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Thomas Jefferson University - Xugang Xia, MD, PhD
Xugang Xia, MD, PhD

Pathology, Anatomy & Cell Biology
Associate Professor
Mailing Address
1020 Locust Street JAH 508
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-503-9152
Xugang.Xia@jefferson.edu
Qualifications
M.D. (equivalent), Hunan Medical University, China, 1990

M.S., rehabilitation and physical therapy, Hunan Medical University, China, 1995

Ph.D. (equivalent), Tuebingen University, Germany, 2001
Expertise and Research Interests
As a medical researcher and educator, I have been trained in medical schools for clinic work and in basic sciences for medical research. My experience in clinical work, as a neurologist, and in basic science, as a neuroscientist, provides me with a unique understanding as to how important medical research is to human health. Using multidisciplinary approaches including molecular genetics, biology, and biochemistry, I devote my energy to understanding how neurons degenerate in degenerative diseases such as Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal lobe degeneration (FTLD). Neurodegenerative diseases preferentially affect one subset of neurons at early stages, but often involve the other neurons at late stages. Comparative study of neurodegenerative diseases may help understand disease mechanisms underlying neurodegeneration and thus help develop effective therapies for these devastating diseases.

The laboratory is currently engaged in three areas of inquiry:

1). Generation of transgenic mouse and rat models for PD and understanding of disease mechanisms underlying dopaminergic neuron death caused by pathogenic mutation in the LRRK2, PINK1, and alpha-synuclein genes

2). Generation of transgenic and knockout rat models for ALS and FTLD and mechanistic study of neurodegeneration in the mutant rats with the TDP-43, the FUS, or the OPTN gene overexpressed or deleted

3). Screening of effective chemicals targeting TDP-43 or FUS for treating ALS
Keywords
Parkinson's disease; amyotrophic lateral sclerosis; frontotemporal lobe degeneration; transgenesis; gene targeting; synaptic neurotransmission; gene therapy; RNA interference; RNA metabolism
Publications
  • Pubmed
  • Zhou H, Huang C, Landel CP, Xia PY, Liu YJ, and Xia XG. Transgenic rat model of neurodegeneration caused by mutation in the TDP gene. PLoS Genet 2010, 6(3):e1000887.
  • Zhou H, Huang C, Yang M, Landel CP, Xia PY, Liu YJ, and Xia XG. Developing tTA transgenic rats for inducible and reversible gene expression, Int J Biol Sci 2009, 2: 171-181
  • Zhou H, Huang C, and Xia XG. A tightly regulated pol III promoter for synthesis of miRNA genes in tandem, Biochim Biophys Acta 2008, 1779: 773-779
  • Zhou H, Falkenburger BH, Schulz JB, Tieu K, Xu Z, and Xia XG. Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice. Int J Biol Sci 2007, 3(4): 242-50.
  • Xia XG, Zhou H, Huang Y and Xu Z. Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo. Neurobiol Dis 2006, 23: 578-86.
  • Xia XG, Zhou H, Samper E, Melov S and Xu Z. Pol II-expressed shRNA Achieves Gene Knockdown and Phenotypes of Gene Knockout in Postnatal Mice. PLOS genetics 2006, 2: e10
  • Xia XG, Zhou H, Zhou S, Yu Y, Wu R and Xu Z. An RNAi strategy for treatment of amyotrophic lateral sclerosis caused by mutant Cu, Zn superoxide dismutase. J Neurochem 2005, 92: 362-67.
  • Xia XG, Zhou H and Xu Z. Promises and Challenges in Developing RNAi as a Research Tool and Therapy for Neurodegenerative Diseases. Neurodegenerative Diseases 2005, 2: 3-7.
  • Zhou H, Xia XG and Xu Z. An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi. Nucleic Acids Research 2005, 33: e62.
  • Xia XG, Zhou H, Ding H, Affar el B, Shi Y and Xu Z. An enhanced U6 promoter for synthesis of short hairpin RNA. Nucleic Acids Research 2003, 31: e100.
  • Xia XG, Hofmann HD, Deller T and Kirsch M. Induction of STAT3 Signaling in Activated Astrocytes and Sprouting Septal Neurons Following Entorhinal Cortex Lesion in Adult Rats. Mol Cell Neurosci 2002, 21: 379-92.
  • Xia XG, Harding T, Weller M, Bieneman A, Uney JB and Schulz JB. Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 2001, 98: 10433-8.
  • Xia XG, Schmidt N, Teismann P, Ferger B and Schulz JB. Reconstitution of striatal malonate toxicity in 6-OHDA lesioned animals by dopamine and D2 but not by D1 agonists. J Neurochem 2001, 279: 63-70.

Individual Expertise profile of Xugang Xia, MD, PhD, Copyright © Xugang Xia, MD, PhD.
Last Updated by Admin : Tuesday, June 5, 2012 4:01:20 PM



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