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Thomas Jefferson University - Steven E McKenzie, MD, PhD
Steven E McKenzie, MD, PhD

Medicine
Cardeza Foundation for Hematologic Research
Professor Thomas Jefferson University
Jefferson Medical College
Appointed: 2000

Thomas Jefferson University
Jefferson Medical College
Department of Pediatrics (secondary appointment)
Appointed: 2000

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Mailing Address
702 Curtis Building
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-955-3900
Fax: 215-955-4050
Steven.McKenzie@jefferson.edu
Qualifications
M.D., University of Pennsylvania, Pediatrics, 1985

Ph.D., University of Pennsylvania, Bioengineering, 1985

B S E, Princeton University, Chemical Engineering, 1978

Other Expertise

REVIEW BOARD MEMBERSHIP
1996 - present
Review Committee Member, National Institutes of Health, National Cancer Institute
Chair, Innovative Technologies for the Molecular Analysis of Cancer study section
Member of reviewer reserve, Innovative Technologies
Ad hoc, National Heart Lung and Blood Institute
Keywords
Pediatrics; Hematology; Thrombosis; Thrombocytapenia; Platelet
Publications
  • Gripp KW, McDonald-McGinn DM, La Rossa D, McGain D, Federman N, Vlachos A, Glader BE, McKenzie SE, Lipton JM, Zackai EH. Bilateral microtia and cleft palate in cousins with Diamond-Blackfan anemia. American Journal of Medical Genetics. 101(3): 268-74, 2001
  • Zhang C, Thornton MA, Kowalska MA, Sachis BS, Feldman M, Poncz M, McKenzie SE, Reilly MP. Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus. Blood. 98(3): 610-7, 2001
  • Guida, J.D., Kunig, A.M., Leef K.H., McKenzie S.E., Paul D.A. Platelet Count and Sepsis: Is There an Organism Specific Response?. Journal of Investigative Medicine. 49(2): 216A, 2001
  • Reilly, M.P., Taylor S.M., Hartman, N.K., Arepally, G., Cines, D.B., Poncz, M., McKenzie, S.E. Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through Fc(RIIA. Blood. 98: 2442-2447, 2001
  • Fortina, P., Graves, D., Stoeckert, C., McKenzie, S., Surrey, S. Technology options in microarray-based DNA analysis. In: BioChip Technology, ed. J. Cheng and L. Kricka, Harwood Academic press, New York. 185-215, 2001
  • Taylor SM, Reilly MP, Schreiber AD, Chien P, Tuckosh JR, McKenzie SE. Thrombosis and shock induced by activating antiplatelet antibodies in human Fc gamma RIIA transgenic mice: the interplay among antibody, spleen, and Fc receptor. Blood. 96(13): 4254-60, 2000
  • Cassel DL, Subudhi SK, Surrey S, McKenzie SE. GATA and NF-Y participate in transcriptional regulation of FcgammaRIIA in megakaryocytic cells. Blood Cells, Molecules, and Diseases. 26(6): 587-97, Dec 2000
  • Fortina P, Delgrosso K, Sakazume T, Santacroce R, Moutereau S, Su HJ, Graves D, McKenzie S, Surrey S. Simple two-color array-based approach for mutation detection. European Journal of Human Genetics. 8(11): 884-94, Nov 2000
  • Manduchi E, Grant GR, McKenzie SE, Overton GC, Surrey S, Stoeckert CJ. Generation of patterns from gene expression data by assigning confidence to differentially expressed genes. Bioinformatics. 16(8): 685-98, Aug 2000
  • McKenzie SE, Mansfield E, Rappaport E, Surrey S, Fortina P. Parallel molecular genetic analysis. European Journal of Human Genetics. 6(5): 417-29, 1998
  • Norris CF, Pricop L, Millard SS, Taylor SM, Surrey S, Schwartz E, Salmon JE, McKenzie SE. A naturally occurring mutation in Fc gamma RIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor. Blood. 91(2): 656-62, 1998
  • Graves DJ, Su HJ, McKenzie SE, Surrey S, Fortina P. System for preparing microhybridization arrays on glass slides. Analytical Chemistry. 70(23): 5085-92, 1998
  • Cui Z, Reilly MP, Surrey S, Schwartz E, McKenzie SE. -245 bp of 5'-flanking region from the human platelet factor 4 gene is sufficient to drive megakaryocyte-specific expression in vivo. Blood. 91(7): 2326-33, 1998
  • McKenzie SE, Schreiber AD. Fc gamma receptors in phagocytes. Current Opinion in Hematology. 5(1): 16-21, Jan 1998
  • Sanguedolce, L.A., Chan, V., McKenzie, S.E., Surrey, S., Fortina, P., Graves, D.J. Fundamental Studies of DNA Adsorption and Hybridization on Solid Surfaces. In: American Chemical Society Symposium Series: Intelligent materials and novel concepts for controlled release technologies (Dinh, S and De Nuzzio, J, eds. , 1998
  • Chan, V, McKenzie, SE, Surrey, S, Fortina, P, Graves, DJ. The Effect of Hydrophobicity and Electrostatics on Adsorption and Surface Diffusion of DNA Oligonucleotides at Liquid/Solid Interfaces. Journal of Colloid and Interface Science. 203: 197-207, 1998
  • Arepally G, McKenzie SE, Jiang XM, Poncz M, Cines DB. Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis. Blood. 89(2): 370-5, 1997
  • Chan, V., Graves, D.J., Fortina, P., McKenzie, S.E. Adsorption and surface diffusion of DNA oligonucleotides at liquid/solid interfaces. Langmuir. 13: 320-329, 1997
  • Jiang XM, Arepally G, Poncz M, McKenzie SE. Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). Journal of Immunological Methods. 199(1): 55-9, 1996
  • Fairchild KD, Hudson RG, Douglas SD, McKenzie SE, Polin RA. Effect of gamma interferon on expression of Fc gamma receptors in monocytes of newborn infants and adults. Clinical and Diagnostic Laboratory Immunology. 3(4): 464-9, Jul 1996
  • Norris CF, Surrey S, Bunin GR, Schwartz E, Buchanan GR, McKenzie SE. Relationship between Fc receptor IIA polymorphism and infection in children with sickle cell disease. Journal of Pediatrics. 128(6): 813-9, Jun 1996

Individual Expertise profile of Steven E McKenzie, MD, PhD, Copyright © Steven E McKenzie, MD, PhD.
Last Updated by Admin : Thursday, June 5, 2008 11:38:01 AM



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