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Thomas Jefferson University - Thomas P. Leist
Thomas P. Leist

Neurology
Thomas Jefferson University
Jefferson Medical College
Department of Neurology
Division of Clinical Neuroimmunology

Mailing Address
900 Walnut St #200
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-955-6871
Fax: 215-503-2990
Qualifications
M.D., University of Miami, 1993

Internship, University of Miami, Medicine, 1994

Ph.D., University of Zurich, Biochemistry, 1985

Diploma, University of Zurich, Biochemistry, 1982

Residency, Cornell University, Neurology, 1997

Keywords
Htlv-1 Myelopathy; Immunology; Immunology; Multiple Sclerosis; Multiple Sclerosis; Neuroimaging; Neuroimaging; Neuroimmunology; Neuroimmunology; Neurology; Neurology; Neurovirology
Publications
  • Kalman B, Albert RH, Leist TP. Genetics of multiple sclerosis: determinants of autoimmunity and neurodegeneration. Autoimmunity. 35(4): 225-34, Jul 2002

  • Frank JA, Richert N, Lewis B, Bash C, Howard T, Civil R, Stone R, Eaton J, McFarland H, Leist T. A pilot study of recombinant insulin-like growth factor-1 in seven multiple sderosis patients. Multiple Sclerosis (houndmills, Basingstoke, England). 8(1): 24-9, Feb 2002

  • Spitsin S, Hooper DC, Leist T, Streletz LJ, Mikheeva T, Koprowskil H. Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease. Multiple Sclerosis (houndmills, Basingstoke, England). 7(5): 313-9, Oct 2001

  • Richert ND, Ostuni JL, Bash CN, Leist TP, McFarland HF, Frank JA. Interferon beta-1b and intravenous methylprednisolone promote lesion recovery in multiple sclerosis. Multiple Sclerosis (houndmills, Basingstoke, England). 7(1): 49-58, Feb 2001

  • Leist TP, Gobbini MI, Frank JA, McFarland HF. Enhancing magnetic resonance imaging lesions and cerebral atrophy in patients with relapsing multiple sclerosis. Archives of Neurology. 58(1): 57-60, Jan 2001

  • Nagai M, Kubota R, Greten TF, Schneck JP, Leist TP, Jacobson S. Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load. Journal of Infectious Diseases. 183(2): 197-205, Jan 2001

  • Muraro PA, Leist T, Bielekova B, McFarland HF. VLA-4/CD49d downregulated on primed T lymphocytes during interferon-beta therapy in multiple sclerosis. Journal of Neuroimmunology. 111(1-2): 186-94, Nov 2000

  • Soldan SS, Leist TP, Juhng KN, McFarland HF, Jacobson S. Increased lymphoproliferative response to human herpesvirus type 6A variant in multiple sclerosis patients. Annals of Neurology. 47(3): 306-13, Mar 2000

  • Azimi N, Jacobson S, Leist T, Waldmann TA. Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor. Journal of Immunology (baltimore, Md. : 1950). 163(7): 4064-72, Oct 1999

  • Soldan SS, Graf MD, Waziri A, Flerlage AN, Robinson SM, Kawanishi T, Leist TP, Lehky TJ, Levin MC, Jacobson S. HTLV-I/II seroindeterminate Western blot reactivity in a cohort of patients with neurological disease. Journal of Infectious Diseases. 180(3): 685-94, Sep 1999

  • Lehky TJ, Levin MC, Kubota R, Bamford RN, Flerlage AN, Soldan SS, Leist TP, Xavier A, White JD, Brown M, Fleisher TA, Top LE, Light S, McFarland HF, Waldmann TA, Jacobson S. Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac. Annals of Neurology. 44(6): 942-7, Dec 1998

  • Greten TF, Slansky JE, Kubota R, Soldan SS, Jaffee EM, Leist TP, Pardoll DM, Jacobson S, Schneck JP. Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19-specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients. Proceedings of the National Academy of Sciences (USA). 95(13): 7568-73, Jun 1998

  • Odermatt B, Eppler M, Leist TP, Hengartner H, Zinkernagel RM. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proceedings of the National Academy of Sciences (USA). 88(18): 8252-6, Sep 1991

  • Leist TP, Meager A, Exley T, Zinkernagel RM. Evidence for a role of IFN gamma in control of Listeria monocytogenes in T cell deficient mice. Experientia. 47(6): 630-2, Jun 1991

  • Ruttner B, Hauser T, Leist TP, Zinkernagel RM. Absence of effects of thymopentin on murine host resistance to Listeria monocytogenes. Thymus. 17(1): 1-10, Feb 1991

  • Keller R, Keist R, Leist TP, van der Meide PH. Resistance to a non-immunogenic tumor, induced by Corynebacterium parvum or Listeria monocytogenes, is abrogated by anti-interferon gamma. International Journal of Cancer. Journal International Du Cancer. 46(4): 687-90, Oct 1990

  • Keller R, Keist R, Wechsler A, Leist TP, van der Meide PH. Mechanisms of macrophage-mediated tumor cell killing: a comparative analysis of the roles of reactive nitrogen intermediates and tumor necrosis factor. International Journal of Cancer. Journal International Du Cancer. 46(4): 682-6, Oct 1990

  • Leist TP, Zinkernagel RM. Treatment with anti-tumor necrosis factor alpha does not influence the immune pathological response against lymphocytic choriomeningitis virus. Cytokine. 2(1): 29-34, Jan 1990

  • Hauser T, Frei K, Zinkernagel RM, Leist TP. Role of tumor necrosis factor in Listeria resistance of nude mice. Medical Microbiology and Immunology. 179(2): 95-104, 1990

  • Leist TP, Kohler M, Zinkernagel RM. Impaired generation of anti-viral cytotoxicity against lymphocytic choriomeningitis and vaccinia virus in mice treated with CD4-specific monoclonal antibody. Scandinavian Journal of Immunology. 30(6): 679-86, Dec 1989

  • Leist TP, Sandri-Goldin RM, Stevens JG. Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus. Journal of Virology. 63(11): 4976-8, Nov 1989

  • Leist TP, Kohler M, Eppler M, Zinkernagel RM. Effects of treatment with IL-2 receptor specific monoclonal antibody in mice. Inhibition of cytotoxic T cell responses but not of T help. Journal of Immunology (baltimore, Md. : 1950). 143(2): 628-32, Jul 1989

  • Leist TP, Eppler M, Zinkernagel RM. Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-gamma interferon-treated mice. Journal of Virology. 63(6): 2813-9, Jun 1989

  • Frei K, Malipiero UV, Leist TP, Zinkernagel RM, Schwab ME, Fontana A. On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases. European Journal of Immunology. 19(4): 689-94, Apr 1989

  • Fontana A, Frei K, Malipiero UV, Leist TP, Schwab M. On the production of immunoglobulins in the central nervous system: an involvement of B cell stimulatory factor 2/interleukin 6 produced intrathecally?. Schweizer Archiv Fur Neurologie Und Psychiatrie (zurich, Switzerland : 1985). 140(1): 38-9, 1989

  • Zinkernagel RM, Pircher HP, Schulz M, Leist T, Oehen S, Hengartner H. Reactivity and tolerance of virus-specific T cells. Cold Spring Harbor Symposia On Quantitative Biology. 54 Pt 2: 843-51, 1989

  • Frei K, Leist TP, Meager A, Gallo P, Leppert D, Zinkernagel RM, Fontana A. Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients. Journal of Experimental Medicine. 168(1): 449-53, Jul 1988

  • Leist TP, Ruedi E, Zinkernagel RM. Virus-triggered immune suppression in mice caused by virus-specific cytotoxic T cells. Journal of Experimental Medicine. 167(5): 1749-54, May 1988

  • Leist TP, Frei K, Kam-Hansen S, Zinkernagel RM, Fontana A. Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients. Journal of Experimental Medicine. 167(5): 1743-8, May 1988

  • Leist TP, Aguet M, Hassig M, Pevear DC, Pfau CJ, Zinkernagel RM. Lack of correlation between serum titres of interferon alpha, beta, natural killer cell activity and clinical susceptibility in mice infected with two isolates of lymphocytic choriomeningitis virus. Journal of General Virology. 68 ( Pt 8): 2213-8, Aug 1987

  • Leist TP, Cobbold SP, Waldmann H, Aguet M, Zinkernagel RM. Functional analysis of T lymphocyte subsets in antiviral host defense. Journal of Immunology (baltimore, Md. : 1950). 138(7): 2278-81, Apr 1987

  • Meager A, Leist T. Antigenic characteristics of glycosylated natural and unglycosylated recombinant human gamma-interferon. Journal of Interferon Research. 6(3): 225-32, Jun 1986

  • Zinkernagel RM, Leist T, Hengartner H, Pestalozzi B, Stitz L. Studies on immunity to lymphocytic choriomeningitis virus. Medical Microbiology and Immunology. 175(2-3): 209-11, 1986

  • Zinkernagel RM, Leist T, Hengartner H, Althage A. Susceptibility to lymphocytic choriomeningitis virus isolates correlates directly with early and high cytotoxic T cell activity, as well as with footpad swelling reaction, and all three are regulated by H-2D. Journal of Experimental Medicine. 162(6): 2125-41, Dec 1985

  • Leist T, Titmas R, Parti S, Meager A. Antibodies to synthetic polypeptides corresponding to hydrophilic regions of human interferon gamma. Molecular Immunology. 22(8): 929-36, Aug 1985

  • Leist T, Thomas RM. Synthesis and physicochemical characterization of major fragments of human leucocyte interferon alpha 1. Biochemistry. 23(12): 2541-7, Jun 1984

  • Arnheiter H, Thomas RM, Leist T, Fountoulakis M, Gutte B. Physicochemical and antigenic properties of synthetic fragments of human leukocyte interferon. Nature. 294(5838): 278-80, Nov 1981

Individual Expertise profile of Thomas P. Leist, Copyright © Thomas P. Leist.
Last Updated by Admin : Friday, April 6, 2007 9:49:05 AM


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