Piera Pasinelli, PhD

Contact Dr. Pasinelli

900 Walnut St.
Suite 451F
Philadelphia, PA 19107

215-955-8394
215-503-9128 fax

Research and Clinical Interests

Neurodegenerative diseases, Amyotrophic Lateral Sclerosis

Show Details

Publications

Most recent Peer-reviewed Publications

1. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS
2. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
3. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2
4. In vivo and in vitro determination of cell death markers in neurons
5. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
6. Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria
7. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2
8. Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: Therapeutic implications for amyotrophic lateral sclerosis
9. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis
10. The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis
11. Molecular biology of amyotrophic lateral sclerosis: Insights from genetics
12. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2
13. Inhibition of SOD1 expression by mitomycin C is a non-specific consequence of cellular toxicity
14. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
15. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice
16. Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter
17. RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells
18. Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity
19. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: Associated mutations develop motor neuron disease
20. Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity

View All Publications