Esther E. Biswas, PhD

Contact Dr. Biswas

130 South 9th Street
Suite 1924
Philadelphia, PA 19107

(215) 503-8184
(215) 503-2189 fax

Education
PhD Molecular Bioscience, Rutgers/UMDNJ, Piscataway, NJ, 1989
MS Biochemistry, University of Maryland, Baltimore, MD, 1999
BS Chemistry, University of Washington, Seattle, WA, 1982

Certification
MB(ASCP) (Formerly, NCA Certification as Clinical Laboratory Specialist in Molecular Biology (CLSp(MB)), Initial - August 2000, Recertification - August 2005, February 2008.

Research and Clinical Interests
Analysis of the structure and function of biologically important proteins, which involves genetic and biochemical characterization of recombinant proteins generated through in vitro mutagenesis.
Current projects include molecular analysis of inherited visual diseases and Hexameric DNA helicases and control of cell proliferation.

Professional Societies
ASEB/ASBMB regular (elected) member, 2001-present
American Association for the Advancement of Science, 1995-present
Association for Research in Vision and Ophthalmology, 1999-present
International Society for Pharmaceutical Engineering, 2007-present
Sigma XI, regular member 2007-present

Publications

Most recent Peer-reviewed Publications

1. Retinoid binding properties of nucleotide binding domain 1 of the Stargardt disease-associated ATP binding cassette (ABC) transporter, ABCA4
2. Quantitative analysis of the mechanism of DNA binding by Bacillus DnaA protein
3. Thermodynamic analysis of DNA binding by a Bacillus single stranded DNA binding protein
4. Interaction of extracellular domain 2 of the human retina-specific ATP-binding cassette transporter (ABCA4) with all-trans-retinal
5. Quantitative analysis of binding of single-stranded DNA by Escherichia coli DnaB helicase and the DnaB·DnaC complex
6. Interaction of the nucleotide binding domains and regulation of the ATPase activity of the human retina specific ABC transporter, ABCR
7. Control of ATP-dependent binding of Saccharomyces cerevisiae origin recognition complex to autonomously replicating DNA sequences
8. The Mcm467 complex of Saccharomyces cerevisiae is preferentially activated by autonomously replicating DNA sequences
9. Modulation of DNA synthesis in Saccharomyces cerevisiae nuclear extract by DNA polymerases and the origin recognition complex
10. Quantitative analysis of nucleotide modulation of DNA binding by DnaC protein of Escherichia coli
11. Functional analysis of genetic mutations in nucleotide binding domain 2 of the human retina specific ABC transporter