Angelo Lepore, PhD

Contact Dr. Lepore

900 Walnut St.
JHN, Suite 469
Philadelphia, PA 19107

(215) 503-5864
(215) 955-4949 fax

Research and Clinical Interests

Overall Goals: Our laboratory has an interest in examining the in vivo role played by astrocyte glutamate transporters in the etiology and treatment of traumatic spinal cord injury (SCI). SCI represents a debilitating group of conditions that affect approximately 1.3 million individuals in the U.S. alone, resulting in physical and psychological burdens on patients and their families and huge economic costs.

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Publications

Most recent Peer-reviewed Publications

1. Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice
2. Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury
3. Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury
4. Intraspinal cell transplantation for targeting cervical ventral horn in amyotrophic lateral sclerosis and traumatic spinal cord injury.
5. Astrocytes carrying the superoxide dismutase 1 (SOD1 G93A) mutation induce wild-type motor neuron degeneration in vivo
6. Stem cell transplantation for spinal cord neurodegeneration
7. Human Glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 G93A mouse model of ALS
8. Intraspinal cell transplantation for targeting cervical ventral horn in amyotrophic lateral sclerosis and traumatic spinal cord injury
9. Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury
10. Transplantation of human glial restricted progenitors and derived astrocytes into a contusion model of spinal cord injury
11. Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats
12. Presynaptic Regulation of Astroglial Excitatory Neurotransmitter Transporter GLT1
13. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease
14. Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration
15. Adult glial precursor proliferation in mutant SOD1G93A mice
16. Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS
17. Targeted stem cell transplantation strategies in ALS
18. Long-term fate of neural precursor cells following transplantation into developing and adult CNS (DOI:10.1016/j.neuroscience.2005.12.043)
19. Erratum to "Long-term fate of neural precursor cells following transplantation into developing and adult CNS". [Neuroscience 139 (2006) 513-530]
20. MR imaging of lineage-restricted neural precursors following transplantation into the adult spinal cord

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