Irwin Levitan, PhD

Contact Dr. Levitan

900 Walnut St.
Suite 467
Philadelphia, PA 19107

215-503-5996
215-955-5861 fax

Research and Clinical Interests

My laboratory is interested in the long term regulation of neuronal excitability and synaptic transmission. We study the molecular mechanisms that nerve cells use to modulate the activity of individual ion channels, since these mechanisms must contribute to long term changes in neuronal function and ultimately in behavior.

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Publications

Most recent Peer-reviewed Publications

1. SLOB, a SLOWPOKE channel binding protein, regulates insulin pathway signaling and metabolism in Drosophila
2. Slob, a slowpoke channel-binding protein, modulates synaptic transmission
3. Editorial for first issue in January 2011
4. Identification of a Neural Circuit that Underlies the Effects of Octopamine on Sleep:Wake Behavior
5. In vivo role of a potassium channel-binding protein in regulating neuronal excitability and behavior
6. miXED Messages in Ion Channel Modulation
7. Drosophila ortholog of succinyl-CoA synthetase β subunit: A novel modulator of Drosophila KCNQ channels
8. Mechanisms of two modulatory actions of the channel-binding protein slob on the Drosophila slowpoke calcium-dependent potassium channel
9. Signaling protein complexes associated with neuronal ion channels
10. Expression and function of variants of Slob, Slowpoke channel binding protein, in Drosophila
11. Expression of a calmodulin-binding KCNQ2 potassium channel fragment modulates neuronal M-current and membrane excitability
12. A Drosophila KCNQ channel essential for early embryonic development
13. MONaKA, a novel modulator of the plasma membrane Na,K-ATPase
14. The amino terminus of slob, slowpoke channel binding protein, critically influences its modulation of the channel
15. Syntaxin-1A binds to and modulates the Slo calcium-activated potassium channel via an interaction that excludes syntaxin binding to calcium channels
16. The slowpoke channel binding protein Slob from Drosophila melanogaster exhibits regulatable protein kinase activity
17. A Well-Stocked Pool
18. Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila
19. An interaction domain in Slob necessary for its binding to the slowpoke calcium-dependent potassium channel
20. Monomeric 14-3-3 protein is sufficient to modulate the activity of the Drosophila Slowpoke calcium-dependent potassium channel

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