Thomas Jefferson University - Kanae Iijima-Ando, Ph.D.
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Qualifications
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Ph.D., The University of Tokyo, Pharmaceutical Sciences, 2001
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Expertise and Research Interests
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Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The cAMP responsive element binding protein (CREB) is an evolutionarily conserved transcription factor that plays a pivotal role in multiple nervous system functions, such as long-term memory formation, resetting the circadian rhythm, sleep homeostasis and energy metabolism in a wide array of organisms, including Drosophila. In vivo reporter assays utilizing transgenic flies revealed that CREB activity cycles in a 24 hour rhythm, with peaks occurring in the morning and evening. My laboratory has been investigating the biological function of, and regulatory mechanisms underlying, circadian oscillation of CREB activity in flies.
Also, in a close collaboration with Dr. Koichi Iijima, we study Alzheimer disease (AD) and Parkinson disease (PD). We use fly models in a genome-wide approach to discover the mechanisms underlying neuronal dysfunction and degeneration in AD and PD. We have found many candidate genes that may be involved in the toxicity of amyloid-beta 42 peptide, which plays a causative role in the pathogenesis of AD.
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Keywords
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cAMP-responsive element binding protein; energy metabolism; circadian rhythm; Alzheimer's disease; Parkinson's disease; Drosophila
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Publications
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- Koichi Iijima*, Lijuan Zhao, Christopher Shenton, and Kanae Iijima-Ando*. REGULATION OF ENERGY STORES AND FEEDING BY NEURONAL AND PERIPHERAL CREB ACTIVITY IN DROSOPHILA. Submitted.*co-corresponding author
- Iijima-Ando, K. and Iijima, K. Transgenic Drosophila models for Alzheimer's disease and Tauopathies. (Review) Brain Structure and Function (2010) in press
- Iijima-Ando*, K., Hearn, S.A., Shenton, C., Gatt, A., Zhao, L. and Iijima, K*. (2009) Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction. PLoS One (in press) *co-corresponding author
- Lee, K-S., Iijima-Ando, K., Iijima, K., Lee, W-J., Lee, J.H., Yu, K., and Lee, D-S. (2009) JNK/FOXO-mediated neuronal expression of fly homologue of Peroxiredoxin II reduces oxidative stress and extends lifespan in Drosophila. J Biol Chem, 2009 Oct 23;284(43):29454-61. Epub 2009 Aug 31.
- Nakaya, T., Iijima-Ando, K., and Suzuki, T. (2009) Cell cycle regulated phosphorylation of the Alzheimer's amyloid-beta protein precursor. Chapter 7, Cell Cycle Regulators in Alzheimer's Disease, Transworld Research Network
- Iijima, K., Iijima-Ando, K., and Zhong, Y. (2009) Drosophila model of Alzheimer's amyloidosis. Chapter 14, Handbook of Behavior Genetics, Springer
- Iijima, K., Iijima-Ando, K. (2008) Drosophila Models of Alzheimer's Amyloidosis: The Challenge of Dissecting the Complex Mechanisms of Toxicity of Amyloid-beta 42. (Review) J Alzheimers Dis. 15(4):523-40
- Iijima-Ando, K*., Hearn, S.A., Granger, L., Shenton, C., Gatt, A., Chiang, H.C., Hakker, I., Zhong, Y., and Iijima, K*. (2008). Overexpression of Neprilysin Reduces Alzheimer Amyloid beta-42 (Abeta42)-induced Neuron Loss and Intraneuronal Abeta42 Deposits but Causes a Reduction in cAMP-responsive Element-binding Protein-mediated Transcription, Age-dependent Axon Pathology, and Premature Death in Drosophila. J Biol Chem 283, 19066-19076 (highlighted by ASBMB) *co-corresponding author
- Iijima, K., Chiang, H. C., Hearn, S. A., Hakker, I., Gatt, A., Shenton, C., Granger, L., Leung, A., Iijima-Ando, K., and Zhong, Y. (2008) Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila. PLoS ONE 3, e1703
- Sano, Y., Nakaya, T., Pedrini, S., Furukori, K., Iijima-Ando, K., Iijima, K., Mathews, P.M., Itohara, S., Gandy, S, and Suzuki, T. (2006) Physiological mouse brain amyloid-beta levels are not related to the phosphorylation state of threonine-668 of Alzheimer APP. PLoS ONE, 1, e51
- Iijima-Ando, K., and Yin, J.C. (2005). Transgenic cAMP response element reporter flies for monitoring circadian rhythms. Methods Enzymol 393, 302-315.
- Iijima-Ando, K.*, Wu, P., Drier, A., Iijima, K. & Yin, J.C.P.* (2005) CREB and HSP70 additively suppress polyglutamine-induced toxicity in Drosophila. Proc. Natl. Acad. Sci. 102, 10261-68. *co-corresponding author
- Ando, K., Iijima, K., Elliott, J.L., Kirino, Y., & Suzuki, T. (2001) Phosphorylation-dependent regulation on the interaction of amyloid precursor protein with Fe65 and the production of beta-amyloid. J. Biol. Chem. 276, 40353-61
- Iijima, K., Ando, K., Takeda, S., Satoh, Y., Seki, T., Itohara, S., Greengard, P., Narin, A.C., Kirino, Y. & Suzuki, T. (2000). Neuron-specific phosphorylation of Alzheimer amyloid precursor protein by Cdk5. J. Neurochem. 75, 1085-91
- Ando, K., Oishi, M., Takeda, S., Iijima, K., Isohara, T., Narin, A.C., Kirino, Y., Greengard, P., & Suzuki, T. (1999). Role of phosphorylation of Alzheimer amyloid precursor protein during neuronal differentiation. J Neurosci. 19, 4421-7
- Isohara, T., Horiuchi, A., Watanabe, T., Ando, K., Czernik, A. J., Uno, I., Greengard, P., Nairn, A. C., and Suzuki, T. (1999). Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase. Biochem Biophys Res Commun 258, 300-5.
- Suzuki, T., Ando, K., Isohara, T., Oishi, M., Lim, G. S., Satoh, Y., Wasco, W., Tanzi, R. E., Nairn, A. C., Greengard, P., Gandy, S. E., and Kirino, Y. (1997). Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry 36, 4643-9
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Individual Expertise profile of
Kanae Iijima-Ando, Ph.D., Copyright © Kanae Iijima-Ando, Ph.D..
Last Updated
by Kanae Iijima-Ando, Ph.D. : Saturday, November 21, 2009 12:36:05 PM
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