University Home | Hospital | Pulse Employment | Contact Us | Search | News 
Thomas Jefferson University Search Jefferson
Jefferson Medical College Jefferson College of Graduate Studies Jefferson College of Health Professions
Menu

Thomas Jefferson University - David S. Strayer, M.D., Ph.D.
David S. Strayer, M.D., Ph.D.

Pathology, Anatomy and Cell Biology
Thomas Jefferson University
Jefferson Medical College
Department of Pathology
Anatomy & Cell Biology
Professor

Mailing Address
1020 Locust Street
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: (215) 503-1087
Fax: (215) 503-1156
David.Strayer@jefferson.edu
Qualifications
M.D., University of Chicago
Ph.D., University of Chicago
Keywords
Aids; Bioterrorism; Botulinum Toxin; Cell Biology; Cell Growth Regulation; Complementary Dna; Dna Footprinting; Gene Expression; Gene Induction Repression; Gene Therapy; Genetic Promoter Element; Genetics; Molecular Cloning; Nucleic Acid Sequence; Poxviruses; Site Directed Mutagenesis; Sv40; Tissue Cell Culture; Transcription Factor; Transfection; Tumor Suppressor Gene; Viral Genetics; Virology
Publications
  • Strayer DS; Hoek JB; Thomas AP; White MK. Cellular activation by Ca2+ release from stores in the endoplasmic reticulum but not by increased free Ca2+ in the cytosol. Biochemical Journal. 344 Pt 1: 39-46, 15 Nov 1999

  • Wali A; Strayer DS. Infection with vaccinia virus alters regulation of cell cycle progression. DNA and Cell Biology. 18(11): 837-43, Nov 1999

  • BouHamdan M; Duan LX; Pomerantz RJ; Strayer DS. Inhibition of HIV-1 by an anti-integrase single-chain variable fragment \(SFv\): delivery by SV40 provides durable protection against HIV-1 and does not require selection. Gene Therapy. 6(4): 660-6, Apr 1999

  • Wali A; Strayer DS. Comparative effects of virulent and avirulent poxviruses on cell cycle progression. Experimental and Molecular Pathology. 66(1): 31-8, Apr 1999

  • Korutla L; Strayer DS. SP-A as a cytokine: surfactant protein-A-regulated transcription of surfactant proteins and other genes. Journal of Cell Physiology. 178(3): 379-86, Mar 1999

  • Zern MA; Ozaki I; Duan L; Pomerantz R; Liu SL; Strayer DS. A novel SV40-based vector successfully transduces and expresses an alpha 1-antitrypsin ribozyme in a human hepatoma-derived cell line. Gene Therapy. 6(1): 114-20, Jan 1999

  • Kondo R; Feitelson MA; Strayer DS. Use of SV40 to immunize against hepatitis B surface antigen: implications for the use of SV40 for gene transduction and its use as an immunizing agent. Gene Therapy. 5(5): 575-82, May 1998

  • Milano J Jr;Strayer D S. Effects of overexpression of Ran/TC4 mammalian cells in vitro. Experimental Cell Research. 239(1): 31-9, 25 Feb 1998

  • Herting E;Strayer D S;Jarstrand C;Sun B;Robertson B. Lung function and bacterial proliferation in experimental neonatal pneumonia in ventilated rabbits exposed to monoclonal antibody to surfactant protein A. Lung. 176(2): 123-31, 1998

  • Strayer D S;Schwarting R. Recognition of normal, neoplastic, and fetal airway epithelial cell membranes by two monoclonal antibodies. Human Pathology. 28(7): 840-6, Jul 1997

  • Strayer D S;Kondo R;Milano J;Duan L X. Use of SV40-based vectors to transduce foreign genes to normal human peripheral blood mononuclear cells. Gene Therapy. 4(3): 219-25, Mar 1997

  • Strayer D S;Duan L X;Ozaki I;Milano J;Bobraski L E;Bagasra O. Titering replication-defective virus for use in gene transfer. Biotechniques. 22(3): 447-50, Mar 1997

  • Strayer D S;Korutla L;Thomas A P. Surfactant protein-A receptor-mediated inhibition of calcium signaling in alveolar type II cells. Receptors and Signal Transduction. 7(2): 111-20, 1997

  • Strayer D S. SV40 as an effective gene transfer vector in vivo. Journal of Biological Chemistry. 271(40): 24741-6, 4 Oct 1996

  • Wali A;Strayer D S. Regulation of p53 gene expression by a poxviral transcription factor. Virology. 224(1): 63-72, 1 Oct 1996

  • Strayer D S;Pinder R;Chander A. Receptor-mediated regulation of pulmonary surfactant secretion. Experimental Cell Research. 226(1): 90-7, 10 Jul 1996

  • Strayer D S;Milano J. SV40 mediates stable gene transfer in vivo. Gene Therapy. 3(7): 581-7, Jul 1996

  • Strayer D S;Herting E;Sun B;Robertson B. Antibody to surfactant protein A increases sensitivity of pulmonary surfactant to inactivation by fibrinogen in vivo. American Journal of Respiratory and Critical Care Medicine. 153(3): 1116-22, Mar 1996

  • Luzi P;Anceschi M;Strayer D S. The upstream region of the SP-B gene: intrinsic promoter activity and glucocorticoid responsiveness related to a new DNA-binding protein. Gene. 165(2): 285-90, 20 Nov 1995

  • Luzi P;Anceschi M;Strayer D S. Glucocorticoid responsiveness conferred by a cloned DNA binding protein. Receptor. 5(2): 93-103, 1 Jul 1995

  • Luzi P;Strayer D S. DNA binding proteins that amplify surfactant protein B gene expression: isolation and characterization. Biochemical and Biophysical Research Communications. 208(1): 153-60, 8 Mar 1995

  • Strayer D S;Merritt T A;Hallman M. Levels of SP-A-anti-SP-A immune complexes in neonatal respiratory distress syndrome correlate with subsequent development of bronchopulmonary dysplasia. Acta Paediatrica. 84(2): 128-31, Feb 1995

  • Strayer D S. The viruses don't always read the books: engineered vaccines and gene therapy using viral vectors [editorial]. Laboratory Investigation. 71(3): 319-23, Sep 1994

  • Spragg R G;Gilliard N;Richman P;Smith R M;Hite R D;Pappert D;Robertson B;Curstedt T;Strayer D. Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome [see comments]. Chest. 105(1): 195-202, Jan 1994

  • Strayer D S. Effect of virus infection on levels of transcripts for cellular genes. Virus Research. 30(3): 259-69, Dec 1993

  • Strayer D S;Yang S;Schwartz M S. Epidermal growth factor-like growth factors. I. Breast malignancies and other epithelial proliferations in transgenic mice. Laboratory Investigation. 69(6): 660-73, Dec 1993

  • Strayer D S;Yang S;Jerng H H. Surfactant protein A-binding proteins. Characterization and structures. Journal of Biological Chemistry. 268(25): 18679-84, 5 Sep 1993

  • Strayer D S;Mathew J. A 34-kd protein with strong homology to ras-like proteins inhibits epidermal growth factor activity. American Journal of Pathology. 142(4): 1141-53, Apr 1993

  • Strayer D S;Jerng H H. Sequence and analysis of the BamHI "D" fragment of Shope fibroma virus: comparison with similar regions of related poxviruses. Virus Research. 25(1-2): 117-32, 1 Sep 1992

  • Strayer D S;Robertson B. Surfactant as an immunogen: implications for therapy of respiratory distress syndrome. Acta Paediatrica. 81(5): 446-7, May 1992

  • Robertson B;Curstedt T;Tubman R;Strayer D;Berggren P;Kok J;Koppe J;van Sonderen L;Halliday H;McClure G;et al. A 2-year follow up of babies enrolled in a European multicentre trial of porcine surfactant replacement for severe neonatal respiratory distress syndrome. Collaborative European Multicentre Study Group. European Journal of Pediatrics. 151(5): 372-6, May 1992

  • Strayer D S. Determinants of virus-related suppression of immune responses as observed during infection with an oncogenic poxvirus. Progress In Medical Virology. 39: 228-55, 1992

  • Strayer D S. Applications of anti-curosurf antibodies to understanding the biology of alveolar surfactant. Biology of The Neonate. 61 Suppl 1: 2-14, 1992

  • Strayer D S;Jerng H H;O'Connor K. Sequence and analysis of a portion of the genomes of Shope fibroma virus and malignant rabbit fibroma virus that is important for viral replication in lymphocytes. Virology. 185(2): 585-95, Dec 1991

  • Eijking E P;Strayer D S;van Daal G J;Tenbrinck R;Merritt T A;Hannappel E;Lachmann B. In vivo and in vitro inactivation of bovine surfactant by an anti-surfactant monoclonal antibody. European Respiratory Journal. 4(10): 1245-50, Nov 1991

  • Strayer D S. Identification of a cell membrane protein that binds alveolar surfactant. American Journal of Pathology. 138(5): 1085-95, May 1991

  • Strayer D S;Hallman M;Merritt T A. Immunogenicity of surfactant. II. Porcine and bovine surfactants. Clinical and Experimental Immunology. 83(1): 41-6, Jan 1991

  • Strayer D S;Hallman M;Merritt T A. Immunogenicity of surfactant. I. Human alveolar surfactant. Clinical and Experimental Immunology. 83(1): 35-40, Jan 1991

  • Eijking E P;Strayer D S;van Daal G J;Lachmann B. Effects of antisurfactant antibodies on the course of mild respiratory distress syndrome. Pathobiology. 59(2): 96-101, 1991

  • Strayer D S;Laybourn K A;Heard H K. Determinants of the ability of malignant fibroma virus to induce immune dysfunction and tumor dissemination in vivo. Microbial Pathogenesis. 9(3): 173-89, Sep 1990

  • Laybourn K A;Hiserodt J C;Hunt J M;Sell S;Strayer D S. Natural cell-mediated immunity in the rabbit. Cellular Immunology. 129(2): 519-27, Sep 1990

  • Heard H K;O'Connor K;Strayer D S. Molecular analysis of immunosuppression induced by virus replication in lymphocytes. Journal of Immunology. 144(10): 3992-9, 15 May 1990
Community of Science Profile Link
View COS profile: http://myprofile.cos.com/strayerd14

Individual Expertise profile of David S. Strayer, M.D., Ph.D., Copyright © David S. Strayer, M.D., Ph.D..
Last Updated by Admin : Tuesday, December 30, 2008 2:28:44 PM



Maintained by Jerome Buescher
Copyright © Thomas Jefferson University. All Rights Reserved.

 Printable Version

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement.
Thomas Jefferson University