University Home | Hospital | Pulse Employment | Contact Us | Search | News 
Thomas Jefferson University Search Jefferson
Jefferson Medical College Jefferson College of Graduate Studies Jefferson College of Health Professions
Menu

Thomas Jefferson University - Saul Surrey, Ph.D.
Saul Surrey, Ph.D.

Medicine
Cardeza Foundation
Thomas Jefferson University
Jefferson Medical College
Department of Medicine
Professor and Associate Director of Research Appointed: 2001

Thomas Jefferson University
Jefferson Medical College
Department of Pediatrics
Professor Appointed: 1996

Mailing Address

Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: (302) 651-6700
Saul.Surrey@jefferson.edu
Qualifications
State College, Pennsylvania State University, B.S., Chemistry and Physics

Ph.D., Temple University, Biology, 1970

Keywords
Pediatrics
Publications
  • Adachi K, Zhao Y, Surrey S. Assembly of Human Hemoglobin (Hb) beta - and gamma -Globin Chains Expressed in a Cell-free System with alpha -Globin Chains to Form Hb A and Hb F. Journal of Biological Chemistry. 277(16): 13415-13420, 19 Apr 2002

  • Graves DJ, Su H-J, Addya S, Surrey S, Fortina P. A four-laser scanning confocal system for microarray analysis. Biotechniques. 32: 346-354, 2002

  • Fortina F, Graves D, Stoeckert Jr, C, McKenzie S, Surrey S. Technology options and applications of DNA microarrays. In: Biochip Technology, Cheng J and Kricka LJ, editors, Harrowed Academic Publishers. 185-215, 2001

  • Adachi K, Zhao Y, Yamaguchi T, Surrey S. Assembly of gamma- with alpha-globin chains to form human fetal hemoglobin in vitro and in vivo. Journal of Biological Chemistry. 275(17): 12424-9, 2000

  • Cassel DL, Subudhi SK, Surrey S, McKenzie SE. GATA and NF-Y participate in transcriptional regulation of FcgammaRIIA in megakaryocytic cells. Blood Cells, Molecules, and Diseases. 26(6): 587-97, Dec 2000

  • Fortina P, Delgrosso K, Sakazume T, Santacroce R, Moutereau S, Su HJ, Graves D, McKenzie S, Surrey S. Simple two-color array-based approach for mutation detection. European Journal of Human Genetics. 8(11): 884-94, Nov 2000

  • Adachi K, Yamaguchi T, Yang Y, Konitzer PT, Pang J, Reddy KS, Ivanova M, Ferrone F, Surrey S. Expression of functional soluble human alpha-globin chains of hemoglobin in bacteria. Protein Expression and Purification. 20(1): 37-44, Oct 2000

  • Manduchi E, Grant GR, McKenzie SE, Overton GC, Surrey S, Stoeckert CJ. Generation of patterns from gene expression data by assigning confidence to differentially expressed genes. Bioinformatics. 16(8): 685-98, Aug 2000

  • McKenzie SE, Taylor SM, Malladi P, Yuhan H, Cassel DL, Chien P, Schwartz E, Schreiber AD, Surrey S, Reilly MP. The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. Journal of Immunology. 162(7): 4311-8, 1999

  • Sanguedolce LA, Chan V, McKenzie SE, Surrey S, Fortina P, Graves DJ. Fundamental studies of DNA adsorption and hybridization on solid surfaces. American Chemical Society Symposium Series, in Intelligent Materials and Novel Concepts for Controlled Release Technologies, Dinh S and DeNuzzio J eds, Oxford University Press New York NY. 728: 190-204, 1999

  • McKenzie SE, Mansfield E, Rappaport E, Surrey S, Fortina P. Parallel molecular genetic analysis. European Journal of Human Genetics. 6(5): 417-29, 1998

  • Yamaguchi T, Pang J, Reddy KS, Surrey S, Adachi K. Role of beta112 Cys (G14) in homo- (beta4) and hetero- (alpha2 beta2) tetramer hemoglobin formation. Journal of Biological Chemistry. 273(23): 14179-85, 1998

  • Norris CF, Pricop L, Millard SS, Taylor SM, Surrey S, Schwartz E, Salmon JE, McKenzie SE. A naturally occurring mutation in Fc gamma RIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor. Blood. 91(2): 656-62, 1998

  • Estivill X, Fortina P, Surrey S, Rabionet R, Melchionda S, D'Agruma L, Mansfield E, Rappaport E, Govea N, Mila M, Zelante L, Gasparini P. Connexin-26 mutations in sporadic and inherited sensorineural deafness. Lancet. 351(9100): 394-8, 1998

  • Adachi K, Yamaguchi T, Pang J, Surrey S. Effects of increased anionic charge in the beta-globin chain on assembly of hemoglobin in vitro. Blood. 91(4): 1438-45, 1998

  • Graves DJ, Su HJ, McKenzie SE, Surrey S, Fortina P. System for preparing microhybridization arrays on glass slides. Analytical Chemistry. 70(23): 5085-92, 1998

  • Cui Z, Reilly MP, Surrey S, Schwartz E, McKenzie SE. -245 bp of 5'-flanking region from the human platelet factor 4 gene is sufficient to drive megakaryocyte-specific expression in vivo. Blood. 91(7): 2326-33, 1998

  • Chan V, McKenzie SE, Surrey S, Fortina P, Graves DJ. The effect of hydrophobicity and electrostatics on adsorption and surface diffusion of DNA oligonucleotides at liquid/solid interfaces. Journal of Colloid and Interface Science. 203: 197-207, 1998

  • Adachi K, Konitzer P, Pang J, Reddy KS, Surrey S. Amino acids responsible for decreased 2,3-biphosphoglycerate binding to fetal hemoglobin. Blood. 90(8): 2916-20, 1997

  • Reddy LR, Reddy KS, Surrey S, Adachi K. Role of beta87 Thr in the beta6 Val acceptor site during deoxy Hb S polymerization. Biochemistry. 36(50): 15992-8, 1997

  • Zelante L, Gasparini P, Estivill X, Melchionda S, D'Agruma L, Govea N, Mila M, Monica MD, Lutfi J, Shohat M, Mansfield E, Delgrosso K, Rappaport E, Surrey S, Fortina P. Connexin26 mutations associated with the most common form of non-syndromic neurosensory autosomal recessive deafness (DFNB1) in Mediterraneans. Human Molecular Genetics. 6(9): 1605-9, Sep 1997

  • Reddy LR, Reddy KS, Surrey S, Adachi K. Role of hydrophobic amino acids at beta85 and beta88 in stabilizing F helix conformation of hemoglobin S. Journal of Biological Chemistry. 271(40): 24564-8, 1996

  • Adachi K, Pang J, Reddy LR, Bradley LE, Chen Q, Trifillis P, Schwartz E, Surrey S. Polymerization of three hemoglobin A2 variants containing Val6 and inhibition of hemoglobin S polymerization by hemoglobin A2. Journal of Biological Chemistry. 271(40): 24557-63, 1996

  • Trifillis P, Adachi K, Yamaguchi T, Schwartz E, Surrey S. Expression studies of delta-globin gene alleles associated with reduced hemoglobin A2 levels in Greek Cypriots. Journal of Biological Chemistry. 271(43): 26931-8, 1996

  • Yamaguchi T, Pang J, Reddy KS, Witkowska HE, Surrey S, Adachi K. Expression of soluble human beta-globin chains in bacteria and assembly in vitro with alpha-globin chains. Journal of Biological Chemistry. 271(43): 26677-83, 1996

  • Kattamis AC, Camaschella C, Sivera P, Surrey S, Fortina P. Human alpha-thalassemia syndromes: detection of molecular defects. American Journal of Hematology. 53(2): 81-91, Oct 1996

  • Kiss C, Surrey S, Schreiber AD, Schwartz E, McKenzie SE. Human c-kit ligand (stem cell factor) induces platelet Fc receptor expression in megakaryoblastic cells. Experimental Hematology. 24(10): 1232-7, Aug 1996

  • Cheng J, Fortina P, Surrey S, Kricka LJ, Wildling P. Microchip-based devices for molecular diagnosis of genetic diseases. Molecular Diagnosis. 1: 183-200, 1996

  • Adachi K, Sabnekar P, Adachi M, Reddy LR, Pang J, Reddy KS, Surrey S. Polymerization of recombinant Hb S-Kempsey (deoxy-R state) and Hb S-Kansas (oxy-T state). Journal of Biological Chemistry. 270(45): 26857-62, 1995

  • Kobayashi M, Rappaport E, Blasband A, Semeraro A, Sartore M, Surrey S, Fortina P. Fluorescence-based DNA minisequence analysis for detection of known single-base changes in genomic DNA. Molecular and Cellular Probes. 9(3): 175-82, Jun 1995

  • Mansfield ES, Worley JM, McKenzie SE, Surrey S, Rappaport E, Fortina P. Nucleic acid detection using non-radioactive labelling methods. Molecular and Cellular Probes. 9(3): 145-56, Jun 1995

  • Ramachandran B, Surrey S, Schwartz E. Megakaryocyte-specific positive regulatory sequence 5' to the human PF4 gene. Experimental Hematology. 23(1): 49-57, Jan 1995

  • Keller MA, McKenzie SE, Cassel DL, Rappaport EF, Schwartz E, Surrey S. Lineage-specific alternative splicing of the human Fc gamma RIIA transmembrane exon requires sequences near the 3' splice site. Gene Expression. 4(4-5): 217-25, 1995

Individual Expertise profile of Saul Surrey, Ph.D., Copyright © Saul Surrey, Ph.D..
Last Updated by Admin : Thursday, June 5, 2008 11:48:04 AM



Maintained by Jerome Buescher
Copyright © Thomas Jefferson University. All Rights Reserved.

 Printable Version

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement.
Thomas Jefferson University
Thomas Jefferson University