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Thomas Jefferson University - Ulrich Rodeck, M.D.
Ulrich Rodeck, M.D.

Dermatology and Cutaneous Biology
Thomas Jefferson University
Jefferson Medical College
Department of Dermatology & Cutaneous Biology
Professor

Mailing Address

Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-503-5622
Ulrich.Rodeck@mail.jci.tju.edu
Keywords
Cancer Biology; Dermatology; Extracellular Matrix; Receptor Tyrosine Kinases; Signal Transduction; Apoptosis; Zebrafish Model System; Cell Stress Response
Publications
  • Donaldson, J.M., Kari, C., Fragoso, R., Rodeck, U. and Williams., J.C. Design and development of masked therapeutic antibodies to limit off-target effects: application to anti-EGFR antibodies. Cancer Biol and Ther. (in press)

  • Surguladze, D., Deevi, D., Claros, N., Corcoran, E., Wang, S., Plym, M.J., Wu, Y. Doody, J., Mauro, D.J., Witte, L., Busam, K.J., Pytowski, B., Rodeck, U., and Tonra, J.R. TNF-alpha and IL-1 antagonists alleviate inflammatory skin changes associated with EGFR antibody therapy in mice. Cancer Res. 69:5643-47, 2009.

  • Rodeck, U. Skin toxicity caused by EGFR antagonists - An autoinflammatory condition triggered by deregulated IL-1 signaling? J. Cell. Physiol. 218:32-4, 2009.

  • Daroczi,B., Kari, G., Ren, Q., Dicker, A.P., and Rodeck, U. NF-kB inhibitors reduce and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos. Mol. Cancer Ther. 8:2625-2634, 2009.

  • Lightcap, C.M., Kari, G., Arias-Romero, L., Chernoff, J., Rodeck, U., and Williams, J.C. Pak1 nuclear import requires dimeric interaction with LC8 and is indispensable for zebrafish development. PLoS ONE 4(6): e6025, 2009.

  • Lightcap, C.M., Sun, S., Lear, J.D., Rodeck, U., Polenova, T., and Williams, J.C. Biochemical and structural characterization of the Pak1-LC8 interaction. J. Biol. Chem. 283:27314, 2008.

  • Kriete, A.A., Mayo, K.L., Yalamanchili, N.N., Beggs, W.W., Bender, P.B., Kari, C. and Rodeck, U. Cell-autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity. Immunity & Aging 5:5, 2008.

  • Kamat, V., Donaldson, J.M., Kari, C., Quadros, M.R., Lelkes, P., Cocklin, S., Williams, J.W., Papazoglou, E. and Rodeck, U. Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic MABs C225 and 425. Cancer Biol. and Ther. 7:728-35, 2008.

  • Davidson, W., Kari, G., McAleer, M.-F. Dicker, A.P. and Rodeck, U. Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos. Cell Cycle 7:1224-30, 2008.

  • Hintze, V., Steplewski, A., Ito, H., Rodeck, U., and Fertala, A. Cells expressing partially unfolded R789C/p.R989C type II procollagen mutant associated with spondyloepiphyseal dysplasias undergo apoptosis. Hum. Mut. 29:841-51, 2008.

  • Seger, R., Rodeck, U., and Yarden Y. Receptor tyrosine kinases: the emerging tip of systems control. IET Systems Biology 2:1, 2008.

  • Chung, C.H., Parker, J., Levy, S., Slebos, R. J., Dicker, A. P. and Rodeck, U. Gene expression profiles as markers of aggressive disease - EGFR as a factor. Int J Radiat Oncol Biol Phys. 69:S102-5, 2007.

  • Kari, G., Rodeck, U., and Dicker, A. Zebrafish  An emerging model system for human disease and drug discovery. Clin. Pharmacol. Therapeut. 82:70-80, 2007.

  • Brennan, D., Hu, Y., Whitaker-Menezes, D., Uitto, J., Rodeck, U., and Mahoney, M.G. Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes. J. Cell Sci. 120:758-71, 2007.

  • Daroczi, B., Kari, G., McAleer, M.F., Rodeck, U., and Dicker, A.P. In vivo radioprotection by the carboxyfullerene DF-1 as assessed in a zebrafish model. Clin. Cancer Res. 12:7086-91, 2006.

  • McAleer, M., Duffy, K., Davidson, W.R., Kari, G., Dicker, A.P., Rodeck, U., and Wickstrom, E. Antisense inhibition of cyclinD1 expression is equivalent to flavopiridol for radiosensitization of zebrafish embryos. Int. J. Rad. Oncol., Biol., Phys. 66:546-51, 2006.

  • Ren, Q., Kari, C., Quadros, M.R., Burd, R., McCue, P., Dicker, A.P., and Rodeck, U. Malignant transformation of immortalized HaCaT keratinocytes through deregulated NF-ºB signaling. Cancer Res. 66: 5209-15, 2006.

  • Bellone, G., Anna Carbone, A., Novarino, A., Smirne, C., Stacchini, A., Bertetto, O., Robecchi, A., Emanuelli, G., and Rodeck U. Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells. J. Immunol. 177:3448-60, 2006.

  • Quadros, M.R., Connelly, S., Kari, C., Abrams, M.T., Wickstrom, E, and Rodeck, U. EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-´ activities. Cancer Biol. and Ther. 5:5, 498-504, 2006.

  • Zhang, W., Alt-Holland, A., Margulis, A., Shamis, J., Fusenig, N.E., Rodeck, U., and Garlick, J.A. A novel role for E-cadherin loss during initiation of squamous cell carcinoma through modulation of integrin-mediated matrix adhesion. J. Cell Sci. 119:283-91, 2006..

  • Duffy. K., McAleer, M., Kari, L., Kari, C, Liu, C-G.., Farber, S.A., Wickstrom, E., Dicker, A., and Rodeck, U. Coordinate control of cell cycle regulatory genes in zebrafish embryos tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids. Nucleic Acids Res. 33:4914-21, 2005.

  • Carbone, A., Mauri, F.A., Sozzi, M., Gaspari, F., Smirne, C., Prati, A., Addeo, A., Novarino, A., Robecchi, A., Berretto, O., Emanuelli, G., Rodeck, U., and Bellone, G. Human pancreatic carcinoma cells secrete bioactive Interleukin-18 after treatment with 5-Fluorouracil: Implications for antitumor immune response. Cancer Biol. and Ther. 4:231-241, 2005.

  • McAleer, M.F., Rodeck, U., Dicker, A. Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers. Int. J. Rad. Oncol., Biol., Phys. 61:10-13, 2005.

  • Quadros, M.R., Peruzzi, F., Kari, C., and Rodeck, U. Complex regulation of signal transducer and activator of transcription 3 activation in normal and malignant keratinocytes. Cancer Res. 64:3934-3939, 2004.

  • Bellone, G., Ferrero, D., Carbone, A., De Quadros, M.R., Gramigni, C., Prati, A., Davidson, W., Mioli, P., Dughera, L., Emanuelli, G., and Rodeck, U. 2004. Inhibition of cell survival and invasive potential of colorectal carcinoma cells by the tyrosine kinase inhibitor STI571. Cancer Biol. and Ther. 3:385-392, 2004.

  • Kari C, Chan TO, Rocha de Quadros M, Rodeck U. Targeting the epidermal growth factor receptor in cancer: apoptosis takescenter stage. Cancer Research. 63(1): 1-5, Jan 2003

  • Emrich JG, Brady LW, Quang TS, Class R, Miyamoto C, Black P, Rodeck U. Radioiodinated (I-125) monoclonal antibody 425 in the treatment of highgrade glioma patients: ten-year synopsis of a noveltreatment. American Journal of Clinical Oncology : the Official Publication of the American Radium Society. 25(6): 541-6, Dec 2002

  • Pistritto G, Jost M, Srinivasula SM, Baffa R, Poyet JL, Kari C, Lazebnik Y, Rodeck U, Alnemri ES. Expression and transcriptional regulation of caspase-14 in simple andcomplex epithelia. Cell Death and Differentiation. 9(9): 995-1006, Sep 2002

  • Wahl ML, Owen JA, Burd R, Herlands RA, Nogami SS, Rodeck U, Berd D, Leeper DB, Owen CS. Regulation of intracellular pH in human melanoma: potential therapeuticimplications. Molecular Cancer Therapeutics. 1(8): 617-28, Jun 2002

  • Aho S, Levansuo L, Montonen O, Kari C, Rodeck U, Uitto J. Specific sequences in p120ctn determine subcellular distribution of itsmultiple isoforms involved in cellular adhesion of normal and malignantepithelial cells. Journal of Cell Science. 115(Pt 7): 1391-402, Apr 2002

  • Chan TO, Rodeck U, Chan AM, Kimmelman AC, Rittenhouse SE, Panayotou G, Tsichlis PN. Small GTPases and tyrosine kinases coregulate a molecular switch in thephosphoinositide 3-kinase regulatory subunit. Cancer Cell. 1(2): 181-91, Mar 2002

  • Mahoney MG, Simpson A, Jost M, Noe M, Kari C, Pepe D, Choi YW, Uitto J, Rodeck U. Metastasis-associated protein (MTA)1 enhances migration, invasion, andanchorage-independent survival of immortalized humankeratinocytes. Oncogene. 21(14): 2161-70, Mar 2002

  • Giambernardi TA, Sakaguchi AY, Gluhak J, Pavlin D, Troyer DA, Das G, Rodeck U, Klebe RJ. Neutrophil collagenase (MMP-8) is expressed during early development inneural crest cells as well as in adult melanoma cells. Matrix Biology : Journal of the International Society for Matrix Biology. 20(8): 577-87, Dec 2001

  • Shin I, Bakin AV, Rodeck U, Brunet A, Arteaga CL. Transforming growth factor beta enhances epithelial cell survival viaAkt-dependent regulation of FKHRL1. Molecular Biology of the Cell. 12(11): 3328-39, Nov 2001

  • Graeven U, Rodeck U, Karpinski S, Jost M, Philippou S, Schmiegel W. Modulation of angiogenesis and tumorigenicity of human melanocytic cellsby vascular endothelial growth factor and basic fibroblast growthfactor. Cancer Research. 61(19): 7282-90, 2001.

  • Simpson A, Uitto J, Rodeck U, Mahoney MG. Differential expression and subcellular distribution of the mousemetastasis-associated proteins Mta1 and Mta3. Gene. 273(1): 29-39, Jul 2001.

  • Jost M, Gasparro FP, Jensen PJ, Rodeck U. Keratinocyte apoptosis induced by ultraviolet B radiation and CD95ligation -- differential protection through epidermal growth factorreceptor activation and Bcl-x(L) expression. The Journal of Investigative Dermatology. 116(6): 860-6, Jun 2001

  • Jost M, Huggett TM, Kari C, Rodeck U. Matrix-independent survival of human keratinocytes through an EGFreceptor/MAPK-kinase-dependent pathway. Molecular Biology of the Cell. 12(5): 1519-27, May 2001

  • Jost M, Huggett TM, Kari C, Boise LH, Rodeck U. Epidermal growth factor receptor-dependent control of keratinocytesurvival and Bcl-xL expression through a MEK-dependentpathway. The Journal of Biological Chemistry. 276(9): 6320-6, Mar 2001

  • Bellone G, Carbone A, Sibona N, Bosco O, Tibaudi D, Smirne C, Martone T, Gramigni C, Camandona M, Emanuelli G, Rodeck U. Aberrant activation of c-kit protects colon carcinoma cells againstapoptosis and enhances their invasive potential. Cancer Research. 61(5): 2200-6, Mar 2001

  • Bellone G, Carbone A, Tibaudi D, Mauri F, Ferrero I, Smirne C, Suman F, Rivetti C, Migliaretti G, Camandona M, Palestro G, Emanuelli G, Rodeck U. Differential expression of transforming growth factors-beta1, -beta2 and-beta3 in human colon carcinoma. European Journal of Cancer (oxford, England : 1990). 37(2): 224-33, Jan 2001

  • Jost M, Kari C, Rodeck U. The EGF receptor - an essential regulator of multiple epidermal functions. European Journal of Dermatology : Ejd. 10(7): 505-10, 2000

  • Graeven U, Rodeck U, Karpinski S, Jost M, Andre N, Schmiegel W. Expression patterns of placenta growth factor in human melanocytic celllines. The Journal of Investigative Dermatology. 115(1): 118-23, Jul 2000

  • Bellone G, Smirne C, Carbone A, Mareschi K, Dughera L, Farina EC, Alabiso O, Valente G, Emanuelli G, Rodeck U. Production and pro-apoptotic activity of soluble CD95 ligand in pancreaticcarcinoma. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 6(6): 2448-55, Jun 2000

  • Graeven U, Fiedler W, Karpinski S, Ergun S, Kilic N, Rodeck U, Schmiegel W, Hossfeld DK. Melanoma-associated expression of vascular endothelial growth factor and its receptors FLT-1 and KDR. Journal of Cancer Research and Clinical Oncology. 125(11): 621-9, Nov 1999

  • Basu A, Rodeck U, Prendergast GC, Howe CC. Loss of insulin-like growth factor I receptor-dependent expression of p107 and cyclin A in cells that lack the extracellular matrix protein secreted protein acidic and rich in cysteine. Cell Growth and Differentiation. 10(11): 721-8, Nov 1999

  • Ge K, DuHadaway J, Du W, Herlyn M, Rodeck U, Prendergast GC. Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma. Proceedings of the National Academy of Sciences (USA). 96(17): 9689-94, Aug 1999

  • Rodeck U, Nishiyama T, Mauviel A. Independent regulation of growth and SMAD-mediated transcription by transforming growth factor beta in human melanoma cells. Cancer Research. 59(3): 547-50, Feb 1999

  • Jost M, Kari C, Rodeck U. An episomal vector for stable tetracycline-regulated gene expression. Nucleic Acids Research. 25(15): 3131-4, Aug 1997

  • Rodeck U, Jost M, DuHadaway J, Kari C, Jensen PJ, Risse B, Ewert DL. Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor. Proceedings of the National Academy of Sciences (USA). 94(10): 5067-72, May 1997

  • Rodeck U, Jost M, Kari C, Shih DT, Lavker RM, Ewert DL, Jensen PJ. EGF-R dependent regulation of keratinocyte survival. Journal of Cell Science. 110 ( Pt 2): 113-21, Jan 1997

  • Simon HG, Risse B, Jost M, Oppenheimer S, Kari C, Rodeck U. Identification of differentially expressed messenger RNAs in human melanocytes and melanoma cells. Cancer Research. 56(13): 3112-7, Jul 1996

  • Van Belle P, Rodeck U, Nuamah I, Halpern AC, Elder DE. Melanoma-associated expression of transforming growth factor-beta isoforms. American Journal of Pathology. 148(6): 1887-94, Jun 1996

  • Bellone G, Aste-Amezaga M, Trinchieri G, Rodeck U. Regulation of NK cell functions by TGF-beta 1. Journal of Immunology. 155(3): 1066-73, Aug 1995

  • Vardy DA, Kari C, Lazarus GS, Jensen PJ, Zilberstein A, Plowman GD, Rodeck U. Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1. Journal of Cellular Physiology. 163(2): 257-65, May 1995

  • Rodeck U, Bossler A, Graeven U, Fox FE, Nowell PC, Knabbe C, Kari C. Transforming growth factor beta production and responsiveness in normal human melanocytes and melanoma cells. Cancer Research. 54(2): 575-81, Jan 1994

  • Rodeck U. Growth factor independence and growth regulatory pathways in human melanoma development. Cancer and Metastasis Reviews. 12(3-4): 219-26, Sep 1993

  • Jensen PJ, Rodeck U. Autocrine/paracrine regulation of keratinocyte urokinase plasminogen activator through the TGF-alpha/EGF receptor. Journal of Cellular Physiology. 155(2): 333-9, May 1993

  • Schmiegel W, Roeder C, Schmielau J, Rodeck U, Kalthoff H. Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells. Proceedings of the National Academy of Sciences (USA). 90(3): 863-7, Feb 1993

  • Rodeck U, Melber K, Kath R, Menssen HD, Varello M, Atkinson B, Herlyn M. Constitutive expression of multiple growth factor genes by melanoma cells but not normal melanocytes. Journal of Investigative Dermatology. 97(1): 20-6, Jul 1991

  • Rodeck U, Williams N, Murthy U, Herlyn M. Monoclonal antibody 425 inhibits growth stimulation of carcinoma cells by exogenous EGF and tumor-derived EGF/TGF-alpha. Journal of Cellular Biochemistry. 44(2): 69-79, Oct 1990

  • Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ. Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens. Proceedings of the National Academy of Sciences (USA). 87(17): 6833-7, Sep 1990

  • Rodeck U, Herlyn M, Herlyn D, Molthoff C, Atkinson B, Varello M, Steplewski Z, Koprowski H. Tumor growth modulation by a monoclonal antibody to the epidermal growth factor receptor: immunologically mediated and effector cell-independent effects. Cancer Research. 47(14): 3692-6, Jul 1987

  • Westermark B, Johnsson A, Paulsson Y, Betsholtz C, Heldin CH, Herlyn M, Rodeck U, Koprowski H. Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor. Proceedings of the National Academy of Sciences (USA). 83(19): 7197-200, Oct 1986

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