Ji-fang Zhang, PhD

Contact Dr. Zhang

900 Walnut St.

Philadelphia, PA 19107

(215) 503-5669
(215) 503-2073 fax

Research and Clinical Interests
Voltage-gated calcium channels, calcium signaling in neurons

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Publications

Most recent Peer-reviewed Publications

1. Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation
2. Characterization of two distinct modes of endophilin in clathrin-mediated endocytosis
3. Identification of the functional binding pocket for compounds targeting small-conductance Ca 2+ -activated potassium channels
4. Structural basis for calmodulin as a dynamic calcium sensor
5. Reply to PDLIM5 is not a neuronal CaV2.2 adaptor protein
6. Structure of the SH3 domain of rat endophilin A2
7. Essential role of the LIM domain in the formation of the PKCε0859-ENH-N-type Ca2+ channel complex
8. A tctex1-Ca2+ channel complex for selective surface expression of Ca2+ channels in neurons
9. Modulation of the cardiac sodium channel Nav1.5 by Fyn, a Src family tyrosine kinase
10. A protein phosphatase 2cα-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C
11. Formation of an endophilin-Ca2+ channel complex is critical for clathrin-mediated synaptic vesicle endocytosis
12. A PKCε-ENH-channel complex specifically modulates N-type Ca2+ channels
13. Multiple structural elements in voltage-dependent Ca2+ channels support their inhibition by G proteins
14. Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions
15. Biophysical and pharmacological characterization of a class A calcium channel
16. Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin
17. Molecular determinants of voltage-dependent inactivation in calcium channels
18. Distinctive biophysical and pharmacological properties of class A (BI) calcium channel α1 subunits
19. Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels
20. Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons

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