Davide Trotti, PhD

Contact Dr. Trotti

900 Walnut St.
Suite 451
Philadelphia, PA 19107

215-955-8416
215-503-9128 fax

Research and Clinical Interests

Amyotrophic Lateral Sclerosis, Neurodegenerative diseases, Glutamate transporters and excitotoxicity, mitochondria ion channels and apoptosis

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Publications

Most recent Peer-reviewed Publications

1. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS
2. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
3. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2
4. Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria
5. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2
6. Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis
7. Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: Therapeutic implications for amyotrophic lateral sclerosis
8. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis
9. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2
10. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
11. Modulation of DMT1 Activity by Redox Compounds
12. A role for glutamate transporters in neurodegenerative diseases
13. Neutral amino acid absorption in the midgut of lepidopteran larvae
14. Regulation of glutamate transporters in health and disease
15. Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters
16. Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity
17. Specific linoleate deficiency in the rat does not prevent substantial carbon recycling from [14C]linoleate into sterols
18. Erratum: SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter (Nature Neuroscience (1999) 2 (247-433))
19. SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
20. Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes

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