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Thomas Jefferson University - Fabienne Paumet
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Qualifications
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2007-present: Assistant Professor, Thomas Jefferson University, Philadelphia, USA
2005-2007: Post-doctoral research associate , Columbia University, New York, USA
2000-2005: Post-doctoral fellow, Memorial Sloan-Kettering Cancer Center / Columbia University , New York, USA
1999: Ph.D., Pasteur Institute, Paris, France
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Expertise and Research Interests
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MOLECULAR MECHANISMS OF PHAGOCYTOSIS: how do pathogens subvert this process?
*Unraveling membrane trafficking involved in the phagocytic pathway and its regulation
*How do intracellular bacteria interfere with the host phagocytic system to escape lysosomal degradation?
CHARACTERIZATION OF EUKARYOTIC MEMBRANE FUSION MACHINERY
*Identification and characterization of primitive membrane fusion machineries (similar to SNARE proteins)
*Characterization of the specificity of fusion encoded in the SNARE proteins
*Characterization of intramolecular SNARE regulation
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Keywords
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Membrane fusion, SNARE protein, Phagocytosis, Endocytosis, Exocytosis, Vesicular trafficking, intracellular pathogens, bacterial SNARE-like protein, SNARE evolution
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Publications
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- F. Paumet*, J. Wesolowski, A. Garcia-Diaz, C. Delevoye, N. Aulner, H.A. Shuman, A. Subtil, J.E. Rothman Intracellular bacteria encode inhibitory SNARE-like proteins , PLoS One (2009) 4:e7375 (*corresponding author)
- C. Delevoye, M. Nilges, P. Dehoux, F. Paumet, S. Perrinet, A. Dautry-Varsat, A. Subtil SNARE protein mimicry by an intracellular bacterium PLOS Pathogens (2008) 4:e1000022
- J. Shen, D. Tareste, F. Paumet, JE. Rothman, T.J. Melia Selective activation of cognate SNAREpins by Sec1/Munc18 (SM) proteins Cell (2007) 128: 183-195
- D. Dao*, C. Dobbs*, A. Goldrath*, MJ. Khoury*, C. Lengsfeld*, A. McBride*, C. McCarty*, F. Paumet*, JE. Wiktorowicz*, Z. Yang* (*Alphabetic order) The Genomic Revolution - Implications for Treatment and Control of Infectious Disease: Can genomics facilitate vaccine development? Keck Futures Initiatives- The National Academies Press, Washington D.C. (2006) p33-9.
- F. Paumet, V. Rahimian, M. DiLiberto, JE. Rothman Concerted auto-regulation in yeast endosomal t-SNAREs Journal of Biological Chemistry (2005) 280: 21137-43
- F. Paumet, V. Rahimian, JE. Rothman The specificity of SNARE-dependent fusion is encoded in the SNARE motif PNAS (2004) 101:3376-80
- O. Varlamov, A. Volchuk, V. Rahimian, CA. Doege, F. Paumet, WS. Eng, N. Arango, F. Parlati, M. Ravazzola, L. Orci, TH. Söllner and JE. Rothman i-SNAREs, inhibitory SNAREs that fine-tune the specificity of membrane fusion , Journal of Cell Biology (2004) 164:79-88.
- F. Paumet, La fusion cellulaire , Médecine/Science, (2003) 6-7:663-4
- T. Galli and F. Paumet, Exocytosis and endocytosis in neurons In: The Encyclopedia of Neuroscience, 3rd Ed. (Web). (2003) Adelman G, Smith BH, Editors. Amsterdam/New York: Elsevier Science.
- *T. Galli and F. Paumet, Du trafic dans les neurones , Pour la Science, (2002) 302: 66-73
- T. Galli, S. Martinez-Arca, F. Paumet Mécanisme de la fusion membranaire , Médecine/Science, (2002) 18:1113-9
- U. Blank, B. Cyprien, S. Martin-Verdeaux, F. Paumet, I. Pombo, J. Rivera, M. Roa and N. Varin-Blank SNAREs and associated regulators in the control of exocytosis in the RBL-2H3 mast cell line , Molecular Immunology, (2002) 1156: 1-5
- F. Paumet, B. Brügger, F. Parlati, JA. McNew, TH. Söllner, JE. Rothman "A t-SNARE of the endocytic pathway must be activated for fusion", Journal of Cell Biology, (2001) 155: 961-8
- JA. McNew, F. Parlati, R. Fukuda, RJ. Johnston, K. Paz, F. Paumet, TH. Söllner, JE. Rothman "Compartmental specificity of cellular membrane fusion encoded in SNARE proteins", Nature, (2000) 407: 153-9
- F. Paumet, J. Le Mao, S. Martin, T. Galli, B. David, U. Blank, M. Roa, "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: Functional role of Syntaxin4 in exocytosis and identification of a VAMP8-containing secretory compartment" Journal of Immunology, (2000) 164: 5850-7
- M. Roa*, F. Paumet*, J. Le Mao, B. David, U. Blank (* co-first authorship), "Involvement of the ras-like GTPase rab3d in RBL-2H3 mast cell exocytosis following stimulation via high affinity IgE receptors (FcµRI)", Journal of Immunology, (1997) 159: 2815-23
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Individual Expertise profile of
Fabienne Paumet, Copyright © Fabienne Paumet.
Last Updated
by Fabienne Paumet : Friday, October 30, 2009 12:30:39 PM
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