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Thomas Jefferson University - Theresa A. Freeman, PHD
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Theresa A. Freeman, PHD
Orthopaedic Surgery
Thomas Jefferson University
Jefferson Medical College
Department of Orthopaedic Surgery
Assistant Professor
Faculty Member TERM Program
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Mailing Address
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501 Curtis Bldg., 1015 Walnut St.
Philadelphia, Pennsylvania 19107
United States
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Qualifications
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1980 - 83 BS University of the Sciences, Philadelphia, PA (Biology)
1992 - 95 MS Rutgers University, Camden, NJ (Biology)
1995 - 96 PhD Rutgers University/University of Medicine and Dentistry of NJ, New Brunswick, NJ (Biomedical Sciences)
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Expertise and Research Interests
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Initiating pathology of osteoarthritis; early factors involving vascular invasion of articular cartilage and subchondral bone remodeling in osteoarthritic progression.
Molecular mechanisms of Arthrofibrosis, an aberrant fibrotic response to total knee replacement surgery.
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Other Expertise
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Industry Associated Positions:
1997 - 2004 Applications Scientist, Phase 3 Imaging Systems, Inc., Glen Mills, PA
Memberships in Professional and Scientific Societies:
1994 - Present American Association for the Advancement of Science
2005 - Present American Society for Bone and Mineral Research
2006 - Present Orthopaedic Research Society
Teaching Experience:
1994 - 96 Comparative Anatomy, Lecture and Lab, Rutgers University, Course Coordinator
1996-97 Functional Histology, Jefferson College of Health Professions
1996 Assistant Professor; Department of Orthopaedic Surgery, Ph.D., Rutgers
1995-96 Histology Laboratory, UMDNJ-SOM
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Publications
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- Ravindra, R., Nagele, R., Patel, S., Freeman, T., (1994) Membrane-associated tubulin in the rat anterior pituitary and GH3 cells. Neuroreport, 5, pgs. 1653-1656
- Nagele, R., Freeman, T.**, McMorrow, L., Lee, H., (1995) Precise spatial positioning of chromosomes during prometaphase: Evidence for chromosomal order in human cells. Science, Vol. 270, pgs. 1831-1835
- Bals, R., Wang, X., Wu, Z., Freeman, T., Bafna, V., Zasloff, M., Wilson, J.M. (1998) Human Beta- Defensin 2 is a salt sensitive peptide antibiotic expressed in human lung. J. Clin. Invest., Vol. 102( 5)
- Nagele, R, Freeman, T., Fazekas, J., Lee, K., Tejera, Z., Lee, H., (1998) Chromosome Spatial Order in Human Cells: Evidence for Early Origin and Faithful Propagation. Chromosoma*, Vol. 102(5), pgs. 874-880
- Nagele, R, Freeman, T., McMorrow, L., Tejera, Z., Kitson-Wind, K., Lee, H., (1999) Chromosomes exhibit preferential positions in nuclei of quiescent Human cells that reflects their arrangement in mitotic chromosome rosettes. J. Cell Sci., Vol. 1124, pgs. 525-535
- Pacifici, M., Shimo, T., Gentili, C., Kirsch, T., Freeman, T.A., Enomoto-Iwamoto, M., Iwamoto, M., Koyama, E. (2005) Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletonogenesis. J. Bone Miner Metab 23:191-199 2005
- Shapiro, I.M., Adams, C.S., Freeman, T., and Srinivas, V., The fate of the hypertrophic chondrocyte: Microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. (2005) Birth Defects Research Part C: Embryo Today: Reviews. 75(4): 330-339
- Szymczyk, K, Kerr BAE, Freeman, TA, Adams, CS, Steinbeck, MJ (2006) Involvement of Hydrogen Peroxide in the Differentiation and Apoptosis of Preosteoclastic Cells Exposed to Arsenite, Biochem Pharmacol. Sep 14;72(6):761-9.
- Szymczyk, K, Freeman, TA, Adams, C, Srinivas, V, Steinbeck, MJ (2006) Active Caspase-3 is Required for Osteoclast Differentiation, J.of Cell. Phys. Dec; 209(3):836-44
- Shapiro, I.M., Adams, C.S., Srinivas, V., and Freeman, T.A..: Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface. In: Bone and Osteoarthritis (2006) Topics in Bone Biology Vol 4, F. Bronner and M.C. Farach-Carson, eds.
- Jacob S, C Wu, TA Freeman, E Koyama, RE Kirschner, Expression of Indian hedgehog, BMP-4 and Noggin in craniosynostosis induced by fetal constraint. (2007) Ann Plast Surg. Feb; 58(2):215-221
- Pucci, B., Adams, C. S., Fertala, J, Snyder, B. C., Mansfield, K. D., Tafani, M, Freeman, T Shapiro, I. M. Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation. (2007) J Cell Physiol. Mar; 210(3):609-15.
- Han, F., Gilbert, J. R., Adams, C.S., Harrison, G., Freeman, T., Tao, Z., Zaka, R., Liang H., Williams, C., Tuan, R. S., Norton, P. A., Hickok, N.J. Transforming Growth Factor s1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation. (2007). Exper. Cell Res. May 1;313(8):1518-32
- Antoci V. Jr, King S.B., Jose B., Parvizi J., Zeiger A.R., Wickstrom E., Freeman T.A., Composto R.J., Ducheyne P., Shapiro I.M., Hickok N.J., Adams C.S. (2007) Vancomycin covalently bonded to titanium alloy prevents bacterial colonization. J. Orthop. Res. Jul;25(7):858-66.
- Kerr, B.A., Otani, T., Koyama, E., Freeman, T.A., Enomoto-Iwamoto, M., (2008) Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes. Exp Cell Res. Jan 18; [Epub ahead of print]
- Watanabe H, Bohensky J, Freeman T, Srinivas V, Shapiro IM (2008) Hypoxic induction of UCP3 in the growth plate: UCP3 suppresses chondrocyte autophagy. J Cell Physiol. Aug;216(2):419-25
- Antoci, V, Adams, CS, Parvizi, J, Davidson, HM, Composto, RJ, Freeman, TA, Wickstrom, E, Ducheyne, P, Jungkind, D, Shapiro, IM, Hickok, NJ (2008) The inhibition of staphylococcus epidermidis biofilm formation by vancomycin-modified Ti alloy and iImplications for the treatment of periprosthetic infection. Biomaterials, Dec;29(35): 4684-90. Epub 2008 Sep 23.
- Freeman, TA, Patel, P, Antoci V. Jr., Shapiro IM (2009) MicroCT Analysis with Multiple Thresholds Allows Detection of Bone Remodeling Events During Ultrasound-Treated Fracture Healing. J Orthop Res. J Orthop Res. May;27(5):673-9.
- Adams, CS, Antoci, V Jr, Harrison, G, Patal, P, Freeman, TA, Shapiro, IM, Parvizi, J, Hickock, NJ, Radin, S, Ducheyne, P (2009) Controlled Release of Vancomycin from Thin Sol-Gel Films on Implant Surfaces Successfully Inhibits Osteomyelitis. J Orthop Res. Jun;27(6):701-9
- Bohensky, J, Terkhorn, S P, Freeman, T, Adams, C S, Garcia, J, Shapiro, I M, Srinivas V
- Regulation of Autophagy in Cartilage: HIF-2 Suppresses Chondrocyte Autophagy (2009) Arthrit. and Rheum., May;60(5):1406-15.
- Zaka R, Dion AS, Kusnierz A, Bohensky J, Srinivas V, Freeman TA, Williams CJ. (2009) Oxygen tension regulates the expression of ANK (progressive ankylosis) in a HIF-1 dependent manner in growth plate and articular chondrocytes. J Bone Min Res Nov;24(11):1869-78
- Steinbeck, M.J., Baxter, R.M., and Freeman, T.A..: Pathophysiologic Reactions to UHMWPE Wear Particles. In: The UHMWPE Biomaterials Handbook, 2nd Edition (2009) SM Kurtz, ed.
- Freeman TA, Parvizi J, Della Valle CJ, Steinbeck MJ.(2009)Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty. Fibrogenesis Tissue Repair. 2009 Nov 13;2(1):5. [Epub ahead of print]
- * Chromosoma paper of the year, 1998
- ** joint first author
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Individual Expertise profile of
Theresa A. Freeman, PHD, Copyright © Theresa A. Freeman, PHD.
Last Updated
by Theresa Freeman, PHD : Friday, November 20, 2009 3:29:13 PM
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