Michael E. O'Leary, PhD

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900 Walnut St.

Philadelphia, PA 19107

(215) 503-9983
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Research and Clinical Interests
Voltage-gated ion channels of primary sensory neurons

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Publications

Most recent Peer-reviewed Publications

1. Differential expression of sodium channel β subunits in dorsal root ganglion sensory neurons
2. Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons
3. Regulatory role of voltage-gated Na+ channel β subunits in sensory neurons
4. Regulation of Na v1.6 and Na v1.8 peripheral nerve Na + channels by auxiliary β-subunits
5. Single-cell analysis of sodium channel expression in dorsal root ganglion neurons
6. Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels
7. Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias
8. Lidocaine promotes the trafficking and functional expression of Na v1.8 sodium channels in mammalian cells
9. Inhibition of the A-type K+ channels of dorsal root ganglion neurons by the long-duration anesthetic butamben
10. State-dependent trapping of flecainide in the cardiac sodium channel
11. Closing and Inactivation Potentiate the Cocaethylene Inhibition of Cardiac Sodium Channels by Distinct Mechanisms
12. Kv1.1 channels of dorsal root ganglion neurons are inhibited by n-butyl-p-aminobenzoate, a promising anesthetic for the treatment of chronic pain
13. Cocaine binds to a common site on open and inactivated human heart (Nav 1.5) sodium channels
14. Inhibition of HERG potassium channels by cocaethylene: A metabolite of cocaine and ethanol
15. Gating properties of Nav1.7 and Nav1.8 peripheral nerve sodium channels
16. Inhibition of human ether-a-go-go potassium channels by cocaine
17. Characterization of the isoform-specific differences in the gating of neuronal and muscle sodium channels
18. A molecular link between activation and inactivation of sodium channels
19. Internal block of human heart sodium channels by symmetrical tetra- alkylammoniums
20. Evidence for a direct interaction between internal tetra-alkylammonium cations and the inactivation gate of cardiac sodium channels

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