Lorraine Iacovitti, PhD

Contact Dr. Iacovitti

900 Walnut St.
Suite 462
Philadelphia, PA 19107

215-955-8118
215-955-2992 fax

Research and Clinical Interests

Neurodegenerative Diseases, Stem Cells, Parkinson's Disease

Show Details

Publications

Most recent Peer-reviewed Publications

1. BMP and TGF-Β pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells
2. Tracking Transplanted Bone Marrow Stem Cells and Their Effects in the Rat MCAO Stroke Model
3. Gremlin is a novel VTA derived neuroprotective factor for dopamine neurons
4. Changes in host blood factors and brain glia accompanying the functional recovery after systemic administration of bone marrow stem cells in ischemic stroke rats
5. Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (ΔE) TorsinA in transgenic mice
6. VTA neurons show a potentially protective transcriptional response to MPTP
7. Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats
8. Heterotopically transplanted CVO neural stem cells generate neurons and migrate with SVZ cells in the adult mouse brain
9. Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain
10. Functional heterogeneity at dopamine release sites
11. Human amniotic fluid stem cells do not differentiate into dopamine neurons in vitro or after transplantation in vivo
12. Circumventricular organs: A novel site of neural stem cells in the adult brain
13. The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease model
14. Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra
15. Transcription and epigenetic profile of the promoter, first exon and first intron of the human tyrosine hydroxylase gene
16. A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: Studies in vitro and in vivo
17. Adult human bone marrow stromal spheres express neuronal traits in vitro and in a rat model of Parkinson's disease
18. Tyrosine hydroxylase gene regulation in human neuronal progenitor cells does not depend on Nurr1 as in the murine and rat systems
19. Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture.
20. Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture

View All Publications