Koichi Iijima, PhD

Contact Dr. Iijima

900 Walnut St.
Suite 411
Philadelphia, PA 19107

215-955-4546
215-955-4949 fax

Research and Clinical Interests
Alzheimer's disease, Tauopathies, Drosophila Neurobiology

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Publications

Most recent Peer-reviewed Publications

1. Transgenic drosophila models of Alzheimer's amyloid-β 42 toxicity
2. Tau Ser262 phosphorylation is critical for Aβ42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease
3. Transgenic drosophila models of Alzheimer's disease and tauopathies
4. A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration
5. Mitochondrial mislocalization underlies aβ42-induced neuronal dysfunction in a drosophila model of alzheimer's disease
6. Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease.
7. Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila
8. JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span
9. Distinctive roles of different β-amyloid 42 aggregates in modulation of synaptic functions
10. Drosophila models of Alzheimer's amyloidosis: The challenge of dissecting the complex mechanisms of toxicity of amyloid-β 42
11. Overexpression of neprilysin reduces alzheimer amyloid-β42 (Aβ42)-induced neuron loss and intraneuronal Aβ42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila
12. Aβ42 mutants with different aggregation profiles induce distinct pathologies in Drosophila
13. Physiological mouse brain Aβ levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP
14. cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila
15. Interaction of N-terminal acetyltransferase with the cytoplasmic domain of β-amyloid precursor protein and its effect on Aβ secretion
16. Dissecting the pathological effects of human Aβ40 and Aβ42 in Drosophila: A potential model for Alzheimer's disease
17. Interaction of Alzheimer's β-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade
18. Phosphorylation-dependent Regulation of the Interaction of Amyloid Precursor Protein with Fe65 Affects the Production of β-Amyloid
19. Neuron-specific phosphorylation of Alzheimer's β-amyloid precursor protein by cyclin-dependent kinase 5
20. Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation

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