Gerald B. Grunwald, PhD

Contact Dr. Grunwald

1020 Locus Street

Philadelphia, PA 19107

(215) 503-4191
(215) 503-6690 fax

Research and Clinical Interests
The role of cell adhesion in retinal development and pathology. Reciprocal expression of N-cadherin (green) and R-cadherin (red) cell adhesion molecules during wound healing of the retinal pigment epithelium.

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Publications

Most recent Peer-reviewed Publications

1. Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression
2. Modulation of MCT3 expression during wound healing of the retinal pigment epithelium
3. Transcriptional regulatory network analysis during epithelial-mesenchymal transformation of retinal pigment epithelium
4. Cadherins and NCAM as potential targets in metal toxicity
5. N-cadherin function is required for differentiation-dependent cytoskeletal reorganization in lens cells in vitro
6. Differential expression of N- and B-cadherin during lens development
7. Chapter 3 Cadherin Cell adhesion molecules in development and disease
8. In vivo analysis ok in-c adhlr1n cell adhesion molecule function in ocular development using transgenic mice expressing tissue-specific dominant-negative mutations
9. Difkereyiiai. spatio temporal expression paturns of v and b-cadherins correlate with specific morphogenetic events during lens development
10. Evidence that tyrosine phosphorylation regulates N-cadherin turnover during retinal development
11. Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos
12. Discovery and Analysis of the Classical Cadherins
13. Cadherin function is required for axon outgrowth in retinal ganglion cells in vivo
14. Cadherin cell adhesion molecules in retinal development and pathology
15. Ca2+ influx and neurite growth in response to purified N-cadherin and laminin
16. The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules
17. Structure/function analysis of the integrin β1 subunit by epitope mapping
18. Analysis of protein variations in adult and postnatal day 11 staggerer and lurcher mutant mice
19. Purification and characterization of NCAD90, a soluble endogenous form of N-cadherin, which is generated by proteolysis during retinal development and retains adhesive and neurite-promoting function
20. Immunohistochemical and biochemical analysis of N-cadherin expression during CNS development

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