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Thomas Jefferson University - Andrew Aplin, Ph.D.
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Expertise and Research Interests
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Malignant melanoma is the deadliest form of skin cancer. It arises from epidermal melanocytes, the pigment producing cells in the skin, or their progenitors. Currently, melanoma metastasis is only preventable by early detection and surgical excision of primary tumors; hence, there is an immediate need to understand the mechanisms underlying melanocyte transformation. We utilize genetic and RNA interference approaches to alter key signaling pathway in primary human melanocytes and a panel of melanoma cells characterizing different stages of melanoma progression. In order to closely mimic the in vivo environment, we test the role of target proteins in a 3-D skin reconstruct model. Ultimately, we expect to identify the mechanisms underlying invasive growth of melanomas and, in doing so, identify novel targets for therapeutic intervention.
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Publications
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- Boisvert-Adamo, K. and Aplin, A.E. (2008) Mutant B-RAF mediates resistance to anoikis via Bad and Bim. Oncogene 27: 3301-3312. PMID: 18246127
- Klein, R.M., Spofford, L.S., Abel, E.V., Ortiz, A., and Aplin, A.E. (2008) B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization. Mol. Biol. Cell 19: 498-508. PMID: 18045987
- Hu, R. and Aplin, A.E. (2008) Skp2 regulates cell cycle progression in a p53-dependent manner. Mol. Biol. Cell 19: 4602-4610. PMID: 18716061
- Klein, R.M. and Aplin, A.E. (2009) Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in 3D. Cancer Res. 69: 2224-2233. PMID: 19244113
- Boisvert-Adamo, K., Longmate, W., Abel, E.V., and Aplin, A.E. (2009) Mcl-1 mediates resistance to anoikis in melanoma. Mol. Cancer Res. 7: 549-556 PMID: 19372583
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Individual Expertise profile of
Andrew Aplin, Ph.D., Copyright © Andrew Aplin, Ph.D..
Last Updated
by Andrew Aplin, Ph.D. : Friday, August 28, 2009 4:10:21 PM
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