Kanae Iijima-Ando, PhD

Contact Dr. Iijima-Ando

900 Walnut St.
Suite 410
Philadelphia, PA 19107

215-503-9897
215-955-4949 fax

Research and Clinical Interests
Drosophila Neurobiology, neurodegenerative diseases,Synucleopathy

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Publications

Most recent Peer-reviewed Publications

1. Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease-Related Tau Phosphorylation Via PAR-1
2. Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue
3. Transgenic drosophila models of Alzheimer's amyloid-β 42 toxicity
4. Tau Ser262 phosphorylation is critical for Aβ42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease
5. Transgenic drosophila models of Alzheimer's disease and tauopathies
6. A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration
7. Mitochondrial mislocalization underlies aβ42-induced neuronal dysfunction in a drosophila model of alzheimer's disease
8. Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease.
9. Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila
10. JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span
11. Drosophila models of Alzheimer's amyloidosis: The challenge of dissecting the complex mechanisms of toxicity of amyloid-β 42
12. Overexpression of neprilysin reduces alzheimer amyloid-β42 (Aβ42)-induced neuron loss and intraneuronal Aβ42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila
13. Aβ42 mutants with different aggregation profiles induce distinct pathologies in Drosophila
14. Synthesis and characterization of Mg-containing nano-apatite
15. Structural characterization and protein adsorption property of hydroxyapatite particles modified with zinc ions
16. Physiological mouse brain Aβ levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP
17. Synthesis and structural characterization of silica-hybridized hydroxyapatite with gas adsorption capability
18. Synthesis and structural characterization of nanoapatite ceramics powders for biomedical applications
19. cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila
20. Transgenic cAMP response element reporter flies for monitoring circadian rhythms

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