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Thomas Jefferson University - Maurizio Pacifici, Ph.D.
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Maurizio Pacifici, Ph.D.
Orthopaedic Surgery
Thomas Jefferson University
Jefferson Medical College
Department of Orthopaedic Research
Professor
Director of Orthopaedic Research
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Mailing Address
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1015 Walnut Street, 501 Curtis Bldg.
Philadelphia, Pennsylvania 19107
United States
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Qualifications
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Dr. Pacifici received a PhD in Developmental Biology from the University of Rome. He received a European Molecular Biology Fellowship at the end of which he was appointed Assistant Professor at the University of Rome School of Medicine. He then joined the faculty at the University of Pennsylvania first in the School of Medicine and subsequently in the School of Dental Medicine where he rose to the rank of Professor in 1997. He joined the faculty of Thomas Jefferson University in 2004 as Professor in the Department of Orthopaedic Surgery where he is currently Director of Research. Dr. Pacificis biomedical research work has been funded continuously by the NIH for over 25 years. He has served and continues to serve on advisory boards, editorial boards and NIH study sections.
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Expertise and Research Interests
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Dr. Pacificis biomedical research work focuses on mechanisms controlling skeletal development and growth in fetal and postnatal life. Emphasis is on identification of molecular regulators acting at the nuclear level that direct commitment, determination and differentiation of progenitor skeletal cells. Aim is to target those regulators in gene- and drug-based therapies to repair and reconstruct skeletal tissues affected by pathologies, including osteoarthritis and congenital skeletal defects. Emphasis is also on signaling diffusible factors that normally act within developing skeletal elements to coordinate growth and morphogenesis. When these factors escape skeletal tissues and diffuse into adjacent non-skeletal tissues due to failure of restraining topographical mechanisms, they can trigger pathologies, including heterotopic ossification and multiple exostosis syndrome. Experimental therapies are being tested to restore normal factor-restraining mechanisms and block or reverse those pathologies.
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Publications
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- Pacifici, M., Koyama, E, Shibukawa, Y., Enomoto-Iwamoto, M., and Iwamoto, M. (2006). Cellular and molecular mechanisms of synovial joint and articular cartilage formation. In Skeletal Development and Remodeling , M. Zaidi, ed., Annu. N.Y. Acad. Sci. 1068, 74-86.
- Young, B., Minugh-Purvis, N., St-Jacques, B., Iwamoto, M., Enomoto-Iwamoto, M., Koyama, E., and Pacifici,M. (2006). Indian and Sonic hedgehog regulate synchondrosis growth plate and cranial base development and function. Dev. Biol. 299, 272-282
- Shibukawa, Y., Young, B., Wu, C., Yamada, S. Long, F., Pacifici, M., and Koyama, E. (2007).Temporo- mandibular joint formation and condylar growth require Indian hedgehog signaling. Dev. Dyn.236, 426-434
- Graziano, A., dquino, R., Cusella-De Angelis, M. G., Laino, G., Piattelli, A., Pacifici, M., De Rosa, A., and Papaccio, G. (2007). Concave pit-containing scaffold surfaces improve stem cell-derived osteoblast performance and lead to significant bone tissue formation. PLoS ONE 6, e496
- Iwamoto, M., Tamamura, Y., Koyama, E., Komori, T., Takeshita, N., Williams, J., Nakamura, T., Enomoto-Iwamoto, M., and Pacifici, M. (2007). Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis. Dev. Biol. 305, 40-51
- Koyama, E., Young, B., Shibukawa, Y., Nagayama, M., Enomoto-Iwamoto, M., Iwamoto, M., Maeda, Y.,Lanske, B., Song, B., Serra, R., and Pacifici, M. (2007). Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction and ectopic cartilage and bone formation in mouse cranial base synchondroses. Development 134, 2159-2169
- Koyama, E., Ochiai, T., Rountree, R. B., Kingsley, D. M., Enomoto-Iwamoto, M., Iwamoto, M., and Pacifici, M.(2007). Synovial joint formation during mouse limb skeletogenesis: Roles of Indian hedgehog signaling. Ann. N. Y. Acad. Sci. 1116, 100-112.
- Nagayama, M., Iwamoto, M., Hargett, A., Young, B., Takeuchi, H., Pacifici, M., Enomoto-Iwamoto, M., and Koyama, M. (2008). Organization and functioning of developing mouse cranial base synchondroses require Wnt/ ²-catenin signaling. J. Dent. Res. (in press).
- Koyama, E., Shibukawa, Y., Nagayama, M., Sugito, H., Young , B., Yuasa, T., Okabe, T., Rountree, R. B.,Kingsley, D. M., Iwamoto, M., Enomoto-Iwamoto, M., and Pacifici. M. (2008). A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. Dev. Biol. (in press)
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Individual Expertise profile of
Maurizio Pacifici, Ph.D., Copyright © Maurizio Pacifici, Ph.D..
Last Updated
by Maurizio Pacifici, Ph.D. : Wednesday, October 21, 2009 2:47:31 PM
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