Residency
The Cardeza Foundation faculty is dedicated
to hematologic research, education and clinical care. Physician
members of the foundation comprise the Division of Hematology in
the Department and are actively involved in inpatient and outpatient
training of residents and fellows.
The elective for medical residents is designed to develop competence
in evaluating and managing hematologic problems. It also aims to
provide an understanding of the pathophysiologic basis of hematologic
problems, and to provide an understanding of the pathophysiologic
basis of hematologic disorders. Medical residents participate in
the care of inpatients on the hematology service and in hematologic
consultations. Outpatient experience in hematology is also available.
During the rotation, residents learn to perform and interpret bone
marrow aspirations and biopsies.
In addition to Hematology Grand Rounds and research seminar, there
are two weekly clinical conferenes primarily for residents and
fellows.
Clinical research and laboratory research are performed under
the guidance of a member of the faculty of the Cardeza foundation
or the Division of Medical Oncology. In addition, laboratory research
is available under the guidance of several members of the Kimmel
Cancer Institute.
Current active research areas in the division include:
-
The role of human endothelial cells in hemostasis
-
The regulatory role of matrix in angiogenesis and endothelial
cell differentation.
-
The role of extracellular matrix-smooth muscle cell interactions
in vascular disease.
-
The mechanisms of action of lupus anticoagulants and their
relationship to thrombosis.
-
Role of proteoglycan interactions with cytokines and extracellular
matrix proteins in hematopoiesis, hematopoietic cell function
and uterine decidual function; structure/function relationships
and regulation of gene expression of proteoglycans in these cells.
-
The cellular and developmental expression of thrombopoietin.
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The mechanisms of growth and maturation of mega-karyocytes
and related cells.
-
The mechanisms of action of erythropoietin in red-cell production
and the factors modulating erthropoietin production at the gene
level.
-
The mechanism of hypoxia-induced gene expression.
- The effect of abnormal hemoglobins and of blood-group antigens
on the structure and function of the red cell membrane.
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