Journal of Biological Chemistry. 269(52): 32999-3008, 30 Dec 1994
  • Baribault H;Penner J;Iozzo R V;Wilson-Heiner M. Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes and Development. 8(24): 2964-73, 15 Dec 1994
  • Cohen I R;Murdoch A D;Naso M F;Marchetti D;Berd D;Iozzo R V. Abnormal expression of perlecan proteoglycan in metastatic melanomas. Cancer Research. 54(22): 5771-4, 15 Nov 1994
  • Scholzen T;Solursh M;Suzuki S;Reiter R;Morgan J L;Buchberg A M;Siracusa L D;Iozzo R V. The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation. Journal of Biological Chemistry. 269(45): 28270-81, 11 Nov 1994
  • Iozzo R V;Cohen I R;Grassel S;Murdoch A D. The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices. Biochemical Journal. 302 ( Pt 3): 625-39, 15 Sep 1994
  • Reginato A M;Iozzo R V;Jimenez S A. Formation of nodular structures resembling mature articular cartilage in long-term primary cultures of human fetal epiphyseal chondrocytes on a hydrogel substrate. Arthritis and Rheumatism. 37(9): 1338-49, Sep 1994
  • Skorski T;Nieborowska-Skorska M;Nicolaides N C;Szczylik C;Iversen P;Iozzo R V;Zon G;Calabretta B. Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide. Proceedings of the National Academy of Sciences (USA). 91(10): 4504-8, 10 May 1994
  • Iozzo R V. Perlecan: a gem of a proteoglycan. Matrix Biology. 14(3): 203-8, Apr 1994
  • Rudnicka L;Varga J;Christiano A M;Iozzo R V;Jimenez S A;Uitto J. Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta. Journal of Clinical Investigation. 93(4): 1709-15, Apr 1994
  • Murdoch A D;Liu B;Schwarting R;Tuan R S;Iozzo R V. Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization. Journal of Histochemistry and Cytochemistry. 42(2): 239-49, Feb 1994
  • Santra M;Danielson K G;Iozzo R V. Structural and functional characterization of the human decorin gene promoter. A homopurine-homopyrimidine S1 nuclease-sensitive region is involved in transcriptional control. Journal of Biological Chemistry. 269(1): 579-87, 7 Jan 1994
  • Iozzo R V;Cohen I. Altered proteoglycan gene expression and the tumor stroma. Exs. 70: 199-214, 1994
  • Cohen I R;Grassel S;Murdoch A D;Iozzo R V. Structural characterization of the complete human perlecan gene and its promoter. Proceedings of the National Academy of Sciences (USA). 90(21): 10404-8, 1 Nov 1993
  • Clark C C;Cohen I;Eichstetter I;Cannizzaro L A;McPherson J D;Wasmuth J J;Iozzo R V. Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. Genomics. 18(2): 249-60, Nov 1993
  • Ponnappa B C;Dodge G R;Dudkowski B;Hoek J B;Iozzo R V;Rubin E. Stimulation of protein synthesis in isolated pancreatic acini from chronically ethanol-fed rats is due to alterations in post-transcriptional regulation. Biochimica Et Biophysica Acta. 1158(2): 113-9, 3 Oct 1993
  • Iozzo R V;Cohen I. Altered proteoglycan gene expression and the tumor stroma. Experientia. 49(5): 447-55, 15 May 1993
  • Webster G F;Iozzo R V;Schwartzman R J;Tahmoush A J;Knobler R L;Jacoby R A. Reflex sympathetic dystrophy: occurrence of chronic edema and nonimmune bullous skin lesions. Journal of The American Academy of Dermatology. 28(1): 29-32, Jan 1993
  • Danielson K G;Fazzio A;Cohen I;Cannizzaro L A;Eichstetter I;Iozzo R V. The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. Genomics. 15(1): 146-60, Jan 1993
  • Murdoch A D;Iozzo R V. Perlecan: the multidomain heparan sulphate proteoglycan of basement membrane and extracellular matrix [editorial]. Virchows Archives A, Pathological Anatomy and Histopathology. 423(4): 237-42, 1993
  • Iozzo R V;Naso M F;Cannizzaro L A;Wasmuth J J;McPherson J D. Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14). Genomics. 14(4): 845-51, Dec 1992
  • Murdoch A D;Dodge G R;Cohen I;Tuan R S;Iozzo R V. Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growt. Journal of Biological Chemistry. 267(12): 8544-57, 25 Apr 1992
  • Ryynanen M;Ryynanen J;Sollberg S;Iozzo R V;Knowlton R G;Uitto J. Genetic linkage of type VII collagen (COL7A1) to dominant dystrophic epidermolysis bullosa in families with abnormal anchoring fibrils. Journal of Clinical Investigation. 89(3): 974-80, Mar 1992
  • Danielson K G;Martinez-Hernandez A;Hassell J R;Iozzo R V. Establishment of a cell line from the EHS tumor: biosynthesis of basement membrane constituents and characterization of a hybrid proteoglycan containing heparan and chondroitin sulfate chains. Matrix. 12(1): 22-35, Feb 1992
  • Alvarez RJ, Sun MJ, Haverty TP, Iozzo RV, Myers JC, Neilson EG. Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines. Kidney International. 41(1): 14-23, Jan 1992
  • Kovalszky, I., Timár, F., Iozzo, R. V., Lapis, K., Schaff, Z., and Jeney, A. Gene expression of proteoglycans in experimental liver injury. In: Molecular and Cell Biology of Liver Fibrogenesis (Gressner A.M. and Ramadori G., eds.) Kluver Academic Press, Boston. 152-154, 1992
  • Klenn P J;Iozzo R V. Larsen's syndrome with novel congenital anomalies. Human Pathology. 22(10): 1055-7, Oct 1991
  • Dodge G R;Kovalszky I;McBride O W;Yi H F;Chu M L;Saitta B;Stokes D G;Iozzo R V. Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter. Genomics. 11(1): 174-8, Sep 1991
  • Dodge G R;Kovalszky I;Chu M L;Hassell J R;McBride O W;Yi H F;Iozzo R V. Heparan sulfate proteoglycan of human colon: partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1. Genomics. 10(3): 673-80, Jul 1991
  • Adany R;Iozzo R V. Hypomethylation of the decorin proteoglycan gene in human colon cancer. Biochemical Journal. 276 ( Pt 2): 301-6, 1 Jun 1991
  • Tan E M;Dodge G R;Sorger T;Kovalszky I;Unger G A;Yang L;Levine E M;Iozzo R V. Modulation of extracellular matrix gene expression by heparin and endothelial cell growth factor in human smooth muscle cells. Laboratory Investigation. 64(4): 474-82, Apr 1991
  • Clark C C;Richards C F;Iozzo R V. Post-translational alterations in newly synthesized cartilage proteoglycans induced by the glutamine analogue 6-diazo-5-oxo-L-norleucine. Time course of inhibition and recovery. Biochemical Journal. 273(Pt 2): 283-8, 15 Jan 1991
  • Iozzo, R. V. Lipid-linked heparan sulfate proteoglycans. Trends in Glycoscience and Glycotechnology. 3: 327-333, 1991
  • Iozzo R V;Kovalszky I;Hacobian N;Schick P K;Ellingson J S;Dodge G R. Fatty acylation of heparan sulfate proteoglycan from human colon carcinoma cells. Journal of Biological Chemistry. 265(32): 19980-9, 15 Nov 1990
  • Iozzo R V;Hacobian N. Myristoylation of heparan sulfate proteoglycan and proteins occurs post-translationally in human colon carcinoma cells. Biochemical and Biophysical Research Communications. 172(2): 905-12, 30 Oct 1990
  • Dodge G R;Kovalszky I;Hassell J R;Iozzo R V. Transforming growth factor beta alters the expression of heparan sulfate proteoglycan in human colon carcinoma cells. Journal of Biological Chemistry. 265(29): 18023-9, 15 Oct 1990
  • Adany R;Iozzo R V. Altered methylation of versican proteoglycan gene in human colon carcinoma. Biochemical and Biophysical Research Communications. 171(3): 1402-13, 28 Sep 1990
  • Adany R;Heimer R;Caterson B;Sorrell J M;Iozzo R V. Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. Hypomethylation of PG-40 gene correlates with increased PG-40 content and mRNA levels. Journal of Biological Chemistry. 265(19): 11389-96, 5 Jul 1990
  • Kaner RJ, Iozzo RV, Ziaie Z, Kefalides NA. Inhibition of proteoglycan synthesis in human endothelial cells after infection with herpes simplex virus type 1 in vitro. American Journal of Respiratory Cell and Molecular Biology. 2(5): 423-31, May 1990
  • Kovalszky I;Pogany G;Molnar G;Jeney A;Lapis K;Karacsonyi S;Szecseny A;Iozzo R V. Altered glycosaminoglycan composition in reactive and neoplastic human liver. Biochemical and Biophysical Research Communications. 167(3): 883-90, 30 Mar 1990
  • Markovitz LJ, Savage EB, Ratcliffe MB, Bavaria JE, Kreiner G, Iozzo RV, Hargrove WC 3d, Bogen DK, Edmunds LH Jr. Large animal model of left ventricular aneurysm. Annals of Thoracic Surgery. 48(6): 838-45, Dec 1989
  • Simionescu D, Iozzo RV, Kefalides NA. Bovine pericardial proteoglycan: biochemical, immunochemical and ultrastructural studies. Matrix. 9(4): 301-10, Aug 1989
  • Tan EM, Levine E, Sorger T, Unger GA, Hacobian N, Planck B, Iozzo RV. Heparin and endothelial cell growth factor modulate collagen and proteoglycan production in human smooth muscle cells. Biochemical and Biophysical Research Communications. 163(1): 84-92, Aug 1989
  • Iozzo RV, Sampson PM, Schmitt GK. Neoplastic modulation of extracellular matrix: stimulation of chondroitin sulfate proteoglycan and hyaluronic acid synthesis in co-cultures of human colon carcinoma and smooth muscle cells. Journal of Cellular Biochemistry. 39(4): 355-78, Apr 1989
  • Iozzo R V. Presence of unsulfated heparan chains on the heparan sulfate proteoglycan of human colon carcinoma cells. Implications for heparan sulfate proteoglycan biosynthesis. Journal of Biological Chemistry. 264(5): 2690-9, 15 Feb 1989
  • Iozzo R V;Hassell J R. Identification of the precursor protein for the heparan sulfate proteoglycan of human colon carcinoma cells and its post-translational modifications. Archives of Biochemistry and Biophysics. 269(1): 239-49, 15 Feb 1989
  • Alvarez JG, Lee MA, Iozzo RV, Lopez I, Touchstone JC, Storey BT. Ethanol accelerates acrosomal loss in human spermatozoa. Journal of Andrology. 9(6): 357-66, 1988
  • Laposata M, Minda M, Capriotti AM, Hartman EJ, Furth EE, Iozzo RV. Reversible phenotypic modulation induced by deprivation of exogenous essential fatty acids. Laboratory Investigation. 59(6): 838-47, Dec 1988
  • Ben-Rafael Z, Benadiva CA, Mastroianni L Jr, Garcia CJ, Minda JM, Iozzo RV, Flickinger GL. Collagen matrix influences the morphologic features and steroid secretion of human granulosa cells. American Journal of Obstetrics and Gynecology. 159(6): 1570-4, Dec 1988
  • Iozzo RV. Cell surface heparan sulfate proteoglycan and the neoplastic phenotype. Journal of Cellular Biochemistry. 37(1): 61-78, May 1988
  • Iozzo RV. Proteoglycans and neoplasia. Cancer and Metastasis Reviews. 7(1): 39-50, Apr 1988
  • Mayock, R. L. and Iozzo, R. V. Eosinophilic pneumonia. In: Pulmonary Diseases and Disorders. A. P. Fishman, ed. New York, McGraw-Hill. 1: 683-698, 1988
  • Frank, T. S., Minda, M., and Iozzo, R. V. Eosinophilic granuloma of the lung. Elect. J. Pathol. Lab. Med. 1(2), 1988
  • Iozzo, R. V. Cell surface heparan sulfate proteoglycan and the neoplastic phenotype. In UCLA Symposia on: Altered glycosylation in tumor cells. (Reading, C. L., Hakamori, S. and Marcus, D. M., eds.) Alan Liss, New York, N. Y. 79: 109-126, 1988
  • Iozzo RV, Clark CC. Modulation of heparan sulfate biosynthesis. Effects of 6-diazo-5-oxo-L-norleucine and low glutamine on the synthesis of heparan sulfate proteoglycan by human colon carcinoma cells. Journal of Biological Chemistry. 262(23): 11188-99, Aug 1987
  • Marchlinski FE, Falcone R, Iozzo RV, Reichek N, Vassallo JA, Eysmann SB. Experimental myocardial cryoinjury: local electromechanical changes, arrhythmogenicity, and methods for determining depth of injury. Pacing and Clinical Electrophysiology. 10(4 Pt 1): 886-901, Jul 1987
  • Clark CC, Richards CF, Pacifici M, Iozzo RV. The effects of 6-diazo-5-oxo-L-norleucine, a glutamine analogue, on the structure of the major cartilage proteoglycan synthesized by cultured chondrocytes. Journal of Biological Chemistry. 262(21): 10229-38, Jul 1987
  • Sayama S, Iozzo RV, Lazarus GS, Schechter NM. Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans. Journal of Biological Chemistry. 262(14): 6808-15, May 1987
  • Iozzo RV. Turnover of heparan sulfate proteoglycan in human colon carcinoma cells. A quantitative biochemical and autoradiographic study. Journal of Biological Chemistry. 262(4): 1888-900, Feb 1987
  • Iozzo RV. Proteoglycans and the intercellular tumor matrix. Current Topics in Pathology. 77: 207-21, 1987
  • Iozzo RV, Clark CC. Chondroitin sulfate proteoglycan is a constituent of the basement membrane in the rat embryo parietal yolk sac. Histochemistry. 88(1): 23-9, 1987
  • Bloch, M. J., Iozzo, R. V., Edmunds, L. H. and Brooks, J. J. Polypoid synovial sarcoma of the esophagus. Gastroenterology. 92: 229-233, 1987
  • Iozzo RV, Ketterer CL, Slaymaker DJ. Evidence of a small hydrophobic domain in the core protein of the heparan sulfate proteoglycan from human colon carcinoma cells. Febs Letters. 206(2): 304-8, Oct 1986
  • Marinelli DL, Albelda SM, Williams TM, Kern JA, Iozzo RV, Miller WT. Nontuberculous mycobacterial infection in AIDS: clinical, pathologic, and radiographic features. Radiology. 160(1): 77-82, Jul 1986
  • Uri AK, Wetmore RF, Iozzo RV. Glycogen-rich clear cell carcinoma in the tongue. A cytochemical and ultrastructural study. Cancer. 57(9): 1803-9, May 1986
  • Iozzo RV, Clark CC. Biosynthesis of proteoglycans by rat embryo parietal yolk sacs in organ culture. Journal of Biological Chemistry. 261(15): 6658-69, May 1986
  • Greene RA, Bloch MJ, Huff DS, Iozzo RV. MURCS association with additional congenital anomalies. Human Pathology. 17(1): 88-91, Jan 1986
  • Iozzo RV, Pacifici M. Ultrastructural localization of the major proteoglycan and type II procollagen in organelles and extracellular matrix of cultured chondroblasts. Histochemistry. 86(2): 113-22, 1986
  • Iozzo RV, Muller-Glauser W. Neoplastic modulation of extracellular matrix: proteoglycan changes in the rabbit mesentery induced by V2 carcinoma cells. Cancer Research. 45(11 Pt 2): 5677-87, Nov 1985
  • Iozzo RV. Proteoglycans: structure, function, and role in neoplasia. Laboratory Investigation. 53(4): 373-96, Oct 1985
  • Miller JE, Whitman GJ, Iozzo RV, Jacobs DO, Ziegler MM. Early diagnosis of experimental necrotizing enterocolitis using proton nuclear magnetic resonance. Journal of Surgical Research. 39(4): 322-30, Oct 1985
  • Kempf FC Jr, Falcone RA, Iozzo RV, Josephson ME. Anatomic and hemodynamic effects of catheter-delivered ablation energies in the ventricle. American Journal of Cardiology. 56(4): 373-7, Aug 1985
  • Iozzo RV. Biosynthesis of heparan sulfate proteoglycan by human colon carcinoma cells and its localization at the cell surface. Journal of Cell Biology. 99(2): 403-17, Aug 1984
  • Iozzo RV. Proteoglycans and neoplastic--mesenchymal cell interactions. Human Pathology. 15(1): 2-10, Jan 1984
  • Iozzo RV, Marroquin R, Wight TN. Analysis of proteoglycans by high-performance liquid chromatography: a rapid micromethod for the separation of proteoglycans from tissue and cell culture. Analytical Biochemistry. 126(1): 190-9, Oct 1982
  • Iozzo RV, Wight TN. Isolation and characterization of proteoglycans synthesized by human colon and colon carcinoma. Journal of Biological Chemistry. 257(18): 11135-44, Sep 1982
  • Iozzo RV, Steinmetz A, Kushwaha RS. Estrogen treatment changes the cellular distribution of apolipoprotein E in the liver. Cell Biology International Reports. 6(9): 875-81, Sep 1982
  • Iozzo RV, Bolender RP, Wight TN. Proteoglycan changes in the intercellular matrix of human colon carcinoma: an integrated biochemical and stereologic analysis. Laboratory Investigation. 47(2): 124-38, Aug 1982
  • Iozzo RV, MacDonald GH, Wight TN. Immunoelectron microscopic localization of catalase in human eosinophilic leukocytes. Journal of Histochemistry and Cytochemistry. 30(7): 697-701, Jul 1982
  • Iozzo RV, Kushwaha RS, Wight TN, Hazzard WR. Cellular and subcellular distribution of 125I-labeled very low density lipoproteins in the liver of normal and estrogen-treated rabbits. American Journal of Pathology. 107(1): 6-15, Apr 1982
  • Iozzo RV, Goldes JA, Chen WJ, Wight TN. Glycosaminoglycans of pleural mesothelioma: a possible biochemical variant containing chondroitin sulfate. Cancer. 48(1): 89-97, Jul 1981
  • Iozzo RV, Haas JE, Chard RL. Symptomatic splenic hemartoma: a report of two cases and review of the literature. Pediatrics. 66(2): 261-5, Aug 1980
  • Wiegenstein L, Iozzo RV. Unusual findings in a conjoined ('Siamese') twin placenta. American Journal of Obstetrics and Gynecology. 137(6): 744-5, Jul 1980
  • Iozzo RV. Case 16-1979--elastic vascular sclerosis and carcinoid tumors [letter]. New England Journal of Medicine. 301(7): 385-6, Aug 1979
  • Ruff RL, Shaw CM, Beckwith JB, Iozzo RV. Cerebral infarction complicating umbilical vein catheterization. Annals of Neurology. 6(1): 85, Jul 1979
  • St Omer FB, Iozzo RV, Casetti P, Dellarolle AC. Focal nodular hyperplasia of the liver and contraceptive steroids. Acta Hepato-gastroenterologica. 25(4): 319-21, Au

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