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Thomas Jefferson University - Edgar Davidson, Ph.D.
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Edgar Davidson, Ph.D.
Biochemistry and Molecular Biology
Thomas Jefferson University
Jefferson Medical College
Department of Biochemistry & Molecular Biology
Research Assistant Professor
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Mailing Address
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233 South 10th Street, BLSB 208
Philadelphia, Pennsylvania 19107
United States
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Expertise and Research Interests
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An increasing number of human diseases are being correlated with mutations of mitochondrial DNA (mtDNA). These diseases are clinically, morphologically, and biochemically diverse. Although the identification of mtDNA mutations aids the genetic counseling of patients, there are currently no reliable treatments or therapies available for respiratory chain deficiencies. I am interested in using cell culture models to investigate genetic therapies for the treatment of mitochondrial respiratory chain deficiencies caused by mtDNA mutations. This will also serve as a model for the eventual treatment of human disease caused by mutations in mtDNA genes. I am also interested in the identification and function of proteins involved in mitochondrial protein synthesis, e.g. mitochondrial aminoacyl-tRNA synthetases.
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Publications
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- Funes, S., Davidson, E., Reyes-Prieto, A., Magallon, S., Herion, P., King, M. P., Gonzalez-Halphen, D. (2002). Apicomplexan split cox2 genes indicate a green algal apicoplast ancestor. Science 298, 2155.
- Perez-Martinez, X., Funes, S., Davidson, E., King, M. P., and Gonzalez-Halphen, D. (2002). Structure of the nuclear cox3 genes in green and colorless Chlamdomonad algae. Current Genetics, 40, 399-404.
- Funes, S., Davidson, E., Claros, M. G., van Lis, R., Perez-Martinez, X., Vazquez-Acevedo, M., King, M. P. and Gonzalez-Halphen, D. (2001). The typically mtDNA-encoded ATP6 subunit of the mitochondrial F1F0-ATPase is encoded by a nuclear gene in Chlamydomonas reinhardtii. J Biol Chem 14, 14.
- Davidson, E., Caffarella, J., Vitseva, O., Hou, Y.-M. and King, M.P. (2001). Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase. Biological Chemistry 382, 399-406.
- Perez-Martinez, X., Antaramian, A., Vazquez-Acevedo, M., Funes, S., Tolkunova, E., d'Alayer, J., Claros, M.G., Davidson, E., King, M.P., Gonzalez-Halphen, D. (2001). Subunit II of cytochrome c oxidase in chlamydomonad algae is a heterodimer encoded by two independent nuclear genes. J. Biol. Chem. 276, 11302-11309.
- Tolkunova, E., Park, H., Xia, J., King, M.P., Davidson, E. (2000). The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript. J. Biol. Chem. 275, 35063-35069.
- Perez-Martinez, X., Vazquez-Acevedo, M., Tolkunova, E., Funes, S., Claros, M. G., Davidson, E., King, M. P. and Gonzalez-Halphen, D. (2000). Unusual location of a mitochondrial gene: Subunit III of cytochrome c oxidase is encoded in the nucleus of chlamydomonad algae. J. Biol. Chem. 275, 30144-30152.
- Hoffbuhr, K. C., Davidson, E., Filiano, B. A., Davidson, M., Kennaway, N. G. and King, M. P. (2000). A Pathogenic 15-Base Pair Deletion in Mitochondrial DNA-encoded Cytochrome c Oxidase Subunit III Results in the Absence of Functional Cytochrome c Oxidase. J. Biol. Chem. 275, 13994-14003.
- Tang, Y., Schon, E. A., Wilichowski, E., Vazquez-Memije, M. E., Davidson, E. and King, M. P. (2000). Rearrangements of human mitochondrial DNA (mtDNA): new insights into the regulation of mtDNA copy number and gene expression. Mol Biol Cell 11, 1471-85.
- Davidson, E. and King, M. P. (1997). Advances in human mitochondrial diseases: molecular genetic analysis of pathogenic mtDNA mutations. Trends in Cardiovascular Medicine 7, 16-24.
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Individual Expertise profile of
Edgar Davidson, Ph.D., Copyright © Edgar Davidson, Ph.D..
Last Updated
by Edgar Davidson, Ph.D. : Wednesday, March 18, 2009 10:42:48 AM
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