For Researchers > Basic/Pre-Clinical Research > Parkinson's Disease
Parkinson's Disease Research at Farber
Led by Associate Director Lorraine Iacovitti, Ph.D., the Parkinson's research program at Farber is aimed at understanding how neurons differentiate into dopamine neurons during development of the brain and how that information may be useful for the treatment of Parkinson's, as well as other neurodegenerative diseases. A central goal is to induce dopaminergic traits in mouse and human stem/progenitor cells and devise ways to isolate those cells as pure dopamine neurons for study after transplantation in rat and monkey models of Parkinson's disease.
Human embryonic stem cells that have been differentiated to become neurons (green = beta tubulin III positive) and further express the dopamine enzyme tyrosine hydroxylase (red = TH positive). Overlapping population of TH-positive, beta tubulin-positive neurons is shown in the merged image as yellow/orange cells.
(Image courtesy of Lorraine Iacovitti) |
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