Ya-Ming Hou, PhD

Contact Dr. Hou

900 Walnut Street

Philadelphia, PA 19107

(215) 503-4480
(215) 923-9162 fax

Research and Clinical Interests
Mechanisms of tRNA functions and protein synthesis by the ribosome

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Publications

Most recent Peer-reviewed Publications

1. High-purity enzymatic synthesis of site-specifically modified tRNA.
2. Recognition of guanosine by dissimilar tRNA methyltransferases
3. Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels
4. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases
5. A recurrent loss-of-function alanyl-tRNA synthetase (AARS) mutation in patients with charcot-marie-tooth disease type 2N (CMT2N)
6. A role for SUMO in nucleotide excision repair
7. Pyrophosphorolysis of CCA addition: Implication for fidelity
8. Allosteric communication in cysteinyl tRNA synthetase: A network of direct and indirect readout
9. Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding.
10. Differentiating analogous tRNA methyltransferases by fragments of the methyl donor
11. Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5
12. Biosynthesis: A new (old) way of hijacking tRNA
13. Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy
14. Apoptotic regulation and tRNA
15. Control of Catalytic Cycle by a Pair of Analogous tRNA Modification Enzymes
16. CCA addition to tRNA: Implications for tRNA quality control
17. Stereochemical mechanisms of tRNA methyltransferases
18. Fluorophore labeling to monitor tRNA dynamics.
19. Distinct kinetic determinants for the stepwise CCA addition to tRNA
20. Incorporation of tellurocysteine into glutathione transferase generates high glutathione peroxidase efficiency

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