Philip Wedegaertner, PhD

Contact Dr. Wedegaertner

233 South 10th Street
839 BLSB
Philadelphia, PA 19107

(215) 503-3137
fax

Research and Clinical Interests
Heterotrimeric G protein, G protein-coupled receptor kinase (GRK), and Rho guanine-nucleotide exchange factor (RhoGEF) signaling and cell biology; mechanisms and functions of regulated subcellular localization and trafficking

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Publications

Most recent Peer-reviewed Publications

1. Non-canonical signaling and localizations of heterotrimeric G proteins
2. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein βγ subunits
3. An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution
4. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF
5. Differences in Gα12- and Gα13-mediated plasma membrane recruitment of p115-RhoGEF
6. N-terminal polybasic motifs are required for plasma membrane localization of Gαs and Gαq
7. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts
8. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated Rho guanine-nucleotide exchange factor
9. Plasma membrane and nuclear localization of G protein-coupled receptor kinase 6A
10. Assembly and trafficking of heterotrimeric G proteins
11. Lipid-protein interactions in GPCR-associated signaling
12. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth
13. Loss of association between activated Gαq and Gβγ disrupts receptor-dependent and receptor-independent signaling
14. Functional consequences of Gα13 mutations that disrupt interaction with p115RhoGEF
15. Identification of a specific domain responsible for JNK2α2 autophosphorylation
16. Palmitoylation and plasma membrane targeting of RGS7 are promoted by αo
17. Characterization of the GRK2 binding site of Gαq
18. Analysis of G-protein-coupled receptor kinase RGS homology domains
19. Exocytic pathway-independent plasma membrane targeting of heterotrimeric G proteins
20. A Predicted Amphipathic Helix Mediates Plasma Membrane Localization of GRK5

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