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Thomas Jefferson University - Masahiro Iwamoto, D.D.S., Ph.D
Masahiro Iwamoto, D.D.S., Ph.D

Orthopaedic Surgery
Thomas Jefferson University
Jefferson Medical College
Department of Orthopaedic Surgery
Associate Professor
Appointed: 2002
Mailing Address
1015 Walnut St. Curtis 501
Philadelphia, Pennsylvania 19107
United States
Contact Information
Phone: 215-955-4076
Fax: 215-955-9159
Masahiro.Iwamoto@jefferson.edu
Qualifications
D.D.S., Tokushima University, School of Dental Medicine, 1984

Ph.D., Osaka University, Graduate School of Dentistry, 1988
Expertise and Research Interests
During embryogenesis, chondrocytes at the epiphyseal tip of long bone models give rise to articular tissue and persist through life, whereas chondrocytes in the shaft undergo hypertrophy, mineralization and apoptosis and are replaced by bone cells. It is not understood how chondrocytes undertake these alternative pathways and fates. We have been reported that C-1-1, a novel isoform of chick ets-related gene (ERG) is preferentially expressed in articular cartilage and its expression is down-regulated during maturation of chondrocytes. Over-expression of C-1-1 not only inhibits maturation of chondrocytes but also converts type X collagen positive trangient chondrocytes to tenascin-C positive permanent articular chondrocytes like cells. In developing mouse skeleton, ERG is highly expressed in future joint region and surface zone of articular cartilage. Those findings suggest that ERG plays an important role in permanent articular cartilage formation. We are studying mechanism of action, regulation of expression, interaction and interplay with other signaling factors, and the effect of down-regulation of ERG in chondrocytes.
Languages
English
Japanese
Publications
  • Kato, Y., M. Iwamoto, T. Koike, and F. Suzuki. Effect of vanadate on cartilage-matrix proteoglycan synthesis in rabbit costal chondrocyte cultures. J Cell Biol 104:311-319, 1987

  • Kato, Y., M. Iwamoto, and T. Koike. Fibroblast growth factor stimulates colony formation of differentiated chondrocytes in soft agar. J Cell Physiol 133:491-498, 1987

  • Kato, Y., M. Iwamoto, T. Koike, F. Suzuki, and Y. Takano. Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: regulation by transforming growth factor beta and serum factors. Proc Natl Acad Sci U S A 85:9552-9556, 1988

  • Kato, Y., T. Koike, M. Iwamoto, M. Kinoshita, K. Sato, Y. Hiraki, and F. Suzuki. Effects of limited exposure of rabbit chondrocyte cultures to parathyroid hormone and dibutyryl adenosine 3'',5''-monophosphate on cartilage-characteristic proteoglycan synthesis. Endocrinology 122:1991-1997, 1988

  • Kato, Y., M. Iwamoto, K. Nakashima, K. Sato, W. Yan, and T. Koike. Rabbit articular chondrocytes in soft agar are useful to test the effect of non-steroidal anti-inflammatory drugs on chondrocyte replication. Scand J Rheumatol Suppl. 77:3-6, 1988

  • Kato, Y., K. Sato, T. Koike, K. Nakashima, W.Q. Yan, A. Shimazu, and M. Iwamoto. Effects of antiinflammatory drugs on soft agar growth of rabbit articular chondrocytes. Semin Arthritis Rheum. 18:7-10, 1989

  • Inoue, H., Y. Kato, M. Iwamoto, Y. Hiraki, M. Sakuda, and F. Suzuki. Stimulation of cartilage-matrix proteoglycan synthesis by morphologically transformed chondrocytes grown in the presence of fibroblast growth factor and transforming growth factor-beta. J Cell Physiol 138:329-337, 1989

  • Iwamoto, M., K. Sato, K. Nakashima, A. Shimazu, and Y. Kato. Hypertrophy and calcification of rabbit permanent chondrocytes in pelleted cultures: synthesis of alkaline phosphatase and 1,25- dihydroxycholecalciferol receptor. Dev Biol 136:500-507, 1989

  • Iwamoto, M., K. Sato, K. Nakashima, H. Fuchihata, F. Suzuki, and Y. Kato. Regulation of colony formation of differentiated chondrocytes in soft agar by transforming growth factor-beta. Biochem Biophys Res Commun 159:1006-1011, 1989

  • Owada, M.K., M. Iwamoto, T. Koike, and Y. Kato. Effects of vanadate on tyrosine phosphorylation and the pattern of glycosaminoglycan synthesis in rabbit chondrocytes in culture. J Cell Physiol 138:484-492, 1989

  • Iwamoto, M., T. Koike, K. Nakashima, K. Sato, and Y. Kato. Interleukin 1: a regulator of chondrocyte proliferation. Immunol Lett 21:153-156, 1989

  • Kato, Y., A. Shimazu, K. Nakashima, F. Suzuki, A. Jikko, and M. Iwamoto. Effects of parathyroid hormone and calcitonin on alkaline phosphatase activity and matrix calcification in rabbit growth-plate chondrocyte cultures. Endocrinology 127:114-118, 1990

  • Yan, W.Q., K. Nakashima, M. Iwamoto, and Y. Kato. Stimulation by concanavalin A of cartilage-matrix proteoglycan synthesis in chondrocyte cultures. J Biol Chem. 265:10125-10131, 1990

  • Sato, K., M. Iwamoto, K. Nakashima, F. Suzuki, and Y. Kato. 1 alpha,25-dihydroxyvitamin D3 stimulates colony formation of chick embryo chondrocytes in soft agar. Exp Cell Res 187:335-338, 1990

  • Kato, Y., and M. Iwamoto. Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation. J Biol Chem. 265:5903-5909, 1990

  • Koike, T., M. Iwamoto, A. Shimazu, K. Nakashima, F. Suzuki, and Y. Kato. Potent mitogenic effects of parathyroid hormone (PTH) on embryonic chick and rabbit chondrocytes. Differential effects of age on growth, proteoglycan, and cyclic AMP responses of chondrocytes to PTH. J Clin Invest 85:626-631, 1990

  • Kato, Y., A. Shimazu, M. Iwamoto, K. Nakashima, T. Koike, F. Suzuki, Y. Nishii, and K. Sato. Role of 1,25-dihydroxycholecalciferol in growth-plate cartilage: inhibition of terminal differentiation of chondrocytes in vitro and in vivo. Proc Natl Acad Sci U S A 87:6522-6526, 1990

  • Inoue, H., K. Hiasa, Y. Samma, O. Nakamura, M. Sakuda, M. Iwamoto, F. Suzuki, and Y. Kato. Stimulation of proteoglycan and DNA syntheses in chondrocytes by centrifugation. J Dent Res 69:1560-1563, 1990

  • Kato, Y., K. Nakashima, K. Sato, W. Yan, M. Iwamoto and F. Suzuki. Purification of growth factors from cartilage. Methods Enzymol 198: 416-424, 1991

  • Iwamoto, M., A. Shimazu, K. Nakashima, F. Suzuki, and Y. Kato. Reduction of basic fibroblasts growth factor receptor is coupled with terminal differentiation of chondrocytes. J Biol Chem. 266:461-467, 1991

  • Pacifici, M., E.B. Golden, M. Iwamoto, and S.L. Adams. Retinoic acid treatment induces type X collagen gene expression in cultured chick chondrocytes. Exp Cell Res 195:38-46, 1991

  • Shimazu, A., A. Jikko, M. Iwamoto, T. Koike, W. Yan, Y. Okada, M. Shinmei, S. Nakamura, and Y. Kato. Effects of hyaluronic acid on the release of proteoglycan from the cell matrix in rabbit chondrocyte cultures in the presence and absence of cytokines. Arthritis Rheum. 36:247-253, 1993

  • Kato, Y., K. Nakashima, M. Iwamoto, H. Murakami, H. Hiranuma, T. Koike, F. Suzuki, H. Fuchihata, Y. Ikehara, M. Noshiro, and et al. Effects of interleukin-1 on syntheses of alkaline phosphatase, type X collagen, and 1,25-dihydroxyvitamin D3 receptor, and matrix calcification in rabbit chondrocyte cultures. J Clin Invest 92:2323-2330, 1993

  • Iwamoto, M., K. Yagami, P. Lu Valle, B.R. Olsen, C.J. Petropoulos, D.L. Ewert, and M. Pacifici. Expression and role of c-myc in chondrocytes undergoing endochondral ossification. J Biol Chem. 268:9645-9652, 1993

  • Iwamoto, M., I.M. Shapiro, K. Yagami, A.L. Boskey, P.S. Leboy, S.L. Adams, and M. Pacifici. Retinoic acid induces rapid mineralization and expression of mineralization-related genes in chondrocytes. Exp Cell Res 207:413-420, 1993

  • Iwamoto, M., E.B. Golden, S.L. Adams, S. Noji, and M. Pacifici. Responsiveness to retinoic acid changes during chondrocyte maturation. Exp Cell Res 205:213-224, 1993

  • Pacifici, M., M. Iwamoto, E.B. Golden, J.L. Leatherman, Y.S. Lee, and C.M. Chuong. Tenascin is associated with articular cartilage development. Dev Dyn 198:123-134, 1993

  • Jikko, A., T. Aoba, H. Murakami, Y. Takano, M. Iwamoto, and Y. Kato. Characterization of the mineralization process in cultures of rabbit growth plate chondrocytes. Dev Biol 156:372-380, 1993

  • Asakai, R., K. Tamura, Y. Eishi, M. Iwamoto, Y. Kato, and R. Okamoto. Basic fibroblast growth factor (bFGF) receptors decrease with luteal age in rat ovarian luteal cells: colocalization of bFGF receptors and bFGF in luteal cells. Endocrinology 133:1074-1084, 1993

  • Lu Valle, P., M. Iwamoto, P. Fanning, M. Pacifici, and B.R. Olsen. Multiple negative elements in a gene that codes for an extracellular matrix protein, collagen X, restrict expression to hypertrophic chondrocytes. J Cell Biol 121:1173-1179, 1993

  • Iwamoto, M., K. Yagami, I.M. Shapiro, P.S. Leboy, S.L. Adams, and M. Pacifici. Retinoic acid is a major regulator of chondrocyte maturation and matrix mineralization. Microsc Res Tech. 28:483-491, 1994

  • Shapiro, I.M., K. Debolt, M. Hatori, M. Iwamoto, and M. Pacifici. Retinoic acid induces a shift in the energetic state of hypertrophic chondrocytes.

  • J Bone Miner Res 9:1229-1237, 1994

  • Iwamoto, M., A. Jikko, H. Murakami, A. Shimazu, K. Nakashima, M. Takigawa, H. Baba, F. Suzuki, and Y. Kato. Changes in parathyroid hormone receptors during chondrocyte cytodifferentiation. J Biol Chem. 269:17245-17251, 1994

  • Takebayashi, T., M. Iwamoto, A. Jikko, T. Matsumura, M. Enomoto-Iwamoto, F. Myoukai, E. Koyama, T. Yamaai, K. Matsumoto, T. Nakamura, and et al. Hepatocyte growth factor/scatter factor modulates cell motility, proliferation, and proteoglycan synthesis of chondrocytes. J Cell Biol 129:1411-1419, 1995

  • Iwamoto, M., A. Shimazu, and M. Pacifici. 1995. Regulation of chondrocyte maturation by fibroblast growth factor-2 and parathyroid hormone. J Orthop Res 13:838-845, 1995

  • Kawakami, Y., T. Ishikawa, M. Shimabara, N. Tanda, M. Enomoto-Iwamoto, M. Iwamoto, T. Kuwana, A. Ueki, S. Noji, and T. Nohno. BMP signaling during bone pattern determination in the developing limb. Development 122:3557-3566, 1996

  • Hiranuma, H., A. Jikko, T. Maeda, S. Matsumura, A. Deguchi, A. Hayami, M. Iwamoto, K. Kurisu, A. Asada and H. Fuchihata. Changes in radiation sensitivity of cultured growth plate chondrocytes during cytodifferentiation. Oral Radiol 12:19-25, 1996

  • Tabata, M.J., K. Kim, J.G. Liu, K. Yamashita, T. Matsumura, J. Kato, M. Iwamoto, S. Wakisaka, K. Matsumoto, T. Nakamura, M. Kumegawa, and K. Kurisu. Hepatocyte growth factor is involved in the morphogenesis of tooth germ in murine molars. Development 122:1243-1251, 1996

  • Hiranuma, H., A. Jikko, M. Iwamoto, and H. Fuchihata. Effects of X-ray irradiation on terminal differentiation and cartilage matrix calcification of rabbit growth plate chondrocytes in culture. Bone. 18:233-238, 1996

  • Jikko, A., H. Hiranuma, M. Iwamoto, Y. Kato, Y. Okada, and H. Fuchihata. Effects of X irradiation on metabolism of proteoglycans. Radiat Res 146:93-99, 1996

  • Aikawa, T., K. Shirasuna, M. Iwamoto, K. Watatani, T. Nakamura, M. Okura, H. Yoshioka, and T. Matsuya. Establishment of bone morphogenetic protein 2 responsive chondrogenic cell line. J Bone Miner Res 11:544-553, 1996

  • Kinto, N., M. Iwamoto, M. Enomoto-Iwamoto, S. Noji, H. Ohuchi, H. Yoshioka, H. Kataoka, Y. Wada, G. Yuhao, H.E. Takahashi, S. Yoshiki, and A. Yamaguchi. Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation. FEBS Lett 404:319-323, 1997

  • Enomoto-Iwamoto, M., M. Iwamoto, K. Nakashima, Y. Mukudai, D. Boettiger, M. Pacifici, K. Kurisu, and F. Suzuki. Involvement of alpha5beta1 integrin in matrix interactions and proliferation of chondrocytes. J Bone Miner Res 12:1124-1132, 1997

  • Nakamura, T., T. Aikawa, M. Iwamoto-Enomoto, M. Iwamoto, Y. Higuchi, M. Pacifici, N. Kinto, A. Yamaguchi, S. Noji, K. Kurisu, T. Matsuya, and P. Maurizio. Induction of osteogenic differentiation by hedgehog proteins. Biochem Biophys Res Commun 237:465-469, 1997

  • Liu, J.G., M.J. Tabata, K. Yamashita, T. Matsumura, M. Iwamoto, and K. Kurisu. Developmental role of PTHrP in murine molars. Eur J Oral Sci. 106 Suppl 1:143-146, 1998

  • Jikko, A., T. Wakisaka, M. Iwamoto, H. Hiranuma, Y. Kato, T. Maeda, M. Fujishita, and H. Fuchihata. Effects of interleukin-6 on proliferation and proteoglycan metabolism in articular chondrocyte cultures. Cell Biol Intl 22: (9-10) 615-621, 1998

  • Enomoto-Iwamoto, M., M. Iwamoto, Y. Mukudai, Y. Kawakami, T. Nohno, Y. Higuchi, S. Takemoto, H. Ohuchi, S. Noji, and K. Kurisu. Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes. J Cell Biol 140:409-418, 1998

  • Jikko, A., K. Yamashita, M. Iwamoto, H. Hiranuma, T. Takebayashi, T. Maeda, M. Sakuda, K. Matsumoto, T. Nakamura, M. Enomoto-Iwamoto, M. J. Tabata, H. Fuchihata and K. Kurisu. The role of hepatocyte growth factor in growth plate cartilage. J Bone Miner. Metab. 16:170-177, 1998

  • Soma, S., M. Iwamoto, Y. Higuchi and K. Kurisu. Effects of continuous infusion of PTH on experimental tooth movement in rats. J Bone Miner Res 14:546-554, 1998

  • Yagami, K., J. Y. Suh, M. Emonoto-Iwamoto, E. Koyama, I.M. Shapiro, W. R. Abrams, M. Pacifici, and M. Iwamoto. Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. J Cell Biol 147: 1097-1108, 1999

  • Enomoto, H., M. Enomoto-Iwamoto, M. Iwamoto, S. Nomura, M. Himeno, Y. Kitamura,T. Kishimoto and T. Komori. Cbfa1 is a positive regulatory factor in chondrocyte maturation. J Biol Chem 275: 8695-8702, 2000

  • Liu, J., M. J. Tabata, T. Fujii, T. Ohmori, M. Abe, Y. Ohsaki, J. Kato, S.

  • Wakisaka, M. Iwamoto and K. Kurisu. Parathyroid hormone-related peptide is involved in protection against invasion of tooth germs by bone via promoting the differentiation of osteoclasts during tooth development. Mech Dev 95: 189-200, 2000

  • Iwamoto, M., Y. Higuchi, E. Koyama, M. Enomoto-Iwamoto, K. Kurisu, H. Yeh, W. R.Abrams, J. Rosenbloom and M. Pacifici. Transcription factor ERG variants and functional diversification of chondrocytes during limb long bone development. J Cell Biol 150: 27-40, 2000

  • Enomoto-Iwamoto, M., T. Nakamura, T. Aikawa, Y. Higuchi, T. Yuasa, A. Yamaguchi, T. Nohno, S. Noji, T. Matsuya, K. Kurisu, E. Koyama, M. Pacifici, and M. Iwamoto. Hedgehog Proteins Stimulate Chondrogenic Cell Differentiation and Cartilage Formation.

  • J Bone Miner Res. 15, 1659-1668, 2000

  • Soma, S., S. Matsumoto, Y. Higuchi, T. Takano-Yamamoto, K. Yamashita, K. Kurisu and M. Iwamoto. Local and chronic application of PTH accelerates tooth movement in rats. J Dent Res 79, 1717-1724, 2000

  • Ueta, C., M. Iwamoto, N. Kanatani, C. Yoshida, Y. Liu, M. Enomoto-Iwamoto, T. Ohmori, H. Enomoto, K. Nakata, K. Takada, K. Kurisu and T. Komori. Skeletal malformations caused by overexpression of Cbfa-1 or its dominant negetive form in chondrocytes. J Cell Biol 153, 87-99, 2001

  • Koyama, E., C. Wu, T. Shimo, M. Iwamoto, T. Ohmori, K. Kurisu, T. Ookura, M. M. Bashir, W. R. Abrams, T. Tucker and M. Pacifici. Development of stratum intermedium and its role as a Sonic hedgehog-signaling structure during odontogenesis. Dev Dyn 222,178-191, 2001

  • Enomoto-Iwamoto M, Kitagaki J, Koyama E, Tamamura Y, Wu C, Kanatani N, Koike T, Okada H, Komori T, Yoneda T, Church V, Francis-West PH, Kurisu K, Nohno T, Pacifici M, Iwamoto M. The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis.

  • Dev Biol. 1;251(1):142-56, 2002

  • Tabata MJ, Fujii T, Liu JG, Ohmori T, Abe M, Wakisaka S, Iwamoto M, Kurisu K. Bone morphogenetic protein 4 is involved in cusp formation in molar tooth germ of mice. Eur J Oral Sci. 110(2):114-20, 2002

  • Yuasa T, Kataoka H, Kinto N, Iwamoto M, Enomoto-Iwamoto M, Iemura S, Ueno N, Shibata Y, Kurosawa H, Yamaguchi A. Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2. J Cell Physiol. 193(2):225-32, 2002

  • Kitagaki J, Iwamoto M, Liu JG, Tamamura Y, Pacifci M, Enomoto-Iwamoto M. Activation of beta-catenin-LEF/TCF signal pathway in chondrocytes stimulates ectopic endochondral ossification. Osteoarthritis Cartilage. 11(1):36-43, 2003

  • Iwamoto M, Kitagaki J, Tamamura Y, Gentili C, Koyama E, Enomoto H, Komori T, Pacifici M, Enomoto-Iwamoto M. Runx2 expression and action in chondrocytes are regulated by retinoid signaling and parathyroid hormone-related peptide (PTHrP). Osteoarthritis Cartilage. 11(1):6-15, 2003

  • Shibaguchi T, Kato J, Abe M, Tamamura Y, Tabata MJ, Liu JG, Iwamoto M, Wakisaka S, Wanaka A, Kurisu K. Expression and role of Lhx8 in murine tooth development. Arch Histol Cytol. 66(1):95-108, 2003

  • Yamada K, Inui K, Iwamoto M, Nakamura H, Tsujio T, Konishi S, Ito Y, Takaoka K, Koike T. High serum levels of menatetrenone in male patients with ossification of the posterior longitudinal ligament. Spine. 28(16):1789-93, 2003

  • Shimo T, Gentili C, Iwamoto M, Wu C, Koyama E, Pacifici M. Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis. Dev Dyn. 229(3):607-17, 2004

  • Shimo T, Kanyama M, Wu C, Sugito H, Billings PC, Abrams WR, Rosenbloom J, Iwamoto M, Pacifici M, Koyama E. Expression and roles of connective tissue growth factor in Meckel''s cartilage development. Dev Dyn. 231(1):136-47, 2004

  • Enomoto H, Furuichi T, Zanma A, Yamana K, Yoshida C, Sumitani S, Yamamoto H, Enomoto-Iwamoto M, Iwamoto M, Komori T. Runx2 deficiency in chondrocytes causes adipogenic changes in vitro. J Cell Sci. 117(Pt 3):417-25, 2004

  • Iwamoto M, Koyama E, Enomoto-Iwamoto M, Pacifici M The balancing act of trascription factors C-1-1 and Runx2 in articular cartilage development. Biochem Biophys Res Commun 328: 777-782, 2005

  • Tamamura Y, Otani T, Kanatani N, Koyama E, Kitagaki J, Komori T, Yamada Y, Costantini F, Wakisaka S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M.

  • Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem. 280(19):19185-95, 2005

  • Young, B., Minugh-Purvis, N., Shimo, T., St-Jacques, B., Iwamoto, M., & Enomoto-Iwamoto, M. et al. Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function. Developmental Biology, 299(1), 272-282, 2006

  • Koyama, E., Blanche, Y., Nagayama, M., Shibukawa, Y., Enomoto-Iwamoto, M., Iwamoto, M., Maeda, Y., Lanske, B., Song, B., Serra, R., Pacifici, M. Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development 134, 2159-2169, 2007

  • Iwamoto, M., Tamamura, Y., Koyama, E., Komori, T., Takeshita, N., & Williams, J. A. et al. Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis. Developmental Biology, 305(1), 40-51, 2007

  • Review articles:

  • Iwamoto, M., M. Enomoto-Iwamoto and K. Kurisu. Actions of Hedgehog Proteins on Skeletal Cells. Critic. Rev. Oral Biol. Med. 10: 477-486, 1999

  • Pacifici, M., E. Koyama, M. Iwamoto and C. Gentili. Development of articular cartilage: What do we know about it and how may it occur? Connective Tissue Res, 41, 175-184, 2000

  • Pacifici M, Shimo T, Gentili C, Kirsch T, Freeman TA, Enomoto-Iwamoto M, Iwamoto M, Koyama E. Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis.

  • J Bone Miner Metab. 23(3):191-9, 2005

  • Pacifici M, Koyama E, Iwamoto M. Mechanisms of synovial joint and articular cartilage formation: recent advances, but many lingering mysteries. Birth Defects Res C Embryo Today 75(3):237-248, 2005

  • Motomi Enomoto-Iwamoto, Tomohiro Otani, Tatsuya Koike and Masahiro Iwamoto Wnt/²-Catenin Signaling in Chondrocyte Function and Cartilage Matrix Disruption Pp. 31-38

  • Current Rheumatology Reviews Volume 2, Number 1, February 2006

  • Proceedings and a chapter of book:

  • Suzuki, F., M. Takigawa, T. Takano-Yamamoto, Y. Hiraki, N. Endo, Y. Kato, M. Silbermann, M. Iwamoto, A. Asada. Cytochemical and biological approaches to masticatory system. Mechanobiological Research on the Masticatory System. Ed. K. Kubota, VEB Verlage fur mMedizin und Biologie, Berlin, 194-199, 1989

  • Koike, T., Y. Kato, M. Iwamoto, F. Suzuki. Parathyroid hormone stimulates colony formation of chick embryo chondrocytes in soft agar. in New actions of parathyroid hormone. Ed. S. G. Massery, Plenum Publishing Corporation, New York, 59-63, 1990

  • Inoue, H., J. Kato, M. Sakuda, M. Iwamoto, F. Suzuki, Y. Kato. Effects of mechanical forces on proliferation of rabbit growth-plate and articular chondrocytes and their extracellular synthesis in pelleted cultures. in Fundamentals of bone growth: Methodology and applications. Ed. A. D. Dixon et al. CRC Press, 407-415, 1991

  • LuValle, P. L. , O. Jacenco, M. Iwamoto, M. Pacifici, B. R. Olsen. From cartilage to bone-the role of collagenous proteins in Molecular basis of morphogenesis, Wiley-Liss, Inc, 189-205, 1993

  • Liu, J. G., M. J. Tabata, K. Yamashita, T. Matsumura, M. Iwamoto and K. Kurisu. Parathyroid hormone-related peptide (PTHrP) is essential in the development of murine molars. Acta Histochem. Cytochem. 29 Suppl.197-198, 1996

  • Maeda, T., K. Yamashita, S. Wakisaka, H. Fuchihata, M. Iwamoto and K. Kurisu. Application of freeze-transfer method to in situ hybridization assay. Acta Histochem. Cytochem. 29 Suppl.764-765, 1996

  • Enomoto-Iwamoto, M., H. Enomoto, T. Komori and M. Iwamoto. Participation of cbfa-1 in regulation of chondrocyte differentiation. Osteoarthritis and Cartilage 9, S76-84, 2001

  • Iwamoto, M., Y. Higuchi, M. Enomoto-Iwamoto, K. Kurisu, E. Koyama, H. Yeh, J. Rosenbloom and M. Pacifici. The role of erg ( ets related gene) in cartilage development. Osteoarthritis and Cartilage 9, S41-47, 2001

  • Motomi Enomoto-Iwamoto, Jirouta Kitagaki, Eiki Koyama, Yoshihiro Tamamura, Naoko Kanatani, Toshihisa Komori, Tsutomu Nohno, Maurizio Pacifici, and Masahiro Iwamoto. Dual roles of the Wnt antagonist,Frzb-1 in cartilage development. The Growth Plate. Edited by Irving M. Shapiro, Barbara Boyan, H. Clarke Anderson, IOS Press, Amsterdam:235-243, 2002

  • Pacifici M., Gentili C., Yin M., Iwamoto M., Enomoto-Iwamoto M., Abrams W. R., and Koyama E. Indian heddgehog and retinoids orchestrate multople growth plate functions in developing long bones: The growth plate as a highly interactive structure. The Growth Plate. Edited by Irving M. Shapiro, Barbara Boyan, H. Clarke Anderson, IOS Press, Amsterdam:1-17, 2002

  • Komori T., Iwamoto M., Kanatani N., Yoshida K., Enomoto-Iwamoto M and Ueta C. Involvement of cbfa1 in chondrocyte differentiation, maturation, endochondral ossification, and specification of the cartilage phenotype. The Growth Plate. Edited by Irving M. Shapiro, Barbara Boyan, H. Clarke Anderson, IOS Press, Amsterdam:19-23, 2002

  • Pacifici M, Koyama E and Iwamoto M.

  • Matrix gamma-carboxyglutamic acid protein regulated the chondrocyte phenotype. Molecular Biology in Orthopaedics. Edited by Randy N. Rosier and Christopher H. Evans, American Academy of Orthopaedic Surgeons 2003

  • Kanyama M, Shimo T, Changshan W, Sugito H, Iwamoto M, Pacifici M, Koyama E. 2005. Expression and roles of CCN2 during osteogenesis. CCN Proteins. Edited by Perbal B, Takigawa M. Imperial College Press, London: 81-94, 2005

  • Pacifici M, Koyama E, Shibukawa Y, Changshan Wu, Tamamura Y, Enomoto-Iwamoto E, Iwamoto M. Cellular and molecular mechanisms synovial joint and articular cartilage formation. Ann N.Y. Acad Sci. 2006 Apr;1068:74-86, 2006

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