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Thomas Jefferson University - Richard R. Hardy, Ph.D.
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Richard R. Hardy, Ph.D.
Microbiology and Immunology
Thomas Jefferson University
Jefferson Medical College
Department of Microbiology and Immunology
Adjunct Research Professor
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Mailing Address
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Fox Chase Cancer Center, 333 Cottman Ave.
Philadelphia, Pennsylvania 19111
United States
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Expertise and Research Interests
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Research interests: the developmental immunology of B lymphocytes, including their generation from stem cells in fetal liver and bone marrow; the regulation of B cell development by pre-BCR and BCR signaling; the development of B cell subsets, including B-1 B cells, with relevance to autoimmunity and leukemia.
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Publications
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- Allman, D., Lindsley, R. C., DeMuth, W., Rudd, K., Shinton, S. A., and Hardy, R. R. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol 167: 6834-6840, 2001.
- Bichi, R., Shinton, S. A., Martin, E. S., Koval, A., Calin, G. A., Cesari, R., Russo, G., Hardy, R. R., and Croce, C. M. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Nat Acad Sci USA 99: 6955-6960, 2002.
- Hayakawa, K., M. Asano, S.A. Shinton, M. Gui, L.J. Wen, J. Dashoff, and R.R. Hardy. Positive selection of anti-Thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J Exp Med 197:87-99, 2003.
- Hardy, R.R. , Wei, C.-J., and Hayakawa, K. Selection during development of VH11+ B cells: A model for natural autoantibody-producing CD5+ B cells. Immunol Rev. 197:60-74, 2004.
- Maier, H., Ostraat, R., Gao, H., Fields, S., Shinton, S.A., Medina, K.L., Ikawa, T., Murre, C., Singh, H., Hardy, R.R., and Hagman, J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol 5:1069-1077, 2004.
- Wen, L., Brill-Dashoff, J., Shinton, S. A., Asano, M., Hardy, R. R., and Hayakawa, K. Evidence of marginal-zone B cell- positive selection in spleen. Immunity 23, 297-308, 2005.
- Wen, L., Shinton, S.A., Hardy, R.R., Hayakawa, K. Association of B-1 B cells with follicular dendritic cells in spleen. J. Immunol. 174:6918-6926, 2005.
- Rumfelt, L.L., Zhou, Y., Rowley, B.M., Shinton, S.A., and Hardy, R.R. Lineage specification and plasticity in CD19- early B cell precursors. J. Exp. Med. 203: 675-687, 2006.
- Hardy, R.R. 2006. B-1 B cells: development, selection, natural autoantibody and leukemia. Current Opinion in Immunology 18:547-555, 2006
- Hardy, R.R., Kincade, P.W., and Dorshkind, K. The protean nature of cells in the B lymphocyte lineage. Immunity 26:703-714, 2007.
- Rowley, B.M., Tang, L., Shinton, S.A., Hayakawa, K., and Hardy, R.R.. Autoreactive B-1 B Cells: Constraints on Natural Autoantibody B Cell Antigen Receptors. Journal of Autoimmunity 29:236-245, 2007.
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Individual Expertise profile of
Richard R. Hardy, Ph.D., Copyright © Richard R. Hardy, Ph.D..
Last Updated
by Richard Hardy, Ph.D. : Thursday, January 31, 2008 10:54:33 AM
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