Manuel Covarrubias, MD, PhD

Contact Dr. Covarrubias

900 Walnut Street, Suite 400

Philadelphia, PA 19107

(215) 503-4341
(215) 955-4949 fax

Research and Clinical Interests

Voltage-gated ion channels; Structure, Function, Regulation and Mechanisms

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Publications

Most recent Peer-reviewed Publications

1. Dipeptidyl-peptidase-like proteins cast in a new role: Enabling scorpion toxin block of A-type K+ channels
2. Insight into the modulation of Shaw2 Kv channels by general anesthetics: Structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR
3. Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels
4. Novel activation of voltage-gated K+ channels by sevoflurane
5. Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons
6. Molecular mapping of general anesthetic sites in a voltage-gated ion channel
7. Cortactin is required for N-cadherin regulation of Kv1.5 channel function
8. Mechanisms of closed-state inactivation in voltage-gated ion channels
9. Alcohol and anesthetic action at the gate of a voltage-dependent K+ channel
10. Molecular physiology and modulation of somatodendritic A-type potassium channels
11. Allosteric modulation of a neuronal K+ channel by 1-alkanols is linked to a key residue in the activation gate
12. Molecular features of an alcohol binding site in a neuronal potassium channel
13. The link between ion permeation and inactivation gating of Kv4 potassium channels
14. Remodelling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein
15. Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain
16. Kv4 channels exhibit modulation of closed-state inactivation in inside-out patches
17. Potent inhibition of the aortic smooth muscle maxi-K channel by clinical doses of ethanol
18. General anesthetic action at an internal protein site involving the S4- S5 cytoplasmic loop of a neuronal K+ channel
19. Inactivation gating of Kv4 potassium channels: Molecular interactions involving the inner vestibule of the pore
20. Injection of Xenopus oocytes with mRNA from cultured neurons induces new currents and susceptibility to the damaging action of ruthenium red

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