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Thomas Jefferson University - Peter Ronner, Ph.D.
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Peter Ronner, Ph.D.
Biochemistry and Molecular Biology
Thomas Jefferson University
Jefferson Medical College
Biochemistry & Molecular Pharmacology
Associate Professor Appointed: 1994
Ph.D., Swiss Federal Institute of Technology, 1978
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Mailing Address
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233 S 10th St, 250 BLSB
Philadelphia, Pennsylvania 19107-5541
United States
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Qualifications
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Ph.D., Swiss Federal Institute of Technology (ETH), Zurich, Switzerland; Biochemistry; 1978
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Expertise and Research Interests
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I am interested in the mechanisms which control the release of insulin and glucagon from the pancreas.
Most of my current work is focused on glucagon release. We found that non-B islet cells (most likely glucagon-secreting A-cells) contain ATP-sensitive K-channels (KATP) that are pharmacologically and electrophysiologically indistinguishable from those in insulin-secreting B-cells. I am interested in defining the role of KATP in the regulation of both insulin and glucagon release.
In our studies of normal and tumoral pancreatic endocrine cells we use electrophysiology, flow-cytometric cell-sorting, immunohistochemistry, radioimmunoassays, and sensitive luminometric microhistochemical assays, which we developed recently.
Previously, I have studied the Ca,Mg-ATPase of human erythrocyte membranes, and hormone release from the in vitro micro-perfused endocrine pancreas (weight ~5 mg) of channel catfish (Ictalurus nebulosus).
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Other Expertise
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Experienced with teaching medical students and coordinating a biochemistry course for first year medical students.
Experienced with the following lecture topics: thermodynamics and pH; carbohydrate uptake; glycolysis; pyruvate kinase deficiency; fructose intolerance and galactosemia; pentose phosphate shunt and glucose-6-phosphate dehydrogenase deficiency; citric acid cycle; pancreatic hormones; type 1 diabetes; exercise, insulin resistance and obesity; type 2 diabetes; phenylketonuria and maple syrup urine disease; one-carbon metabolism; purine nucleotide metabolism; hyperuricemia and gout; pyrimidines and chemotherapy.
Experienced with whole-class discussions of problem sets on hypophosphatemia, glucose-6-phosphate dehydrogenase deficiency, debranching enzyme deficiency, insulinoma, hypoalaninemia/insufficient cortisol release of childhood, diabetic ketoacidosis, abetalipoproteinemia, propionyl-CoA carboxylase deficiency, preeclampsia/HELLP syndrome, glucagonoma. Experienced with small group sessions(~12 students) on oncogenes, sickle cell anemia, diabetes, familial hypercholesterolemia, and gene therapy.
Director of Molecular and Cellular Basis of Medicine course for medical students (the course includes cell biology, cell physiology, molecular biology, genetics, and biochemistry). Writing a textbook on biochemistry focused on clinical relevance and designed for medical students.
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Keywords
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Adenosine Diphosphate; Adenosine Triphosphate; Atp; Atp-Sensitive K+ Channel; Bcecf; Blood Glucose; Creatine Kinase; Diabetes; Digestive Diseases And Disorders; Digestive System; Drug Receptor; Education; Electrophysiology; Electrophysiology; Endocrinologic Diseases; Flow Cytometry; Glucagon; Glucagonoma; Glyburide; Green Fluorescent Protein; Hyperglucagonemia; Hyperkalemia; Instruction (Medical); Insulin; Insulin; Insulinoma; Katp-Channel; Laboratory Mouse; Laboratory Rat; Luciferase; Membrane Potential; Membrane Protein; Noninsulin Dependent Diabetes Mellitus; Pancreatic Islet; Perfusion; Ph; Potassium Channel; Radioimmunoassay; Somatostatin; Sulfonylurea; Tissue Cell Culture; Transfection; Transgenic Animal; Type 1 Diabetes
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Languages
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English, German, Swiss-German, Some French, Some Italian
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Publications
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- Ronner P, Naumann CM, and Friel E. Effects of glucose and amino acids on free ADP in beta HC9 insulin-secreting cells. Diabetes. 50(2): 291-300, Feb 2001
- Ronner P, Friel E, Czerniawski K, Frankle S. Luminometric assays of ATP, phosphocreatine, and creatine for estimation of free ADP and free AMP. Analytical Biochemistry. 275(2): 208-16, Nov 1999
- Ronner P. Perfusion of pancreatic endocrine tissue of teleost fish. Biochemistry and Molecular Biology of Fishes, vol. 3, Analytical Techniques; Hochachka PW and Mommsen TP, eds.; Elsevier Science, Amsterdam. pp. 179-189, 1994
- Li G, Kesavan P, Najafi H, Wang L, Ronner P, Liang Y, and Matschinsky FM. Fundamentals of fuel sensing and intermediary metabolism in pancreatic A and B cells. Contemporary Biomedicine, vol. on 'Molecular Biology of Diabetes', Draznin B and Leroith D, eds.; Humana Press, Totowa, NJ. pp. 175-192, 1994
- Ronner P, Matschinsky FM, Hang TL, Epstein AJ, Buettger C. Sulfonylurea-binding sites and ATP-sensitive K channels in alpha-TC glucagonoma and beta-TC insulinoma cells. Diabetes. 42(12): 1760-72, Dec 1993
- Ronner P, Hang TL, Kraebber MJ, Higgins TJ. Effect of the hypoglycaemic drug (-)-AZ-DF-265 on ATP-sensitive potassium channels in rat pancreatic beta-cells. British Journal of Pharmacology. 106(2): 250-5, Jun 1992
- Ghosh A, Ronner P, Cheong E, Khalid P, Matschinsky FM. The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas. Journal of Biological Chemistry. 266(34): 22887-92, Dec 1991
- Ronner P, Higgins TJ, Kimmich GA. Inhibition of ATP-sensitive K channels in pancreatic beta-cells by nonsulfonylurea drug linogliride. Diabetes. 40(7): 885-92, Jul 1991
- Ronner P, Cheong E, Khalid P, Tuman RW, Matschinsky FM. Effect of linogliride on hormone release from perfused rat pancreas. Fuel dependence and desensitization by tolbutamide. Diabetes. 40(7): 878-84, Jul 1991
- Ronner P. 2-Deoxyglucose stimulates the release of insulin and somatostatin from the perfused catfish pancreas. General and Comparative Endocrinology. 81(2): 276-83, Feb 1991
- Ronner P, Scarpa A. Secretagogues for pancreatic hormone release in the channel catfish (Ictalurus punctatus). General and Comparative Endocrinology. 65(3): 354-62, Mar 1987
- Ronner P. Transmembrane ion distribution and insulin secretion. Annals of the New York Academy of Sciences. 488: 341-55, 1986
- Dettori-Gera C, Ronner P, Scarpa A. Difference in dose-response curves for glucose-induced insulin and somatostatin release in rat pancreas. Biochimica Et Biophysica Acta. 839(3): 281-6, May 1985
- Andrews PC, Ronner P. Isolation and structures of glucagon and glucagon-like peptide from catfish pancreas. Journal of Biological Chemistry. 260(7): 3910-4, Apr 1985
- Ronner P, Scarpa A. Difference in glucose dependency of insulin and somatostatin release. American Journal of Physiology. 246(6 Pt 1): E506-9, Jun 1984
- Ronner P, Scarpa A. Isolated perfused Brockmann body as a model for studying pancreatic endocrine secretion. American Journal of Physiology. 243(5): E352-9, Nov 1982
- Niggli V, Ronner P, Carafoli E, Penniston JT. Effects of calmodulin on the (Ca2 Mg2 )ATPase partially purified from erythrocyte membranes. Archives of Biochemistry and Biophysics. 198(1): 124-30, Nov 1979
- Ronner P. Calcium transport in resealed erythrocytes and the use of a calcium electrode. Membrane Biochemistry; a Laboratory Manual on Transport and Bioenergetics, Carafoli E and Semenza G, eds.; Springer Verlag, Berlin. pp. 41-50, 1979
- Schatzmann H-J, Ronner P, Niggli V. Net Na+ and K+ movements in human red blood cells after cold storage. Membrane Biochemistry; a Laboratory Manual on Transport and Bioenergetics, Carafoli E and Semenza G, eds.; Springer Verlag, Berlin. pp. 35-40, 1979
- Peterson SW, Ronner P, Carafoli E. Partial purification and reconstitution of the (Ca2 Mg2 )-ATPase of erythrocyte membranes. Archives of Biochemistry and Biophysics. 186(1): 202-10, Feb 1978
- Ronner P. Further characterization and partial purification of the calcium, magnesium-stimulated adenosine triphosphatase of human erythrocyte membranes. Thesis no. 6191, Swiss Federal Institute of Technology, Zurich, Switzerland. , 1978
- Ronner P, Gazzotti P, Carafoli E. A lipid requirement for the (Ca2 Mg2 )-activated ATPase of erythrocyte membranes. Archives of Biochemistry and Biophysics. 179(2): 578-83, Mar 1977
- Sigrist H, Ronner P, Semenza G. A hydrophobic form of the small-intestinal sucrase-isomaltase complex. Biochimica Et Biophysica Acta. 406(3): 433-46, Oct 1975
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Individual Expertise profile of
Peter Ronner, Ph.D., Copyright © Peter Ronner, Ph.D..
Last Updated
by Peter Ronner, Ph.D. : Tuesday, August 12, 2008 4:32:34 PM
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