Thomas Jefferson University - Richard Horn, Ph.D.
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Richard Horn, Ph.D.
Physiology
Thomas Jefferson University
Jefferson Medical College
Department of Physiology
Professor Appointed: 1992
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Mailing Address
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Department of Physiology
Philadelphia, Pennsylvania 19107-6799
United States
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Qualifications
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Los Angeles, University of California, Ph.D., Anatomy
Los Angeles, University of California, M.S., Anatomy
Cornell University, B.S., Biological Sciences
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Expertise and Research Interests
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The long-term objective of my laboratory is to elucidate the molecular correlates of the biophysical properties of voltage-dependent ion channels, using a combination of patch recording, molecular biology, cysteine scanning mutagenesis, and immobilization of the moving parts of the channels (voltage sensors and gates) by photocross-linking. We use both sodium and potassium channels in these studies.
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Other Expertise
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EDITORIAL BOARD:
Biophysical Journal, 1984-1989. 1999-present
Journal of General Physiology, 1996-present
UNIVERSITY ACTIVITY:
Physiology Coordinator, Medical Neurosciences, 1992-present.
Course Co-coordinator, Graduate Neuroscience, 1992-present
Statistics, Woodworking, Latin dancing, Music (keyboards)
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Keywords
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Benzophenone Photocrosslinking; Channel Gating; Chemical Kinetics; Ion Channelopathies; Patch Clamp; Point Mutation; Potassium Channel; Protein Isoform; S4 Segment; Sodium Channel; Striated Muscle; Transfected Mammalian Cells; Voltage Gated Ion Channel; Xenopus Oocyte
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Publications
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- Horn, R. and Vandenberg, C. A. Statistical properties of single sodium channels. J. Gen. Physiol. 84: 505-534. (1984).
- Weiss, R. E. and Horn, R. Functional differences between two classes of sodium channels in developing myoblasts and myotubes of rat skeletal muscle. Science 233: 361-364. (1986).
- Horn, R. and Marty, A. Muscarinic activation of ionic currents measured by a new whole-cell recording method. J. Gen. Physiol. 92: 145-159. (1988).
- Morris, C. and Horn, R. Failure to elicit neuronal macroscopic mechanosensitive currents anticipated by single-channel studies. Science 251:1246-1249. (1991).
- Chahine, M., George, A. L., Zhou, M., Ji, S., Sun, W., Barchi, R. L., and Horn, R. Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation. Neuron 12:281-294. (1994).
- Yang, N., Ji, S., Zhou, M., Ptácek, L. G., Barchi, R. L., Horn, R., and George, A. L. Sodium channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro. Proc. Natl. Acad. Sci. 91:12785-12789. (1994).
- Yang, N. and Horn, R. Evidence for voltage dependent S4 movement in sodium channels. Neuron 15:213-218. (1995).
- Yang, N., George, A. L., and Horn, R. Molecular basis of charge movement in voltage-gated sodium channels. Neuron 16:113-122. (1996).
- French, R. J., Prusak-Sochaczewski, E., Zamponi, G. W., Becker, S., Kularatna, A. S., and Horn, R. Electrostatic interactions between a pore-blocking peptide and the voltage sensor of the sodium channel - a novel approach to channel geometry. Neuron 16:407-413, (1996).
- Horn, R., Ding, S., and Gruber. H. J. Immobilizing the moving parts of voltage-gated ion channels. Journal of General Physiology 116: 461-476. (2000).
- Ding, S. and Horn, R. Tail end of the S6 segment: Role in permeation in Shaker potassium channels. Journal of General Physiology 120:87 -97. (2002).
- Nguyen, T. P. and Horn, R. Movement and crevices around a sodium channel S3 segment. Journal of General Physiology 120:419-436. (2002).
- Ahern, C. A. and Horn, R. Specificity of charge-carrying residues in the voltage sensor of potassium channels. Journal of General Physiology 123:205-216. (2004).
- Ahern, C. A. and Horn, R. Stirring up controversy with a voltage sensor paddle. Trends in Neurosciences 27:303-307. (2004).
- Ahern, C. A., Zhang, J.-F., Woolkalis, M. J. and Horn, R. Modulation of the cardiac sodium channel NaV1.5 by the Src family tyrosine kinase Fyn. Circulation Research 96:991-998. (2005).
- Ahern, C. A. and Horn, R. Focused electric field across the voltage sensor of potassium channels. Neuron 48:25-29. (2005).
- Horn, R. Electrifying phosphatases. Science STKE pe50. (2005).
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Individual Expertise profile of
Richard Horn, Ph.D., Copyright © Richard Horn, Ph.D..
Last Updated
by Admin
: Monday, November 19, 2007 9:06:57 AM
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