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Thomas Jefferson University - Jianke Zhang, Ph.D.
Jianke Zhang, Ph.D.

Microbiology and Immunology
Thomas Jefferson University
Jefferson Medical College
Department of Microbiology and Immunology
Assistant Professor

Director, Flow Cytometry Facility
http://www.kcc.tju.edu/kcc/kccnew/research/resources/flowcytometry/index.htm

Mailing Address
233 S. 10th St. Room 731 BLSB
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-503-4559
Fax: 215-923-4153
jzhang@mail.jci.tju.edu
Expertise and Research Interests
apoptosis and proliferation signal transduction
Keywords
Immunology and Microbiology
Publications
  • Zhang, H., Hou, Y-J., Han, S-Y., Zhang, E. C., Huebner, K., and Zhang, J. 2009 Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells. Intl. Immunol. 21:691-703.

  • Imtiyaz, H. Z., Zhou, X., Zhang, H., Chen, D., Hu, T., and Zhang, J. 2009 The death domain of FADD is essential for embryonic development and lymphocyte proliferation. J. Biol. Chem. 284:9917-9926

  • Zhang, H., Rosenberg. S., Coffey, F., Manser, T., He, Y-W., Hardy, R. R., Zhang, J. 2008. A role for cFLIP in B cell proliferation and stress MAP kinase regulation. J. Immunol. 182(1):207-215.

  • Fernandes-Alnemri, T., Wu, J., Yu, J. W., Datta, P., Miller, B., Jankowski, W., Rosenberg, S., Zhang, J., Alnemri, E.S. 2007. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ. 14:1590-1604

  • Imtiyaz, H. Z., Rosenberg, S. Zhang, Y., Rahman, Z. S. M., Hou, Y-J., Manser, T., and Zhang, J. 2006. The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B Cells. J. Immunol. 176 6852-6861.

  • Tang, J., Qu, L., Zhang, J., Wang, W., Michaelson, J. S., Degenhardt, Y. Y., El-Deiry, W. S., and Yang, X. 2006. Critical role for Daxx in regulating Mdm2. Nature Cell Biol. 8:855-862.

  • Zhang, Y., Rosenberg, S., Wang, H., Imtiyaz, H. Z., Hou, Y. J., and Zhang, J. 2005. Conditional Fas-associated death domain protein (FADD):GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis. J. Immunol. 175:3033-3044.

  • Imtiyaz, H. Z., Zhang, Y., and Zhang, J. 2005. Structural requirements for signal-induced target binding of FADD determined by functional reconstitution of FADD deficiency. J. Biol. Chem. 280:31360-31367.

  • Shen, H. M., Lin, Y., Choksi S., Tran, J., Jin, T., Chang, L., Karin, M., Zhang, J., and Liu, Z. G. 2004. Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol. Cell. Biol. 24:5914-5922.

  • Li, W., Zhang, J., Yu, W., Liu, G., and Chen, Q. 2003. Expression of stage-specific genes during zygotic gene activation in preimplantation mouse embryos. Zoolog. Sci. 20:1389-1393.

  • Zhang, J., Kabra, N. H., Cado, D., Kang, C., and Winoto, A. 2001. FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery. J. Biol. Chem. 276:29815-29818.

  • Kabra, N. H., Kang, C., Hsing, L. C., Cado, D., Zhang, J., and Winoto, A. 2001. T-cell specific FADD-deficient mice: FADD is required for early T cell development. Proc. Natl. Acad. Sci. 98:6307-6312.

  • Kuang, A. A., Diehl, G. E., Zhang, J., and Winoto, A. 2000. FADD is required for DR4- and DR5-mediated apoptosis: Lack of TRAIL-induced apoptosis in FADD-deficient mouse embryonic fibroblasts. J. Biol. Chem. 275: 25065-25068.

  • Zhang, J., DeYoung, A., Kasler, H. G., Kabra, N. H., Kuang, A. A., Diehl, D., Sohn, S. J., Bishop, C., and Winoto, A. 1999. Receptor-mediated apoptosis in T lymphocytes. Cold Spring Harb. Symp. Quant. Biol. 64:363-371.

  • Zhang, J., Cado, D., Chen, A., Kabra, N. H., and Winoto, A. 1998. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392:296-300.

  • Zhang, J. and Winoto, A. 1996. A Mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-Induced apoptosis. Mol. Cell. Biol. 16:2756-2763.

  • Chan, F. K., Zhang, J., Cheng, L., Shapiro, D. N., and Winoto, A. 1995. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol. Cell. Biol. 15:2682-2688.

Individual Expertise profile of Jianke Zhang, Ph.D., Copyright © Jianke Zhang, Ph.D..
Last Updated by Jianke Zhang, Ph.D. : Thursday, May 28, 2009 9:03:14 AM



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