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Thomas Jefferson University - Steven McMahon, Ph.D.

Steven McMahon, Ph.D.

Cancer Biology

Department of Cancer Biology
Kimmel Cancer Center
Jefferson Medical College
Associate Professor
Appointed: 2006

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Mailing Address
Contact Info.
Publications

Mailing Address

233 S. 10th St. (Room 609-Bluemle)
Philadelphia, Pennsylvania 19107
United States

Contact Information

Phone: 215-503-9064
Steven.McMahon@jci.tju.edu

Publications

Selected Publications (from 1998-present)

A. Saleh, D. Schieltz, N. Ting, S.B. McMahon, D.W. Litchfield, J.R. Yates III, S.P. Lees Miller, M.D. Cole and C.J. Brandl. 1998. Tra1p is a component of the yeast ADA/SPT transcriptional regulatory complexes. J. Biol. Chem. 273: 26559 26570.

S.B. McMahon, H.A. Van Buskirk, K.A. Dugan, T.D. Copeland and M.D. Cole. 1998. The novel ATM related protein TRRAP is an essential cofactor for the c Myc and E2F oncoproteins. Cell 94: 363 374.

M.D. Cole and S.B. McMahon. 1999. The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation. Oncogene 18: 2916 2924.

S.B. McMahon, M.A. Wood and M.D. Cole. 2000. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c Myc. Mol. Cell. Biol. 20: 556 562.

M.A. Wood, S.B. McMahon and M.D. Cole. 2000. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c Myc. Molecular Cell 5: 321 330.

J. Park, S. Kunjibettu, S.B. McMahon, M.D. Cole. 2001. The ATM related domain of TRRAP is required for histone acetyltransferase recruitment and Myc dependent oncogenesis. Genes and Development 15: 1619 24.

S.E. Lang, S.B. McMahon, M.D. Cole and P. Hearing. 2001. E2F transcriptional activation requires TRRAP and GCN5 cofactors. J. Biol. Chem. 276: 32627 34.

J. Yanagisawa, H. Kitagawa, M. Yanagida, O. Wada, S. Ogawa, M. Nakagomi, H. Oishi, Y. Yamamoto, H. Nagasawa, S.B. McMahon, M.D. Cole, L. Tora, N. Takahashi, and S. Kato. 2002. Nuclear Receptor function requires a TFTC type histone acetyl transferase complex. Molecular Cell 9: 553 562.

M.A. Nikiforov, S. Chandriani, J. Park, I. Kotenko, D. Matheos, A. Johnsson, S.B. McMahon, and M. D. Cole. 2002. TRRAP dependent and TRRAP independent Transcriptional Activation by Myc Family Oncoproteins. Mol. Cell. Biol. 22: 5054 5063.

D.S. Vieyra, R. Loewith, M. Scott, P. Bonnefin, F.M. Boisvert, P. Cheema, S. Pastyryeva, M. Meijer, R. Johnston, D. P. Bazett Jones, S.B. McMahon, M.D. Cole, D. Young and K. Riabowol. 2002. Human ING1 Proteins Differentially Regulate Histone Acetylation. J. Biol. Chem. 277: 29832 29839.

P.G. Ard, S. Kunjibettu, C. Chatterjee, L. Adside, L.E. Gralinski and S.B. McMahon. 2002. Transcriptional regulation of the mdm2 oncogene by p53 involves TRRAP acetyltransferase complexes. Mol. Cell. Biol. 22: 5650 5661.

J.H. Patel, A.P. Loboda, M.K. Showe, L.C. Showe and S.B. McMahon. 2004. Analysis of genomic targets reveals complex functions of MYC. Nature Reviews Cancer 4: 562 568.

J.H. Patel, Y. Du, P.G. Ard, C. Phillips, B. Carella, C.J. Chen, C. Rakowski, C. Chatterjee, P.M. Lieberman, W.S. Lane, G.A. Blobel and S.B. McMahon. 2004. The c MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol. Cell. Biol. 24: 10826 34.

X. Zhang, L.M. DeSalle, J.H. Patel, A.J. Capobianco, D. Yu, A. Thomas-Tikhonenko and S.B. McMahon. 2005. Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein. P.N.A.S. (USA) 102: 13968-73.

X. Zhang, L.M. DeSalle and S.B. McMahon. 2006. Identification of novel targets of MYC whose transcription requires the essential MbII domain. Cell Cycle 5: 238-241.

J.H. Patel and S.B. McMahon. 2006. Targeting of MIZ-1 is essential for MYC-mediated apoptosis. J. Biol. Chem. 281:3283-3289.

P.S. Knoepfler, X. Zhang, P.F. Cheng, P.R. Gafken, S.B. McMahon and R.N. Eisenman. 2006. Myc regulates global chromatin structure. EMBO J. 12: 2723-34.

C.M. Chau, X. Zhang, S.B. McMahon and P.M. Lieberman. 2006. Regulation of Epstein-Barr Virus latency type by the chromatin boundary factor CTCF. J. Virology. 80:5723-5732.

S.M. Sykes, H.S. Mellert, M.A. Holbert, K. Li, W.S. Lane, R. Marmorstein and S.B. McMahon. 2006. Acetylation of the p53 DNA-Binding Domain Regulates Apoptosis Induction. Molecular Cell 24:841-851.

J.H. Patel and S.B. McMahon. 2007. BCL2 Is a Downstream Effector of MIZ-1 Essential for Blocking c-MYC-induced Apoptosis. J. Biol. Chem. 282: 5-15.

H. Mellert, S.M. Sykes, M.E. Murphy and S.B. McMahon. 2007. The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle 6:1304-1306.

X. Zhang, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL, McMahon S.B. 2008. The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression. Molecular Cell. 29:102-11.

X. Zhang, H. Pfeiffer, A.W. Thorne, S.B. McMahon. 2008. USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A. Cell Cycle 7:1-3

Individual Expertise profile of Steven McMahon, Ph.D., Copyright © Steven McMahon, Ph.D..
Last Updated by Admin : Monday, August 25, 2008 12:05:20 PM

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