James S. Schwaber, PhD

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900 Walnut St.

Philadelphia, PA 19107

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Research and Clinical Interests
Systems Biology/Computational Neuroscience: development of molecular systems biology approaches; studies of adaptive processes in neuronal function; computational modeling of cardiorespiratory regulatory circuits; systems approach to identify and model the dynamic contributions of the panoply of signaling mechanisms and related gene networks involved in homeostatic regulation by the brain.

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Publications

Most recent Peer-reviewed Publications

1. Coordinated Dynamic Gene Expression Changes in the Central Nucleus of the Amygdala During Alcohol Withdrawal
2. Rapid Temporal Changes in the Expression of a Set of Neuromodulatory Genes During Alcohol Withdrawal in the Dorsal Vagal Complex: Molecular Evidence of Homeostatic Disturbance
3. Integrative gene regulatory network analysis reveals light-induced regional gene expression phase shift programs in the mouse suprachiasmatic nucleus
4. Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei
5. Adaptive transcriptional dynamics of A2 neurons and central cardiovascular control pathways
6. Robust dynamic balance of AP-1 transcription factors in a neuronal gene regulatory network
7. The effect of biological variability on the angiotensin II gene regulatory network in the central regulation of blood pressure
8. Elucidating the transcriptional regulatory network underlying the Nts response to acute hypertension
9. A control system hypothesis of the N-methyl-D-aspartate glutamate receptor's role in alcoholism and
10. Modeling the control of an excitatory neurotransmitter receptor during alcoholism and alcohol withdrawal
11. A fast carrier chromatin immunoprecipitation method applicable to microdissected tissue samples
12. Dynamic transcriptomic response to acute hypertension in the nucleus tractus solitarius
13. From promoter analysis to transcriptional regulatory network prediction using PAINT.
14. Epidermal growth factor receptor-induced circadian-time-dependent gene regulation in suprachiasmatic nucleus
15. Quantifying gene network connectivity in silico: Scalability and accuracy of a modular approach
16. Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling
17. Epidermal growth factor receptor induced Erk phosphorylation in the suprachiasmatic nucleus
18. A universal reference sample derived from clone vector for improved detection of differential gene expression
19. Modeling the VPAC2-activated cAMP/PKA signaling pathway: From receptor to circadian clock gene induction
20. Chronic alcohol exposure alters transcription broadly in a key integrative brain nucleus for homeostasis: The nucleus tractus solitarius

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