Fellowship
Program Director
Joseph A. DeSimone, Jr., MD
Fellowship Director
211 S. 9th Street, Suite 210
Philadelphia, PA 19107
Phone: 215 955-7785
e-mail: Joseph.DeSimone@jefferson.edu
Program overview
The Division of Infectious Diseases of the Jefferson Medical
College offers an Infectious Diseases Fellowship based at
the Thomas Jefferson University Hospital (TJUH). TJUH is
an 800-bed university teaching hospital based in Center City
Philadelphia with a broad referral base from the Pennsylvania-New
Jersey – Delaware tri-state Area. Clinical activities at
TJUH include active oncology, hematology, and transplantation
programs; a full array of medical and surgical subspecialties;
a regional spinal cord trauma and rehabilitation unit; and
active obstetrical, gynecological, and pediatric services.
Clinical consults are also performed at Jefferson Hospital
for Neurosciences and Wills Eye Hospital , both of which
are nationally recognized in their respected fields and are
located on the Jefferson campus.
In July of 1997 an important expansion of the Clinical Fellowship
occurred when the Infectious Diseases Section of Lankenau
Hospital merged with the Infectious Diseases Section at Jefferson
. Lankenau Hospital is a 500-bed community teaching hospital,
with a strong academic tradition. It is located on City Avenue
in Wynnewood , PA about 25 minutes by car from Center City
, Philadelphia . Lankenau Hospital 's I.D. Section is a busy
inpatient and outpatient consultative service, seeing patients
with community acquired infections, surgically related infections,
infections in high risk obstetrical patients and patients
with HIV.
The infectious diseases consultation service sees 55 to
70 in-patients a month on all hospital services. Residents
rotating on the consultation service are involved in the
management of a wide variety of clinical infectious disease
problems. Emphasis is placed on a logical approach to evaluating
possible infections, decision making in diagnosis and therapy
of infected patients and familiarity with the use of antibiotics.
Divisional faculty and fellows lead an infectious disease
out-patient clinic that meets weekly. Educational activities
include weekly divisional and inter-city infectious disease
conferences, a monthly case conference for medical house
staff, monthly divisional research conferences and journal
club conferences.
A diverse patient population, collaboration with the clinical
Microbiology laboratory, the Department of Microbiology and
numerous divisional studies allow for many opportunities
to pursue basic and clinical research activities including:
- Gene therapy for HIV-1 infection.
- Molecular control mechanisms of HIV-1 replication.
- Pathogenesis of HIV-1 infections of the brain
- Molecular mechanisms of HIV-1 maternal-fetal transmission.
- Cellular immune response to adenovirus; and hepatitis
C virus.
- Immune modulation to HIV-1 infection.
- Role of cytokine elaboration in progression of HIV-1
infection.
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